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Search Results: 1 - 10 of 1669 matches for " Ulf Hinz "
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AB0 blood group and prognosis in patients with pancreatic cancer
Rahbari Nuh N,Bork Ulrich,Hinz Ulf,Leo Albrecht
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-319
Abstract: Background Although blood group 0 is associated with a reduced risk of pancreatic cancer, little is known about the role of AB0 blood group antigens in disease progression. We assessed the prognostic relevance of AB0 blood status in a large cohort of patients with resected pancreatic cancer. Methods A total of 627 patients, who underwent resection for pancreatic ductal adenocarcinoma between October 2001 and December 2008 were enrolled. The relationship between AB0 blood group status and outcome was analyzed using univariate and multivariate Cox regression analyses. Results In patients with pancreatic cancer the incidence of blood group 0 (31%) was lower compared to 13.044 patients without pancreatic cancer (38%) (p = 0.0005). There were no significant differences in clinicopathologic characteristics among patients with different AB0 blood groups. The 3-year and 5-year overall survival rates were 29% and 14%. On univariate analysis AB0 blood group status did not correlate with survival (p = 0.39). Multivariate analysis, however, revealed a favorable and independent impact of blood group 0 on survival (Hazard ratio 0.78; 95% confidence interval 0.62 – 0.99; p = 0.037). Conclusion AB0 blood group status is associated independently with the prognosis of patients with resected pancreatic cancer.
Transcript levels of different cytokines and chemokines correlate with clinical and endoscopic activity in ulcerative colitis
Alexandra Zahn, Thomas Giese, Max Karner, Annika Braun, Ulf Hinz, Wolfgang Stremmel, Robert Ehehalt
BMC Gastroenterology , 2009, DOI: 10.1186/1471-230x-9-13
Abstract: Cytokine and chemokine transcripts were quantified using real-time PCR in 49 mucosal biopsies from 27 different patients with UC. Cytokine transcript levels were correlated with CAI and EAI.There was a statistically significant positive correlation between CXCL8 (r = 0.30; p < 0.05), CXCL10 (r = 0.40; p < 0.02), calgranulin B (r = 0.36; p < 0.03), CXCL2 (r = 0.31; p < 0.05) and CAI. Concerning EAI significant positive correlations for CXCL8 (r = 0.37; p < 0.02), CXCL10 (r = 0.33; p < 0.04), calgranulin B (r = 0.31; p < 0.05) and CXCL2 (r = 0.44; p < 0.05) were found. Low clinical and endoscopic activity was accompanied by low cytokine levels whereas high CAI and EAI were associated with high cytokine levels.From our data, we conclude that real-time PCR quantification of CXCL8, CXCL10, calgranulin B and CXCL2 in colonic biopsies is a simple and objective method for grading inflammation of intestinal mucosa in UC. CXCL8, CXCL10, calgranulin B and CXCL2 might be used as biomarkers and thus as an objective tool especially in clinical trials to evaluate anti-inflammatory and immunomodulatory regimens.Inflammatory bowel disease (IBD) like ulcerative colitis (UC) and Crohn's disease (CD) are characterized by a relapsing and remitting clinical course. Disease activity and severity are variable and include both segmental processes with slight impairment of state of health and pancolitis with extensive gastrointestinal and systemic symptoms. Thus, the definition of disease activity in UC is often difficult. The clinical activity index (CAI) is only an indirect assessment tool of bowel inflammation and the endoscopic activity index (EAI) is sometimes unable to reflect the severity of disease to the full extent.Cytokine and chemokine mRNA expression profiles in UC have been characterized in former studies [1-3] and interleukin 8 (CXCL8), interferon γ inducible protein 10 (CXCL10), myeloid-related protein 14 (calgranulin B) and macrophage inflammatory protein 2 α (CXCL2) were id
Renal tumors and second primary pancreatic tumors: a relationship with clinical impact?
Müller Sascha A,Pahernik Sascha,Hinz Ulf,Martin David J
Patient Safety in Surgery , 2012, DOI: 10.1186/1754-9493-6-18
Abstract: Background The occurrence of synchronous or metachronous renal cell carcinoma and pancreatic tumors has been described only in a few cases in the scientific literature. The study of double primary cancers is important because it might provide understanding of a shared genetic basis of different solid tumors and to detect patients at risk for secondary malignancy. Methods In a combined analysis of patient registries from University Departments of Urology and Visceral Surgery, 1178 patients with pancreatic tumors and 518 patients with renal cell carcinoma treated between 2001 and 2008 were evaluated, Results Overall 16 patients with renal cancer and synchronous (n = 6) or metachronous (n = 10) primary pancreatic tumors were detected. The median survival of all patients was 12.6 months, for the patients with synchronous resections 25.7 months and for the patients with metachronous resections 12.2 months, respectively. Conclusions The association between these two etiologies of malignancy demands more detailed epidemiological and molecular investigation. Clinical outcomes would support a resection as a recommended clinically valid option.
Quality of life after curative liver resection: A single center analysis
Helge Bruns, Kirsten Kr?tschmer, Ulf Hinz, Anette Brechtel, Monika Keller, Markus W Büchler, Peter Schemmer
World Journal of Gastroenterology , 2010,
Abstract: AIM: To evaluate quality of life (QoL) after curative liver resection and identify variables associated with decreased QoL.METHODS: From October 2001 to July 2004, 323 patients underwent liver resection. At 3-36 mo after discharge, 188 patients were disease free. QoL was assessed using the Short Form (SF)-12 Health Survey with mental and physical component scales (SF-12 MCS and PCS), supplemented with generic questions concerning pain and liver-specific items.RESULTS: Sixty-eight percent (128/188) returned the questionnaire, which was completed in 75% (96/128) of cases. Median SF-12 PCS and MCS were 46.7 (interquartile range: 34.2-53.9) and 54.1 (42.8-58.2). Fifty percent were pain free with a median symptom score of 1.75 (1.38-2.13). PCS was higher after major hepatectomy [57% (55/96)] compared to minor resection (P = 0.0049), which represented an improved QoL. QoL was not affected by sex but by age compared to the general German population. MCS was higher after liver surgery for metastatic disease [55.9 (47.5-58.8)] compared to primary carcinoma [49.6 (36.5-55.1)] and benign disease [49.2 (37.7-56.3)] (P = 0.0317). There was no correlation between length of postoperative period and QoL. Pain, deficiencies in everyday life and a high symptom score significantly decreased MCS and PCS.CONCLUSION: Most patients were only marginally affected even after major liver resection; however, minor complications were associated with decreased SF-12 MCS and PCS and need careful attention.
Prediction of Postoperative Mortality in Liver Transplantation in the Era of MELD-Based Liver Allocation: A Multivariate Analysis
Helge Bruns, Vladimir J. Lozanovski, Daniel Schultze, Norbert Hillebrand, Ulf Hinz, Markus W. Büchler, Peter Schemmer
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098782
Abstract: Background and Aims Liver transplantation is the only curative treatment for end-stage liver disease. While waiting list mortality can be predicted by the MELD-score, reliable scoring systems for the postoperative period do not exist. This study's objective was to identify risk factors that contribute to postoperative mortality. Methods Between December 2006 and March 2011, 429 patients underwent liver transplantation in our department. Risk factors for postoperative mortality in 266 consecutive liver transplantations were identified using univariate and multivariate analyses. Patients who were <18 years, HU-listings, and split-, living related, combined or re-transplantations were excluded from the analysis. The correlation between number of risk factors and mortality was analyzed. Results A labMELD ≥20, female sex, coronary heart disease, donor risk index >1.5 and donor Na+>145 mmol/L were identified to be independent predictive factors for postoperative mortality. With increasing number of these risk-factors, postoperative 90-day and 1-year mortality increased (0–1: 0 and 0%; 2: 2.9 and 17.4%; 3: 5.6 and 16.8%; 4: 22.2 and 33.3%; 5–6: 60.9 and 66.2%). Conclusions In this analysis, a simple score was derived that adequately identified patients at risk after liver transplantation. Opening a discussion on the inclusion of these parameters in the process of organ allocation may be a worthwhile venture.
Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer
Nuh N Rahbari, Thomas Schmidt, Christine S Falk, Ulf Hinz, Magdalene Herber, Ulrich Bork, Markus W Büchler, Jürgen Weitz, Moritz Koch
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-286
Abstract: Serum samples were collected preoperatively in patients undergoing surgery for localized pancreatic cancer (n = 74), metastatic pancreatic cancer (n = 24) or chronic pancreatitis (n = 20) and in healthy controls (n = 48). Quantitative enzyme-linked immunosorbent assays and multiplex protein arrays were used to determine circulating levels of VEGF, VEGFR-1, PlGF, PDGF-AA, PDGF-BB, Ang-1 and EGF. Multivariate analyses on cancer-specific survival were performed with a Cox proportional hazards model.VEGF (p < 0.0001), PDGF-AA (p < 0.0001), Ang-1 (p = 0.002) and EGF (p < 0.0001) were differentially expressed in patients with pancreatic cancer compared to healthy controls. The presence of lymph node metastases was associated with increased levels of all CAC except for PlGF, whereas there were only minor associations of CAC with other clinicopathologic variables. The multivariate model including the entire angiogenic panel revealed high levels of circulating PDGF-AA (hazard ratio 4.58; 95% confidence interval 1.43 - 14.69) as predictor of poor cancer-specific survival, whereas high levels of PDGF-BB (0.15; 0.15 - 0.88), Ang-1 (0.30; 0.10 - 0.93) and VEGF (0.24; 0.09 - 0.57) were associated with a favorable prognosis.Circulating levels of certain angiogenic cytokines correlate with patients' prognosis after resection for pancreatic cancer, if a panel of several CAC is considered simultaneously. These data should be considered in future studies evaluating angiogenic factors as prognostic biomarkers and therapeutic targets in patients with pancreatic cancer.Pancreatic cancer is ranked within the ten most common malignancies in both genders, yet it is responsible for one forth of cancer-related deaths in Western countries [1]. The poor prognosis of this disease is reflected by a dismal overall 5-year survival rate of less than 5%. Surgical resection is the only treatment modality providing a chance for cure and together with adjuvant chemotherapy may improve 5-year survival ra
LigaSure Impact? versus conventional dissection technique in pylorus-preserving pancreatoduodenectomy in clinical suspicion of cancerous tumours on the head of the pancreas: study protocol for a randomised controlled trial
Tobias Gehrig, Phillip Knebel, Verena Scheel, Ulf Hinz, Christoph M Seiler, Beat P Müller-Stich, Markus W Büchler, Carsten N Gutt
Trials , 2011, DOI: 10.1186/1745-6215-12-162
Abstract: A single-center, randomized, single-blinded, controlled superiority trial to compare two different techniques for dissection in a pp-Whipple procedure. 102 patients will be included and randomized pre-operatively. All patients aged 18 years or older scheduled for primary elective pp-Whipple procedure who signed the informed consent will be included. The primary endpoint is the operating time of the randomized technique. Control Intervention: Conventional dissection technique; experimental intervention: LigaSureTM dissection technique. Duration of study: Approximately 15 months; follow up time: 3 years. The trial is registered at German ClinicalTrials Register (DRKS00000166).The procedure was originally described by Alessandro Codivilla in 1898, A.O. Whipple improved it in 1935. The Whipple procedure is the standard method for therapy of cancerous tumours, inflammation and stenosis near the head of the pancreas. In the classic Whipple-procedure (c-Whipple) the head of the pancreas, the duodenum, the regional lymph nodes, the gastric antrum, the gallbladder, and the distal bile duct are removed. The pylorus-preserving-Whipple procedure (pp-Whipple) was established by Traverso and Longmire in 1978. During this procedure the gastric antrum is not removed. In recent years the pp-Whipple procedure is preferred because several studies have shown that the classic Whipple procedure is not superior to the pp-Whipple procedure regarding the oncological outcome or peri- and postoperative complication rates [1-5].About 300 patients are operated on following the pp-Whipple procedure at the department each year. As the pancreas is fed by many vessels [6], it is necessary to use lots of ligatures, clips and sutures for hemostasis after dissection. This dissection technique is very time-consuming and requires numerous changes of instruments. The use of high-frequency feedback-controlled electrothermal bipolar vessel sealant technology, known as the LigaSure? Vessel Sealing System (L
Serum Protein Signatures Differentiating Autoimmune Pancreatitis versus Pancreatic Cancer
Klaus Felix, Oliver Hauck, Stefan Fritz, Ulf Hinz, Martina Schn?lzer, Tore Kempf, Uwe Warnken, Angelika Michel, Michael Pawlita, Jens Werner
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082755
Abstract: Autoimmune pancreatitis (AIP) is defined by characteristic lymphoplasmacytic infiltrate, ductal strictures and a pancreatic enlargement or mass that can mimic pancreatic cancer (PaCa). The distinction between this benign disease and pancreatic cancer can be challenging. However, an accurate diagnosis may pre-empt the misdiagnosis of cancer, allowing the appropriate medical treatment of AIP and, consequently, decreasing the number of unnecessary pancreatic resections. Mass spectrometry (MS) and two-dimensional differential gel electrophoresis (2D-DIGE) have been applied to analyse serum protein alterations associated with AIP and PaCa, and to identify protein signatures indicative of the diseases. Patients' sera were immunodepleted from the 20 most prominent serum proteins prior to further 2D-DIGE and image analysis. The identity of the most-discriminatory proteins detected, was performed by MS and ELISAs were applied to confirm their expression. Serum profiling data analysis with 2D-DIGE revealed 39 protein peaks able to discriminate between AIP and PaCa. Proteins were purified and further analysed by MALDI-TOF-MS. Peptide mass fingerprinting led to identification of eleven proteins. Among them apolipoprotein A-I, apolipoprotein A-II, transthyretin, and tetranectin were identified and found as 3.0-, 3.5-, 2-, and 1.6-fold decreased in PaCa sera, respectively, whereas haptoglobin and apolipoprotein E were found to be 3.8- and 1.6-fold elevated in PaCa sera. With the exception of haptoglobin the ELISA results of the identified proteins confirmed the 2D-DIGE image analysis characteristics. Integration of the identified serum proteins as AIP markers may have considerable potential to provide additional information for the diagnosis of AIP to choose the appropriate treatment.
The process of hispanizaton in early New Spain transformation of collective identities during and after the conquest of Mexico
Hinz, Felix
Revista de Indias , 2008,
Abstract: This article examines the methods and results of cultural change during the conquest of Mexico and in the early New Spain. It is the attempt to systemize the mechanisms of Christianisation and Hispanization — which can be understood as a reciprocal process of the transformation of collective identities. The fact that an indigenous clergy was not created was generally misunderstood as the Nahuas’ incapability to meet to the requirements of Spanish morality and civilization ( policía ). This had effects on the political as well as on the architectural or historiagraphical spheres. But also the Spaniards and Europeans in general had to question themselves after their contact with the Nahua culture. To be Spanish before and after the conquest as well as to be Spanish in Spain and in Las Indias did not mean the same. Este artículo examina los métodos aplicados, y los resultados surgidos del cambio cultural que ocurrieron con la conquista de México y los comienzos de la Nueva Espa a. Es el intento de sistematizar los mecanismos de la evangelización y la hispanización, comprendida como un proceso recíproco de transformación de las identidades colectivas. El hecho de que no se creara un clero indígena, en general fue malinterpretado como el resultado de una poca capacidad de los nahuas de adaptarse a la civilización ( policía ) y a la moral espa ola. Esto tuvo efectos tanto en las esferas políticas como arquitectónicas y historiográficas. Pero también los espa oles y los demás europeos tuvieron que cuestionar su autognosis después del contacto con la cultura nauahtl. Ser espa ol antes y después de la conquista, no fue lo mismo, como tampoco lo fue ser espa ol en Espa a y en las Indias.
Sup-norm-closable bilinear forms and Lagrangians
Michael Hinz
Mathematics , 2014,
Abstract: We consider symmetric non-negative definite bilinear forms on algebras of bounded real valued functions and investigate closability with respect to the supremum norm. In particular, any Dirichlet form gives rise to a sup-norm closable bilinear form. Under mild conditions a sup-norm closable bilinear form admits finitely additive energy measures. If, in addition, there exists a (countably additive) energy dominant measure, then a sup-norm closable bilinear form can be turned into a Dirichlet form admitting a carr\'e du champ. Moreover, we can always transfer the bilinear form to an isometrically isomorphic algebra of bounded functions on the Gelfand spectrum, where these measures exist. Our results complement a former closability study of Mokobodzki for the locally compact and separable case.
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