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Biological Effects of Cigarette Smoke in Cultured Human Retinal Pigment Epithelial Cells
Alice L. Yu, Kerstin Birke, Johannes Burger, Ulrich Welge-Lussen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048501
Abstract: The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured human RPE cells were exposed to 2, 4, 8, and 12% of CSE concentration for 24 hours. Cell loss was detected by cell viability assay. Lipid peroxidation was assessed by loss of cis-parinaric acid (PNA) fluorescence. Senescence-associated ?-galactosidase (SA-?-Gal) activity was detected by histochemical staining. Expression of apolipoprotein J (Apo J), connective tissue growth factor (CTGF), fibronectin, and laminin were examined by real-time PCR, western blot, or ELISA experiments. The results showed that exposure of cells to 12% of CSE concentration induced cell death, while treatment of cells with 2, 4, and 8% CSE increased lipid peroxidation. Exposure to 8% of CSE markedly increased the number of SA-?-Gal positive cells to up to 82%, and the mRNA expression of Apo J, CTGF, and fibronectin by approximately 3–4 fold. Treatment with 8% of CSE also increased the protein expression of Apo J and CTGF and the secretion of fibronectin and laminin. Thus, treatment with CSE can induce cell loss, senescent changes, and ECM synthesis in primary human RPE cells. It may be speculated that cigarette smoke could be involved in cellular events in RPE cells as seen in age-related macular degeneration.
Preventive Effects of Omega-3 and Omega-6 Fatty Acids on Peroxide Mediated Oxidative Stress Responses in Primary Human Trabecular Meshwork Cells
Theofilos Tourtas, Marco T. Birke, Friedrich E. Kruse, Ulrich-Christoph Welge-Lüssen, Kerstin Birke
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031340
Abstract: Pathologic processes in glaucoma include increased apoptosis, accumulation of extracellular material in the trabecular meshwork and optic nerve, condensations of the cytoskeleton and precocious cellular senescence. Oxidative stress was shown to generate these alterations in primary ocular cells. Fatty acids omega-3 and -6 are alleged to constitute a prophylaxis against these deleterious effects. Here, we tested actual preventive effects omega-3 and -6 against peroxide induced stress responses in primary human trabecular meshwork cells. Changes of mitochondrial activity, proliferation, heat shock proteins, extracellular matrix components, and inflammatory markers were evaluated. Alterations of the cytoskeleton were evaluated by phalloidin labeling. Here we report a repressive effect of omega-6 on metabolic activity and proliferation, which was not detected for omega-3. Both agents were able to prevent the anti-proliferative effect of H2O2, but only omega-3 prevented metabolic repression. Expression of heat shock protein 27 was unaltered by both fatty acids, whereas heat shock protein 90 was significantly induced by both. Omega-6 increased fibronectin and connective tissue growth factor synthesis, as well as the amount of secreted fibronectin. Omega-3, instead, induced plasminogen activator inhibitor 1 synthesis. H2O2 further increased fibronectin production in omega-6 supplemented cells, which was not the case in omega-3 treated cells. H2O2 stimulation of plasminogen activator inhibitor 1 and connective tissue growth factor was repressed by both fatty acids. Both fatty acids appeared to abolish H2O2 mediated stimulation of nuclear factor κB and IL-6, but not IL-1α and IL-8. H2O2 induced formation of cross-linked actin networks and stress fibers, which was reduced by preemptive application of omega-3. Omega-6, in contrast, had no protective effect on that, and even seemed to promote condensation. Based on the observed side effects of omega-6, omega-3 appears to be the more beneficial fatty acid in respect of prophylactic intake for prevention of a glaucomatous disease.
Re-establishment of olfactory and taste functions
Welge-Lüssen, Antje
GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery , 2005,
Abstract: The incidence of olfactory disorders is appoximately 1-2% and they can seriously impact on the quality of life. Quantitative disorders (hyposmia, anosmia) are distinguished from qualitative disorders (parosmia, phantosmia). Olfactory disorders are classified according to the etiology and therapy is planned according to the underlying pathophysiology. In ENT patients olfactory disorders caused by sinonasal diseases are the most common ones, followed by postviral disorders. Therapy consists of topical and systemic steroids, whereas systemic application seems to be of greater value. It is very difficult to predict the improvement of olfactory function using surgery, moreover, the long term - success in surgery is questionable. Isolated taste disorders are rare and in most often caused by underlying diseases or side effects of medications. A meticulous history is necessary and helps to choose effective treatment. In selected cases zinc might be useful.


物理学报 , 1988,
Abstract: 本文利用脉冲紫外激光(UV)选择激发氨分子到?1A″2电子激发态的两个最低振动能级ν′2=0和ν′2=1(ν2振动),然后检测新生态H原子的飞行谱(TOF),研究了氨分子的光碎片动力学。光谱证实了最近所测的离解能D00(H-NH2)=4.645eV;绝大多数生成的NH2(X2B1)基处于非振动激发,但是具有围绕a惯性轴的高度转动激发。通过NH3(?)的ν′2=1光离解产生的NH2(X)基具有较高的内部激发,并且显示了在N=Ka转动能级上的反转布居。
Mathematical Rotordynamic Model Regarding Excitation Due to Elliptical Shaft Journals in Electrical Motors Considering the Gyroscopic Effect  [PDF]
Ulrich Werner
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.48A009

The paper presents a mathematical rotordynamic model regarding excitation due to elliptical shaft journals in sleeve bearings of electrical motors also considering the gyroscopic effect. For this kind of excitation, a mathematical rotordynamic model was developed considering the influence of the oil film stiffness and damping of the sleeve bearings, the stiffness of the end-shields and bearing housings, the stiffness of the rotor, the electromagnetic stiffness in the air gap of the electrical motor and the mass moment of inertia of the rotor and therefore also considering the gyroscopic effect. The solution of the linear differential equation system leads to the mathematical description of the absolute orbits of the shaft centre, the shaft journals and the bearing housings and to the relative orbits between the shaft journals and the bearing housings. Additionally, the bearing housing velocities can also be derived with this mathematical rotordynamic model.

Mathematical Multibody Model of a Soft Mounted Induction Motor Regarding Forced Vibrations Due to Dynamic Rotor Eccentricities Considering Electromagnetic Field Damping  [PDF]
Ulrich Werner
Journal of Applied Mathematics and Physics (JAMP) , 2017, DOI: 10.4236/jamp.2017.52032
Abstract: The paper presents a mathematical multibody model of a soft mounted induction motor with sleeve bearings regarding forced vibrations caused by dynamic rotor eccentricities considering electromagnetic field damping. The multibody model contains the mass of the stator, rotor, shaft journals and bearing housings, the electromagnetic forces with respect of electromagnetic field damping, stiffness and internal (rotating) damping of the rotor, different kinds of dynamic rotor eccentricity, stiffness and damping of the bearing housings and end shields, stiffness and damping of the oil film of the sleeve bearings and stiffness and damping of the foundation. With this multibody model, the bearing housing vibrations and the relative shaft vibrations in the sleeve bearings can be derived.
Influence of the Foundation on the Threshold of Stability for Rotating Machines with Roller Bearings—A Theoretical Analysis  [PDF]
Ulrich Werner
Journal of Applied Mathematics and Physics (JAMP) , 2017, DOI: 10.4236/jamp.2017.56114
Abstract: The paper presents a mathematical model for analyzing the threshold of stability for rotating machines, where the rotor is linked to the stator by roller bearings, bearing housings and end-shields and where the stator feet are mounted on a soft foundation. The internal (rotating) damping of the rotor is the only source of instability, which is considered in the paper. After the mathematical coherences of the multibody model are described, a procedure is presented for deriving the threshold of stability. Additionally, a numerical example is shown, where the threshold of stability is calculated for different boundary conditions. It could be demonstrated, that the stiffness of the foundation—even if the foundation stiffness is isotropic—can help stabilizing this kind of vibration system in the same way as orthotropic bearing stiffness or orthotropic bearing housing and end-shield stiffness for a rigid foundation.
Analysis of Different Vibration Control Strategies for Soft Mounted Induction Motors with Sleeve Bearings Using Active Motor Foot Mounts  [PDF]
Ulrich Werner
Journal of Applied Mathematics and Physics (JAMP) , 2019, DOI: 10.4236/jamp.2019.73045
Abstract: The paper presents a theoretical analysis of different vibration control strategies of soft mounted induction motors with sleeve bearings, using active motor foot mounts. After the vibration model is presented, different controllers in combination with different feedback strategies are mathematically investigated. The focus is here on the forced vibrations, caused by dynamic rotor eccentricityrotor mass eccentricity, magnetic eccentricity and bent rotor deflection. After the mathematically coherences are described, a numerical example is shown, where the forced vibrations caused by bent rotor deflection are investigated, for different control strategies, where the mass matrix, the stiffness matrix and the damping matrix are influenced by different control parameters. The aim of the paper is to show the mathematically coherences and the possibility to influence the vibration behaviour, by different control strategies to optimize the vibration behaviour of soft mounted induction motors.
HIV Infection of Hepatocytes Results in a Modest Increase in Hepatitis C Virus Expression In Vitro
Ling Kong, Jeffrey A. Welge, Eleanor A. Powell, Jason T. Blackard
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0083728
Abstract: Previous studies demonstrate that soluble HIV proteins impact both hepatocyte function and HCV replication in vitro. It has also been reported that HIV can productively infect hepatocytes. We therefore investigated the impact of HIV infection of hepatocytes on HCV expression. The Huh7.5JFH1 cell line that constitutively expresses infectious HCV was infected with the lab-adapted strains HIVNL4-3 or HIVYK-JRCSF. HCV expression was quantified via HCV core antigen ELISA, Western blot, and strand-specific real-time PCR for positive-sense and negative-sense HCV RNA. After HIVNL4-3 infection of Huh7.5JFH1 cells, positive-sense and negative-sense HCV RNA levels were elevated compared to HIV uninfected cells. Increased HCV RNA synthesis was also observed after infection of Huh7.5JFH1 cells with HIVYK-JRCSF. HIV-induced HCV core production was decreased in the presence of the anti-HIV drugs AZT, T20, and raltegravir, although these medications had a minimal effect on HCV expression in the absence of HIV. HCV core, NS3, and NS5A protein expression were increased after HIV infection of Huh7.5JFH1 cells. Chemically inactivated HIV had a minimal effect on HCV expression in Huh7.5JFH1 cells suggesting that ongoing viral replication was critical. These data demonstrate that HIV induces HCV RNA synthesis and protein production in vitro and complement previous in vivo reports that HCV RNA levels are elevated in individuals with HIV/HCV co-infection compared to those with HCV mono-infection. These findings suggest that HIV suppression may be a critical factor in controlling liver disease, particularly if the underlying liver disease is not treated.
Dirac Hamiltonian with Imaginary Mass and Induced Helicity—Dependence by Indefinite Metric  [PDF]
Ulrich D. Jentschura
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.39116
Abstract: It is of general theoretical interest to investigate the properties of superluminal matter wave equations for spin one-half particles. One can either enforce superluminal propagation by an explicit substitution of the real mass term for an imaginary mass, or one can use a matrix representation of the imaginary unit that multiplies the mass term. The latter leads to the tachyonic Dirac equation, while the equation obtained by the substitution m im in the Dirac equation is naturally referred to as the imaginary-mass Dirac equation. Both the tachyonic as well as the imaginary-mass Dirac Hamiltonians commute with the helicity operator. Both Hamiltonians are pseudo-Hermitian and also possess additional modified pseudo-Hermitian properties, leading to constraints on the resonance eigenvalues. Here, by an explicit calculation, we show that specific sum rules over the The spectrum is found to consist of well-defined real energy eigenvalues and complex resonance and anti-resonance energies. In the quantized imaginary-mass Dirac field, one-particle states of right-handed helicity acquire a negative norm (“indefinite metric”) and can be excluded from the physical spectrum by a Gupta-Bleuler type condition.
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