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Search Results: 1 - 10 of 969 matches for " Ulrike Hoeller "
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Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy
Annette Raabe, Katharina Derda, Sebastian Reuther, Silke Symczak, Kerstin Borgmann, Ulrike Hoeller, Andreas Ziegler, Cordula Petersen, Ekkehard Dikomey
Radiation Oncology , 2012, DOI: 10.1186/1748-717x-7-65
Abstract: Retrospective analysis of 83 breast cancer patients treated with breast conserving radiotherapy. A total dose of 50.4?Gy was administered, applying 1.8?Gy/fraction within 42?days. Erythema was evaluated according to the Radiation Therapy Oncology Group (RTOG) score. DNA was extracted from blood samples and polymorphisms were determined using either the Polymerase Chain Reaction based Restriction-Fragment-Length-Polymorphism (PCR-RFL) technique or Matrix-Assisted-Laser-Desorption/Ionization –Time-Of-Flight-Mass-Spectrometry (MALDI-TOF). Relative excess heterozygosity (REH) was investigated to check compatibility of genotype frequencies with Hardy-Weinberg equilibrium (HWE). In addition, p-values from the standard exact HWE lack of fit test were calculated using 100,000 permutations. HWE analyses were performed using R.Fifty-six percent (46/83) of all patients developed erythema of grade 2 or 3, with this risk being higher for patients with large breast volume (odds ratio, OR?=?2.55, 95% confidence interval, CI: 1.03–6.31, p?=?0.041). No significant association between SNPs and risk of erythema was found when all patients were considered. However, in patients with small breast volume the TGFB1 SNP was associated with erythema (p?=?0.028), whereas the SNP in XPD showed an association in patients with large breast volume (p?=?0.046). A risk score based on all risk alleles was neither significant in all patients nor in patients with small or large breast volume. Risk alleles of most SNPs were different compared to a previously identified risk profile for fibrosis.The genetic risk profile for erythema appears to be different for patients with small and larger breast volume. This risk profile seems to be specific for erythema as compared to a risk profile for fibrosis.
Diagnosis of Rabies via RT-PCR on Skin Samples of Wild and Domestic Animals  [PDF]
Ulrike Zieger
Open Journal of Veterinary Medicine (OJVM) , 2015, DOI: 10.4236/ojvm.2015.59026
Abstract: In developing countries, brain tissues from rabies suspect animals are not always available for diagnosis for a variety of reasons, such as lack of transport to submit a carcass or the difficulty of removing an animal’s head or brain under field conditions. To enable diagnosis in such cases, there is a need for a reliable method, using an alternative non-neural tissue, which can be removed and submitted to the diagnostic laboratory without special training or equipment. In human medicine, skin is used successfully for the detection of rabies virus antigen using RT-PCR technology. Little work has been done in animals using RT-PCR on skin or extracted hair follicles. The current study was conducted in Grenada on skin from 36 wild and domestic animals, in which rabies virus infection had been confirmed in brain tissue via the direct fluorescent antibody (DFA) test, and in 31 negative control animals. RT-PCR on skin yielded a sensitivity of 97.2% (35/36) and a specificity of 100% (31/31). It is concluded that the examination of skin samples via RT-PCR provides a valuable diagnostic alternative in those cases where brain tissue is not readily available.
Grey Zone Lymphomas: Lymphomas with Intermediate Features
Sylvia Hoeller,Christiane Copie-Bergman
Advances in Hematology , 2012, DOI: 10.1155/2012/460801
Abstract: The current classification of lymphoid neoplasms is based on clinical information, morphology, immunophenotype, and molecular genetic characteristics. Despite technical and scientific progress, some aggressive B-cell lymphomas with features overlapping between two different types of lymphomas remain difficult to classify. The updated 2008 World Health Organization (WHO) classification of Tumours of the Hematopoietic and Lymphoid Tissues has addressed this problem by creation of two new provisional categories of B-cell lymphomas, unclassifiable; one with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma and the second with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. We review here the diagnostic criteria of these two provisional entities and discuss new scientific findings in light of the 2008 WHO classification. 1. Introduction The current classification of lymphoid neoplasms is based on clinical information morphology, immunophenotype, and molecular genetic characteristics. Most lymphomas can be accurately classified. However, some lymphomas present with features transitional between diffuse large B-cell lymphomas (DLBCLs) and classical Hodgkin lymphoma (cHL) or DLBCL and Burkitt lymphoma (BL), and these are difficult to classify [1]. These lymphomas have been reported in the literature using different terms, such as borderline lymphomas, B-cell lymphomas unclassifiable, atypical Burkitt lymphoma, Burkitt-like lymphomas, or gray zone lymphomas. The term “Gray Zone Lymphoma” was firstly used in 1998 at the “Workshop on Hodgkin’s disease and related diseases” to designate lymphomas at the border of cHL and other entities [2]. This term was then further extended to lymphomas with overlapping features between BL and DLBCL. The 2008 updated WHO classification of Tumours of the Hematopoietic and Lymphoid Tissues proposed to assign these gray zone lymphomas to provisional categories called B-cell lymphomas unclassifiable with features intermediate between DLBCL and cHL (BCLu-DLBCL/cHL) and B-cell lymphomas unclassifiable with features intermediate between DLBCL and BL (BCLu-DLBCL/BL) [3]. The reason to create these provisional categories is to enable to collect for further studies and to maintain the “purity” of well-defined categories. This would be particularly relevant for conducting clinical studies. This paper focuses on these two provisional entities introduced in the 2008 WHO classification of Tumours of the Hematopoietic and Lymphoid Tissues. 2. B-Cell Lymphoma,
The Discursive Constitution of Ocean Sustainability  [PDF]
Ulrike Kronfeld-Goharani
Advances in Applied Sociology (AASoci) , 2015, DOI: 10.4236/aasoci.2015.512030
Abstract: As part of a search for political responses to protect and conserve marine ecosystems, this study explores the discourse on ocean affairs with a special emphasis on the articulation of the concept of sustainability. Drawing on the discourse theory of Ernesto Laclau and Chantal Mouffe, it is argued that post structuralism offers important insights on the construction of the discourse on maritime-related affairs. The analysis shows that the discourse on ocean affairs is closely tied to the empty signifier “management”, while the analysis of the empty signifier “sustainability” confirms the traditional three dimensional structure comprising economic, social and environmental dimensions, supplemented by an institutional one. The article shows that the use of such signifiers is necessary to define sustainability in all its complexity. In this context, it is argued that Laclau and Mouffe’s discourse theory provides an approach to grasp the ambiguity of the concept of sustainability. It helps to explain the practice of institutions in rephrasing existing objectives and activities in compliance with sustainability without really changing their business as usual approach. The paper concludes with an estimation of how useful it is to adhere to sustainability in ocean affairs especially in view of the complexity, uncertainty and continuous change of marine ecosystems.
Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression
Joseph Schwager, Ulrich Hoeller, Swen Wolfram, Nathalie Richard
BMC Complementary and Alternative Medicine , 2011, DOI: 10.1186/1472-6882-11-105
Abstract: (1) Inflammatory processes were induced in RAW264.7 cells or human peripheral blood leukocytes (PBL) with LPS. Inflammatory mediators (nitric oxide (NO), prostaglandin E2 (PGE2) and cytokines/chemokines) were determined by the Griess reaction, EIA and multiplex ELISA, respectively. Gene expression was quantified by RT-PCR. RHP or its constituent galactolipid, GLGPG (galactolipid (2S)-1, 2-di-O-[(9Z, 12Z, 15Z)-octadeca-9, 12, 15-trienoyl]-3-O-β-D-galactopyranosyl glycerol), were added at various concentrations and the effects on biochemical and molecular parameters were evaluated. (2) SW1353 chondrosarcoma cells and primary human knee articular chondrocytes (NHAC-kn) were treated with interleukin (IL)-1β to induce in vitro processes similar to those occurring during in vivo degradation of cartilage. Biomarkers related to OA (NO, PGE2, cytokines, chemokines, metalloproteinases) were measured by multiplex ELISA and gene expression analysis in chondrocytes. We investigated the modulation of these events by RHP and GLGPG.In macrophages and PBL, RHP and GLGPG inhibited NO and PGE2 production and reduced the secretion of cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-12) and chemokines (CCL5/RANTES, CXCL10/IP-10). In SW1353 cells and primary chondrocytes, RHP and GLGPG diminished catabolic gene expression and inflammatory protein secretion as shown by lower mRNA levels of matrix metalloproteinases (MMP-1, MMP-3, MMP-13), aggrecanase (ADAMTS-4), macrophage inflammatory protein (MIP-2, MIP-3α), CCL5/RANTES, CXCL10/IP-10, IL-8, IL-1α and IL-6. The effects of GLGPG were weaker than those of RHP, which presumably contains other chondro-protective substances besides GLGPG.RHP and GLGPG attenuate inflammatory responses in different cellular systems (macrophages, PBLs and chondrocytes). The effects on cytokine production and MMP expression indicate that RHP and its constituent GLGPG down-regulate catabolic processes associated with osteoarthritis (OA) or rheumatoid arthritis (RA). These
MATERIAL DIDáTICO E A INTERNET: PRINCíPIOS BáSICOS
PAULA, Vera Mariza Chaud de,BOEING, Carolina Hoeller da Silva
Nucleus , 2009,
Abstract: The objective of the work was to identify the basic principles that conduct theelaboration of the didactic material for Education in the distance (EaD) intermediated by computer anddisponibility through the Internet. It approaches the concept of EaD and the evolution of the medias andtechnologies used for this modality of education in five generations. It identifies the elements to beconsidered in the production of the didactic material as: team to interdisciplinary, proper language,dialogic and others that take care of to the proposal philosophical and pedagogical of the courses.O objetivo do trabalho foi identificar os princípios básicos que regem a elabora o domaterial didático para Educa o a Distancia (EaD) intermediado por computador e disponibilizadoatravés da internet. Aborda o conceito de EaD e a evolu o das mídias e tecnologias utilizadas por estamodalidade de ensino em cinco gera es. Identifica os elementos a serem considerados na produ o domaterial didático como: equipe interdisciplinar, linguagem própria, dialogicidade e outros que atendam àproposta filosófica e pedagógica dos cursos.
Instru o e educa o higiênica da infancia catarinense na Primeira República (1910-1930)
Solange Aparecida de Oliveira Hoeller,Gizele de Souza
Roteiro , 2010,
Abstract: Este texto discorre acerca dos modos eleitos para se solucionar os problemas educacionais de higiene no estado de Santa Catarina, a partir da these de Oswaldo Rodrigues Cabral (1929). Como, na vis o de Cabral, se efetivaram ou n o, as inten es de se empreender a profilaxia da infancia por meio das propagandas de princípios higiênicos, tendo como parceiras a escola e a família? Além disso, outra quest o procura responder: como se constituiu a instru o e a educa o higiênica da infancia catarinense – o que fazer e o que ensinar –, no intuito de formar cidad os sadios que contribuíssem com o progresso do Estado e da na o brasileira? A análise diz respeito aos cinco primeiros subtítulos – educa o e instruc o – da segunda parte da these citada.
Evaluation of Energy-Efficient Heuristics for ACO-based Routing in Mobile Wireless Sensor Networks
Arliones Hoeller Jr.,Ant?nio Augusto Fr?hlich
Computer Science , 2015,
Abstract: Mobile ad-hoc networks demand routing algorithms able to adapt to network topologies subject to constant change. Moreover, with the advent of the Internet-of-Things (IoT), network nodes tend not only to show increased mobility, but also impose further restrictions to these mobile network systems. These restrictions include non-functional requirements of low-power consumption, small-size, and low-cost. ADHOP (Ant-based Dynamic Hop Optimization Protocol) is a routing algorithm based on ant-colony optimizations that target such small-size and low-cost platforms, consuming little amounts of memory and processing power. This paper elaborates on ADHOP to investigate the use of energy-related heuristics to guide routing decisions. The goal is to minimize network usage without jeopardizing network operation. We replace the original ADHOP heuristic of network latency by two energy-related heuristics based on the battery charge and the estimated node lifetime. Simulations compare the energy-aware versions of ADHOP to its original version, to AODV and to AOER. Results show that the proposed approaches are able to balance network load among nodes, resulting in a lower number of failures due to battery depletion. The energy-aware versions of ADHOP also deliver more packets than their counter-parts in the simulated scenario, delivering 2x more packets than the original ADHOP, and, respectively, 5x and 9x more packets than AOER and AODV.
Kompetenzorientierung im Fremdsprachenunterricht: was heiβt das eigentlich?
Arras, Ulrike;
Pandaemonium Germanicum , 2009, DOI: 10.1590/S1982-88372009000100011
Abstract: in recent years, the teaching of foreign languages in schools, universities and other institutions involved with language learning has faced several changes and new orientations. the main reason for these changes certainly is the common european framework of languages, published in 2001 by the european council. in germany we additionally develop new educational standards, considering as representative examples english and french as first foreign languages taught in our school system (kultusministerkonferenz (ed.) 2004; tesch et al. (eds.) 2008). normally, such changes in educational systems lead to uncertainty and confusion, a context this article intends to clarify. are we now asked to design our classes, our material and our curricula in completely new modes? what consequences do teachers as well as learners face up to following these new approaches in teaching and learning? what does competence orientation mean exactly? and which chances does it offer?
Die Bibliothek der Medizinischen Universit t Graz: Visionen – Konzepte – Fakten / The library of the Medical University of Graz: visions – concepts – facts
Kortschak, Ulrike
GMS Medizin-Bibliothek-Information , 2009,
Abstract: This article gives short overview of the history and the philosophy of the Library of the Medical University of Graz. The library was founded in 2004 and developed in the last five years modern standards.
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