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Search Results: 1 - 10 of 866 matches for " Tsuyoshi Tatsui "
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Enhanced Cytotoxicity for Colon 26 Cells Using Doxorubicin-Loaded Sorbitan Monooleate (Span 80) Vesicles
Keita Hayashi, Tsuyoshi Tatsui, Toshinori Shimanouchi, Hiroshi Umakoshi
International Journal of Biological Sciences , 2013,
Abstract: Span 80 (sorbitan monooleate) vesicles behaved differently from conventional phospholipid vesicles (liposomes) because the former had a more fluid interface. After doxorubicin hydrochloride (DOX) was encapsulated into the Span 80 vesicle (loading efficiency: 63 %), DOX-loaded Span 80 vesicles (DVs) were thereafter added to Colon 26 cells. It was suggested, from the flow cytometric analysis and confocal laser microscopic observation, that DVs directly deliver DOX into the cytoplasm of Colon 26 cells. DVs showed the different delivery manner from the DOX-loaded liposomes (DLs). It is considered that the difference of delivery manner between DVs and DLs resulted in the difference of cytotoxicity (IC50); i.e. IC50 values for DVs and DLs were 5 and > 30 μM, respectively. The results obtained herein would give the fundamental findings which can contribute to the improvement of formulation of conventional liposome-based carrier and its cytotoxicity.
Minocycline for Schizophrenia: A critical review  [PDF]
Tsuyoshi Miyaoka
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.224056
Abstract: Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestoractive or neuroprotective properties in various models of neurodegenerative diseases. In particular, it has been shown to delay motor alterations, inflammation and apoptosis in models of Huntington’s disease, amyotrophic lateral sclerosis and Parkinson’s disease. Despite controversies about its efficacy, the relative safety and tolerability of minocycline have led to the launching of various clinical trials. Previously, we reported the antipsychotic effects of minocycline in patients with schizophrenia. In a pilot investigation, we administered minocycline as an open-label adjunct to antipsychotic medication to patients with schizophrenia. The results of this trial suggested that minocycline might be a safe and effective adjunct to antipsychotic medications, and that augmentation with minocycline may prove to be a viable strategy for “boosting” antipsychotic efficacy and for treating schizophrenia. Recently, in randomized double-blind placebo-controlled clinical trials, the addition of minocycline to treatment as usual early in the course of schizophrenia predominantly improves negative symptoms. The present review summarizes the available data supporting the clinical testing of minocycline for patients with schizophrenia. In addition, we extend our discussion to the potential applications of minocycline for combining this treatment with cellular and molecular therapy.
Electrodeposition of Bi-Sb alloy using Cu electrodes  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.37069
Abstract: Bi-Sb alloys were grown by means of an electrodeposition method using Cu electrodes. The alloys were studied with the help of an x-ray diffractometer and an electron probe microanalysis. The both investigations have shown no trace of Cu in the obtained alloys. It can be concluded that Cu electrodes can be used for the deposition of Bi-Sb alloys; which results in an advantage of availability of the electrode.
Scoping the Possibilities: Student Preferences towards Open Textbooks Adoption for E-Learning  [PDF]
Deepak Prasad, Tsuyoshi Usagawa
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.524227
Abstract: Many universities have begun implementing e-Learning systems due to their low cost. However, publishers of expensive textbooks stand in the way of e-Learning’s ability to provide a cost-effective educational delivery model. While many universities aim to overcome this opposition and replace traditional publishers’ textbooks with free open textbooks, such plans cannot be executed successfully unless students are open to their use. As such, a study into students’ preferences towards open textbook adoption is vital to provide clear indication as to their opinions regarding open textbook use. Thus, this study conducted a study of University of the South Pacific (USP) students’ preferences towards open textbook adoption for e-Learning using a survey administered during Semester 2, 2013 which generated 1077 responses. Areas examined include: Impacts of textbook costs on students’ academic careers; preferences towards open textbook adoption; perceived barriers to and motivations for adoption of open textbooks; and preferred digital features and reading devices. Results show that textbook prices adversely impact students. Furthermore, a high level of acceptance towards the adoption of open textbooks was found. The study revealed that the preference for reading printed material was the highest rated barrier to open textbook adoption, while the free availability of open textbooks was rated the greatest motivator. Study findings are being used to inform efforts to develop open textbooks at the USP and may assist other universities seeking to start similar projects.
Comparison between Amorphous and Tandem Silicon Solar Cells in Practical Use  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.54002
Abstract: Solar cells are now widely used as a clean method for electric energy generation. Among various type of solar cells, we compared the ability between amorphous and tandem (amorphous and polycrystalline) silicon solar cells by means of simultaneous running test. This kind of comparison is of importance practically, because the comparison of only inherent characteristics cannot include environmental parameters such as temperature totally. It was concluded that both types of solar cells provided almost the same energy for one year. The amorphous silicon solar cell provided more energy in summer while the tandem solar cell was advantageous in winter. It is due to the fact that the decrease in energy conversion at the higher cell temperature is more noticeable in tandem solar cells.
Simulation Suggests Origin of Potential Induced Degradation of Solar Cell  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.56004
Abstract: Solar cells are well known as devices for sustainable electric energy generation. Nowadays the potential induced degradation has been brought up as an obstacle problem for practical use. In order to determine the cause of this kind of degradation, numerical simulation by a finite difference time domain method has been performed for computational electromagnetics in the case that the thunder attacks the solar modules. The results show that the dielectric breakdown in the glass covered over the solar cells triggered by the thunderstroke is critical. So it is helpful to protect the dielectric breakdown in the glass from the thunderstroke.
Effect of Parameters on Potential Induced Degradation of Solar Cell  [PDF]
Masato Ohmukai, Akira Tsuyoshi
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.56003
Abstract: Solar cells are widely used to generate electric energy even at homes. It surely has a great advantage of sustainability. However, the potential induced degradation has been found to be an obstacle problem for practical use. It was reported that the main cause is the dielectric breakdown in the glass covered over the solar cells triggered by the thunderstroke. In this paper, the effects of the parameters such as the position of thunderstroke, the wave form, the peak value and the front duration of the lightning current, were examined by means of numerical calculation. For the lightning current, a step-like waveform and an impulse waveform were examined. The effect of the induced voltage was found to be independent of the waveform. The peak value, the front duration of the lightning current greatly affects the induced voltage.
Potential Impact of Blended Learning on Teacher Education in Mongolia  [PDF]
Narangerel Jachin, Tsuyoshi Usagawa
Creative Education (CE) , 2017, DOI: 10.4236/ce.2017.89104
Abstract: Mongolia is a developing country with little infrastructure capacities, but with rapid economic growth for the past few years. Within the past few years, internet and mobile technologies have become more affordable and widespread. Even though there are improvements, it is no secret that quality in all levels of educational sector in Mongolia is inadequate. E-Learning is becoming a driving force of the pedagogical and technological innovations in the higher education institutions worldwide. The most practiced form of the e-Learning in the higher education institutions is blended learning. Some researches show that use of a blended learning course in higher education can result in better quality in instruction. Design and implementation of blended course in particular situation, revision and assessment of quality, would not only enable to share the experience with the similar higher education institutions but also contribute to the overall research in quality in higher education. This paper presents implementation and improvement of the blended “Pedagogy course,” using Moodle Learning Management System and discusses the potential impact on teacher education in Mongolia. Pilot blended “Pedagogy course” was designed and implemented during 2012-2013 school year then revised in 2014-2015 school year. To ensure effectiveness, Keller’s ARCS model of motivational design, validated by many researches was chosen. At the end of the implementation, the students’ blended learning experience survey was completed followed by focus group discussion and statistical analysis. Results show that students in blended class could achieve better grades than traditional class, with high satisfaction. The outcome of the research shows that blended learning implemen-tation can improve quality in higher education has a potential to improve teacher education and should be recommended in similar educational institu-tions in developing countries with similar situation in Mongolia.
Change in E-learning Readiness and Challenge for Myanmar Higher Education  [PDF]
Mon Mon The, Tsuyoshi Usagawa
Creative Education (CE) , 2018, DOI: 10.4236/ce.2018.99095
Abstract: The advantage of technology has paved way for innovation in higher education. Because of being cost-effective, unlimited time and place, the universities from the developing world are also trying to integrate e-learning into their traditional education system. However, as a fundamental process, they require the readiness assessment before their e-learning implementation. Moreover, the evaluation on readiness should be done as on-going process so that readiness movements are able to be confirmed, and necessary preparations in line with their updates can be effectively done. The purpose of this study was to investigate if the e-learning readiness of two Myanmar technological universities are stable or not, and to find out which items happened the highest difference between 2016 and 2017. To examine the changes in e-learning readiness, the paper-based data collection was done using questionnaires and shared toward 648 students in 2016 and 1024 students in 2017. Data analysis was done by indexes of descriptive statistics and independent t-test. Findings reveal that their readiness was a significant decline in 2017. Moreover, the items with highest changes were addressed, and the readiness levels on each studied dimension were also measured. In addition, the study points out blackout problems found in Myanmar universities. Understanding the barriers directed by e-learning readiness encourages Myanmar universities to make an e-learning effort on what kind of strategies and preparation should be emphasized.
Forecasting on Indonesian Coal Production and Future Extraction Cost: A Tool for Formulating Policy on Coal Marketing  [PDF]
Fadhila Achmadi Rosyid, Tsuyoshi Adachi
Natural Resources (NR) , 2016, DOI: 10.4236/nr.2016.712054
Abstract: Since 2011 Indonesia has become the world’s largest exporter of steam coal. Two supporting factors of Indonesia to be the largest exporter are its enormous production and low operating cost. This paper foresees the production and extraction cost of Indonesian coal in the coming period to evaluate marketing policies and estimate the cost of Indonesian coal supply in domestic market as well as in export market. The production forecasting is carried out by Gompertz curve. Peak production of Indonesian coal is expected to take place in 2026. Moreover, the extraction cost in coal basins which produce high calorific value of coal, in accordance to the operating cost forecasting, is higher than the one with low calorific value of coal due to its higher stripping ratio. Three main basins of Central Sumatra, Tarakan, and Barito basins play major rule in supplying coal for domestic use in short term. And other coal basins such as South Sumatra, Kutai, Bengkulu, and Ombilin basins provide long term supply in the domestic and export markets.
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