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Search Results: 1 - 10 of 1049 matches for " Vaibhav Rajan Parulkar "
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Evaluation of Pro-Inflammatory Cytokines Expression in Mouse Splenocytes After Incubation with Biofield Treated Herbomineral Formulation: Effect of Biofield Energy Healing Treatment - The Trivedi Effect
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Alan Joseph Balmer, Dimitrius Anagnos, Janice Patricia Kinney, Joni Marie Holling, Joy Angevin Balmer, Lauree Ann Duprey-Reed, Vaibhav Rajan Parulkar, Mayank Gangwar, Snehasis Jana
American Journal of Biomedical and Life Sciences , 2016, DOI: 10.11648/j.ajbls.20160406.12
Abstract: The use of herbomineral formulations in the healthcare sector has increased due to their high safety and better therapeutic action. A new proprietary herbomineral formulation was formulated with a mixture of the herbal root extract of ashwagandha and three minerals viz. zinc chloride, magnesium gluconate, and sodium selenate. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect) on the formulation when applied to splenocyte cells isolated from mice spleen. The formulation was divided into two parts; one was the control without any Biofield Energy Treatment, while the other part was defined as the Biofield Energy Treated sample, which received Biofield Energy Healing Treatment remotely by seven renowned Biofield Energy Healers. The test formulation was evaluated to find the expression of pro-inflammatory cytokines such as TNF-α, MIP-1α, and IL-1β along with non-cytotoxic concentrations by MTT assay. The splenocytes were given the Biofield Energy Treated and untreated sample at concentrations range (0.00001053 to 10.53 μg/mL) for 48 hours and was reported with safe concentration up to 1.053 μg/mL with percentage viability range from 76.7% to 109.2% in both samples. Biofield Energy Healing significantly enhanced the cell viability as compared with the untreated formulation. The expression of TNF-α was significantly inhibited in the Biofield Treated formulation at 0.01053, 0.1053, and 1.053 μg/mL by 1.77%, 1.93%, and 3.55%, respectively compared with the untreated formulation. The rest of the tested concentrations of the Biofield Treated formulation showed an increase in TNF-α expression at 0.00001053, 0.0001053, and 0.001053 μg/mL by 7.26%, 8.50%, and 8.50%, respectively compared to the vehicle control group. Similarly, the MIP-1α expression was inhibited by the Biofield Energy Treated formulation and showed immunosuppression activity at 0.01053 μg/mL by 18.47% (p≤0.001) compared to the untreated formulation. MIP-1α expression was reported as 628.94 ± 13.0 pg/mL in the untreated formulation, while it decreased to 512.74 ± 1.9 pg/mL in the Biofield Treated formulation at 0.01053 μg/mL. In addition, the IL-1β secretion was also significantly inhibited by the Biofield Treated formulation at concentrations 0.001053, 0.01053, 0.1053, and 1.053 μg/mL by 72.02%, 50.16%, 30.68%, and 22.11%, respectively as compared with the untreated formulation. Overall, The Trivedi Effect? significantly down-regulated the pro-inflammatory cytokines and potentiated the immunosuppressive effect of the treated formulation, which can be better utilized in organ transplants, anti-aging, stress management, autoimmune disorders, and inflammatory disorders, etc. to modulate the immune system by improving overall health.
Evaluation of Structural Properties and Isotopic Abundance Ratio of Biofield Energy Treated (The Trivedi Effect) Magnesium Gluconate Using LC-MS and NMR
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Alan Joseph Balmer, Dimitrius Anagnos, Janice Patricia Kinney, Joni Marie Holling, Joy Angevin Balmer, Lauree Ann Duprey-Reed, Vaibhav Rajan Parulkar, Parthasarathi Panda, Kalyan Kumar Sethi, Snehasis Jana
European Journal of Biophysics , 2017, DOI: 10.11648/j.ejb.20170501.12
Abstract: The current research work was designed to explore the impact of The Trivedi Effect - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) by using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect- Biofield Energy Healing Treatment remotely by seven renowned Biofield Energy Healers and defined as The Trivedi Effect Treated sample. The LC-MS analysis of the both control and treated samples revealed the presence of the mass of the protonated magnesium gluconate at m/z 415 at the retention time of 1.53 min with similar fragmentation pattern. The relative peak intensities of the fragment ions of the treated sample were significantly changed compared with the control sample. The proton and carbon signals for CH, CH2 and CO groups in the proton and carbon NMR spectra were found almost similar for the control and the treated samples. The isotopic abundance ratio analysis revealed that the isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 17O/16O or 25Mg/24Mg) in the treated sample was significantly increased by 34.33% compared with the control sample. Subsequently, the percentage change of the isotopic abundance ratio of PM+2/PM (18O/16O or 26Mg/24Mg) was significantly decreased in the treated sample by 64.08% as compared to the control sample. Briefly, 13C, 2H, 17O, and 25Mg contributions from (C12H23MgO14)+ to m/z 416; 18O and 26Mg contributions from (C12H23MgO14)+ to m/z 417 in the treated sample were significantly changed compared with the control sample. Thus, the treated magnesium gluconate could be valuable for designing better pharmaceutical and/or nutraceutical formulations through its changed physicochemical and thermal properties, which might be providing better therapeutic response against various diseases such as diabetes mellitus, allergy, aging, inflammatory diseases, immunological disorders, and other chronic infections. The Biofield Energy Treated magnesium gluconate might be supportive to design the novel potent enzyme inhibitors by using its kinetic isotope effects.
Evaluation of Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect)
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Alan Joseph Balmer, Dimitrius Anagnos, Janice Patricia Kinney, Joni Marie Holling, Joy Angevin Balmer, Lauree Ann Duprey-Reed, Vaibhav Rajan Parulkar, Parthasarathi Panda, Kalyan Kumar Sethi, Snehasis Jana
Journal of Drug Design and Medicinal Chemistry , 2017, DOI: 10.11648/j.jddmc.20170301.12
Abstract: Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the physicochemical, structural, thermal and behavioral properties using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control, while another part was treated with The Trivedi Effect - Energy of Consciousness Healing Treatment remotely by seven renowned Biofield Energy Healers and defined as the Biofield Energy Treated sample. The PXRD analysis exhibited significant alteration of the crystal morphology of the treated sample compared with the control sample. The crystallite size of the treated sample was remarkably changed from range -69.99% to 71.40% compared with the control sample. The average crystallite size was significantly decreased in the treated sample by 13.61% compared with the control sample. Particle size analysis revealed that the particle size in the treated sample at d10, d50, and d90 value was significantly decreased by 5.19%, 26.77%, and 18.22%, respectively compared with the control sample. The treated sample’s surface area was significantly enhanced (12.82%) compared with the control sample. The FT-IR and UV-vis analysis showed that the structure of the magnesium gluconate remained the same in both the treated and control samples. The TGA analysis revealed the four steps thermal degradation of the both samples and the total weight loss of the Biofield Energy Treated sample was increased by 0.55% compared with the control sample. The DSC analysis revealed that the melting temperature of the treated sample (171.72°C) was increased by 0.21% compared with the control sample (171.36°C). The latent heat of fusion was increased by 4.66% in the treated sample compared with the control sample. This result indicated that the thermal stability of treated sample was improved compared with the control sample. The current study infers that The Trivedi Effect - Biofield Energy Healing might lead to a new polymorphic form of magnesium gluconate, which would be more soluble, bioavailable, and thermally stable compared with the untreated compound. Hence, the treated magnesium gluconate would be very useful to design better nutraceutical/pharmaceutical formulations that might offer better therapeutic responses against inflammatory diseases, immunological disorders, stress, aging and other chronic infections.
An Impact of the Trivedi Effect - Biofield Energy Healing on Herbomineral Formulation for Immunomodulation of Pro-inflammatory Cytokines in Biofield Treated Mouse Splenocytes
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Alan JosephMahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Alan Joseph Balmer, Dimitrius Anagnos, Janice Patricia Kinney, Joni Marie Holling, Joy Angevin Balmer, Lauree Ann Duprey-Reed, Vaibhav Rajan Parulkar, Mayank Gangwar, Snehasis Jana
Advances in Biochemistry , 2016, DOI: 10.11648/j.ab.20160406.12
Abstract: Herbomineral formulations have increased in recognition and popularity due to their high safety and better therapeutic action. A new proprietary herbomineral formulation was formulated with a mixture of the herbal root extract of ashwagandha and three minerals viz. zinc, magnesium, and selenium. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect) on the test formulation when applied to splenocyte cells isolated from the Biofield Treated mice. The test formulation was divided into two parts. One part was denoted as the control without any Biofield Energy Treatment. The other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely by seven renowned Biofield Energy Healers. A wide concentration range (0.00001053 to 10.53 μg/mL) of the test formulation was used to determine non-cytotoxic concentrations using MTT assay. Further, the expression of pro-inflammatory cytokines (TNF-α, MIP-1α, and IL-1β) was determined by ELISA method. The test formulation was evaluated and found to be safe up to 1.053 μg/mL with a percentage cell viability range of 73% to 97% using MTT assay. The Biofield Treated formulation improved the cell viability up to 6.61% compared with the untreated test formulation. TNF-α expression was significantly inhibited by 16.72% at 0.1053 μg/mL compared with the untreated test formulation, however expression was significantly altered by 53.67% and 25.62% at 0.01053 and 1.053 μg/mL, respectively compared to the untreated test formulation. TNF-α expression was also suppressed in the Biofield Treated test formulation at 0.001053 and 0.1053 μg/mL by 4.0% and 8.56%, respectively as compared with the vehicle control. MIP-1α suppression was reported in the Biofield Treated test formulation at 0.00001053 to 1.053 μg/mL by 8.43%, 22.02%, 21.92%, 20.54%, 5.40%, and 19.82%, respectively compared with the vehicle control. However, the Biofield Treated formulation further exhibited substantial suppression of MIP-1α at 0.0001053, 0.001053, 0.01053, and 0.1053 μg/mL by 13.50%, 7.38%, 36.83% (p≤0.001), and 2.53%, respectively compared with the untreated test formulation. In addition, significant inhibition of IL-1β secretion was reported in the Biofield Treated formulation at 0.0001053, 0.001053, 0.01053, and 0.01053 μg/mL by 32.40%, 14.99%, 60.42%, and 15.15%, respectively compared with the untreated test formulation. The Biofield Energy Healing Treatment significantly potentiated the immunosuppressive effect of the test formulation in Biofield Treated mouse splenocytes, which can be used for autoimmune and inflammatory diseases, stress management and anti-aging by improving overall health.
Bootstrapping phylogenies inferred from rearrangement data
Lin Yu,Rajan Vaibhav,Moret Bernard ME
Algorithms for Molecular Biology , 2012, DOI: 10.1186/1748-7188-7-21
Abstract: Background Large-scale sequencing of genomes has enabled the inference of phylogenies based on the evolution of genomic architecture, under such events as rearrangements, duplications, and losses. Many evolutionary models and associated algorithms have been designed over the last few years and have found use in comparative genomics and phylogenetic inference. However, the assessment of phylogenies built from such data has not been properly addressed to date. The standard method used in sequence-based phylogenetic inference is the bootstrap, but it relies on a large number of homologous characters that can be resampled; yet in the case of rearrangements, the entire genome is a single character. Alternatives such as the jackknife suffer from the same problem, while likelihood tests cannot be applied in the absence of well established probabilistic models. Results We present a new approach to the assessment of distance-based phylogenetic inference from whole-genome data; our approach combines features of the jackknife and the bootstrap and remains nonparametric. For each feature of our method, we give an equivalent feature in the sequence-based framework; we also present the results of extensive experimental testing, in both sequence-based and genome-based frameworks. Through the feature-by-feature comparison and the experimental results, we show that our bootstrapping approach is on par with the classic phylogenetic bootstrap used in sequence-based reconstruction, and we establish the clear superiority of the classic bootstrap for sequence data and of our corresponding new approach for rearrangement data over proposed variants. Finally, we test our approach on a small dataset of mammalian genomes, verifying that the support values match current thinking about the respective branches. Conclusions Our method is the first to provide a standard of assessment to match that of the classic phylogenetic bootstrap for aligned sequences. Its support values follow a similar scale and its receiver-operating characteristics are nearly identical, indicating that it provides similar levels of sensitivity and specificity. Thus our assessment method makes it possible to conduct phylogenetic analyses on whole genomes with the same degree of confidence as for analyses on aligned sequences. Extensions to search-based inference methods such as maximum parsimony and maximum likelihood are possible, but remain to be thoroughly tested.
Advancing laparoscopic surgery in urology.
Parulkar B
Journal of Postgraduate Medicine , 2002,
Abstract:
Study of reaction time in hemiplegics.
Malathi A,Parulkar V
Journal of Postgraduate Medicine , 1989,
Abstract: Visual reaction time and auditory reaction time (VRT and ART) were measured in 25 right hemiplegics and 25 left hemiplegics in the age group of 40-60 years. There was a significant prolongation of VRT and ART in both the right and left hemiplegics as compared to normals of the same age group. ART following mono-aural stimulation i.e. sound input into the right and left ear separately, was also studied in the subjects. Mono-aural stimulation revealed a prolongation of the ART on contralateral stimulation (i.e. auditory stimulation on the side, opposite to the brain damage) as compared to ipsilateral stimulation (auditory stimulation on the side of brain damage) in the right and left hemiplegics.
iPhone Security Analysis  [PDF]
Vaibhav Ranchhoddas Pandya, Mark Stamp
Journal of Information Security (JIS) , 2010, DOI: 10.4236/jis.2010.12009
Abstract: The release of Apple’s iPhone was one of the most intensively publicized product releases in the history of mobile devices. While the iPhone wowed users with its exciting design and features, it also angered many for not allowing installation of third party applications and for working exclusively with AT & T wireless services (in the US). Besides the US, iPhone was only sold only in a few other selected countries. Software attacks were developed to overcome both limitations. The development of those attacks and further evaluation revealed several vulnerabilities in iPhone security. In this paper, we examine some of the attacks developed for the iPhone as a way of investigating the iPhone’s security structure. We also analyze the security holes that have been discovered and make suggestions for improving iPhone security.
A Study of “Inflation Indexed Bonds” in Indian Debt Market
Vaibhav Jain
International Journal of Economics and Finance , 2012, DOI: 10.5539/ijef.v4n10p93
Abstract: This research attempts to explain India as an upcoming Debt Market with the introduction of the new instruments like “Inflation Indexed Bonds” (both for the retail and the institutional buyers) followed by the explanation about both the technical and the conceptual aspect of the “Inflation Indexed Bonds (IIB)” and their applicability in Indian Debt Market. After discussing about the literature on IIB’s, in the last section, we have seen the yield of a hypothetical “Inflation Indexed Bond” higher as compared to “Normal bond” (non-inflation adjusted). We have also commented upon the real value of the returns keeping in mind the Investor’s perspective (purchasing power) and his behavior in buying and evaluating such instruments. Lastly, we have compared both the bonds in the rising inflation scenario. We have analyzed that for an Inflation Indexed Bond, bond value increases with increase in the Inflation and vice-versa but for a Normal Bond, it remains unaffected by the rising Inflation levels (keeping interest/reinvestment rate as constant for both the bonds).
Implementation of Network Community Profile using Local Spectral algorithm and its application in Community Networking
Vaibhav VPrakash
International Journal of Distributed and Parallel Systems , 2012,
Abstract: The problem that is addressed here and being investigated is to empirically review the paper entitled"Empirical comparison of algorithms for network community detection" - Jure Leskovec, Kevin J Langand Michael W Mahoney”wherein we look at the characteristics and specific properties of varioussocial networks used in the public and private domain. The objective of the investigation is to understandcompletely the network community detection using Local Spectral and Metis+MQI algorithms and toanalyse how communities are created and ranked on specific metrics. Five communities have beencompared using the same heuristics of the established functions in the entitled paper and an inference isdrawn based on the graph generated by the same.
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