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Search Results: 1 - 10 of 2022 matches for " Valentina Perissi "
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The Co-Repressor SMRT Delays DNA Damage-Induced Caspase Activation by Repressing Pro-Apoptotic Genes and Modulating the Dynamics of Checkpoint Kinase 2 Activation
Claudio Scafoglio, Marcus Smolka, Huilin Zhou, Valentina Perissi, Michael G. Rosenfeld
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059986
Abstract: Checkpoint kinase 2 (Chk2) is a major regulator of DNA damage response and can induce alternative cellular responses: cell cycle arrest and DNA repair or programmed cell death. Here, we report the identification of a new role of Chk2 in transcriptional regulation that also contributes to modulating the balance between survival and apoptosis following DNA damage. We found that Chk2 interacts with members of the NCoR/SMRT transcriptional co-regulator complexes and serves as a functional component of the repressor complex, being required for recruitment of SMRT on the promoter of pro-apoptotic genes upon DNA damage. Thus, the co-repressor SMRT exerts a critical protective action against genotoxic stress-induced caspase activation, repressing a functionally important cohort of pro-apoptotic genes. Amongst them, SMRT is responsible for basal repression of Wip1, a phosphatase that de-phosphorylates and inactivates Chk2, thus affecting a feedback loop responsible for licensing the correct timing of Chk2 activation and the proper execution of the DNA repair process.
A 29-year-old pregnant woman with a history of anthracycline-induced clinical heart failure  [PDF]
Valentina Scheggi, Fabio Mori
Health (Health) , 2011, DOI: 10.4236/health.2011.31007
Abstract: The number of women with heart disease who reach childbearing age in a good functional state increases continuously as advances in diagnosis and treatment improve overall health and prognosis. The cardiologist’s role is to give the woman an estimate of both maternal and fetal risk to allow her to make an informed decision about embarking on a pregnancy, and to provide appropriate antenatal care. There are only a few data about the natural history of anthracycline-induced cardiomyopathy during preg- nancy; we report our experience of a 29-year- old pregnant woman with a history of anthracycline-induced clinical heart failure.
ICT and Inclusion in Higher Education: A Comparative Approach  [PDF]
Valentina Della Volpe
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.39007
Abstract:

The following research describes an attempt to combine ICT and Special Education through an inclusive pedagogical perspective. It examines how an innovative use of Information and Communication Technology can help create inclusive environments on the web. Specifically, the study focuses on the way the University responds to diversity and to e-inclusion through some development phases of an experimental research project, which is most far-reaching called “Network@ccessible: teaching/learning together and for everyone in a life project” carried out by six Italian universities and research institutions, from 2009 to 2014, and involved 1174 students (1.6% disabled students). This study is split into two main parts: 1) description and analysis of the data collected following the administration of an inquiry tool, developed to detect the climate experienced by the students involved in the online working groups; 2) investigation and detection of the elements of change that can encourage the process of inclusion in online learning environments to acquire credits allocated to the university courses. This study proposes further research to take place in the area of inclusive online university courses.

Recent Trends in Occupational Injuries and Diseases in Argentina: A Panel Data Approach  [PDF]
Valentina Viego, Nicolas Sagui
Occupational Diseases and Environmental Medicine (ODEM) , 2015, DOI: 10.4236/odem.2015.34007
Abstract: Occupational injuries pose major public health and development related problems. However, efforts towards identification of determinants of labor incidents among salaried workers are still scarce in developing countries. This study aimed to identify sector and time effects on occupational accidents and diseases among Argentinean workers during 2004-2013. A negative binomial panel data model is estimated based on official data on injuries and fatalities in workplaces collected by the Board of Occupational Risks. Business cycle and profitability indicators are used as explanatory variables. Estimations also are adjusted by sector and time effects. Argentina business cycle tends to be negatively related with occupational injuries rates. In contrast, accidents at work reported tend to exhibit longer losses in working days. We also find a positive relationship between profitability and fatal injuries. These results may suggest incentives for under reporting and lower investments in safety by more profitable activities, which can imply some level of endogeneity between profit rate and occupational injuries.
Food Packaging Permeability Behaviour: A Report
Valentina Siracusa
International Journal of Polymer Science , 2012, DOI: 10.1155/2012/302029
Abstract: The use of polymer materials in food packaging field is one of the largest growing market area. Actually the optimization behaviour of packaging permeability is of crucial importance, in order to extend the food shelf-life and to reach the best engineering solution. Studying the permeability characterization of the different polymer material (homogeneous and heterogeneous polymer system) to the different packaging gases, in different environmental condition, is crucial to understand if the selected material is adapted to the chosen food contact field. Temperature and humidity parameters are of crucial importance for food quality preservation, especially in real life situations, like food market, and house long-life use. The aim of this report was to collect information about the state of the art on the permeability characteristics of the polymer packages used on food field. 1. Introduction In contrast to glass or metal packaging materials, packages made with plastic are permeable at different degrees to small molecules like gases, water vapour, and organic vapour and to other low molecular weight compounds like aromas, flavour, and additives present into food. As a consequence of the barrier properties of the material, the transfer of this molecules ranges from high to low. The knowledge of the solution/diffusion/permeation behaviours of these molecules through the polymer film has become more and more important in recent years, especially for polymers used in the food packaging field where contamination from external environment has to be avoided and the shelf life of the food controlled by the use of modified atmosphere packaging (MAP) techniques. Many factors that can influence the polymer packages performance must be taken into consideration to design the correct package market solution. The use of different polymers in food packaging industry depends on the properties of the food product. Also, manufacturing, handling, and packaging engineering procedures can influence the final properties of packaging material, especially in terms of barrier properties which are, further, strictly correlated to the intrinsic structure of the polymer such as degree of crystallinity, crystalline/amorphous phase ratio, nature of polymer, thermal and mechanical treatment before and after food contact, chemical groups present into the polymer (polar or not), degree of cross-linking, and glass transition temperature ( ) [1, 2]. The selection of the best packaging material is a crucial point for food market, because it needs to be versatile enough to withstand handling
Regularization method for parabolic equation with variable operator
Valentina Burmistrova
Journal of Applied Mathematics , 2005, DOI: 10.1155/jam.2005.383
Abstract: Consider the initial boundary value problem for the equation ut=−L(t)u, u(1)=w on an interval [0,1] for t>0, where w(x) is a given function in L2(Ω) and Ω is a bounded domain in ℝn with a smooth boundary ∂Ω. L is the unbounded, nonnegative operator in L2(Ω) corresponding to a selfadjoint, elliptic boundary value problem in Ω with zero Dirichlet data on ∂Ω. The coefficients of L are assumed to be smooth and dependent of time. It is well known that this problem is ill-posed in the sense that the solution does not depend continuously on the data. We impose a bound on the solution at t=0 and at the same time allow for some imprecision in the data. Thus we are led to the constrained problem. There is built an approximation solution, found error estimate for the applied method, given preliminary error estimates for the approximate method.
Wind Technology: A Framework for the Evaluation of Innovations’ Impacts on the Diffusion Potential
Valentina Dinica
Sustainability , 2010, DOI: 10.3390/su2030757
Abstract: This paper proposes a framework based on which innovations in wind power technologies can be evaluated from the standpoint of their contribution to diffusion expansion. The framework helps build up a missing link between the technical literature on innovations and policy-oriented contributions concerned with the diffusion potential of wind power in national energy systems. The ideas are applied for the evaluation of wind technology innovations adopted in Spain. The framework can help policy-makers prioritize their innovation objectives and funding, so as to support the adoption of innovations that deserve the highest priority, given the country’s resources and energy system characteristics.
Empresarialidad e instituciones: dos nuevas perspectivas del análisis regional contemporáneo
Viego,Valentina;
EURE (Santiago) , 2004, DOI: 10.4067/S0250-71612004009000004
Abstract: this paper offers a review of the main progress made in entrepreneurship analysis and institutional economics, discussing its possible integration to general theory of economic development, considering the increasing importance that these topics have gained in contemporary approaches of terriorial development
PROBLEMAS BIOéTICOS DE LA INVESTIGACIóN BIOMéDICA CON PUEBLOS INDíGENAS DE CHILE
Fajreldin,Valentina;
Acta bioethica , 2010, DOI: 10.4067/S1726-569X2010000200012
Abstract: in chile there are diverse governmental and social instances to work with the health of indigenous populations and there has been fruitful outcome; nevertheless, some health care access and coverage inequities persist in these populations. biomedical research effort carried out with aboriginal populations in our country is hidden, what threatens many times the genetic patrimony of these communities. this text would like to build a bridge between medical anthropology, public health and bioethics. considering the state of the art in the issue, we propose some elemental work axis on the issue, which serves as basis to get a place within bioethics endeavors at chile, with the goal of contributing to a process both necessary and urgent: the formulation of a public health culturally aware.
Paralelismo, ciclicidad y creatividad en el arte verbal maya yucateco
Vapnarsky, Valentina;
Estudios de cultura maya , 2008,
Abstract: in this paper we argue that parallelism as a discursive recourse in the maya oral tradition plays a crucial role at different levels of discursive organization, and not only at the level of the verse and contiguous units as is generally assumed. we analyze the variety of levels at which parallelisms are at play, as well as the relation of parallelism with other rhetorical figures, in particular cyclicity which stands out as an important recourse for the deployment of parallelisms through distant units. the analysis is based on a detailed study of a ritual dialogue of san juan bautista's peregrination among the maya macehuales (cruso'ob) from quintana roo (mexico). it confirms that discursive parallelisms must be considered not only as esthetical or poetical elements, with their emotional and emphatic effects, but also as procedures of macro-discursive organization, with thematic, semantic and pragmatic functions.
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