oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Search Results: 1 - 10 of 1040 matches for " Vijayashree Murthy "
All listed articles are free for downloading (OA Articles)
Page 1 /1040
Display every page Item
Skin Sparing Mastectomy in Locally Advanced Breast Cancer: A Possibility?  [PDF]
Vijayashree Murthy, K. S. Gopinath, Anand Krishna
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.34044
Abstract: Breast cancer is the second most common cause of cancer death in women in India in spite of advances in the adjuvant treatment of breast cancer. Locally advanced breast cancer (LABC) still represents the major presenting picture in many urban and rural institutions in our country. Skin Sparing Mastectomy (SSM) and primary reconstruction is a popular option for patients with breast cancer. There are similar local and distant recurrences in SSM compared to the traditional non-skin sparing mastectomy. A 57-year-old lady presented with a locally advanced left breast cancer. After undergoing neoadjuvant chemotherapy and a PET-CT to accurately detect residual disease in breast and axilla, she underwent skin sparing mastectomy with nipple-areola complex preservation and primary reconstruction with silicon prosthesis implant over a latissimus dorsi myocutaneous flap for primary reconstruction. SSM in LABC has not been reported in the literature so far. This patient is disease free for the past 24 months.
Males at High Risk for Breast Cancer: Who Are They and How Should We Screen Them?  [PDF]
Natalie Swergold, Vijayashree Murthy, Ronald S. Chamberlain
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.57054
Abstract:

Background: It is estimated that 2240 males in the United States will develop invasive breast cancer (BC) in 2013, resulting in 410 deaths. Overall, male breast cancers (MBCs) are diagnosed with larger tumor size, more frequent lymphatic invasion, and advanced tumor stage compared to their female counterparts. Several risk factors have been elucidated for the development of MBC, and this paper aims to critically review the existing literature on at-risk populations and provide screening recommendations. Methods: A comprehensive search for all published studies on populations at risk for MBC using PubMed, EBSCOhost, and Google Scholar was performed (1982- 2013). The search focused specifically on genetic and epidemiologic risk factors, and screening for MBC. Keywords searched included “male breast cancer risk factors”, “male breast cancer epidemiology”, and “male breast cancer genetics”. A total of 34 studies involving 4,865,819 patients were identified. Results: Five studies (N = 327,667) focused primarily on family history of breast cancer as a risk factor for MBC. 15% - 20% of men with BC have a family history of breast or ovarian cancer, and a family history of BC among first-degree relatives confers a 2-to 3-fold increase in MBC risk (odds ratio = 3.3). Seventeen studies (N = 5451) analyzed associations between several heritable genes and MBC. Lifetime MBC risk among BRCA1 mutation carriers is 1% - 5%, while MBC risk in BRCA2 mutation carriers is higher and varies between 4% - 40%. Less clear associations between MBC and PALB2, Androgen Receptor gene, CYP17, and CHEK2 mutations have also been documented. Five studies (N = 16,667) have addressed occupational risk factors for MBC. An 8-fold increase in MBC is reported in males working in the cosmetic cream manufacturing, and the motor vehicle industries. A meta-analysis of 18 trials also identified electromagnetic field exposure as a potential MBC risk, though causation remains undocumented. Eleven studies (N = 4,843,598) analyzed the role of abnormalities in the androgen-to-estrogen ratio as a risk factor for MBC. Conditions associated with increased MBC risk include Klinefelter’s syndrome (relative risk, RR = 29.64), obesity (RR = 1.98), orchitis/epididymitis (RR = 1.84), and gynecomastia (RR = 5.86). Conclusion: Routine screening for MBC should be considered in all high risk male populations, including those with a prior history of breast carcinoma, a strong family history of BC

The Impact of Ethnicity on the Incidence, Tumor Characteristics and Treatment of Ductal Carcinoma in Situ—An 11-Year Clinical Experience at a High Volume Teaching Hospital  [PDF]
Lauren S. Sparber, Vijayashree Murthy, Ronald S. Chamberlain
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.78050
Abstract: Introduction: Screening mammography has led to a marked increase in detection of in situ breast tumors in the United States. The University of Southern California/Van Nuys Prognostic Index (USC/VNPI) predicts the recurrence rates of ductal carcinoma in situ (DCIS); however variations in tumor characteristics, USC/VNPI scores, receptor and human epithelial growth factor receptor (HER)-2/neu status across different ethnicities/races have not been well studied. This study aimed to evaluate the racial trends in incidence, patient demographics, tumor characteristics and treatment variations for patients with DCIS at a high volume teaching hospital. Methods: 395 women underwent surgical intervention for DCIS between 2000 and 2011. Their race/ethnicity was divided into five mutually exclusive categories and demographic and clinicopathological data was collected. Multivariate analysis was performed to evaluate variations in patient and tumor factors with respect to age, size and surgical management among different ethnicities and races. Results: 82.1% of Caucasian women underwent simple mastectomy with sentinel lymph node biopsy (SLNB) while lumpectomy with SLNB was highest in Hispanics (40%, p = 0.005). Overall, there was no significant difference in the incidence of receptor or HER-2/neu
Multidisciplinary Breast Conference Improves Patient Management and Treatment  [PDF]
Vijayashree Murthy, Silvana Nobre, Lauren Sparber, Sarah Schaefer, Elissa Santoro, Janette McDermott, Ronald Chamberlain, Michele Blackwood
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.57053
Abstract:

Introduction: Multidisciplinary breast conference (BC) that discusses different clinicopathological aspects of disease creates a sound, complete and unique treatment plan for each patient. The aim of this study was to investigate the role of weekly breast tumor boards in patient management and treatment modifications. Methods: From June 2010 to June 2011, 242 patients (Stage 0 to Stage 4 breast cancer) were prospectively presented before a multidisciplinary team. Presentation included clinical data, imaging and pathological review followed by prospective treatment plan formulated by the physician group. If postoperative presentation, final histopathology of the tumor and adjuvant treatment relevant to each patient was discussed. Breast conference was performed via teleconference, including video projection of pathology slides and images. Feedback evaluations were completed and returned to the Tumor Registry for consistent weekly improvement of BC. Results: 102 patients (42%) had modified management after being presented at BC,  38% (n = 39) surgical, 33% (n = 34) medical (chemotherapy/endocrine therapy), 17% (n = 17) radiation, 6% (n = 6) both medical and radiation treatment and 6% (n = 6) imaging changes. Majority of changes were made to patients with Stage IA (27%) followed by Stage 0 (21%) breast cancer. Conclusion: Breast conference presents a significant impact on patient management and serves as a model for best practice in cancer care. Consultative discussion of each case permits every team member to be acutely aware of the patient’s condition, contribute to treatment plan and permit a harmonious and cooperative team approach while assuring best treatment for the patient.

Primary Myeloid Sarcoma Masquerading as an Obstructing Duodenal Carcinoma
Preeti Narayan,Vijayashree Murthy,Mu Su,Rosemonde Woel,I. Robert Grossman,Ronald S. Chamberlain
Case Reports in Hematology , 2012, DOI: 10.1155/2012/490438
Abstract: Myeloid Sarcoma (MS), a rare extra hematopoietic carcinoma composed of blast cells, is located primarily in extramedullary sites such as skin, soft tissue, lymph nodes, and bone. MS usually presents in the setting of coexisting acute myeloid leukemia (AML) and myeloproliferative disorders. Gastrointestinal involvement (GI) is extremely rare from nonspecific abdominal symptoms to obstruction. Eight cases of myeloid sarcoma involving the duodenum including the current case have been reported, overall mean age being 40 years (range 17–71) and M : F ratio 7 : 1. The prognosis of patients with de novo MS cases has been reported to be better than those who have a coexisting leukemia. MS is a rare extramedullary tumor, which should be considered in the differential diagnosis of a soft tissue mass involving the duodenum, especially if there is a coexisting hematological disorder. De novo cases often progress to AML, and current therapy involves Daunorubicin- and Cytarabine-based chemotherapy. The wide cytogenetic and molecular heterogeneity of MS implies a potential role for more targeted MS therapies, which may offer a curative strategy.
Primary Myeloid Sarcoma Masquerading as an Obstructing Duodenal Carcinoma
Preeti Narayan,Vijayashree Murthy,Mu Su,Rosemonde Woel,I. Robert Grossman,Ronald S. Chamberlain
Case Reports in Hematology , 2012, DOI: 10.1155/2012/490438
Abstract: Myeloid Sarcoma (MS), a rare extra hematopoietic carcinoma composed of blast cells, is located primarily in extramedullary sites such as skin, soft tissue, lymph nodes, and bone. MS usually presents in the setting of coexisting acute myeloid leukemia (AML) and myeloproliferative disorders. Gastrointestinal involvement (GI) is extremely rare from nonspecific abdominal symptoms to obstruction. Eight cases of myeloid sarcoma involving the duodenum including the current case have been reported, overall mean age being 40 years (range 17–71) and M?:?F ratio 7?:?1. The prognosis of patients with de novo MS cases has been reported to be better than those who have a coexisting leukemia. MS is a rare extramedullary tumor, which should be considered in the differential diagnosis of a soft tissue mass involving the duodenum, especially if there is a coexisting hematological disorder. De novo cases often progress to AML, and current therapy involves Daunorubicin- and Cytarabine-based chemotherapy. The wide cytogenetic and molecular heterogeneity of MS implies a potential role for more targeted MS therapies, which may offer a curative strategy. 1. Introduction Myeloid sarcomas (MS) are rare and potentially destructive extramedullary tumors consisting of immature myeloid cells that most often present in the skin, soft tissues, bone, and lymph nodes [1, 2]. Although MS was first described in 1911 by Burns, it has come to be referred to by many names [3]. The name “chloroma” was termed by King (1953), when he described multiple tumors with green color secondary to the presence of myeloperoxidase [4]. MS was coined “granulocytic sarcoma” by Rappaport, when he described tumors made up of granulocytes [5]. Today myeloid sarcoma is the preferred pathological term to describe tumors composed primarily of blast cells. These terms are also more reflective of the fact that many of the tumors are not green and have a white or pink color depending on their state of oxidation. Many MS patients (if not most) have either a coexisting acute myeloid leukemia (AML), myeloproliferative, or myelodysplastic disorder at the time of diagnosis, or it appears at the first sign of relapse from one of these disorders. In rare cases, MS occurs de novo with no evidence of bone marrow involvement as seen in the current case. We report the case of a de novo MS presenting as a compressive mass involving the 3rd portion of the duodenum in a 48-year-old man who presented with nausea and vomiting. A comprehensive review of the literature with similar clinical presentation, diagnosis, management, and
Privacy Policies Considerations in Socio-Technical Systems  [PDF]
Murthy Rallapalli
Technology and Investment (TI) , 2012, DOI: 10.4236/ti.2012.32009
Abstract: The idea of a socio-technical system (STS) is an intellectual tool to help recognize patterns in the way technology is used and produced. Identification of these patterns will help in analyzing the ethical issues associated with the technology-and-its-social-system [1]. By way of example, consider a relatively simple technology: a set of twenty laptops connected by a local area network. The social and ethical issues associated with these networked devices will change dramatically depending upon the socio-technical system in which they are embedded. Few technologies have ever had the capability of gathering information (with or without the user’s knowledge) as effectively as the World Wide Web. Internet has the greatest potential of targeting precise marketing demographics. Internet is also capable of disseminating information widely and quickly. This paper will study the role of privacy policies in web based socio-technical systems. This paper will research the role played by privacy policies in web user adaptation in the context of web based sociotechnical systems.
LOCUS OF CONTROL AND JOB SATISFACTION: PSU EMPLOYEES
Lakshman Vijayashree,Mali Vishalkumar Jagdischchandra
Serbian Journal of Management , 2011,
Abstract: Previous research studies have demonstrated that internal/external locus of control impacts jobsatisfaction. The present study thus aims to analyze type of locus of control and its relation with jobsatisfaction. The study will be of great help for organization to understand and know what type oflocus of control their employees has and how it has an impact on job satisfaction.The objectives of this study were: 1- To identify the type of Locus of Control (i.e. Internal orExternal) present in Public Sector Units (PSU) in Bangalore and 2- To analyze the impact of differenttype of Locus of Control on job satisfaction of PSU Employees. Further hypothesis was also set tocheck the relationship between locus of control and job satisfaction. In addition, the relationshipbetween different demographic factors was also examined. The tool used for this study was LocoInventory. The concept of locus of control by Levenson (1972) was used to develop Loco Inventory(Locus of Control in Organization Inventory). The survey used a questionnaire, which had thirty fivestatements which highlights the factors that determine the locus of control and job satisfaction levelof the employees. The Ratio, ANOVA, and Correlation analysis were used as statistical techniquesfor analysis.The results indicate that there is a positive correlation between internal locus of control and jobsatisfaction as well as between External (other) locus of control and job satisfaction. And in case ofExternal (Chance) locus of control and job satisfaction there exists partial positive correlation. As perthis study Job satisfaction level among the employees is also good as the mean is 17, which is closerto maximum scale value of 25. As per ANOVA table there is a significant variance betweeninternality and age as well as between externality (chance) and age. There is no significantrelationship between internality and demographic factors like gender and education. There is nosignificant relationship between externality (others) and demographic factors like gender, age andeducation. There is no significant relationship between externality (chance) and demographic factorslike gender and education.
Fluid queues driven by a discouraged arrivals queue
P. R. Parthasarathy,K. V. Vijayashree
International Journal of Mathematics and Mathematical Sciences , 2003, DOI: 10.1155/s0161171203203203
Abstract: We consider a fluid queue driven by a discouraged arrivals queue and obtain explicit expressions for the stationary distribution function of the buffer content in terms of confluent hypergeometric functions. We compare it with a fluid queue driven by an infinite server queue. Numerical results are presented to compare the behaviour of the buffer content distributions for both these models.
Housing Programs In Mandya District
C. N. Vijayashree And K. V. Aiyanna
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: The problem of housing is very common in developing countries. Though housing is an individualproblem, the affordability of constructing house is the major constraints. The poor people cannot afford to spendmoney for constructing houses. Therefore it is necessary that the state need to intervene in solving housing problem.In India right from the period of independence importance is given to the housing. Various housing policiesare launched to provide houses to the needy people. At present the Indira Awas Yojana and Ambedkar Awas Yojanaare the popularly known housing schemes implemented throughout India. These schemes are aiming to constructhouses to the SC/ST and OBCs.The study focused to analyse the housing programmes in Mandya District of Karnataka.
Page 1 /1040
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.