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Search Results: 1 - 10 of 199384 matches for " Ulf Thilén "
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Noninvasive Assessment of Autonomic Cardiovascular Function in Patients after Arterial Switch Operation for Transposition of the Great Arteries  [PDF]
Joanna Hlebowicz, Maja Rooth, Sandra Lindstedt, Johan Holm, Ulf Thilén
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.63020

Background: Children born with transposition of the great arteries (TGA) must undergo corrective surgery for survival, arterial switch being the standard surgical procedure. The sympathetic innervation of the heart may be damaged during the operation. This study was designed to determine whether adults who were born with TGA and who had arterial switch operation (ASO) in infancy exhibit denervation of the heart, measured as heart rate variability (HRV) with electrocardiography (ECG). Methods: Nine patients with transposition of the great arteries (four men and five women; mean age 26 ± 1 years) who underwent the ASO at a mean age of 85 ± 35 days, and nine healthy adults (five men and five women; mean age 26 ± 2) were included in the study. Cardiac autonomic nerve function was determined by the variation in RR intervals during maximal deep breathing, monitored by continuous ECG. The mean values were calculated for each group from six inspirations (I) and expirations (E), and the E:I ratios were calculated. Results: The E:I ratio did not differ between patients with an arterial switch and healthy controls (P= 0.161). Two patients had signs of denervation of the heart up to 30 years after the arterial switch operation. Conclusions: Reinnervation of the heartmay take place in patients who have undergone the ASO in infancy, and these patients would not necessarily suffer from autonomic dysfunction. The HRV, measured by ECG, has the potential to identify arterially switched patients at risk of developing silent myocardial ischemia.


吴媛,Ulf Nürnberger
腐蚀科学与防护技术 , 2008,
Abstract: Bridge cables are supposed to take the high tensile force with relatively small cross-section.Conventionally bridge cables are made of unalloyed and/or low-alloyed steel ropes.Regarding a long durability application of high-strength stainless steel strand is considerable.In Germany,cold-drawn stainless steels are produced about 25 years since,which possess comparable characteristics in strength and deformation with conventional high-strength steels.In this contribution the cold-drawn high-strength strands,w...
腐蚀科学与防护技术 , 2008,
Abstract: 检测了冷拉高强Cr-Ni-Mo不锈钢绞索的力学和物理性能;并从实验室研究和项目跟踪观察两方面介绍高强度不锈钢绞索的抗腐蚀性能;最后,展望了高强度不锈钢绞索在桥梁工程方面的应用.
What is the Relation between Human Practical Action and an Accompanying Discourse? Discussing the Status of Practical Theory
N?rholm, Ulf Brinkkj?r and Morten
Social Work and Society , 2005,
Abstract: The article discusses the function of an accompanying discourse in relation to the genesis of human practical action. On the one side, theory cannot be taken as the ground for practical action; practical action is not a realisation of intentions. On the other hand, human practical action is accompanied by series of explanations, justifications, declarations of intent, pre and post-rationalisations, motivations etc. These accompanying discourses seem in one way or the other to be necessary for the actual realisation of human practical action. Following Pierre Bourdieu, it is suggested that an accompanying discourse cannot in a meaningful manner be separated from the human practical action, that practical theory should be regarded not as theory but as part of practice, and that practical theory first of all provides a common language for talking about practice and hence for reproducing a fundamentally arbitrary idea of the genesis of human practical action. Parallels are drawn to the education/formal training of semi-professionals.
Strategy Diversity Stabilizes Mutualism through Investment Cycles, Phase Polymorphism, and Spatial Bubbles
Gergely Boza ,ádám Kun,István Scheuring,Ulf Dieckmann
PLOS Computational Biology , 2012, DOI: 10.1371/journal.pcbi.1002660
Abstract: There is continuing interest in understanding factors that facilitate the evolution and stability of cooperation within and between species. Such interactions will often involve plasticity in investment behavior, in response to the interacting partner's investments. Our aim here is to investigate the evolution and stability of reciprocal investment behavior in interspecific interactions, a key phenomenon strongly supported by experimental observations. In particular, we present a comprehensive analysis of a continuous reciprocal investment game between mutualists, both in well-mixed and spatially structured populations, and we demonstrate a series of novel mechanisms for maintaining interspecific mutualism. We demonstrate that mutualistic partners invariably follow investment cycles, during which mutualism first increases, before both partners eventually reduce their investments to zero, so that these cycles always conclude with full defection. We show that the key mechanism for stabilizing mutualism is phase polymorphism along the investment cycle. Although mutualistic partners perpetually change their strategies, the community-level distribution of investment levels becomes stationary. In spatially structured populations, the maintenance of polymorphism is further facilitated by dynamic mosaic structures, in which mutualistic partners form expanding and collapsing spatial bubbles or clusters. Additionally, we reveal strategy-diversity thresholds, both for well-mixed and spatially structured mutualistic communities, and discuss factors for meeting these thresholds, and thus maintaining mutualism. Our results demonstrate that interspecific mutualism, when considered as plastic investment behavior, can be unstable, and, in agreement with empirical observations, may involve a polymorphism of investment levels, varying both in space and in time. Identifying the mechanisms maintaining such polymorphism, and hence mutualism in natural communities, provides a significant step towards understanding the coevolution and population dynamics of mutualistic interactions.
In the shadow of bad news – views of patients with acute leukaemia, myeloma or lung cancer about information, from diagnosis to cure or death
Lena Hoff, Ulf Tidefelt, Lars Thaning, G?ran Hermerén
BMC Palliative Care , 2007, DOI: 10.1186/1472-684x-6-1
Abstract: Twelve patients with malignant haematological diseases or lung cancer were followed with interviews from diagnosis to recovery or into the terminal phase or at most for two years. The method is qualitative, using semi-structured interviews.Setting: ?rebro University Hospital or the patient's home.All patients described themselves as well informed from the start but in later phases of their disease some of them came to express a great uncertainty about the progressing disease and about the approaching death. Most of them, regardless of whether they had a haematological malignancy or lung cancer, expressed a wish to be well informed all through the disease and even when the messages were bad. Different strategies for coping with information, however, affected how they then dealt with the information received. Four such coping strategies were found: 1) Information-dependent and accepting; 2) Information-dependent but denying; 3) Medically informed and accepting; 4) Medically informed but denying.To several patients there was an unmet need for information about the progressing disease and the approaching death. To optimize the care of these patients it seems important that the physician is aware of patients' need for information even when the news is bad. Knowing the patient's information strategy could probably function as a key for the physician to communicate with patients on these matters.Many studies have been published about giving and receiving bad messages. However, only a few of them have followed the patients all the way through a disease as is done in this study. Many studies have been written about patients' coping strategies since the fundamental work of Lazarus & Folkman on stress and coping [1]. In this work, however, we will confine ourselves to coping through information only, which of course is only a small part of the coping process as an entity.Ptacek & Eberhardt [2] reviewed studies published 1985–1996, studies about the importance of where, when an
The relationship between antibody status to bovine corona virus and bovine respiratory syncytial virus and disease incidence, reproduction and herd characteristics in dairy herds
Anna Ohlson, Ulf Emanuelson, Madeleine Tr?vén, Stefan Alenius
Acta Veterinaria Scandinavica , 2010, DOI: 10.1186/1751-0147-52-37
Abstract: We collected a pooled milk sample from five primiparous cows from 79 Swedish dairy herds in September 2006. The samples were analysed for immunoglobulin G antibodies to BCV and BRSV with indirect enzyme-linked immunosorbent assays. Herd level data from 1 September 2005 to 30 August 2006 were accessed retrospectively. The location of the herds was mapped using a geographical information system.Ten herds were antibody negative to both viruses and were compared with 69 herds positive to BCV or BRSV or both. Positive herds had a higher (P = 0.001) bulk tank milk somatic cell count (BMSCC) compared with negative herds. The medians for all other analyzed health and reproductive parameters were consistently in favour of the herds negative to both viruses although the differences were not statistically significant. A higher proportion (P = 0.01) of herds used professional technicians for artificial insemination, rather than farm personnel, amongst the 33 herds negative to BCV compared with the 46 positive herds.Our result shows that herds that were antibody positive to BCV and/or BRSV had a higher BMSCC compared with herds negative to BCV and BRSV. There was also tendency that negative herds had a better general herd health compared with positive. A higher proportion amongst the BCV negative herds used external technicians for AI instead of farm personnel, indicating that it is possible to avoid infection although having regular visits. Negative herds were located in close proximity to positive herds, indicating that local spread and airborne transmission between herds might not be of great importance and that herds can stay free from these infection transmission although virus is circulating in the area.Bovine corona virus (BCV) and bovine respiratory syncytial virus (BRSV) are two worldwide distributed viruses [1,2]. BCV causes diarrhoea in calves, winter dysentery in adults and various degrees of respiratory symptoms [3-5]. BRSV is regarded as one of the most important c
Canine atopic dermatitis: validation of recorded diagnosis against practice records in 335 insured Swedish dogs
Ane N?dtvedt, Kerstin Bergvall, Ulf Emanuelson, Agneta Egenvall
Acta Veterinaria Scandinavica , 2006, DOI: 10.1186/1751-0147-48-8
Abstract: Canine atopic dermatitis (CAD) is a genetically-predisposed inflammatory and pruritic allergic skin disease, most commonly associated with IgE antibodies to environmental allergens [1]. Among humans, the prevalence of allergic diseases has been increasing in industrialized countries over the past decades, and this has been related to factors regarding lifestyle and environment [2]. Many similarities exist between human and canine atopy, and it is of interest to investigate whether this increase is seen among dogs as well. The available knowledge on the epidemiology of CAD is limited, and more studies within this area are in demand according to the International Task Force on Canine Atopic Dermatitis [3].At present, no definite diagnostic test exists for CAD and the diagnosis is based upon a typical clinical presentation after the exclusion of plausible differential diagnoses [4]. The main clinical sign of CAD is pruritus, particularly of the face, ears, paws, extremities and/or ventrum [5]. Hence, before a diagnosis is made it is important to rule out other pruritic diseases like flea allergy dermatitis, sarcoptic mange and other ectoparasites, bacterial pyoderma, Malassezia dermatitis and cutaneous adverse food reactions (AFR). A set of major and minor criteria for CAD has been proposed, out of which a patient needs to fulfil at least three in each group to be considered having CAD [6]. However, it must be kept in mind that the manifestations of CAD are highly variable between individuals and a patient that fails to fulfil these criteria may still actually be atopic. Also, the criteria proposed by Willemse (1986) [6] have not been properly evaluated regarding sensitivity and specificity and other authors have proposed different criteria [4]. Due to these uncertainties regarding the diagnosing of CAD, it is paramount that individuals included in studies regarding epidemiology, aetiology, therapy or diagnosis of the disease are properly characterized in order to ensu
Bystander suppression of collagen-induced arthritis in mice fed ovalbumin
N Fredrik B?ckstr?m, Ulf IH Dahlgren
Arthritis Research & Therapy , 2004, DOI: 10.1186/ar1150
Abstract: It is now well established that intestinal exposure to antigen decreases T-cell-mediated inflammation and specific B-cell responses to the antigen in question. This ability of the intestinal immune system has been demonstrated, for example, with respect to antigens such as food proteins [1] and bacteria [2]. The capacity of the gut-associated lymphoid tissue to suppress certain immune responses to intestinal antigen is known as oral tolerance [3]. Several mechanisms have been suggested to be involved in this process, for instance anergy, clonal deletion of antigen-specific cells, and induction of antigen-specific regulatory cells [3,4]. Regulatory cells induced by feeding exert their action through secretion of nonspecific suppressive cytokines and/or by direct interactions with other cells [5-8]. Consequently, when the regulatory cells are activated, they suppress immune responses in their vicinity irrespective of the eliciting antigen. It has previously been demonstrated that rats fed ovalbumin (OVA) and subsequently immunized subcutaneously with a mixture of OVA and human serum albumin have significantly lower IgE antibody and lower delayed-type hypersensitivity reactions to human serum albumin than controls [1]. The results of that study provided evidence that rats orally tolerant to one antigen suppressed T- and B-cell responses to an unrelated antigen, provided that the two antigens were injected subcutaneously in a mixture during the inductive phase.Collagen-induced arthritis (CIA) is the most common model for rheumatoid arthritis. Autologous or heterologous collagen type II (CII) emulsified in Freund's complete adjuvant induces arthritis, with edema of the synovial tissue, synovial-cell proliferation, inflammatory-cell infiltration, and erosions of cartilage and bone. The changes are histologically similar to those seen in human rheumatoid arthritis [9]. Previous studies have shown that anti-CII antibodies [10,11] and CII-specific T-cell responses [12,13] pa
A cost-utility analysis of nursing intervention via telephone follow-up for injured road users
Carin Franzén, Ulf Bj?rnstig, Christine Brulin, Lars Lindholm
BMC Health Services Research , 2009, DOI: 10.1186/1472-6963-9-98
Abstract: To evaluate the cost-effectiveness of nursing intervention via telephone follow-up by examining costs and quality-adjusted life years (QALYs).A randomised controlled study was conducted between April 2003 and April 2005. Car occupants, cyclists, and pedestrians aged between 18 and 70 years and attending the Emergency Department of Ume? University Hospital in Sweden after an injury event in the traffic environment were randomly assigned to an intervention (n = 288) or control group (n = 280). The intervention group received routine care supplemented by nursing via telephone follow-up during half a year, while the control group received routine care only. Data were collected from a mail survey using the non-disease-specific health-related quality of life instrument EQ5D, and a cost-effectiveness analysis was performed including the costs of the intervention and the QALYs gained.Overall, the intervention group gained 2.60 QALYs (260 individuals with an average gain of 0.01 QALYs). The car occupants gained 1.54 QALYs (76 individuals, average of 0.02). Thus, the cost per QALY gained was 16 000 Swedish Crown (SEK) overall and 8 500 SEK for car occupants.Nursing intervention by telephone follow-up after an injury event, is a cost effective method giving improved QALY to a very low cost, especially for those with minor injuries.This trial registration number is: ISRCTN11746866.Road traffic injuries are a major global problem. The World Health Organisation (WHO) currently ranks traffic crashes as the ninth leading cause of disability, and it has been estimated that by 2020 they will have risen to third place, behind heart disease and depression [1]. In Sweden, 1.4 per 100 inhabitants are injured in the traffic environment each year [2]; the three most frequently injured categories are car occupants, cyclists, and pedestrians, injured for example by falls (Swedish Institute for Transport and Communication Analysis, SIKA 2006:31). The economic cost of road crashes and injuries
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