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Search Results: 1 - 10 of 488550 matches for " V. M.; "
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Cross Skin Reactivity to Tyrosine Kinase Inhibitors in a Patient with Chronic Myelogenous Leukemia  [PDF]
V. Broshtilova, M. Balabanova
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.47130
Abstract:

Tyrosine kinase inhibitors (TKI) targeting the bcr-abl protein, c-kit and the platelet-derived growth factor receptors, are significant part of the pathogenic therapy of chronic myelogenous leukemia. A broad spectrum of cutaneous side effects has been described with the clinical use of imatinib mesylate, ranging from various acute rashes to toxic epidermal necrolysis. Herein, a case of cross skin toxicity to TKI in a patient with chronic myelogenous leukemia is presented. In the course of imatinib mesylate therapy the patient developed a grade 4 diffuse lichenoid drug eruption. Six months after switching to nilotinib, hyperpigmented macules and patches spread over his trunk and extremities. To date, few cases of cross skin reactivity to imatinib and nilotinib have been described, none of which showing different clinical phenotypes. Further understanding of the underlying mechanisms and leading to the development of skin rashes from different class of TKI is important to highlight new drug targets and modify the current therapies to a level of maximal efficacy.

Macroscopic Quantum System, Highly Correlated Electron State, and High-Temperature Superconductivity in Iron Pnictides  [PDF]
M. V. Krasinkova
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.57063
Abstract:

The qualitative model of the high-temperature superconductivity suggested earlier for cuprates and based on the idea that the superconductivity is associated with delocalized π bonding between ions is not only confirmed by experimental data on iron pnictides but is also improved. It is shown that the FeAs layer state is similar to that of a macroscopic quantum system characterized by a sandwich-type charge distribution in which negatively charged planes are two-dimensional electron crystals of pairs and positively charged planes are formed by positively charged ions. Superconductivity in such a system is accomplished by a two-dimensional Wigner crystal of bosons condensed into one and the same state. The crystal occupies a middle position with respect to charged planes in the sandwich structure, which leads to mutual compensation of all its interactions with all charged planes. The model can prove useful for development of the theory of superconductivity taking into consideration the highly correlated state of all valence electrons that manifests itself in formation of electron crystals with strong Coulomb interactions between them.

Performance Analysis of OFDM Synchronization Using Customized Floating Point for Low Complexity  [PDF]
V. Janakiraman, M. Kannan
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.710264
Abstract: Orthogonal frequency-division multiplexing (OFDM) is a multi carrier modulation scheme mainly used for digital communications. The performance of OFDM system heavily depends on the synchronization scheme used. In most cases, the accuracy level of synchronization will be worsened by the error caused in fixed point arithmetic involved. In this paper, we analyze the impact of the fixed point arithmetic on the performance of the coarse timing and frequency synchronization. Here with an analytical approach through numerical simulations bit length of IEEE 754 standard single precision format is optimized according to the required degree of accuracy for low complexity. Also, a complete precision level requirement for FFT computations with all possible modulation types is obtained. The proposed precision model is compared with IEEE standard single precision model and its efficiency in OFDM synchronization process is proved through MATLAB simulations. Finally, the complexity reduction of proposed precision model in both addition and subtraction is proved against single precision format using hardware synthesis. Here we proved that more than 50% complexity reduction is achieved as compared to standard precision models without compromising quality. The quality retention of proposed model is proved in both timing and frequency synchronization process.
Non-Linearity of Dynamics of the Non-Equilibrium Systems  [PDF]
V. M. Somsikov
World Journal of Mechanics (WJM) , 2017, DOI: 10.4236/wjm.2017.72002
Abstract: The role of nonlinearities in the dynamics of the non-equilibrium systems is considered. Various types of nonlinearities for dynamical systems with holonomic and nonholonomic constraints are studied. Features of the nonlinearity responsible for the evolution of the systems to the equilibrium are considered. The interrelation of the nonlinearities with the concepts of symmetry breaking is analyzed. Mathematical justification of the irreversibility of the dynamics of systems is offered. Peculiarities of nonlinear nonequilibrium systems connected with hierarchical structure of natural objects are studied.
Suggestion to Create a New Foraminiferal System  [PDF]
V. M. Podobina
Open Journal of Geology (OJG) , 2017, DOI: 10.4236/ojg.2017.74039
Abstract: The paper discusses a new conception of the foraminiferal system, which constitutes an extensive but rapidly developing group of organisms. In the author’s view, this system is based on five criteria those of morphological, ontophylogenetic, geochronological, paleogeographical, and paleobiogeo-graphical ones. The morphological criterion is a cardinal one with regard to the chemical composition and microstructure of test walls. The rank of the established 15 subclasses of foraminifera is assigned to the class Foraminifera d’Orbigny, 1826. Thus, the scientists generalized the data on the foraminiferal studies and raised this group of organisms from a rank to a class in comparison with orders in the system known from “Basics of Paleontology” [1]. The phylogeny of separate subclasses established on the basis of five foraminifera development stages is of great importance because it corresponds to the morphological structure and crucial tectonic movements during the Phanerozoic. The studies of the morphological peculiarities of the foraminiferal tests are based on the various methods elaborated mainly by the author.
Cenomanian-Turonian Foraminiferal Zones of West Siberian Province and Their Correlation with Canadian Province  [PDF]
V. M. Podobina
Open Journal of Geology (OJG) , 2017, DOI: 10.4236/ojg.2017.78078
Abstract: Data on Late Cenomanian and Early Turonian foraminiferal assemblages in the northern palaeo biogeographical district of the West Siberian province are summarized in the paper. In addition, the section of borehole 1016 of the Parusovaya area located in the far north of the province is considered. New information on the foraminiferal zones of this stratigraphic level along with the previously known sections of the Tazovskaya, Purpeiskaya, Van-Eganskaya areas provided an opportunity to carry out a correlation of these zones between the West Siberian and the Canadian provinces (Western Canada, Northern Alaska). The West Siberian Late Cenomanian Trochammina wetteri tumida, Verneuilinoides kansasensis and the Early Turonian Gaudryinopsis angustus foraminiferal zones have their analogues as similar zones in the Canadian province. Due to the provided correlation of the micropalaeontological (foraminiferal) zones, their age in the West Siberian province has been clarified. Besides, similarity of the conditions of dwelling within the boundaries of the entire Arctic palaeobiogeographical realm has been observed.
Spreading Agglutinated Foraminifera near Rift Structures of West-Siberian and Other Provinces  [PDF]
V. M. Podobina
Open Journal of Geology (OJG) , 2017, DOI: 10.4236/ojg.2017.711116
Abstract: Agglutinated quartz-siliceous foraminifera are widely spread in West Siberian, at least in Canadian and Middle Asia provinces. Considerable amounts of these forms are assigned to the rift structures which stretch out in the meridional direction in these provinces. The foraminifera assemblages of these forms may have been formed in the Arctic basin. As an example, we have studied agglutinated foraminifera of the Cenomanian-Turonian in the provinces along the rift to which industrial hydrocarbon field is assigned. The Plates 1-4—Cenomanian-Turonian agglutinated foraminifera of West-Siberian provinces are presented. Correlation of Foraminiferal zones and layers of West Siberian and Canadian provinces, showing the agglutinated index-species foraminifera are presented.
A Modified Method for Deriving Self-Conjugate Dirac Hamiltonians in Arbitrary Gravitational Fields and Its Application to Centrally and Axially Symmetric Gravitational Fields  [PDF]
M. V. Gorbatenko, V. P. Neznamov
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.63034
Abstract: We have proposed previously a method for constructing self-conjugate Hamiltonians Hh in the h-representation with a flat scalar product to describe the dynamics of Dirac particles in arbitrary gravitational fields. In this paper, we prove that, for block-diagonal metrics, the Hamiltonians Hh can be obtained, in particular, using “reduced” parts of Dirac Hamiltonians, i.e. expressions for Dirac Hamiltonians derived using tetrad vectors in the Schwinger gauge without or with a few summands with bispinor connectivities. Based on these results, we propose a modified method for constructing Hamiltonians in the h-representation with a significantly smaller amount of required calculations. Using this method, here we for the first time find self-conjugate Hamiltonians for a number of metrics, including the Kerr metric in the Boyer-Lindquist coordinates, the Eddington-Finkelstein, Finkelstein-Lemaitre, Kruskal, Clifford torus metrics and for non-stationary metrics of open and spatially flat Friedmann models.
Thermoelectrical Investigation of Rare Earth Sulfide Materials  [PDF]
V.V. Sokolov, V.V. Bakovetz, S.M. Luguev, N.V. Lugueva
Advances in Materials Physics and Chemistry (AMPC) , 2012, DOI: 10.4236/ampc.2012.24B007
Abstract: Results  are presented on synthesis   and crystal growth of  Gd2S3-Dy2S3 solid solution sulfides and study of their thermoelectric properties in the range of temperatures 80-400 K. Gd0.2Dy0.8S1.48 composition has the best values of thermoelectric efficiency 0.39 x 10-3/K at 400 K.
Extending the Network Lifetime of Wireless Sensor Networks Using Residual Energy Extraction—Hybrid Scheduling Algorithm  [PDF]
T. V. PADMAVATHY, M. CHITRA
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2010, DOI: 10.4236/ijcns.2010.31015
Abstract: Wireless sensor networks (WSNs) are mostly deployed in a remote working environment, since sensor nodes are small in size, cost-efficient, low-power devices, and have limited battery power supply. Because of limited power source, energy consumption has been considered as the most critical factor when designing sensor network protocols. The network lifetime mainly depends on the battery lifetime of the node. The main concern is to increase the lifetime with respect to energy constraints. One way of doing this is by turning off redun-dant nodes to sleep mode to conserve energy while active nodes can provide essential k-coverage, which improves fault-tolerance. Hence, we use scheduling algorithms that turn off redundant nodes after providing the required coverage level k. The scheduling algorithms can be implemented in centralized or localized schemes, which have their own advantages and disadvantages. To exploit the advantages of both schemes, we employ both schemes on the network according to a threshold value. This threshold value is estimated on the performance of WSN based on network lifetime comparison using centralized and localized algorithms. To extend the network lifetime and to extract the useful energy from the network further, we go for compromise in the area covered by nodes.
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