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Search Results: 1 - 10 of 247 matches for " VC;Calvi "
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Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
Oliveira, LRC;Picka, MCM;Nicolete, VC;Calvi, SA;Marcondes-Machado, J;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2012, DOI: 10.1590/S1678-91992012000100005
Abstract: the aim of the present study was to investigate the presence of trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and pcr analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. parasitemia curves revealed strain-specific biological behaviors. for the y and jlp strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. when the two strains were compared, the jlp strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. however, parasites were detected in all studied organs using pcr analysis. the capacity of both strains to infect different organs likely influences disease pathogenesis.
Targeting estrogen to kill ER-positive and ER-negative breast cancer
VC Jordan
Breast Cancer Research , 2005, DOI: 10.1186/bcr1053
Abstract:
Kinase inhibitors: a new class of antirheumatic drugs
Kyttaris VC
Drug Design, Development and Therapy , 2012, DOI: http://dx.doi.org/10.2147/DDDT.S25426
Abstract: ase inhibitors: a new class of antirheumatic drugs Review (3845) Total Article Views Authors: Kyttaris VC Published Date September 2012 Volume 2012:6 Pages 245 - 250 DOI: http://dx.doi.org/10.2147/DDDT.S25426 Received: 18 July 2012 Accepted: 24 August 2012 Published: 21 September 2012 Vasileios C Kyttaris Division of Rheumatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA Abstract: The outlook for patients with rheumatoid arthritis has improved significantly over the last three decades with the use of disease-modifying antirheumatic drugs. However, despite the use of methotrexate, cytokine inhibitors, and molecules targeting T and B cells, a percentage of patients do not respond or lose their response over time. The autoimmune process in rheumatoid arthritis depends on activation of immune cells, which utilize intracellular kinases to respond to external stimuli such as cytokines, immune complexes, and antigens. In the past decade, small molecules targeting several kinases, such as p38 MAPK, Syk, and JAK have been developed. Several p38 MAPK inhibitors proved ineffective in treating rheumatoid arthritis. The Syk inhibitor, fostamatinib, proved superior to placebo in Phase II trials and is currently under Phase III investigation. Tofacitinib, a JAK1/3 inhibitor, was shown to be efficacious in two Phase III trials, while VX-509, a JAK3 inhibitor, showed promising results in a Phase II trial. Fostamatinib and tofacitinib were associated with increased rates of infection, elevation of liver enzymes, and neutropenia. Moreover, fostamatinib caused elevations of blood pressure and diarrhea, while tofacitinib was associated with an increase in creatinine and elevation of lipid levels.
Neonatal Tetanus in African Children: Causes, Symptoms, Predisposing Factors, Prevention and Control
VC Emeribe
Arts and Social Sciences Journal , 2011,
Abstract: This is a paper which examines the causes, symptoms, predisposing factors, prevention, and control of neonatal tetanus in African children. Neonatal tetanus was found to be the leading cause of death among neonates. It was found to result mainly from social and environmental factors, such as poor hygiene, use of non-sterile materials in treating the stump of umbilical cords in newborns, poor attendance to antenatal clinic, high-level illiteracy, and non-utilization of tetanus toxoid immunization. Based on the findings recommendations were proffered, which include: legislation in favor of anti-tetanus immunization as prerequisite for contracting marriages in courts in African countries; strategic and vigorous immunization exercise should be embarked upon at various levels; public enlightenment campaign targeted at exposing the nature of the disease to the entire public be carried out by ministries of health at state and federal level, Non-Governmental Organizations, and other health agencies.
Kinase inhibitors: a new class of antirheumatic drugs
Kyttaris VC
Drug Design, Development and Therapy , 2012,
Abstract: Vasileios C KyttarisDivision of Rheumatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USAAbstract: The outlook for patients with rheumatoid arthritis has improved significantly over the last three decades with the use of disease-modifying antirheumatic drugs. However, despite the use of methotrexate, cytokine inhibitors, and molecules targeting T and B cells, a percentage of patients do not respond or lose their response over time. The autoimmune process in rheumatoid arthritis depends on activation of immune cells, which utilize intracellular kinases to respond to external stimuli such as cytokines, immune complexes, and antigens. In the past decade, small molecules targeting several kinases, such as p38 MAPK, Syk, and JAK have been developed. Several p38 MAPK inhibitors proved ineffective in treating rheumatoid arthritis. The Syk inhibitor, fostamatinib, proved superior to placebo in Phase II trials and is currently under Phase III investigation. Tofacitinib, a JAK1/3 inhibitor, was shown to be efficacious in two Phase III trials, while VX-509, a JAK3 inhibitor, showed promising results in a Phase II trial. Fostamatinib and tofacitinib were associated with increased rates of infection, elevation of liver enzymes, and neutropenia. Moreover, fostamatinib caused elevations of blood pressure and diarrhea, while tofacitinib was associated with an increase in creatinine and elevation of lipid levels.Keywords: rheumatoid arthritis, kinase inhibitors, mitogen-activated phosphokinase p38, spleen tyrosine kinase, Janus kinases
Experimental review on moment analyses
Marta Calvi
Physics , 2003,
Abstract: Moments of the photon energy spectrum in B -> Xs gamma decays, of the hadronic mass spectrum and of the lepton energy spectrum in B -> Xc l nu decays are sensitive to the masses of the heavy quarks as well as to the non-perturbative parameters of the heavy quark expansion. Several measurements have been performed both at the Upsilon(4S) resonance and at Z0 center of mass energies. They provide constraints on the non-perturbative parameters, give a test of the consistency of the theoretical predictions and of the underlying assumptions and allow to reduce the uncertainties in the extraction of |Vcb|.
B Physics Prospects at LHC
Marta Calvi
Physics , 2005,
Abstract: Future Experiments at LHC will have the opportunity to pursue an extensive program on B Physics and CP violation. The expected performance are presented here.
Status and Physics Reach of LHCb
Marta Calvi
Physics , 2009,
Abstract: LHCb is the experiment at the Large Hadron Collider devoted to studies of new phenomena in CP violation and in rare decays. This review summarizes the status of the experiment in the imminence of the data taking, the prospects for the first measurements and highlights of its full physics program.
Chaperonins and the regulation of immunity
GS Panayi, VC Corrigall
Arthritis Research & Therapy , 2005, DOI: 10.1186/ar1507
Abstract: GSP and VCC are shareholders in Immune Regulation Ltd that is investigating the potential of BiP as an immunotherapeutic agent for the treatment of rheumatoid arthritis.
Two new species of gall midges (Diptera, Cecidomyiidae) associated with Erythroxylum ovalifolium Peyr. (Erythroxylaceae) from the Barra de Maricá restinga, Maricá, Rio de Janeiro, Brazil
Maia, VC;Fernandes, SPC;
Brazilian Journal of Biology , 2011, DOI: 10.1590/S1519-69842011000300024
Abstract: two new species of gall midges (diptera, cecidomyiidae) dasineura ovalifoliae and clinodiplosis maricaensis are described based on material from the barra de maricá restinga, maricá, rio de janeiro, brazil. both species are associated with erythroxylum ovalifolium peyr. (erythroxylaceae). the former is the gall inducer and the latter an inquiline.
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