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Comparison of CT Dose Reduction Algorithms in a Porcine Model  [PDF]
Mohammed Nazir Khan, Idris Elbakri, Blair Henderson, Jeffrey Mottola, Azeez Omotayo
Advances in Computed Tomography (ACT) , 2015, DOI: 10.4236/act.2015.44008
Abstract: The present study utilized a porcine model for qualitative and quantitative assessment of the diagnostic quality of non-contrast abdominal computed tomography (CT) images generated by Adaptive Statistical Iterative Reconstruction (ASIR, GE Healthcare, Waukesha, Wisconsin, USA), Model-Based Iterative Reconstruction (GE company name VEO), and conventional Filtered back projection (FBP) technique. Methods: Multiple CT whole-body scans of a freshly euthanized pig carcass were performed on a 64-slice GE CT scanner at varying noise indices (5, 10, 15, 20, 30, 37, 40, 45), and with three different algorithms (VEO, FBP, and ASIR at 30%, 50%, and 70% levels of ASIR-FBP blending). Abdominal CT images were reviewed and scored in a blinded and randomized manner by two board-certified abdominal radiologists. The task was to evaluate the clarity of the images according to a rubric involving edge sharpness, presence of artifact, anatomical clarity (assessed at four regions), and perceived diagnostic acceptability. This amounted to seven criteria, each of which was graded on a scale of 1 to 5. A weighted formula was used to calculate a composite score for each scan. Results: VEO outperforms ASIR and FBP by an average of 0.5 points per the scoring system used (p < 0.05). Above a threshold noise index of 30, diagnostic acceptability is lost by all algorithms, and there is no diagnostic advantage to increasing the dose beyond a noise index of 10. Between a noise index of 25 - 30, VEO retains diagnostic acceptability, as opposed to ASIR and FBP which lose acceptability above noise index of 25. Conclusion: Model-based iterative reconstruction provides superior image quality and anatomical clarity at reduced radiation dosages, supporting the routine use of this technology, particularly in pediatric abdominal CT scans.
生物工程学报 , 2013,
Abstract: 旨在研究单纯疱疹病毒2型潜伏相关转录体(lat)开放读码框1(orf1)对放线菌素d诱导的凋亡作用的影响。以hsv-2333基因组为模板pcr扩增orf1片段,构建重组质粒pegfp-orf1,转染vero细胞,rt-pcr鉴定orf1的表达。放线菌素d诱导vero细胞凋亡,通过荧光显微镜观察凋亡小体,hochest33258荧光染色观察细胞形态变化,mtt检测细胞活性,流式细胞术检测细胞凋亡率。双酶切和测序确认pegfp-orf1构建成功,rt-pcr表明该真核表达载体能在vero细胞中高效表达。转染了pegfp-orf1的vero细胞经放线菌素d凋亡诱导后,hochest33258染色显示细胞形态正常。mtt结果表明转染了重组质粒pegfp-orf1的vero细胞经放线菌素d凋亡诱导后vero细胞活性与未经任何处理的正常对照组相比,无显著差异(p>0.05),但高于放线菌素d诱导凋亡的vero细胞组及与转染空质粒pegfp-c2且放线菌素d诱导凋亡的vero细胞组,差异具有统计学意义(p<0.05)。流式结果表明,转染重组质粒pegfp-orf1且经放线菌素d诱导凋亡组与正常对照组凋亡率差异不显著(p>0.05),而显著低于放线菌素d诱导凋亡组和转染空质粒pegfp-c2且经放线菌素d诱导凋亡组(p<0.05)。hsv-2latorf1具有抗放线菌素d诱导的vero细胞的凋亡作用。
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