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Search Results: 1 - 10 of 4685 matches for " Uyen Thao Nguyen "
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Survey Evaluating Sleep Education Catalyzed Change in Residency Training  [PDF]
Demetra S. Stamm, Sandra Taylor, Uyen Thao Nguyen, Kimberly Hardin
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.67058
Background: Despite the high prevalence and negative effects of sleep disorders, sleep issues often remain unexplored during medical encounters. Research has shown that primary care physicians regard their knowledge as inadequate. Objective: We investigated residents’ perceived adequacy of sleep education and level of competency in diagnosing and treating sleep disorders. Methods: A questionnaire via Survey Monkey was administered to senior residents in University of California, Davis (UCD) from family medicine, internal medicine, neurology, and psychiatry to assess perception of their knowledge and training of sleep disorders. Likert scale ratings were used, from 1 (not adequate/competent) to 5 (extremely adequate/competent). Non-parametric statistical methods were used to evaluate differences in survey responses among specialties and assess the correlation between survey responses. Results: Only 33 residents responded with a 29.5% response rate. Neurology residents routinely rotate with a sleep medicine attending and subsequently reported the highest self-competency, adequacy of training, hours of didactics received and frequency of asking patients about sleep. All other residents reported receiving insufficient sleep medicine education. The combined mean score was 1.5 across the specialties regarding adequacy of sleep education in their respective medical schools with 31.3% reporting no sleep medicine training. Conclusions: This study demonstrated that there is a perceived deficit in most residents’ training and competency regarding sleep disorders. These results prompted 2 of the 4 residency programs to change their educational structure with electives in clinical sleep medicine. We believe that this paper illuminates potential need for increasing sleep medicine education throughout various levels of training. Nationwide educational research is needed to promote ACGME to incorporate the fundamentals of sleep medicine into core curriculum. Current Knowledge/Study Rationale: There are no studies, to our knowledge, directly measuring residents’ perceived adequacy of sleep medicine education provided and their perceived level of competency in diagnosing and treating sleep disorders. The aim of this study was to evaluate both the amount of time and quality of sleep education provided to residents as insufficient knowledge in addressing sleep problems may reflect gaps in educational
Comparison of Accuracy of Diabetes Risk Score and Components of the Metabolic Syndrome in Assessing Risk of Incident Type 2 Diabetes in Inter99 Cohort
Tracy B. Shafizadeh, Edward J. Moler, Janice A. Kolberg, Uyen Thao Nguyen, Torben Hansen, Torben Jorgensen, Oluf Pedersen, Knut Borch-Johnsen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022863
Abstract: Background Given the increasing worldwide incidence of diabetes, methods to assess diabetes risk which would identify those at highest risk are needed. We compared two risk-stratification approaches for incident type 2 diabetes mellitus (T2DM); factors of metabolic syndrome (MetS) and a previously developed diabetes risk score, PreDx? Diabetes Risk Score (DRS). DRS assesses 5 yr risk of incident T2DM based on the measurement of 7 biomarkers in fasting blood. Methodology/Principal Findings DRS was evaluated in baseline serum samples from 4,128 non-diabetic subjects in the Inter99 cohort (Danes aged 30–60) for whom diabetes outcomes at 5 years were known. Subjects were classified as having MetS based on the presence of at least 3 MetS risk factors in baseline clinical data. The sensitivity and false positive rate for predicting diabetes using MetS was compared to DRS. When the sensitivity was fixed to match MetS, DRS had a significantly lower false positive rate. Similarly, when the false positive rate was fixed to match MetS, DRS had a significantly higher specificity. In further analyses, subjects were classified by presence of 0–2, 3 or 4–5 risk factors with matching proportions of subjects distributed among three DRS groups. Comparison between the two risk stratification schemes, MetS risk factors and DRS, were evaluated using Net Reclassification Improvement (NRI). Comparing risk stratification by DRS to MetS factors in the total population, the NRI was 0.146 (p = 0.008) demonstrating DRS provides significantly improved stratification. Additionally, the relative risk of T2DM differed by 15 fold between the low and high DRS risk groups, but only 8-fold between the low and high risk MetS groups. Conclusions/Significance DRS provides a more accurate assessment of risk for diabetes than MetS. This improved performance may allow clinicians to focus preventive strategies on those most in need of urgent intervention.
Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
Rima Kaddurah-Daouk, Rebecca A. Baillie, Hongjie Zhu, Zhao-Bang Zeng, Michelle M. Wiest, Uyen Thao Nguyen, Katie Wojnoonski, Steven M. Watkins, Miles Trupp, Ronald M. Krauss
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025482
Abstract: Although statins are widely prescribed medications, there remains considerable variability in therapeutic response. Genetics can explain only part of this variability. Metabolomics is a global biochemical approach that provides powerful tools for mapping pathways implicated in disease and in response to treatment. Metabolomics captures net interactions between genome, microbiome and the environment. In this study, we used a targeted GC-MS metabolomics platform to measure a panel of metabolites within cholesterol synthesis, dietary sterol absorption, and bile acid formation to determine metabolite signatures that may predict variation in statin LDL-C lowering efficacy. Measurements were performed in two subsets of the total study population in the Cholesterol and Pharmacogenetics (CAP) study: Full Range of Response (FR), and Good and Poor Responders (GPR) were 100 individuals randomly selected from across the entire range of LDL-C responses in CAP. GPR were 48 individuals, 24 each from the top and bottom 10% of the LDL-C response distribution matched for body mass index, race, and gender. We identified three secondary, bacterial-derived bile acids that contribute to predicting the magnitude of statin-induced LDL-C lowering in good responders. Bile acids and statins share transporters in the liver and intestine; we observed that increased plasma concentration of simvastatin positively correlates with higher levels of several secondary bile acids. Genetic analysis of these subjects identified associations between levels of seven bile acids and a single nucleotide polymorphism (SNP), rs4149056, in the gene encoding the organic anion transporter SLCO1B1. These findings, along with recently published results that the gut microbiome plays an important role in cardiovascular disease, indicate that interactions between genome, gut microbiome and environmental influences should be considered in the study and management of cardiovascular disease. Metabolic profiles could provide valuable information about treatment outcomes and could contribute to a more personalized approach to therapy.
On the Polyconvolution with the Weight Function for the Fourier Cosine, Fourier Sine, and the Kontorovich-Lebedev Integral Transforms
Nguyen Xuan Thao
Mathematical Problems in Engineering , 2010, DOI: 10.1155/2010/709607
Abstract: The polyconvolution with the weight function of three functions ,, and ? for the integral transforms Fourier sine (), Fourier cosine (), and Kontorovich-Lebedev (), which is denoted by ?(,,?)(x), has been constructed. This polyconvolution satisfies the following factorization property (?(,,?))()=sin00000()()?()()?(?)(), for all >0. The relation of this polyconvolution to the Fourier convolution and the Fourier cosine convolution has been obtained. Also, the relations between the polyconvolution product and others convolution product have been established. In application, we consider a class of integral equations with Toeplitz plus Hankel kernel whose solution in closed form can be obtained with the help of the new polyconvolution. An application on solving systems of integral equations is also obtained.
Thermal modeling of lesion growth with radiofrequency ablation devices
Isaac A Chang, Uyen D Nguyen
BioMedical Engineering OnLine , 2004, DOI: 10.1186/1475-925x-3-27
Abstract: We present an axisymmetric two-dimensional finite element model that calculates cell damage in tissues and compare lesion sizes using common tissue damage and iso-temperature contour definitions. The model accounts for both temperature-dependent changes in the electrical conductivity of tissue as well as tissue damage-dependent changes in local tissue perfusion. The data is validated using excised porcine liver tissues.The data demonstrate the size of thermal lesions is grossly overestimated when calculated using traditional temperature isocontours of 42°C and 47°C. The computational model results predicted lesion dimensions that were within 5% of the experimental measurements.When modeling radiofrequency ablation problems, temperature isotherms may not be representative of actual tissue damage patterns.The mitigation of primary and metastatic tumors by radiofrequency ablation is a developing research area. The goal of ablation is to necrose treatment volumes by raising the temperature of targeted tissues. Ablation probes are inserted percutaneously, laparoscopically, or during surgery into cancerous tumors. Once positioned, high frequency alternating current (450–550 kHz) is delivered through an uninsulated electrode into the surrounding tissues to a dispersive ground pad that is applied to the patient. The electromagnetic energy is converted to heat by resistive heating.While the usage of radiofrequency ablation devices is well established, efforts to optimize treatment strategies are ongoing. An important consideration in optimizing ablation is determining what treatment volumes are necessary and acceptable. In liver ablation, for example, treatment volumes generally extend a centimeter beyond the dimensions of a tumor [1-3]. Since the liver possesses regenerative characteristics, it is more critical to insure that necrosis is achieved in 100% of the cancerous cell volume than to minimize damage to healthy tissues. In contrast, a centimeter margin in cardiac abla
Etanercept in the treatment of plaque psoriasis
Thao U Nguyen, John Koo
Clinical, Cosmetic and Investigational Dermatology , 2009, DOI: http://dx.doi.org/10.2147/CCID.S3412
Abstract: anercept in the treatment of plaque psoriasis Review (5607) Total Article Views Authors: Thao U Nguyen, John Koo Published Date May 2009 Volume 2009:2 Pages 77 - 84 DOI: http://dx.doi.org/10.2147/CCID.S3412 Thao U Nguyen, John Koo Department of Dermatology, Psoriasis and Skin Treatment Center, University of California, San Francisco, San Francisco, California, USA Abstract: Etanercept is approved for the treatment of moderate to severe plaque psoriasis at a dose of 50 mg twice weekly for 3 months followed by a maintenance dosage of 50 mg weekly thereafter. Clinical studies have shown excellent efficacy, favorable benefit to side-effects ratio, and safe long-term usage. Extensive information on safety is available as etanercept has been used for many years for other indications such as rheumatoid arthritis and psoriatic arthritis and is the first of the tumor necrosis factor antagonists to gain approval in psoriasis.
Regional Conflict Management: Challenges of the Border Disputes of Cambodia, Laos, and Vietnam
Ramses Amer,Nguyen Hong Thao
ASEAS : ?sterreichische Zeitschrift für Südostasienwissenschaften , 2009,
Abstract: This study analyzes the border disputes of Cambodia, Laos, and Vietnam, respectively. Both settled and unsettled disputes are encompassed. The study outlines the settlements reached and the remaining unsettled disputes. Furthermore, the broader trends in managing the border disputes are analyzed and remaining challenges, both in implementing agreements and in managing the unsettled disputes, are addressed. So are the implications for regional conflict management. The study displays that both Laos and Vietnam have made considerable progress in both managing and settling their existing border disputes, whereas Cambodia has thus far been less successful. --- Dieser Beitrag analysiert Grenzstreitigkeiten Kambodschas, Laos und Vietnams. Gelo ste und ungelo ste Konflikte, als auch weitere Trends im Management von Grenzstreitigkeiten werden dabei betrachtet. Herausforderungen in der Umsetzung von Vereinbarungen sowie in der Schlichtung noch ungelo ster Dispute und deren Implikationen auf das regionale Konfliktmanagement werden adressiert. Die Studie zeigt auf, dass Laos und Vietnam betra chtliche Fortschritte im Management und in der Lo sung ihrer Grenzstreitigkeiten gemacht machen, wa hrend Kambodscha bis dato weniger erfolgreich war.
Etanercept in the treatment of plaque psoriasis
Thao U Nguyen,John Koo
Clinical, Cosmetic and Investigational Dermatology , 2009,
Abstract: Thao U Nguyen, John KooDepartment of Dermatology, Psoriasis and Skin Treatment Center, University of California, San Francisco, San Francisco, California, USAAbstract: Etanercept is approved for the treatment of moderate to severe plaque psoriasis at a dose of 50 mg twice weekly for 3 months followed by a maintenance dosage of 50 mg weekly thereafter. Clinical studies have shown excellent efficacy, favorable benefit to side-effects ratio, and safe long-term usage. Extensive information on safety is available as etanercept has been used for many years for other indications such as rheumatoid arthritis and psoriatic arthritis and is the first of the tumor necrosis factor antagonists to gain approval in psoriasis.Keywords: etanercept, plaque psoriasis, tumor necrosis factor antagonist
Quantitative Characterizations of Regularity Properties of Collections of Sets
Alexander Kruger,Nguyen Hieu Thao
Mathematics , 2013, DOI: 10.1007/s10957-014-0556-0
Abstract: Several primal and dual characterizations of regularity properties of collections of sets in normed linear spaces are discussed. Relationships between regularity properties of collections of sets and those of set-valued mappings are provided.
Green Synthesis of Carvenone by Montmorillonite-Catalyzed Isomerization of 1,2-Limonene Oxide  [PDF]
Thao-Tran Thi Nguyen, Duy-Khiem Nguyen Chau, Fritz Duus, Thach Ngoc Le
International Journal of Organic Chemistry (IJOC) , 2013, DOI: 10.4236/ijoc.2013.33027
Abstract: Montmorillonite was considered as a good heterogeneous catalyst for the isomerization of 1,2-limonene oxide into car-venone under solvent-free condition. Both conventional heating and green activations were tested in this research. The microwave-assisted isomerization afforded carvenone in high yield within only 6 minutes.
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