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Search Results: 1 - 10 of 1014 matches for " Tsuyoshi Otani "
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Resurrection of a Bull by Cloning from Organs Frozen without Cryoprotectant in a ?80°C Freezer for a Decade
Yoichiro Hoshino, Noboru Hayashi, Shunji Taniguchi, Naohiko Kobayashi, Kenji Sakai, Tsuyoshi Otani, Akira Iritani, Kazuhiro Saeki
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004142
Abstract: Frozen animal tissues without cryoprotectant have been thought to be inappropriate for use as a nuclear donor for somatic cell nuclear transfer (SCNT). We report the cloning of a bull using cells retrieved from testicles that had been taken from a dead animal and frozen without cryoprotectant in a ?80°C freezer for 10 years. We obtained live cells from defrosted pieces of the spermatic cords of frozen testicles. The cells proliferated actively in culture and were apparently normal. We transferred 16 SCNT embryos from these cells into 16 synchronized recipient animals. We obtained five pregnancies and four cloned calves developed to term. Our results indicate that complete genome sets are maintained in mammalian organs even after long-term frozen-storage without cryoprotectant, and that live clones can be produced from the recovered cells.
Role of 18F-fluorodeoxyglucose positron emission tomography imaging in surgery for pancreatic cancer
Hisao Wakabayashi, Yoshihiro Nishiyama, Tsuyoshi Otani, Takanori Sano, Shinichi Yachida, Keiichi Okano, Kunihiko Izuishi, Yasuyuki Suzuki
World Journal of Gastroenterology , 2008,
Abstract: AIM: To evaluate the role of positron emission tomo-graphy using 18F-fluorodeoxyglucose (FDG-PET) in the surgical management of patients with pancreatic cancer, including the diagnosis, staging, and selection of patients for the subsequent surgical treatment.METHODS: This study involved 53 patients with proven primary pancreatic cancer. The sensitivity of diagnosing the primary cancer was examined for FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of carcinoembrionic antigens (CEA) and carbohydrate antigen 19-9 (CA19-9). Next, the accuracy of staging was compared between FDG-PET and CT. Finally, FDG-PET was analyzed semiquantitatively using the standard uptake value (SUV). The impact of the SUV on patient management was evaluated by examining the correlations between the SUV and the histological findings of cancer.RESULTS: The sensitivity of FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of CEA and CA19-9 were 92.5%, 88.7%, 46.4%, 37.7% and 69.8%, respectively. In staging, FDG-PET was superior to CT only in diagnosing distant disease (bone metastasis). For local staging, the sensitivity of CT was better than that of FDG-PET. The SUV did not correlate with the pTNM stage, grades, invasions to the vessels and nerve, or with the size of the tumor. However, there was a statistically significant difference (4.6 ± 2.9 vs 7.8 ± 4.5, P = 0.024) in the SUV between patients with respectable and unresectable disease.CONCLUSION: FDG-PET is thus considered to be useful in the diagnosis of pancreatic cancer. However, regarding the staging of the disease, FDG-PET is not considered to be a sufficiently accurate diagnostic modality. Although the SUV does not correlate with the patho-histological prognostic factors, it may be useful in selecting patients who should undergo subsequent surgical treatment.
Domain Nucleation and Annihilation in Uniformly Magnetized State under Current Pulses in Narrow Ferromagnetic Wires
Yoshihiko Togawa,Takashi Kimura,Ken Harada,Tetsuya Akashi,Tsuyoshi Matsuda,Akira Tonomura,Yoshichika Otani
Physics , 2006, DOI: 10.1143/JJAP.45.L1322
Abstract: We investigate the current-driven magnetization dynamics in narrow Permalloy wires by means of Lorentz microscopy and electron holography. Current pulses are found to transform the magnetic structure in the uniformly magnetized state below the Curie temperature. A variety of magnetic states including reversed magnetic domains are randomly obtained in low probability. The dynamics of vortices found in most of observed magnetic states seems to play a key role in triggering the magnetization reversal.
Current-excited magnetization dynamics in narrow ferromagnetic wires
Yoshihiko Togawa,Takashi Kimura,Ken Harada,Tetsuya Akashi,Tsuyoshi Matsuda,Akira Tonomura,Yoshichika Otani
Physics , 2006, DOI: 10.1143/JJAP.45.L683
Abstract: We investigate the current-excited magnetization dynamics in a narrow ferromagnetic Permalloy wire by means of Lorentz microscopy, together with the results of simultaneous transport measurements. A detailed structural evolution of the magnetization is presented as a function of the applied current density. Local structural deformation, bidirectional displacement, and magnetization reversal are found below the Curie temperature with increasing the current density. We discuss probable mechanisms of observed features of the current-excited magnetization dynamics.
Minocycline for Schizophrenia: A critical review  [PDF]
Tsuyoshi Miyaoka
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.224056
Abstract: Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestoractive or neuroprotective properties in various models of neurodegenerative diseases. In particular, it has been shown to delay motor alterations, inflammation and apoptosis in models of Huntington’s disease, amyotrophic lateral sclerosis and Parkinson’s disease. Despite controversies about its efficacy, the relative safety and tolerability of minocycline have led to the launching of various clinical trials. Previously, we reported the antipsychotic effects of minocycline in patients with schizophrenia. In a pilot investigation, we administered minocycline as an open-label adjunct to antipsychotic medication to patients with schizophrenia. The results of this trial suggested that minocycline might be a safe and effective adjunct to antipsychotic medications, and that augmentation with minocycline may prove to be a viable strategy for “boosting” antipsychotic efficacy and for treating schizophrenia. Recently, in randomized double-blind placebo-controlled clinical trials, the addition of minocycline to treatment as usual early in the course of schizophrenia predominantly improves negative symptoms. The present review summarizes the available data supporting the clinical testing of minocycline for patients with schizophrenia. In addition, we extend our discussion to the potential applications of minocycline for combining this treatment with cellular and molecular therapy.
Enhanced Intestinal Motility during Oral Glucose Tolerance Test after Laparoscopic Sleeve Gastrectomy: Preliminary Results Using Cine Magnetic Resonance Imaging
Vo Nguyen Trung, Hiroshi Yamamoto, Akira Furukawa, Tsuyoshi Yamaguchi, Satoshi Murata, Masahiro Yoshimura, Yoko Murakami, Shigetaka Sato, Hideji Otani, Satoshi Ugi, Katsutaro Morino, Hiroshi Maegawa, Tohru Tani
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065739
Abstract: Background Enhanced secretion of glucagon-like peptide-1 (GLP-1) has been suggested as a possible mechanism underlying the improvement in type 2 diabetes mellitus (T2DM) after laparoscopic sleeve gastrectomy (LSG). However, the reason for enhanced GLP-1 secretion during glucose challenge after LSG remains unclear because LSG does not include intestinal bypass. In this study, we focused on the effects of LSG on GLP-1 secretion and intestinal motility during the oral glucose tolerance test (OGTT) using cine magnetic resonance imaging (MRI) before and 3 months after LSG. Methods LSG was performed in 12 obese patients with a body mass index >35 kg/m2. Six patients had T2DM. OGTT was performed before and 3 months after the surgery. Body weight, hemoglobin A1c (HbA1c), and GLP-1 levels during OGTT were examined, and intestinal motility during OGTT was assessed using cine MRI. Results Body weight was significantly decreased after surgery in all the cases. HbA1c was markedly decreased in all the diabetic subjects. In all cases, GLP-1 secretion during OGTT was enhanced and cine MRI showed markedly increased intestinal motility at 15 and 30 min during OGTT after LSG. Conclusions LSG leads to accelerated intestinal motility and reduced intestinal transit time, which may be involved in the mechanism underlying enhanced GLP-1 secretion during OGTT after LSG.
Rede de saúde do trabalhador para o estado de S?o Paulo
Otani, Koshiro;
S?o Paulo em Perspectiva , 2003, DOI: 10.1590/S0102-88392003000100009
Abstract: this article considers various ministry of health documents and contributions by members of the intra-sectorial commission on workers' health, created to integrate and harmonize the work of various sectors of the s?o paulo state secretariat of workers' health to address the issue of health and labor. this commission developed the action plan for workers' health for the state of s?o paulo (for the years 2002-2003-2004), which set as its top priority the creation of a model for workers' health that envisioned a network of technical references for treatment, prevention, and training.
Erratum to “Site-Specific Antioxidative Therapy for Prevention of Atherosclerosis and Cardiovascular Disease”
Hajime Otani
Oxidative Medicine and Cellular Longevity , 2013, DOI: 10.1155/2013/936436
An entropy formula for a non-self-affine measure with application to Weierstrass-type functions
Atsuya Otani
Mathematics , 2015,
Abstract: Let $ \tau : [0,1] \rightarrow [0,1] $ be a piecewise expanding map with full branches. Given $ \lambda : [0,1] \rightarrow (0,1) $ and $ g : [0,1] \rightarrow \mathbb{R} $ satisfying $ \tau ' \lambda > 1 $, we study the Weierstrass-type function \[ \sum _{n=0} ^\infty \lambda ^n (x) \, g (\tau ^n (x)), \] where $ \lambda ^n (x) := \lambda(x) \lambda (\tau (x)) \cdots \lambda (\tau ^{n-1} (x)) $. Under certain conditions, Bedford proved that the box counting dimension of its graph is given as the unique zero of the topological pressure function \[ s \mapsto P ((1-s) \log \tau ' + \log \lambda) . \] We give a sufficient condition under which the Hausdorff dimension also coincides with this value. We adopt a dynamical system theoretic approach which was originally used to investigate special cases including the classical Weierstrass functions. For this purpose we prove a new Ledrappier-Young entropy formula, which is a conditional version of Pesin's formula, for non-invertible dynamical systems. Our formula holds for all lifted Gibbs measures on the graph of the above function, which are generally not self-affine.
Smart Inverter Functionality Testing for Battery Energy Storage Systems  [PDF]
Jun Hashimoto, Taha Selim Ustun, Kenji Otani
Smart Grid and Renewable Energy (SGRE) , 2017, DOI: 10.4236/sgre.2017.811022
Abstract: Variable distributed energy resources (DERs) such as photovoltaic (PV) systems and wind power systems require additional power resources to control the balance between supply and demand. Battery energy storage systems (BESSs) are one such possible resource for providing grid stability. It has been proposed that decentralized BESSs could help support microgrids (MGs) with intelligent control when advanced functionalities are implemented with variable DERs. One key challenge is developing and testing smart inverter controls for DERs. This paper presents a standardized method to test the interoperability and functionality of BESSs. First, a survey of grid-support standards prevalent in several countries was conducted. Then, the following four interoperability functions defined in IEC TR 61850-90-7 were tested: the specified active power from storage test (INV4), the var-priority Volt/VAR test (VV) and the specified power factor test (INV3) and frequency-watt control (FW). This study then out-lines the remaining technical issues related to basic BESS smart inverter test protocols.
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