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Search Results: 1 - 10 of 2645 matches for " Trinh Thi Minh Lien "
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Stimulating the development of national Streptococcus suis guidelines in Viet Nam through a strategic research partnership
Horby,Peter; Wertheim,Heiman; Ha,Nguyen Hong; Trung,Nguyen Vu; Trinh,Dao Tuyet; Taylor,Walter; Ha,Nguyen Minh; Lien,Trinh Thi Minh; Farrar,Jeremy; Kinh,Nguyen Van;
Bulletin of the World Health Organization , 2010, DOI: 10.1590/S0042-96862010000600015
Abstract: problem: streptococcus suis is a common cause of adult bacterial meningitis in viet nam, and possibly other parts of asia, yet this disabling infection has been largely neglected. prevention, diagnosis and treatment are relatively straightforward and affordable but, in early 2007, no national diagnostic, case management or prevention guidelines existed in viet nam. approach: enhanced detection of s. suis infections was established in 2007 as part of a collaborative research programme between the national hospital for tropical diseases, a key national hospital with very close links to the ministry of health, and a research group affiliated with oxford university based in viet nam. the results were reported directly to policy-makers at the ministry of health. local setting: viet nam is a low-income country with a health-care system that has seen considerable improvements and increased autonomy. however, parts of the system remain fairly centralized the ministry of health. relevant changes: following the improved detection and reporting of s. suis cases, the ministry of health issued guidance to all hospitals in viet nam on the clinical and laboratory diagnosis, treatment and prevention of s. suis. a public health laboratory diagnostic service was established at the national institute of hygiene and epidemiology and training courses were conducted for clinicians and microbiologists. ministry of health guidance on surveillance and control of communicable diseases was updated to include a section on s. suis. lessons learnt: research collaborations can efficiently inform and influence national responses if they are well positioned to reach policy-makers.
Immunological and Viral Determinants of Dengue Severity in Hospitalized Adults in Ha Noi, Viet Nam
Annette Fox ,Le Nguyen Minh Hoa,Cameron P. Simmons,Marcel Wolbers,Heiman F. L. Wertheim,Pham Thi Khuong,Tran Thi Hai Ninh,Trinh Thi Minh Lien,Nguyen Thi Lien,Nguyen Vu Trung,Nguyen Duc Hien,Jeremy Farrar,Peter Horby,Walter R. Taylor,Nguyen Van Kinh
PLOS Neglected Tropical Diseases , 2011, DOI: 10.1371/journal.pntd.0000967
Abstract: Background The relationships between the infecting dengue serotype, primary and secondary infection, viremia and dengue severity remain unclear. This cross-sectional study examined these interactions in adult patients hospitalized with dengue in Ha Noi. Methods and Findings 158 patients were enrolled between September 16 and November 11, 2008. Quantitative RT-PCR, serology and NS1 detection were used to confirm dengue infection, determine the serotype and plasma viral RNA concentration, and categorize infections as primary or secondary. 130 (82%) were laboratory confirmed. Serology was consistent with primary and secondary infection in 34% and 61%, respectively. The infecting serotype was DENV-1 in 42 (32%), DENV-2 in 39 (30%) and unknown in 49 (38%). Secondary infection was more common in DENV-2 infections (79%) compared to DENV-1 (36%, p<0.001). The proportion that developed dengue haemorrhagic fever (DHF) was 32% for secondary infection compared to 18% for primary infection (p = 0.14), and 26% for DENV-1 compared to 28% for DENV-2. The time until NS1 and plasma viral RNA were undetectable was shorter for DENV-2 compared to DENV-1 (p≤0.001) and plasma viral RNA concentration on day 5 was higher for DENV-1 (p = 0.03). Plasma viral RNA concentration was higher in secondary infection on day 5 of illness (p = 0.046). We didn't find an association between plasma viral RNA concentration and clinical severity. Conclusion Dengue is emerging as a major public health problem in Ha Noi. DENV-1 and DENV-2 were the prevalent serotypes with similar numbers and clinical presentation. Secondary infection may be more common amongst DENV-2 than DENV-1 infections because DENV-2 infections resulted in lower plasma viral RNA concentrations and viral RNA concentrations were higher in secondary infection. The drivers of dengue emergence in northern Viet Nam need to be elucidated and public health measures instituted.
Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam
Heiman F. L. Wertheim, Huyen Nguyen Nguyen, Walter Taylor, Trinh Thi Minh Lien, Hoa Thi Ngo, Thai Quoc Nguyen, Bich Ngoc Thi Nguyen, Ha Hong Nguyen, Ha Minh Nguyen, Cap Trung Nguyen, Trinh Tuyet Dao, Trung Vu Nguyen, Annette Fox, Jeremy Farrar, Constance Schultsz, Hien Duc Nguyen, Kinh Van Nguyen, Peter Horby
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005973
Abstract: Background Streptococcus suis can cause severe systemic infection in adults exposed to infected pigs or after consumption of undercooked pig products. S. suis is often misdiagnosed, due to lack of awareness and improper testing. Here we report the first fifty cases diagnosed with S. suis infection in northern Viet Nam. Methodology/Principal Findings In 2007, diagnostics for S. suis were set up at a national hospital in Hanoi. That year there were 43 S. suis positive cerebrospinal fluid samples, of which S. suis could be cultured in 32 cases and 11 cases were only positive by PCR. Seven patients were blood culture positive for S. suis but CSF culture and PCR negative; making a total of 50 patients with laboratory confirmed S. suis infection in 2007. The number of S. suis cases peaked during the warmer months. Conclusions/Significance S. suis was commonly diagnosed as a cause of bacterial meningitis in adults in northern Viet Nam. In countries where there is intense and widespread exposure of humans to pigs, S. suis can be an important human pathogen.
Predictors of Weight Change in Male HIV-Positive Injection Drug Users Initiating Antiretroviral Therapy in Hanoi, Vietnam
Alice M. Tang,Heidi B. Sheehan,Michael R. Jordan,Dang Van Duong,Norma Terrin,Kimberly Dong,Trinh Thi Minh Lien,Nguyen Vu Trung,Christine A. Wanke,Nguyen Duc Hien
AIDS Research and Treatment , 2011, DOI: 10.1155/2011/890308
Abstract: We examined clinical and nutritional predictors of weight change over two consecutive 6-month intervals among 99 HIV-positive male injection drug users initiating antiretroviral therapy (ART) in Hanoi, Vietnam. The average weight gain was 3.1 ± 4.8?kg in the first six months after ART and 0.8 ± 3.0?kg in the following six months. Predictors of weight change differed by interval. In the first interval, CD4 < 200?cells/μL, excellent/very good adherence to ART, bothersome nausea, and liquid supplement use were all associated with positive weight changes. Moderate to heavy alcohol use and tobacco smoking were associated with negative weight changes. In the second interval, having a CD4 count <200?cells/μL at the beginning of the interval and tobacco smoking were the only significant predictors and both were associated with negative weight changes. We identified several potential areas for interventions to promote weight gain immediately after starting ART in this population. Studies are needed to determine whether improving weight prior to, or at, ART initiation will result in improved outcomes on ART. 1. Introduction Access to antiretroviral treatment (ART) has expanded rapidly in many moderate-to low-income countries affected by the HIV epidemic. In addition to reducing mortality rates, ART has many favorable effects among people living with HIV (PLHIV), such as improving weight and lean body mass, particularly in patients with greater pretreatment immunological and virological compromise [1, 2]. Several large-scale ART programs in sub-Saharan Africa indicate that malnutrition (low BMI) at the start of ART is significantly and independently associated with subsequent mortality [3–6], while weight gain after ART is associated with survival [7, 8]. It is unclear whether this association is causal. Although weight changes appear to parallel the success of ART, it is unknown whether interventions to improve weight prior to or at ART initiation will improve subsequent outcomes. In Vietnam, the number of PLHIV is estimated to be 293,000 with an HIV prevalence rate of 0.53% among adults [9]. Injection drug use (IDU) remains the main driver of HIV in Vietnam. The HIV prevalence rate among IDUs is estimated to be 30% overall, with rates of over 50% in Ho Chi Minh City and Quang Ninh [10]. In Hanoi, the most recent estimates of HIV among IDUs are around 25% [9]. Rapid scale-up of ART in Vietnam began in 2005 with support from the Vietnam Ministry of Health, the United States President’s Emergency Plan for AIDS Relief (PEPFAR), and the Global Fund. To our knowledge,
Using Isotope Technology for Surface Water Environment Research in Southern Hanoi  [PDF]
Vo Thi Anh, Tran Khanh Minh, Trinh Van Giap, Ha Lan Anh, Nguyen Thanh Cong, Nguyen Hong Thinh, Vu Hoai
Journal of Environmental Protection (JEP) , 2016, DOI: 10.4236/jep.2016.78100
Abstract: The surface water in the southern of Hanoi capital is researched by identifying δ2H and δ18O stable isotopes together with EC, DO, BOD5, COD, TSS. Surface water samples for studying include the Red river, Nhue river and Kim Nguu river, Thanh Nhan lake, Yen So lake and Van Quan lake were collected in the dry season (April) and the rainy season (August) in 2015. The stable isotope analysis results showed that the δ18O values is a range from -42.53 to -64.05 and, the δ2H values is the range from -5.09 to -8.79 under global meteoric waterline (in the water vapor region). The δ2H results of the rivers and lakes in the dry season are more negative than the rainy season with a small difference. The δ18O results of lakes in the dry season are more negative than the rainy season, but the δ18O results of river in the dry season are more positive than the rainy season. The results of the EC, BOD, COD, DO, TSS analysis showed that surface water environment has changed clearly in the two seasons and the contamination level in the dry season is usually higher than the rainy season. The lakes and rivers strongly influenced by human activities led to seriously pollution are Van Quan lake and Yen So lake, Nhue river and Kim Nguu river.
Oseltamivir Is Adequately Absorbed Following Nasogastric Administration to Adult Patients with Severe H5N1 Influenza
Walter R. J. Taylor, Bui Nghia Thinh, Giang Thuc Anh, Peter Horby, Heiman Wertheim, Niklas Lindegardh, Menno D. de Jong, Kasia Stepniewska, Tran Thuy Hanh, Nguyen Duc Hien, Ngo Minh Bien, Ngo Quy Chau, Annette Fox, Nghiem My Ngoc, Martin Crusat, Jeremy J. Farrar, Nicholas J. White, Nguyen Hong Ha, Trinh Thi Lien, Nguyen Vu Trung, Nicholas Day, Nguyen Gia Binh
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003410
Abstract: In the absence of a parenteral drug, oral oseltamivir is currently recommended by the WHO for treating H5N1 influenza. Whether oseltamivir absorption is adequate in severe influenza is unknown. We measured the steady state, plasma concentrations of nasogastrically administered oseltamivir 150 mg bid and its active metabolite, oseltamivir carboxylate (OC), in three, mechanically ventilated patients with severe H5N1 (male, 30 yrs; pregnant female, 22 yrs) and severe H3N2 (female, 76 yrs). Treatments were started 6, 7 and 8 days after illness onset, respectively. Both females were sampled while on continuous venovenous haemofiltration. Admission and follow up specimens (trachea, nose, throat, rectum, blood) were tested for RNA viral load by reverse transcriptase PCR. In vitro virus susceptibility to OC was measured by a neuraminidase inhibition assay. Admission creatinine clearances were 66 (male, H5N1), 82 (female, H5N1) and 6 (H3N2) ml/min. Corresponding AUC0–12 values (5932, 10,951 and 34,670 ng.h/ml) and trough OC concentrations (376, 575 and 2730 ng/ml) were higher than previously reported in healthy volunteers; the latter exceeded 545 to 3956 fold the H5N1 IC50 (0.69 ng/ml) isolated from the H5N1 infected female. Two patients with follow-up respiratory specimens cleared their viruses after 5 (H5N1 male) and 5 (H3N2 female) days of oseltamivir. Both female patients died of respiratory failure; the male survived. 150 mg bid of oseltamivir was well absorbed and converted extensively to OC. Virus was cleared in two patients but two patients died, suggesting viral efficacy but poor clinical efficacy.
Analysis of Inter-Regional Relationship between Vietnam Coastal Zones and the Rest of Vietnam  [PDF]
Hoang Ngoc Phong, Nguyen Quang Thai, Bui Trinh, Nguyen Hong Nhung, Nguyen Quang Tung, Nguyen Thi Ai Lien
Theoretical Economics Letters (TEL) , 2019, DOI: 10.4236/tel.2019.95102
Abstract: The paper presents the importance of Vietnam’s coastal economy, including 28 of the 63 provinces and cities and analyzes six priority economic sectors according to Resolution 36/TW/2018 “About the sustainable development strategy of Vietnam’s marine economy to 2030, vision to 2045”. Based on the Resolution, the Interdisciplinary Balance sheet with 2 areas—coastal and the rest of Vietnam—is used (separate use of products in each region and imports) to analyze the spillover effects and sensitivity to income and related issues. Many new findings show that the efficiency of coastal economic zones already plays an important role in the Vietnamese economy and needs to be further exploited. This article is the result of the research conducted in the framework of the independent topic KC09.26/16-20 “Scientific foundations and breakthrough solutions for sustainable coastal economic development in focal economic regions in Vietnam” chaired by Dr. Hoang Ngoc Phong.
Study the Changes in Soil Organic Carbon of Rice-Maize Cropping System in the Top Layer of Alluvisol Soil in Dan Phuong: A Study of C-13 Stable Isotope Composition (δ13C)  [PDF]
Nguyen Thi Hong Thinh, Vu Hoai, Ha Lan Anh, Vo Thi Anh, Truong Viet Chau, Trinh Van Giap, Tran Minh Tien
Journal of Environmental Protection (JEP) , 2019, DOI: 10.4236/jep.2019.1010080
Abstract: In this study, the experiments on field were conducted to examine the change in the content of soil organic carbon (SOC), its C-13 stable isotope composition (δ 13C) and some main physical, chemical parameters (soil moisture, pH, soil density, content of humic, fulvic, total N, total P, total K) in alluvial soil of Dan Phuong region—Vietnam at a depth of 0 - 30 cm when we changed the regime from 2 maize -1 rice crop to 2 rice - 1 maize crop per 1 year. In addition to analyzing the main parameters in soil, C content and its δ 13C value in parts of rice and maize (root, stem and leaf) were also analyzed to assess the contribution of plant residues on soil organic carbon content after harvest. The experiment was carried out in 2016-2017 on the field with the traditional farming method of local farmers along with the tropical monsoon weather conditions of the North-Vietnam. The results showed that SOC had positive correlation with total N, total P parameters and negative correlation with δ 13C values of soil samples at two layers (0 - 15 cm and 15 - 30 cm). The average of total dry biomass (stem, stump + roots and leaf parts) per 1 rice and 1 maize crop was 10.64 Mg/ha and 9.09 Mg/ha, respectively. The average of δ 13C value of rice (C3 plant) was -29.78‰ and its value of maize (C4 plant) was -12.61‰. The new plant (rice) contributes to the total soil organic carbon content from 11.31% to 44.14% at the 0 - 15 cm layer and from 6.55% to 11.31% at the 15 - 30 cm layer in one-year experiment period.
High Prevalence of Beijing and EAI4-VNM Genotypes among M. tuberculosis Isolates in Northern Vietnam: Sampling Effect, Rural and Urban Disparities
Van Anh Thi Nguyen, Marc Choisy, Duy Hung Nguyen, Thanh Hoa Thi Tran, Kim Lien Thi Pham, Phuong Thao Thi Dinh, Jules Philippe, Thai Son Nguyen, Minh Ly Ho, Sang Van Tran, Anne-Laure Ba?uls, Duc Anh Dang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045553
Abstract: A total of 221 isolates of M. tuberculosis were sampled from hospitals and the general population in the northern plain of Vietnam, one of the most populated region of the country. Genotypic composition and diversity were characterized, and we investigated how they are affected by sampling (hospital vs. general population), correcting for potential confounding effects (location, age and gender of the patients). Spoligotyping and 12 MIRU-VNTR typing were used as first line. Then 15 MIRU-VNTR standard set was used, making 21 MIRU-VNTR typing for the clustered isolates. Result showed that 8 lineages and 13 sub-lineages were circulating in the region. The most predominant lineages were Beijing (38.5%) and EAI (38.5%). Others appeared with small proportions H (1.4%), LAM (1.8%), T (8.1%), X (0.9%), MANU (2.3%), and Zero (0.4%). Higher clustering rate was found in the hospital samples (17.9% in urban and 19.2% in rural areas) compared to the population ones (0%). The typical Vietnamese EAI4-VNM sub-lineage of EAI lineage accounted for 67% of EAI strains and was associated with older ages. Beijing genotypes were associated with younger, urban population and were characterized by high clustering rates. These characteristics strongly suggest that Beijing strains are invading the population, replacing the local EAI-VNM4, thus predicting a more serious tuberculosis situation in the future in the absence of more effective control strategies.
Self-Esteem Scale of the Vietnam Minors: Cross-Cultural Adaptation of ETES  [PDF]
Trinh Thi Linh, Nguyen Thi Anh Thu, Nguyen Dieu Huong
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.513167
Abstract: The purpose of this article is to introduce self-esteem scale associated with the culture of Vietnam. In essence, this is the process of cross-cultural adaptation of self-esteem scales that colleagues from the University of Toulouse II-Le Mirail (French Republic) establish for participant groups who are Vietnam minors. Results factor analysis with SPSS and Lisrel software has allowed us to obtain the scale consisting of 21 items, focusing for 4 contents: family self, social self, physical self, and academic self. Comparing with the study that the Vietnamese colleagues have conducted, we found that the research results have confirmed the importance of self of family to participant groups who are Vietnam minors, whereas emotional self and future self do not get results possible. We believe that Vietnam culture, especially Confucianism and Buddhism may explain the result of this research.
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