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Search Results: 1 - 10 of 21481 matches for " Vinay Kumar Nandicoori "
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Localization of Nucleoporin Tpr to the Nuclear Pore Complex Is Essential for Tpr Mediated Regulation of the Export of Unspliced RNA
Kalpana Rajanala, Vinay Kumar Nandicoori
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029921
Abstract: Nucleoporin Tpr is a component of the nuclear pore complex (NPC) that localizes exclusively to intranuclear filaments. Tpr functions as a scaffolding element in the nuclear phase of the NPC and plays a role in mitotic spindle checkpoint signalling. Export of intron-containing mRNA in Mason Pfizer Monkey Virus is regulated by direct interaction of cellular proteins with the cis-acting Constitutive Transport Element (CTE). In mammalian cells, the transport of Gag/Pol-CTE reporter construct is not very efficient, suggesting a regulatory mechanism to retain this unspliced RNA. Here we report that the knockdown of Tpr in mammalian cells leads to a drastic enhancement in the levels of Gag proteins (p24) in the cytoplasm, which is rescued by siRNA resistant Tpr. Tpr's role in the retention of unspliced RNA is independent of the functions of Sam68 and Tap/Nxf1 proteins, which are reported to promote CTE dependent export. Further, we investigated the possible role for nucleoporins that are known to function in nucleocytoplasmic transport in modulating unspliced RNA export. Results show that depletion of Nup153, a nucleoporin required for NPC anchoring of Tpr, plays a role in regulating the export, while depletion of other FG repeat-containing nucleoporins did not alter the unspliced RNA export. Results suggest that Tpr and Nup153 both regulate the export of unspliced RNA and they are most likely functioning through the same pathway. Importantly, we find that localization of Tpr to the NPC is necessary for Tpr mediated regulation of unspliced RNA export. Collectively, the data indicates that perinuclear localization of Tpr at the nucleopore complex is crucial for regulating intron containing mRNA export by directly or indirectly participating in the processing and degradation of aberrant mRNA transcripts.
Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen
Vijay Soni?,Sandeep Upadhayay?,Priyanka Suryadevara?,Ganesh Samla?,Archana Singh?,Perumal Yogeeswari?,Dharmarajan Sriram?,Vinay Kumar Nandicoori
PLOS Pathogens , 2015, DOI: 10.1371/journal.ppat.1005235
Abstract: M. tuberculosis N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmUMtb) is a bi-functional enzyme engaged in the synthesis of two metabolic intermediates N-acetylglucosamine-1-phosphate (GlcNAc-1-P) and UDP-GlcNAc, catalyzed by the C- and N-terminal domains respectively. UDP-GlcNAc is a key metabolite essential for the synthesis of peptidoglycan, disaccharide linker, arabinogalactan and mycothiols. While glmUMtb was predicted to be an essential gene, till date the role of GlmUMtb in modulating the in vitro growth of Mtb or its role in survival of pathogen ex vivo / in vivo have not been deciphered. Here we present the results of a comprehensive study dissecting the role of GlmUMtb in arbitrating the survival of the pathogen both in vitro and in vivo. We find that absence of GlmUMtb leads to extensive perturbation of bacterial morphology and substantial reduction in cell wall thickness under normoxic as well as hypoxic conditions. Complementation studies show that the acetyl- and uridyl- transferase activities of GlmUMtb are independently essential for bacterial survival in vitro, and GlmUMtb is also found to be essential for mycobacterial survival in THP-1 cells as well as in guinea pigs. Depletion of GlmUMtb from infected murine lungs, four weeks post infection, led to significant reduction in the bacillary load. The administration of Oxa33, a novel oxazolidine derivative that specifically inhibits GlmUMtb, to infected mice resulted in significant decrease in the bacillary load. Thus our study establishes GlmUMtb as a strong candidate for intervention measures against established tuberculosis infections.
Time-Frequency Analysis of Asymmetric Triaxial Galaxy Model Including Effect of Spherical Dark Halo Component  [PDF]
Beena R. Gupta, Vinay Kumar
International Journal of Astronomy and Astrophysics (IJAA) , 2015, DOI: 10.4236/ijaa.2015.52014
Abstract: A method of time-frequency analysis (TFA) based on wavelets is applied to study the phase space structure of three-dimensional asymmetric triaxial galaxy enclosed by spherical dark halo component. The investigation is carried out in the presence and absence of dark halo component. Time-frequency analysis is based on the extraction of instantaneous frequency from the phase of the continuous wavelet transform. This method is comparatively fast and reliable. This method can differentiate periodic from quasi-periodic, chaotic sticky from chaotic non-sticky, ordered from chaotic and also, it can accurately determine the time interval of the resonance trapping and transitions too. Apart from that, the phenomenon of transient chaos can be explained with the help of time-frequency analysis. Comparison with the method of total angular momentum (denoted as Ltot) proposed recently is also presented.
Smartphone Based Fall Detection and Logic Testing Application Using Android SDK  [PDF]
Vinay Kumar Suryadevara, Maher Rizkalla
Journal of Biomedical Science and Engineering (JBiSE) , 2015, DOI: 10.4236/jbise.2015.89057
Abstract: Smart systems aimed at detecting the fall of a person have increased significantly due to recent technological advances and availability of modular electronics. This work presents the use of embedded accelerometer and gyroscope in mobile phones to accurately detect and classify the type of fall a person is experiencing before suffering an impact. Early classification of fall type helps in optimizing the algorithm of the fall detection. User acceptance, feasibility and the limitations in the accuracy of the existing devices have also been considered in this study. High efficiency and low power approaches were emphasized with wireless capability that enhanced the system performance for variety of applications. There is a need of reducing the time for analyzing the smart algorithms designed. It is also emphasized that this application will be a good platform that can be used to test various algorithms and multiple sensors at a time with ease and obtain data analysis in a short period.
Knowledge Management through Technology: Exploring Extant Research Using nVivo  [PDF]
Vinay Kumar Sharma, Madhurima Deb
Theoretical Economics Letters (TEL) , 2019, DOI: 10.4236/tel.2019.94050
Abstract: This research paper aims to systematically explore the knowledge management and knowledge management system through technology by performing a rigorous and computer assisted review. The research attempts to further the understanding of issued and innovations related to knowledge management in organizations and helps us see the future avenues in this field. The key contribution of this research is its computer based qualitative content analysis across genres to attain the above objectives. The finding of the study suggests that Knowledge Management is spread across three factors namely, 1) Knowledge acquisition, 2) Knowledge application, and 3) Knowledge storage. These three factors are linked to IT platform or technology then it leads to dissemination, awareness, accessibility etc of the Knowledge.
Mathematics Is Science: A Topic Revisited in Context of FCS of India
Vinay Kumar
International Journal of Modern Education and Computer Science , 2012,
Abstract: Mathematics is universally accepted as mother of all science. Despite that, Department of Personnel and Training (DOPT) has recently issued a circular mentioning that a person having master degree in mathematics cannot be considered for the post of scientists. The open question of ‘Is mathematics a science?’ is revisited in this paper under the new perspective to explore scientific practices that sans mathematics arrived knocking, challenging basic understanding of precision and practical sense that makes science. Considering the fact that in India, most crucial policy decisions at a higher level of abstraction in every conceivable arena of our national life are taken by either GOM (Group of Ministers) or GOS (Group of Secretaries), apprehension raises a basic query 'Who decides?' Some decision causes much unexpected consequence, which is noticed when it takes its toll and becomes virtually irreversible. This recent decision of Flexible Complementing Scheme (FCS), wherein mathematics is not considered as science, has potential to damage the very scientific culture and practices in India. This paper is an attempt to place mathematics in its right perspective and to highlight the damage that this decision might do. The paper also suggests ways to control the damage.
Restricted Backtracked Algorithm For Hamiltonian Circuit in Undirected Graph
Vinay Kumar
BVICAM's International Journal of Information Technology , 2010,
Abstract: While determining whether a graph is Hamiltonian, it is enough to show existence of a Hamiltonian cycle in it. An algorithm based on restricted backtracking is presented in the paper that uses tie breaking rules to reduce the possible number of backtrackings. If x is any intermediate node in HC then once its neighbour y has been visited from x, x is no longer required so drop it and process is continued on the remaining subgraph. Each node is visited exactly once in a HC except the start node. Adjacency matrix is used to encode the graph. Prevention of backtracking is achieved up to next node from start node. From third node onward, wherever it is not possible to break tie uniquely, a provision for backtracking is kept only for tied nodes. Time complexity of algorithm is O(n4)*B(n) in the worst case where B(n) is a factor due to possible backtracking. It returns O(n2) in the best case and O(n3)*B(n) on the average.
Phosphorylation of Mycobacterium tuberculosis Ser/Thr Phosphatase by PknA and PknB
Andaleeb Sajid,Gunjan Arora,Meetu Gupta,Sandeep Upadhyay,Vinay K. Nandicoori,Yogendra Singh
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017871
Abstract: The integrated functions of 11 Ser/Thr protein kinases (STPKs) and one phosphatase manipulate the phosphorylation levels of critical proteins in Mycobacterium tuberculosis. In this study, we show that the lone Ser/Thr phosphatase (PstP) is regulated through phosphorylation by STPKs.
Modified Efficient Families of Two and Three-Step Predictor-Corrector Iterative Methods for Solving Nonlinear Equations  [PDF]
Sanjeev Kumar, Vinay Kanwar, Sukhjit Singh
Applied Mathematics (AM) , 2010, DOI: 10.4236/am.2010.13020
Abstract: In this paper, we present and analyze modified families of predictor-corrector iterative methods for finding simple zeros of univariate nonlinear equations, permitting near the root. The main advantage of our methods is that they perform better and moreover, have the same efficiency indices as that of existing multipoint iterative methods. Furthermore, the convergence analysis of the new methods is discussed and several examples are given to illustrate their efficiency.
Routing in IPv6 over Low-Power Wireless Personal Area Networks (6LoWPAN): A Survey
Vinay Kumar,Sudarshan Tiwari
Journal of Computer Networks and Communications , 2012, DOI: 10.1155/2012/316839
Abstract: 6LoWPANs (IPv6-based Low-Power Personal Area Networks) are formulated by devices that are compatible with the IEEE 802.15.4 standard. To moderate the effects of network mobility, the Internet Protocol (IP) does not calculate routes; it is left to a routing protocol, which maintains routing tables in the routers. 6LowPAN uses an adaptation layer between the network (IPv6) and data link layer (IEEE802.15.4 MAC) to fragment and reassemble IPv6 packets. The routing in 6LoWPAN is primarily divided on the basis of routing decision taken on adaptation or network layer. The objective of this paper is to present a state-of-the-art survey of existing routing protocols: LOAD, M-LOAD, DYMO-Low, Hi-Low, Extended Hi-Low, and S-AODV. These routing protocols have compared on the basis of different metric like energy consumption, memory uses, mobility, scalability, routing delay, an RERR message, a Hello message, and local repair. We have also presented the taxonomy of routing requirement; parameter for evaluating routing algorithm, and it was found that the routing protocol has its own advantages depending upon the application where it is used. 1. Introduction 6LoWPANs are formed by devices that are compatible with the IEEE 802.15.4. However, ZigBee uses the IEEE 802.15.4 standard as its communication protocol for Medium Access Control (MAC) layer and Physical (PHY) layer. IEEE 802.15.4 devices are characterized by low computational power, scarce memory capacity, lower bit rate, short range, and low cost [1]. LoWPAN have devices that work together and connect the physical working environment to real-world applications like sensors with wireless application. Some protocols exist in sensor networks that have a non-IP network layer protocol such as ZigBee, where the TCP/IP protocol is not used. As node density in sensor networks increases and these networks required connection with other networks via internet, then Internet Engineering Task Force (IETF) [2] defines IPv6 over LoWPAN as techniques to implement the TCP/IP protocol in WSNs [3]. 6LoWPAN provides a WSN node with IP communication capabilities by putting an adaptation layer above the IEEE 802.15.4 link layer for the packet fragmentation and reassembly purpose [4–6]. IP routing protocols are used to maintain routing tables on IP routers which indicates on which next-hop forwarding decision should be made for the destination of an IP packet. In this paper, we have surveyed a number of existing routing protocols in 6LoWPAN like: LOAD (6LoWPAN Ad-hoc On-Demand Distance Vector), MLOAD (Multipath-based 6LoWPAN Ad-hoc
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