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Search Results: 1 - 10 of 195597 matches for " Ulrich;G?rg "
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?''Globalización sostenible''? Desarrollo sostenible como pegamento para el montón de cristales trizados del neoliberalismo
Brand, Ulrich;Grg, Christoph;
Ambiente & Sociedade , 2003, DOI: 10.1590/S1414-753X2003000200004
Abstract: during the world summit on sustainable development, held in johannesburg by mid 2001, it was clearly observed that our understandings and practices concerning sustainable development are on a dead end. this is due to the fact that the much more dynamic processes of neo-liberal globalization and of world restructuring had been ignored, including the new legitimacy of wars in the '90s. after september 11th, 2001, it was evident that we live in a non-hegemonic context with particular consequences. nevertheless, ?sustainable development'' did not emerge as a counter-discourse. on the contrary, its directions and practices were more and more compatible with dominant rebuilding processes. sustainable development lost its critical impact through its focus on cooperation and western modern knowledge, its technocratic concept of politics, the prevailing of environmental issues over the ones of development and nation-state as privileged areas for implementation of policies. in addition, international sustainable development organizations (in the article the biological diversity convention is given as an example) takes part in nature's economic exploitation process. finally, in a recent past, actions aiming at establishing military structure in southern cone countries _ justified by the necessity of sustainable development policies _ gained legitimacy. currently, the ?rio process'' tries to reconcile globalization processes to sustainable development and, eventually, the concept of ?sustainable globalization'' will emerge as a new paradigm for dominant trends and practices. at last, the authors argue that the most dynamic challenges to neo-liberal globalization and militarization arise in a different political background which is, until now, hardly linked to sustainable development policies: the so called movements of globalization criticism. from a theoretical perspective, the article reports on the regulation theory and critical theory of the state, as well as on concepts of
''Globalización sostenible''? Desarrollo sostenible como pegamento para el montón de cristales trizados del neoliberalismo
Brand Ulrich,Grg Christoph
Ambiente & Sociedade , 2003,
Abstract: En la Cumbre Mundial sobre Medio Ambiente y Desarrollo en Johannesburgo a mediados del a o 2002, se pudo ver claramente que los entendimientos y las prácticas del desarrollo sostenible están en un callejón sin salida. Eso tiene que ver con el hecho que se habían ignorado los procesos mucho más dinámicos de la globalización neoliberal y de la reestructuración del mundo, incluyendo la nueva legitimidad de las guerras en los a os 90s. Después del 11 de septiembre del a o 2001, argumentan los autores, se hizo evidente que vivimos en una situación no hegemónica con implicaciones específicas. Pero el ''desarrollo sostenible'' no se fracturó como contra discurso. Al contrario, sus orientaciones y prácticas eran cada vez más compatibles con la reestructuración dominante. El desarrollo sostenible perdió sus implicaciones críticas con su enfoque en la cooperación y el conocimiento moderno occidental, su conceptualización tecnócrata de la política, la predominancia de las cuestiones medioambientales sobre las del desarrollo y el Estado-nación como área privilegiada para la implementación de políticas. Además, las instituciones internacionales del desarrollo sostenible (en el artículo se toma como ejemplo del Convenio sobre Diversidad Biológica) son parte de la economización de la naturaleza. Finalmente, en el último tiempo ganaron legitimidad las iniciativas que intentan establecer mecanismos militares en países del Sur que se justifican con la necesidad de políticas de desarrollo sostenible. Actualmente, el ''proceso de Río'' trata de reconciliar los procesos de globalización con el desarrollo sostenible y, eventualmente, el término ''globalización sostenible'' va a surgir como nuevo paradigma para las orientaciones y prácticas dominantes. Al final del artículo, los autores argumentan que los desafíos más dinámicos contra la globalización neoliberal y la militarización emergen en otro terreno político que hasta ahora no está muy vinculado con las políticas de desarrollo sostenible: los así llamados movimientos críticos a la globalización. Desde un punto de vista teórico, el texto está informando sobre la teoría de regulación y la teoría crítica del Estado así como sobre los conceptos del medio ambiente politizado y las relaciones de la sociedad con la naturaleza.
Regimes in Global Environmental Governance and the Internationalization of the State: The Case of Biodiversity Politics
Ulrich Brand,Christoph Grg
International Journal of Social Science Studies , 2013, DOI: 10.11114/ijsss.v1i1.75
Abstract: Scholarly debates on the relative (in-)effectiveness of global environmental governance increasingly focus on problems of cooperation across regime boundaries and on the missing knowledge base for such interlinkages. Global environmental change and related politics are increasingly seen as taking place in a complex field in which several ecological processes are interlinked – e.g. climate change, biodiversity, water, and land-use change – and these processes are deeply interconnected with societal processes, such as food supply and nutrition and the economic and financial crisis. We argue that institutionalist approaches have their merits but they are nevertheless inadequate because they do not seriously address questions concerning the root causes of problems, power, and domination. Furthermore, they do not critically scrutinise how the political institutions of current global environmental governance may in fact support broader socio-economic and political developments. This could effectively undermine the supposed goals of global environmental governance institutions and could seriously threaten other social or ecological processes. Informed by critical research on global environmental governance and adding to this literature insight from critical state theory, we develop an understanding of the internationalized state as well as its role and function in globalized capitalism. We illustrate our argument with recent developments in international biodiversity politics. We show that the predominant forms of politics are not very effective with respect to the ongoing erosion of biodiversity. However, the complicated and conflictive political processes within an apparatus of the internationalised state are mainly in line with hegemonic developments and dominant interest, i.e. the increasing valorization of biodiversity and especially of genetic resources.
Ateriovenous subclavia-shunt for head and neck reconstruction
Rita A Depprich, Christian D Naujoks, Ulrich Meyer, Norbert R Kübler, J?rg G Handschel
Head & Face Medicine , 2008, DOI: 10.1186/1746-160x-4-27
Abstract: We describe the reconstruction of the facial hard- and soft tissues with a free parasacpular flap in a patient who had received ablative tumor surgery and radical cervical lymphadenectomy as a treatment regimen for squamous cell carcinoma (SCC). To replace the missing cervical blood vessels an arteriovenous subclavia-shunt using a saphena magna graft was created. Microvascular free flap transfer was performed as a 2-stage procedure two weeks after the shunt operation. The microvascular reconstructive technique is described in detail.Various reconstructive options have been used in the past for the reconstruction of head and neck tissues. In a high number of patients, mainly treated because of head and neck carcinoma, tissue defects may develop following tumor therapy because of extensive resection or chronic effects of radiotherapy. In the initial years, reconstruction was limited to the use of pedicled flaps such as the pectoralis major, latissimus dorsi, and deltopectoral flap [1-3]. Introduction of free flap surgery in the 1970s due to technological advances in microsurgery led to significant refinements of reconstruction techniques [4-6]. Although most cases can be managed with free flaps some patients present with unavailable blood vessels due to the consequences of radical cervical lymphadenectomy [7]. The absence of anastomotic sites, especially venous recipient sites, obviate reconstruction of the maxillofacial region by a 1-stage microvascular reconstruction technique. For these challenging cases construction of an arteriovenous fistula as alternative arteriovenous recipient site is necessary before free tissue transfer is indicated.This report describes the use of a vena saphena magna interposition ateriovenous subclavia-shunt for the reconstruction of complex defect in the head and neck region.In a 61-year-old male with a history of alcohol and nicotin abuse but no other serious diseases the initial diagnosis of a SCC of the right anterior floor of the mo
Integrating Chemistry, Electricity and Magnetism into Dynamical Natural Philosophy: J. F. Fries’s Extension of Kant’s Metaphysical Foundations  [PDF]
Erdmann Grg
Advances in Historical Studies (AHS) , 2014, DOI: 10.4236/ahs.2014.31006
Abstract: Kant’s Metaphysical Foundations of Natural Science has an almost exclusive focus on Newton’s Philosophiae Naturalis Principia Mathematica. Other research fields like electrostatics, magnetism, chemistry or biology are hardly dealt with. A successor of Kant, the philosopher, natural scientist and mathematician Jakob Friedrich Fries (1773-1843), accommodates Kant’s major thoughts on a metaphysical foundation but aims at assisting natural science of his time by employing a heuristic interpretation of Kant’s fundamental forces. In my paper, I will trace Fries’s application of his heurist maxims on the development of other evolving fields of research. This will provide concrete examples on how Fries thought philosophy to support science. For that reason, I will highlight the different status that Kant and Fries concede non-mechanic research areas. To restrict the analysis, I will focus on the actual incorporation of chemical dissolution, Coulomb’s law and magnetism into Kantian Dynamics as a concrete example of Fries’s methodology.
Seroprevalence of 34 Human Papillomavirus Types in the German General Population
Kristina M. Michael ,Tim Waterboer,Peter Sehr,Annette Rother,Ulrich Reidel,Heiner Boeing,Ignacio G. Bravo,J?rg Schlehofer,Barbara C. G?rtner,Michael Pawlita
PLOS Pathogens , 2008, DOI: 10.1371/journal.ppat.1000091
Abstract: The natural history of infections with many human papillomavirus (HPV) types is poorly understood. Here, we describe for the first time the age- and sex-dependent antibody prevalence for 29 cutaneous and five mucosal HPV types from 15 species within five phylogenetic genera (alpha, beta, gamma, mu, nu) in a general population. Sera from 1,797 German adults and children (758 males and 1,039 females) between 1 and 82 years (median 37 years) were analysed for antibodies to the major capsid protein L1 by Luminex-based multiplex serology. The first substantial HPV antibody reactions observed already in children and young adults are those to cutaneous types of the genera nu (HPV 41) and mu (HPV 1, 63). The antibody prevalence to mucosal high-risk types, most prominently HPV 16, was elevated after puberty in women but not in men and peaked between 25 and 34 years. Antibodies to beta and gamma papillomaviruses (PV) were rare in children and increased homogeneously with age, with prevalence peaks at 40 and 60 years in women and 50 and 70 years in men. Antibodies to cutaneous alpha PV showed a heterogeneous age distribution. In summary, these data suggest three major seroprevalence patterns for HPV of phylogenetically distinct genera: antibodies to mu and nu skin PV appear early in life, those to mucosal alpha PV in women after puberty, and antibodies to beta as well as to gamma skin PV accumulate later in life.
Infection, vascularization, remodelling - are stem cells the answers for bone diseases of the jaws?
J?rg Handschel, Ulrich Meyer
Head & Face Medicine , 2011, DOI: 10.1186/1746-160x-7-5
Abstract: In maxillofacial surgery clinicians face three diseases of the jaws predominantly: osteonecrosis after craniofacial radiation (ORN), osteomyelitis and bisphosphonates related necrosis of the jaw (BRONJ). Numerous reports exist suggesting various pathological mechanisms and treatment modalities for these diseases [1,2]. Although these publications elucidate the prevalence, risk factors and treatment strategies, they have provided limited data on details of the underlying pathophysiology, especially differences in the three above mentioned diseases. The local or total immunsupressive therapy of many patients (e.g. cancer patients) and the universal presence of hundreds of microorganisms in the oral cavity provide a perfect environment for chronic infections like osteomyelitis. It is unclear if this contributes to BROMJ too. Currently, most evidence exist that the necrotic tissue becomes infected as opposed to the infected tissue becomes necrotic [3]. Regarding the effects on the immune system inconsistent data are reported in the literature. On the one hand bisphosphonates inhibit T lymphocyte activation and proliferation and suppress monocytes production of various pro-inflammatory cytokines [4]. On the other hand they increase the production of pro-inflammatory cytokines by lymphocytes [5]. Whereas the most widely accepted theory to explain the cause of ORN is the theory of hypoxia, radio-induced hypovascularity and hypocellularity [6,7] there is no evidence that the necrotic regions in BRONJ have reduced vasculature or blood supply. However, antiangiogenic effects of bisphosphonates have been reported by other authors [8]. Remoddeling suppression is an other causative factor held responsible for BRONJ despite the fact that there are no published data in humans showing the effects of bisphosphonates on jaw remodeling [2]. Taken together there are only very few studies (e.g. animal studies) clarifying the basic pathophysiological mechanisms of these bone diseases. Ve
mRuby, a Bright Monomeric Red Fluorescent Protein for Labeling of Subcellular Structures
Simone Kredel, Franz Oswald, Karin Nienhaus, Karen Deuschle, Carlheinz R?cker, Michael Wolff, Ralf Heilker, G. Ulrich Nienhaus, J?rg Wiedenmann
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004391
Abstract: A monomeric variant of the red fluorescent protein eqFP611, mRuby, is described. With excitation and emission maxima at 558 nm and 605 nm, respectively, and a large Stokes shift of 47 nm, mRuby appears particularly useful for imaging applications. The protein shows an exceptional resistance to denaturation at pH extremes. Moreover, mRuby is about ten-fold brighter compared to EGFP when being targeted to the endoplasmic reticulum. The engineering process of eqFP611 revealed that the C-terminal tail of the protein acts as a natural peroxisomal targeting signal (PTS). Using an mRuby variant carrying the eqFP611-PTS, we discovered that ordered inheritance of peroxisomes is widespread during mitosis of different mammalian cell types. The ordered partitioning is realized by the formation of peroxisome clusters around the poles of the mitotic spindle and ensures that equal numbers of the organelle are inherited by the daughter cells. The unique spectral properties make mRuby the marker of choice for a multitude of cell biological applications. Moreover, the use of mRuby has allowed novel insights in the biology of organelles responsible for severe human diseases.
A Green Fluorescent Protein with Photoswitchable Emission from the Deep Sea
Alexander Vogt, Cecilia D'Angelo, Franz Oswald, Andrea Denzel, Charles H. Mazel, Mikhail V. Matz, Sergey Ivanchenko, G. Ulrich Nienhaus, J?rg Wiedenmann
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003766
Abstract: A colorful variety of fluorescent proteins (FPs) from marine invertebrates are utilized as genetically encoded markers for live cell imaging. The increased demand for advanced imaging techniques drives a continuous search for FPs with new and improved properties. Many useful FPs have been isolated from species adapted to sun-flooded habitats such as tropical coral reefs. It has yet remained unknown if species expressing green fluorescent protein (GFP)-like proteins also exist in the darkness of the deep sea. Using a submarine-based and -operated fluorescence detection system in the Gulf of Mexico, we discovered ceriantharians emitting bright green fluorescence in depths between 500 and 600 m and identified a GFP, named cerFP505, with bright fluorescence emission peaking at 505 nm. Spectroscopic studies showed that ~15% of the protein bulk feature reversible ON/OFF photoswitching that can be induced by alternating irradiation with blue und near-UV light. Despite being derived from an animal adapted to essentially complete darkness and low temperatures, cerFP505 maturation in living mammalian cells at 37°C, its brightness and photostability are comparable to those of EGFP and cmFP512 from shallow water species. Therefore, our findings disclose the deep sea as a potential source of GFP-like molecular marker proteins.
Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease
Yazi Ke, Joe Dramiga, Ulrich Schütz, Jillian J. Kril, Lars M. Ittner, Hannsj?rg Schr?der, Jürgen G?tz
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035678
Abstract: Tau dysfunction characterizes neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). Here, we performed an unbiased SAGE (serial analysis of gene expression) of differentially expressed mRNAs in the amygdala of transgenic pR5 mice that express human tau carrying the P301L mutation previously identified in familial cases of FTLD. SAGE identified 29 deregulated transcripts including Sfpq that encodes a nuclear factor implicated in the splicing and regulation of gene expression. To assess the relevance for human disease we analyzed brains from AD, Pick's disease (PiD, a form of FTLD), and control cases. Strikingly, in AD and PiD, both dementias with a tau pathology, affected brain areas showed a virtually complete nuclear depletion of SFPQ in both neurons and astrocytes, along with cytoplasmic accumulation. Accordingly, neurons harboring either AD tangles or Pick bodies were also depleted of SFPQ. Immunoblot analysis of human entorhinal cortex samples revealed reduced SFPQ levels with advanced Braak stages suggesting that the SFPQ pathology may progress together with the tau pathology in AD. To determine a causal role for tau, we stably expressed both wild-type and P301L human tau in human SH-SY5Y neuroblastoma cells, an established cell culture model of tau pathology. The cells were differentiated by two independent methods, mitomycin C-mediated cell cycle arrest or neuronal differentiation with retinoic acid. Confocal microscopy revealed that SFPQ was confined to nuclei in non-transfected wild-type cells, whereas in wild-type and P301L tau over-expressing cells, irrespective of the differentiation method, it formed aggregates in the cytoplasm, suggesting that pathogenic tau drives SFPQ pathology in post-mitotic cells. Our findings add SFPQ to a growing list of transcription factors with an altered nucleo-cytoplasmic distribution under neurodegenerative conditions.
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