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Search Results: 1 - 10 of 1688 matches for " Uma Rani Potunuru "
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Inhibition of Vascular Smooth Muscle Cell Proliferation by Gentiana lutea Root Extracts
Rushendhiran Kesavan, Uma Rani Potunuru, Branislav Nastasijevi?, Avaneesh T, Gordana Joksi?, Madhulika Dixit
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061393
Abstract: Gentiana lutea belonging to the Gentianaceae family of flowering plants are routinely used in traditional Serbian medicine for their beneficial gastro-intestinal and anti-inflammatory properties. The aim of the study was to determine whether aqueous root extracts of Gentiana lutea consisting of gentiopicroside, gentisin, bellidifolin-8-O-glucoside, demethylbellidifolin-8-O-glucoside, isovitexin, swertiamarin and amarogentin prevents proliferation of aortic smooth muscle cells in response to PDGF-BB. Cell proliferation and cell cycle analysis were performed based on alamar blue assay and propidium iodide labeling respectively. In primary cultures of rat aortic smooth muscle cells (RASMCs), PDGF-BB (20 ng/ml) induced a two-fold increase in cell proliferation which was significantly blocked by the root extract (1 mg/ml). The root extract also prevented the S-phase entry of synchronized cells in response to PDGF. Furthermore, PDGF-BB induced ERK1/2 activation and consequent increase in cellular nitric oxide (NO) levels were also blocked by the extract. These effects of extract were due to blockade of PDGF-BB induced expression of iNOS, cyclin D1 and proliferating cell nuclear antigen (PCNA). Docking analysis of the extract components on MEK1, the upstream ERK1/2 activating kinase using AutoDock4, indicated a likely binding of isovitexin to the inhibitor binding site of MEK1. Experiments performed with purified isovitexin demonstrated that it successfully blocks PDGF-induced ERK1/2 activation and proliferation of RASMCs in cell culture. Thus, Gentiana lutea can provide novel candidates for prevention and treatment of atherosclerosis.
Immunomodulatory effect of S. thermophilus : An experimental study
Aruna Bhatia,Uma Rani
Calicut Medical Journal , 2008,
Abstract: The most promising development in the area of functional foods has been the use of probiotics & their role in human health and disease. Much of the research work in probiotics has been focused on the gastrointestinal tract. One of these putative effects is the alteration of immune function. Studies reveal that the probiotics have a positive effect on the gut immunity. But hardly any work has been carried out on the effect of probiotics on the systemic immunity. Moreover this effect varies with not only the genera andspecies of the probiotic but also with type of probiotic. It has been shown in the literature that only the live probiotics are capable of showing an effect. In the present study experiments were carried out to see the effect of probiotics Streptococcus thermophilus (S. thermophilus) both live and dead on systemicimmune response. Results reveal that S.thermophilus feeding, both in dead and alive form, could modify both the humoral and cellmediated immune response, however, the effect was more pronounced with the live form.”
A Novel Approach to Scheduling in Grid Environment: Enhanced Ant Colony Optimizer
D. Maruthanayagam,Dr.R. Uma Rani
International Journal of Advanced Research in Computer Engineering & Technology (IJARCET) , 2013,
Abstract: In this paper we compared and evaluated the scheduling performances of existing heuristic scheduling algorithms with our proposed Enhanced Ant Colony Optimization (EACO). We take the algorithms for comparison Modified Ant Colony Optimization (MACO), MAX-MIN and RASA scheduling algorithms. We also presented a new job scheduling algorithm based on Resource Aware Scheduling Algorithm (RASA). Our algorithm aims to improve the makespan of the job scheduling, avoiding starvation, proper resource selection and allocation according to the system and network performance in dynamic Grid Environment. We achieved our goal with the help of the proposed simulator Grid Network Listing Tool (GNLT). It performed simulation process in real time environment. Thus, the task scheduling can be performed more effectively by achieving lower makespan time than the existing scheduling algorithms.
Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) in Breast Cancer
Uma Sharma, Rani Gupta Sah and Naranamangalam R. Jagannathan
Magnetic Resonance Insights , 2012,
Abstract: Breast cancer is a major health problem in women and early detection is of prime importance. Breast magnetic resonance imaging (MRI) provides both physical and physiologic tissue features that are useful in discriminating malignant from benign lesions. Contrast enhanced MRI is valuable for diagnosis of small tumors in dense breast and the structural and kinetic parameters improved the specificity of diagnosing benign from malignant lesions. It is a complimentary modality for preoperative staging, to follow response to therapy, to detect recurrences and for screening high risk women. Diffusion, perfusion and MR elastography have been applied to breast lesion characterization and show promise. In-vivo MR spectroscopy (MRS) is a valuable method to obtain the biochemical status of normal and diseased tissues. Malignant tissues contain high concentration of choline containing compounds that can be used as a biochemical marker. MRS helps to increase the specificity of MRI in lesions larger than 1cm and to monitor the tumor response. Various MR techniques show promise primarily as adjunct to the existing standard detection techniques, and its acceptability as a screening method will increase if specificity can be improved. This review presents the progress made in different MRI and MRS techniques in breast cancer management.
Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) in Breast Cancer
Uma Sharma,Rani Gupta Sah,Naranamangalam R. Jagannathan
Magnetic Resonance Insights , 2008,
Abstract:
Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) in Breast Cancer
Uma Sharma,Rani Gupta Sah,Naranamangalam R. Jagannathan
Magnetic Resonance Insights , 2008,
Abstract: Breast cancer is a major health problem in women and early detection is of prime importance. Breast magnetic resonance imaging (MRI) provides both physical and physiologic tissue features that are useful in discriminating malignant from benign lesions. Contrast enhanced MRI is valuable for diagnosis of small tumors in dense breast and the structural and kinetic parameters improved the specificity of diagnosing benign from malignant lesions. It is a complimentary modality for preoperative staging, to follow response to therapy, to detect recurrences and for screening high risk women. Diffusion, perfusion and MR elastography have been applied to breast lesion characterization and show promise.In-vivo MR spectroscopy (MRS) is a valuable method to obtain the biochemical status of normal and diseased tissues. Malignant tissues contain high concentration of choline containing compounds that can be used as a biochemical marker. MRS helps to increase the specificity of MRI in lesions larger than 1cm and to monitor the tumor response. Various MR techniques show promise primarily as adjunct to the existing standard detection techniques, and its acceptability as a screening method will increase if specificity can be improved. This review presents the progress made in different MRI and MRS techniques in breast cancer management.
Impact of Yoga Nidra on psychological general wellbeing in patients with menstrual irregularities: A randomized controlled trial
Rani Khushbu,Tiwari S,Singh Uma,Agrawal G
International Journal of Yoga , 2011,
Abstract: Background: Yogic relaxation therapy (Yoga Nidra) has been effectively prescribed in conjunction with other medical and yogic procedures in the management of severe psychosomatic diseases, including cancer, bronchial asthma, colitis, peptic ulcer and menstrual irregularities. Aim of the study: To assess the impact of Yoga Nidra on psychological problems in patients with menstrual disorders. Materials and Methods: Patients were recruited from the Department of Obstetrics and Gynecology, C.S.M. Medical University (erstwhile KGMU), Lucknow, Uttar Pradesh, India. A total of 150 female subjects were randomly divided into two groups: 1) group of 75 subjects (with yogic intervention) and 2) a control group of 75 subjects (without yogic intervention). Assessment of psychological general wellbeing (tool) was used for all the subjects Assessment of psychological general well being (tool) was used for all the subjects (Cases and controls). This assessment was done twice first time in the beginning (baseline) and then after six months. Results : Anxiety decreased significantly (P<0.003) and depression decreased significantly (P<0.01) in the Yoga group. Positive wellbeing and general health improved significantly (P<0.02), and vitality improved significantly (P<0.01) after six months of Yoga therapy (Yoga Nidra) in the Yoga group compared with the control group. Conclusion : The current findings suggest that patients with menstrual irregularities having psychological problems improved significantly in the areas of their wellbeing, anxiety and depression by learning and applying a program based on Yogic intervention (Yoga Nidra).
Porous Layer Characterization of Anodized and Black-Anodized Aluminium by Electrochemical Studies
M. Franco,S. Anoop,R. Uma Rani,A. K. Sharma
ISRN Corrosion , 2012, DOI: 10.5402/2012/323676
Abstract:
Porous Layer Characterization of Anodized and Black-Anodized Aluminium by Electrochemical Studies
M. Franco,S. Anoop,R. Uma Rani,A. K. Sharma
ISRN Corrosion , 2012, DOI: 10.5402/2012/323676
Abstract: Three types of black anodic coatings, namely, black dyeing (BD), inorganic colouring (IC), and electrolytic colouring (EC) were prepared by conventional type II sulphuric acid anodizing on Al6061 alloys. Electrochemical behaviour of these coatings was studied by exposure to 3.5% wt sodium chloride solution for prolonged immersion periods up to 360 hours. The porous layer characteristics of all sealed, fresh and autosealed coatings were investigated by means of electrochemical impedance spectroscopy (EIS). An equivalent circuit that reproduces the a.c. impedance results of porous aluminium oxide films is proposed. The breakpoint frequency and damage function analysis were carried out to analyse the coating's electrochemical behaviour. Corrosion morphology was studied by scanning electron microscopy. It was observed that BD and IC behaved in a very similar manner to sulphuric acid anodising (SAA). However EC was behaving in an entirely different manner. Among all colouring methods BD was showing very less values. All these findings were further confirmed by linear polarisation studies. No major evidence of localised corrosion or pitting of the black anodic coatings was observed in SEM micrographs. 1. Introduction Black anodic coatings are widely used in space components for various reasons such as passive thermal control of satellites and absorption of stray lights in the optical components. They have the advantages of providing very high corrosion resistance, wear resistance, thermal control properties, and so forth to components made of aluminium alloys. The unique duplex porous structure of the anodic oxide layer formed on the surface of aluminium alloys helps in impregnation of various colouring pigments providing required colour to the components. Variety of black anodizing processes were studied by us for thermal control applications, namely, organic black dyeing, black permanganate conversion coating, inorganic colouring, integral black colouring, electrolytic black colouring, and so forth [1–5]. Hydrothermal sealing (HTS) of the pores after black anodizing is done to avoid penetration of foreign elements into the pores which may deteriorate the resistance to corrosion. Electrochemical impedance spectroscopy (EIS) has been the most widely used technique to study the porous and barrier layer properties of anodic oxide coatings. Hoar and Wood investigated on dependence of various processing parameters on anodization of aluminium using impedance data [6]. It was established that the barrier layer thickness, pore diameter, and the hexagonal cell
Synthesis, characterisation and antimicrobial-activity of 3-thio-1,5-dihydro-2,4,3-benzodioxaphosphepin-3-amino acid esters
Chinthaparthi Radha Rani,Gangireddy Chandra Sekhar Reddy,Chereddy Syama Sundar,Kunda Uma Maheswara Rao
Organic Communications , 2011,
Abstract: A new series of 3-thio-1,5-dihydro-2,4,3-benzodioxaphosphepin-3-amino acid esters (4a-k) were synthesized by treating different amino acid ester hydrochlorides (3a-k) with phosphorus monochloride intermediate (2) which was previously formed in situ from 1,2-phenylenedimethanol (1) and thiophosphoryl chloride in the presence of triethylamine in dry tetrahydrofuran (THF) at 0-5 oC to room temperature. The structures of the title compounds (4a-k) were established by analytical, IR, NMR (1H, 13C and 31P) and mass spectra, and they have been screened for their antimicrobial activity. They exhibited significant antibacterial, and antifungal activity.
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