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Search Results: 1 - 10 of 211660 matches for " Victoria L. Revell "
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Efficacy of a Topical Aromatic Rub (Vicks VapoRub) on Effects on Self-Reported and Actigraphically Assessed Aspects of Sleep in Common Cold Patients  [PDF]
Nayantara Santhi, David Ramsey, Gill Phillipson, David Hull, Victoria L. Revell, Derk-Jan Dijk
Open Journal of Respiratory Diseases (OJRD) , 2017, DOI: 10.4236/ojrd.2017.72009
Common cold sufferers frequently report sleep disruption during the symptomatic period of infections. We examined the effects of treatment with a topical aromatic pharmaceutical ointment (Vicks VapoRub), on associated sleep disturbances. The effects of Vicks VapoRub versus placebo (petrolatum ointment) on subjective and objective measured sleep parameters were assessed in an exploratory study of 100 common cold patients, in a randomized, single blind, controlled, two-arm, parallel design study. The primary efficacy variable was subjective sleep quality measured with the SQSQ (Subjective Quality of Sleep Questionnaire). Additional measures included, ease of falling asleep and depth of sleep (measured with a post-sleep Visual Analog Scale), total sleep time, sleep onset latency, activity score, percentage of sleep, sleep efficiency (measured with actigraphy and SQSQ) and sleep quality index measured with a modified Karolinska Sleep Diary (KSD). The primary endpoint, “How was the quality of your sleep last night?” showed a statistically significant difference in change from baseline in favour of VapoRub treatment (p = 0.0392) versus placebo. Positive effects of VapoRub versus placebo were also observed for “How refreshed did you feel upon waking up?” (p = 0.0122) (SQSQ), “Did you get enough sleep?” (p = 0.0036) (KSD), “How was it to get up?” (p = 0.0120) (KSD) and “Do you feel well-rested?” (p = 0.0125) (KSD). No statistically significant changes from baseline versus placebo were detected in the Actiwatch endpoints. Vicks VapoRub when applied before retiring to bed can reduce subjective sleep disturbances during a common cold. The results of this exploratory study support the belief among patients that the use of VapoRub improves subjective sleep quality during common cold which was associated with more refreshing sleep.
The Physiological Period Length of the Human Circadian Clock In Vivo Is Directly Proportional to Period in Human Fibroblasts
Lucia Pagani,Ekaterina A. Semenova,Ermanno Moriggi,Victoria L. Revell,Lisa M. Hack,Steven W. Lockley,Josephine Arendt,Debra J. Skene,Fides Meier,Jan Izakovic,Anna Wirz-Justice,Christian Cajochen,Oksana J. Sergeeva,Sergei V. Cheresiz,Konstantin V. Danilenko,Anne Eckert,Steven A. Brown
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013376
Abstract: Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype (“larks” and “owls”), clock properties measured in human fibroblasts correlated with extreme diurnal behavior.
The sensitivity of stratospheric ozone changes through the 21st century to N2O and CH4
L. E. Revell, G. E. Bodeker, P. E. Huck, B. E. Williamson,E. Rozanov
Atmospheric Chemistry and Physics (ACP) & Discussions (ACPD) , 2012,
Abstract: Through the 21st century, anthropogenic emissions of the greenhouse gases N2O and CH4 are projected to increase, thus increasing their atmospheric concentrations. Consequently, reactive nitrogen species produced from N2O and reactive hydrogen species produced from CH4 are expected to play an increasingly important role in determining stratospheric ozone concentrations. Eight chemistry-climate model simulations were performed to assess the sensitivity of stratospheric ozone to different emissions scenarios for N2O and CH4. Global-mean total column ozone increases through the 21st century in all eight simulations as a result of CO2-induced stratospheric cooling and decreasing stratospheric halogen concentrations. Larger N2O concentrations were associated with smaller ozone increases, due to reactive nitrogen-mediated ozone destruction. In the simulation with the largest N2O increase, global-mean total column ozone increased by 4.3 DU through the 21st century, compared with 10.0 DU in the simulation with the smallest N2O increase. In contrast, larger CH4 concentrations were associated with larger ozone increases; global-mean total column ozone increased by 16.7 DU through the 21st century in the simulation with the largest CH4 concentrations and by 4.4 DU in the simulation with the lowest CH4 concentrations. CH4 leads to ozone loss in the upper and lower stratosphere by increasing the rate of reactive hydrogen-mediated ozone loss cycles, however in the lower stratosphere and troposphere, CH4 leads to ozone increases due to photochemical smog-type chemistry. In addition to this mechanism, total column ozone increases due to H2O-induced cooling of the stratosphere, and slowing of the chlorine-catalyzed ozone loss cycles due to an increased rate of the CH4 + Cl reaction. Stratospheric column ozone through the 21st century exhibits a near-linear response to changes in N2O and CH4 surface concentrations, which provides a simple parameterization for the ozone response to changes in these gases.
Memory transfer optimization for a lattice Boltzmann solver on Kepler architecture nVidia GPUs
Mark Mawson,Alistair Revell
Computer Science , 2013,
Abstract: The Lattice Boltzmann method (LBM) for solving fluid flow is naturally well suited to an efficient implementation for massively parallel computing, due to the prevalence of local operations in the algorithm. This paper presents and analyses the performance of a 3D lattice Boltzmann solver, optimized for third generation nVidia GPU hardware, also known as `Kepler'. We provide a review of previous optimisation strategies and analyse data read/write times for different memory types. In LBM, the time propagation step (known as streaming), involves shifting data to adjacent locations and is central to parallel performance; here we examine three approaches which make use of different hardware options. Two of which make use of `performance enhancing' features of the GPU; shared memory and the new shuffle instruction found in Kepler based GPUs. These are compared to a standard transfer of data which relies instead on optimised storage to increase coalesced access. It is shown that the more simple approach is most efficient; since the need for large numbers of registers per thread in LBM limits the block size and thus the efficiency of these special features is reduced. Detailed results are obtained for a D3Q19 LBM solver, which is benchmarked on nVidia K5000M and K20C GPUs. In the latter case the use of a read-only data cache is explored, and peak performance of over 1036 Million Lattice Updates Per Second (MLUPS) is achieved. The appearance of a periodic bottleneck in the solver performance is also reported, believed to be hardware related; spikes in iteration-time occur with a frequency of around 11Hz for both GPUs, independent of the size of the problem.
Examination of Complementarity in Speech and Emotional Vocalization Perception  [PDF]
Victoria L. Harms, Lorin J. Elias
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.58098

Lateralization of cognitive functioning is a well-established principle of cerebral organization. The left and right hemispheres are known to play distinct and complementary roles in the processing of information. What is still unclear is whether these asymmetrically lateralized functions have a common or distinct developmental origin; are left and right processes lateralized through causal influences, or is the laterality of each function independently influenced? Left- and right-lateralized functions are commonly assessed in isolation, with little attention to the relationship in the degree and direction of lateralization within individuals. This relationship between left-hemisphere processing of speech sounds and right-hemisphere processing of emotional vocalizations was examined using dichotic listening tasks. An overall complementary pattern of lateralization was observed across participants, but no significant relationship was found for degree of lateralization of speech and emotional vocalization processing within individuals. These results support the view that functions in the left and right hemispheres are independently lateralized.

Lymphoid Aggregates That Resemble Tertiary Lymphoid Organs Define a Specific Pathological Subset in Metal-on-Metal Hip Replacements
Saloni Mittal, Matthew Revell, Francesca Barone, Debbie L. Hardie, Gulraj S. Matharu, Alison J. Davenport, Richard A. Martin, Melissa Grant, Frederick Mosselmans, Paul Pynsent, Vaiyapuri P. Sumathi, Owen Addison, Peter A. Revell, Christopher D. Buckley
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063470
Abstract: Aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) has been used to describe the histological lesion associated with metal-on-metal (M-M) bearings. We tested the hypothesis that the lymphoid aggregates, associated with ALVAL lesions resemble tertiary lymphoid organs (TLOs). Histopathological changes were examined in the periprosthetic tissue of 62 M-M hip replacements requiring revision surgery, with particular emphasis on the characteristics and pattern of the lymphocytic infiltrate. Immunofluorescence and immunohistochemistry were used to study the classical features of TLOs in cases where large organized lymphoid follicles were present. Synchrotron X-ray fluorescence (XRF) measurements were undertaken to detect localisation of implant derived ions/particles within the samples. Based on type of lymphocytic infiltrates, three different categories were recognised; diffuse aggregates (51%), T cell aggregates (20%), and organised lymphoid aggregates (29%). Further investigation of tissues with organised lymphoid aggregates showed that these tissues recapitulate many of the features of TLOs with T cells and B cells organised into discrete areas, the presence of follicular dendritic cells, acquisition of high endothelial venule like phenotype by blood vessels, expression of lymphoid chemokines and the presence of plasma cells. Co-localisation of implant-derived metals with lymphoid aggregates was observed. These findings suggest that in addition to the well described general foreign body reaction mediated by macrophages and a T cell mediated type IV hypersensitivity response, an under-recognized immunological reaction to metal wear debris involving B cells and the formation of tertiary lymphoid organs occurs in a distinct subset of patients with M-M implants.
El banquete nerudiano
Mc Card,Victoria L.;
Literatura y lingüística , 1997, DOI: 10.4067/S0716-58111997001000001
Abstract: ha publicado los siguientes artículos: "el subalterno en cortázar," en la revista de estudios hispánicos de la u. de puerto rico; y "el mundo mítico y mágico de salvador dalí. con "ortega y freud para crear orden del caos," en literatura, arte, historia y mito en la obra de carlos rojas, editado por cecilia lee y publicado por la fundación universidad central de colombia. también ha presentado ponencias sobre la obra de federico garcía lorca, salvador dalí, pablo picasso y gabriel garcía márquez. actualmente está completando un trabajo sobre el poscolonialismo y la literatura cubana posrrevolucionaria
El banquete nerudiano
Victoria L. Mc Card
Literatura y lingüística , 1997,
Abstract: Ha publicado los siguientes artículos: "El subalterno en Cortázar," en la Revista de Estudios Hispánicos de la U. de Puerto Rico; y "El mundo mítico y mágico de Salvador Dalí. Con "Ortega y Freud para crear orden del caos," en Literatura, arte, historia y mito en la obra de Carlos Rojas, editado por Cecilia Lee y publicado por la Fundación Universidad Central de Colombia. También ha presentado ponencias sobre la obra de Federico García Lorca, Salvador Dalí, Pablo Picasso y Gabriel García Márquez. Actualmente está completando un trabajo sobre el poscolonialismo y la literatura cubana posrrevolucionaria
Las intrincadas relaciones entre investigación, desarrollo e innovación con progreso y bienestar y la importancia de su divulgación
Victoria López Rodas
Circunstancia , 2008,
Abstract: Entre los temas prioritarios en divulgación científica está el explicar porqué hay que invertir esfuerzo y dinero en ciencia y tecnología. A menudo se argumenta que la pujanza económica de un país está íntimamente ligada a su capacidad para la innovación y que ésta a su vez depende de la inversión estatal en investigación básica y aplicada. El rápido crecimiento de EEUU durante el siglo XX se pone a menudo como ejemplo de sociedad innovadora resultante de una elevada inversión estatal. Sin embargo la realidad es mas compleja y no siempre las grandes inversiones estatales en I+D+i han sido garantía de desarrollo económico. Además de la inversión, también se necesita un conjunto de actitudes sociales frente a la ciencia (tradición científica-tecnológica). Como la capacidad para hacer Ciencia es una de las características esenciales de los seres humanos, invertir en Ciencia y difundirla es, sin duda, alguna invertir en Humanidad.
Examining Gait Patterns after Total Knee Arthroplasty Using Parameterization and Principal Component Analysis  [PDF]
Kevin E. Roy, Victoria L. Chester, Chris A. McGibbon
Open Journal of Orthopedics (OJO) , 2013, DOI: 10.4236/ojo.2013.32028

The use of parameterization in assessing gait waveforms has been widely accepted, although it is recognized that this approach excludes the majority of information contained in the waveform. Waveform analysis techniques, such as principal component analysis (PCA), have gained popularity in recent years as a more effective approach to extracting important information from human movement waveforms, but are more challenging to interpret. Few studies have compared these two different approaches to determine which yields the most relevant information. This study compared the kinematic patterns during gait of six total knee arthroplasty (TKA) subjects (10 TKA knees), to a group of 10 age-matched asymptomatic control subjects (19 control knees). An eight-camera Vicon M-cam system was used to track movement and compute joint angles. Group differences in parameterization (max and min peaks) values and principal component scores were tested using one-way ANOVA and Kruskal-Wallis tests. Using parameterization, the TKA group was characterized by reduced hip extension, increased hip flexion, increased anterior pelvic tilt, increased trunk tilt, and reduced sagittal ankle angles compared to the control group. Waveform analysis, by means of PCA, showed-magnitude shifts in sagittal ankle waveforms between groups, rather than solely reporting differences in peaks. Waveform analysis also indicated a significant shift in the magnitude of the entire waveform for hip angles, pelvic tilt, and trunk tilt, indicating no change in range of motion between groups, but rather a change in the way in which range of motion is achieved at the hip. This study has identified several gait variables that were significantly different between the TKA and control groups. Our results suggest that waveform analysis is effective at identifying magnitude shifts as sources of variability between groups, which would not necessarily be analyzed using conventional parameterization techniques unless one knew a priori where the variability would exist.

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