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Search Results: 1 - 10 of 325697 matches for " Vineet S Mahajan "
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Complete radiological clearance in bilateral loculated pyopneumothorax managed conservatively
Verma S,Mahajan Vineet
Lung India , 2009,
Abstract: We are reporting a case of bilateral loculated pyopneumothorax in a 30-year-old male patient, who was treated conservatively with antibiotics alone, and had complete radiological clearance.
Purification and characterization of an extreme halothermophilic protease from a halophilic bacterium Chromohalobacter sp. TVSP101
Vidyasagar, Malashetty;Prakash, S.;Mahajan, Vineet;Shouche, Yogesh S.;Sreeramulu, K.;
Brazilian Journal of Microbiology , 2009, DOI: 10.1590/S1517-83822009000100002
Abstract: an extreme halophilic bacterium was isolated from solar saltern samples and identified based on biochemical tests and 16s r rna sequencing as chromohalobacter sp. strain tvsp101. the halophilic protease was purified using ultrafiltration, ethanol precipitation, hydrophobic interaction column chromatography and gel permeation chromatography to 180 fold with 22% yield. the molecular mass of the protease determined by sds page was 66 kda. the purified enzyme was salt dependent for its activity and stability with an optimum of 4.5 m nacl. the optimum temperature for maximum protease activity was 75°c. the protease was optimally active at ph 8 and retained more than 80% of its activity in the range of ph 7-10. sucrose and glycine at 10% (w/v) were the most effective osmolytes, retained 100% activity in the absence of nacl. the activity was completely inhibited by zncl2 (2 mm), 0.1% sds and pmsf (1mm). the enzyme was not inhibited by 1mm of pepstatin, edta and pcmb. the protease was active and retained 100% it activity in 10% (v/v) dmso, dmf, ethanol and acetone.
Tuberculous otitis media with postaural abscess and submandibular lymphadenopathy
Verma Sanjeev,Mahajan Vineet,Srivastava Anand
Lung India , 2009,
Abstract: We are reporting a case of right-sided tuberculous otitis media with postaural abscess and multiple submandibular lymphadenopathy which has been reported very infrequently. A high level of suspicion by the treating physician is mandatory to avoid long delay in diagnosis and increased complications in the modern chemotherapy era.
Diffuse alveolar hemorrhage in Wegener′s granulomatosis
Mahajan Vineet,Whig Jagdeep,Kashyap Anil,Gupta Sushil
Lung India , 2011,
Abstract: Diffuse alveolar hemorrhage is a life-threatening though rare manifestation of Wegener′s granulomatosis (WG). An active diagnostic workup, intensive observation, and aggressive immunosuppressive treatment are cornerstones of the management. The treatment modalities available for such complications are pulse cyclophosphamide therapy with steroids. We report here a case of WG with diffuse alveolar hemorrhage as the first manifestation of the disease in life that responded to steroids and cyclophosphamide.
Erythema nodosum: Atypical presentation of common disease
Whig Jagdeep,Mahajan Vineet,Kashyap Anil,Gupta Sushil
Lung India , 2010,
Abstract: Tuberculosis is a very common disease often presenting in an uncommon form. High level of suspicion is required to diagnose it, thereby preventing its morbidity and mortality. We present a case of young female with multiple tuberculo-protein hypersensitivity reactions without any evidence of active tuberculosis in the body.
Generation, annotation, and analysis of ESTs from midgut tissue of adult female Anopheles stephensi mosquitoes
Deepak P Patil, Santosh Atanur, Dhiraj P Dhotre, D Anantharam, Vineet S Mahajan, Sandeep A Walujkar, Rakesh K Chandode, Girish J Kulkarni, Pankaj S Ghate, Abhishek Srivastav, Kannayakanahalli M Dayananda, Neha Gupta, Bhakti Bhagwat, Rajendra R Joshi, Devendra T Mourya, Milind S Patole, Yogesh S Shouche
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-386
Abstract: We obtained 7061 and 8306 ESTs from the sugar-fed and P. yoelii infected mosquito midgut tissue libraries, respectively. ESTs from the combined dataset formed 1319 contigs and 2627 singlets, totaling to 3946 unique transcripts. Putative functions were assigned to 1615 (40.9%) transcripts using BLASTX against UniProtKB database. Amongst unannotated transcripts, we identified 1513 putative novel transcripts and 818 potential untranslated regions (UTRs). Statistical comparison of annotated and unannotated ESTs from the two libraries identified 119 differentially regulated genes. Out of 3946 unique transcripts, only 1387 transcripts were mapped on the A. gambiae genome. These also included 189 novel transcripts, which were mapped to the unannotated regions of the genome. The EST data is available as ESTDB at http://mycompdb.bioinfo-portal.cdac.in/cgi-bin/est/index.cgi webcite.3946 unique transcripts were successfully identified from the adult female A. stephensi midgut tissue. These data can be used for microarray development for better understanding of vector-parasite relationship and to study differences or similarities with other malaria vectors. Mapping of putative novel transcripts from A. stephensi on the A. gambiae genome proved fruitful in identification and annotation of several genes. Failure of some novel transcripts to map on the A. gambiae genome indicates existence of substantial genomic dissimilarities between these two potent malaria vectors.Anopheles stephensi is a major malaria vector in the Indian subcontinent [1]. Rapid urbanization and development in the region has stimulated a corresponding increase in their population resulting in frequent malaria outbreaks [2]. Although, recent malaria epidemics occurred at higher frequencies, mortality was considerably low. For example during 2003, of the reported 1.78 million cases, only 1006 deaths were recorded in India [3].Absence of an efficient vaccine [4], evolution of drug-resistance in the parasites [5]
Green oxidations: Titanium dioxide induced tandem oxidation coupling reactions
Vineet Jeena,Ross S. Robinson
Beilstein Journal of Organic Chemistry , 2009, DOI: 10.3762/bjoc.5.24
Abstract: The application of titanium dioxide as an oxidant in tandem oxidation type processes is described. Under microwave irradiation, quinoxalines have been synthesized in good yields from the corresponding α-hydroxyketones.
Leptospirosis : A Re-emerging Disease
Mahajan,S and Chhabra,Daljeet
Veterinary World , 2008,
Abstract: [Veterinary World 2008; 1(6.000): 182-185]
Invitro activity of Framycetin and Gentamicin against microbes producing ocular infection
Mahajan V,Angra S
Indian Journal of Ophthalmology , 1976,
Abstract:
SYNTHESIS AND EVALUATION OF NOVEL THIAZOLIDINEDIONES FOR ANTI INFLAMMATORY ACTIVITY
Rekha S,Shantharam U,Vineet chandy
International Research Journal of Pharmacy , 2011,
Abstract: The aim of our study was to review on synthesis and various pharmacological activities associated with thaizolidinediones. Thiazolidinediones (TZDs) or glitazones forms a significant class of drugs which exhibit an array of biological activities ranging from anti diabetic, anti-inflammatory, antibacterial, antifungal, antiviral and anticancer. 1, 3-Thiazolidine-2, 4-dione contains basic skeleton of thiazole or thiazolidine. Presence of one carbonyl group in thiazole at 4th position makes it thiazolidine-4-one which is known for various activities, such as anti-inflammatory and presence of another carbonyl group at 2nd position makes it thiazolidine-2, 4-dione which is basically known for its antidiabetic activity. Various studies report the effects of TZDs on the metabolism of lipids, on cell differentiation and on some cardiovascular risk factors. Success of thiazolidinediones (TZDs), the ligand of peroxisome proliferator-activated receptor γ (PPARγ) has generated a lot of interest for new drug discovery. In the present study we were reporting a systematic synthesis of thiazolidinediones analogues. The basic ring of thiazolidinedione was prepared by 1, 3 dipolar cycloaddition reaction using thiourea and monochloroaceticacid. Knoevenagel condensation with substituted aromatic aldehydes was carried out to yield various substituted benzylidenethiazolidine-2, 4-dione. These were subjected to further alkylation and/or substitution reaction to yield our targets compound as described in scheme 1. The synthesized molecules were screened for bovine serum denaturation (in vitro). Characterization was done by using various physicochemical and spectral techniques. All molecules were weakly active in bovine serum denaturation assay.
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