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Huge Sacrococcygeal Teratoma in an Adult Female: A Case Report  [PDF]
Yasutake Uchima, Naoki Aomatsu, Takuma Okada, Hironari Miyamoto, Gen Tsujio, Shigeaki Kurihara, Toshiki Hirakawa, Takehiko Iwauchi, Junya Morimoto, Kazuhiro Takeuchi
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.103016
Abstract: Background: Teratomas are a type of germ cell tumor, which are mostly benign, and dominative in adult females. Sacococcygeal teratomas are usually found in newborns or children, and can be detected prenatally; they are exceedingly rare in adults. We reported a case of a sacrococcygeal teratoma in adult female. Case presentation: A 26-year-old female was diagnosed with a presacral tumor 6 years ago. Pelvic computed tomography (CT) demonstrated a presacral heterogeneous tumor, containing multi-located cystic area and enhanced solid component with calcification. Magnetic resonance imaging (MRI) showed a presacral non-enhanced cystic lesion with solid component, 128 mm × 104 mm × 102 mm, which was suspected of having invaded the rectal wall, fifth sacral vertebra (S5), and coccyx. She underwent abdomino-sacral total excision of tumor with coccygectomy. Histopathological examination revealed a tumor with intricate admixture of ectodermal (epidermis, sebaceous glands and squamous), mesenchymal (cartilage, adipose tissue, blood vessels, nerves and skeletal muscle) and endodermal components (respiratory epithelium and intestinal epithelium) respectively. After 24 months of
Efficacy and Safety of Transanal Tube Drainage for Prevention of Anastomotic Leakage Following Laparoscopic Low Anterior Resection for Rectal Cancers  [PDF]
Yasutake Uchima, Naoki Aomatsu, Hironari Miyamoto, Takuma Okada, Shigeaki Kurihara, Toshiki Hirakawa, Takehiko Iwauchi, Junya Morimoto, Shigehito Yamagata, Kazunori Nakazawa, Kazuhiro Takeuchi
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.97045
Abstract: Introduction: Laparoscopic surgery is widely used for the treatment of colorectal cancer. But anastomotic leakage is one of the most serious complications following laparoscopic low anterior resection (LAR) for rectal cancer. The purpose of this study was to investigate whether transanal drainage tube placement can reduce anastomotic leakage and avoid re-operation after laparoscopic LAR. Methods: Retrospective assessment was performed on 143 patients with rectal cancers who underwent laparoscopic LAR between April 2009 and March 2016. A diverting stoma was not created in all 143 patients. A transanal drainage tube was placed after anastomosis using a double stapling technique, in 90 patients (group TT). In group TT, a 24 Fr. Silicon catheter was inserted into the anus and was placed approximately 20 - 25 cm in the descending colon. Another 53 patients were operated on without a transanal drainage tube (group NTT). Clinicopathological and operative variables, the frequencies of anastomotic leakage and re-operation after leakage were investigated. Results: Between the two groups (Group TT and NTT), age, gender, body mass index, tumor size, Dukes’ stage, the number of Liniar stapler firings for rectal transaction, and the rate of left colic artery preservation were comparable. Intra-operative blood loss and operation time decreased group TT from group NTT (p < 0.05). The frequency of leakage was 2.8% (2/69) in group TT and was 13.2% (7/53) in group NTT. The rate of leakage was significantly lower in group TT (p = 0.03). Furthermore, the re-operation rate for symptomatic anastomotic leakage was 0% (0/2) in group TT, while in contrast it was 28.5% (2/7) in group NTT. The rate of re-operation was lower in group TT than group NTT (p
Plasma pharmacokinetics after combined therapy of gemcitabine and oral S-1 for unresectable pancreatic cancer
Bunzo Nakata, Ryosuke Amano, Shigetomi Nakao, Tatsuro Tamura, Osamu Shinto, Toshiki Hirakawa, Yoshihiro Okita, Nobuya Yamada, Kosei Hirakawa
Journal of Experimental & Clinical Cancer Research , 2010, DOI: 10.1186/1756-9966-29-15
Abstract: Six patients with advanced pancreatic cancer were enrolled in this pharmacokinetics (PK) study. These patients were treated by oral administration of S-1 30 mg/m2 twice daily for 28 consecutive days, followed by a 14-day rest period and intravenous administration of GEM 800 mg/m2 on days 1, 15 and 29 of each course. The PK parameters of GEM and/or 5-FU after GEM single-administration, S-1 single-administration, and co-administration of GEM with pre-administration of S-1 at 2-h intervals were analyzed.The maximum concentration (Cmax), the area under the curve from the drug administration to the infinite time (AUCinf), and the elimination half-life (T1/2) of GEM were not significantly different between GEM administration with and without S-1. The Cmax, AUCinf, T1/2, and the time required to reach Cmax (Tmax) were not significantly different between S-1 administration with and without GEM.There were no interactions between GEM and S-1 regarding plasma PK of GEM and 5-FU.Unresectable pancreatic cancer is known to have a poor prognosis, with most patients dying within several months of diagnosis. However, recent progress in chemotherapy using gemcitabine (GEM) for this disease has improved patient survival. A number of phase III clinical trials have been performed to determine the GEM regimens that lead to the greatest increases in survival compared with GEM monotherapy. To date, only one regimen has been shown to yield significantly longer survival periods than GEM alone in phase III studies: GEM with erlotinib, an epidermal growth factor receptor (EGFR)-targeting agent [1].S-1 is an oral fluoropyrimidine derivative that contains tegafur (a 5-FU prodrug) and a reversible competitive dihydropyrimidine dehydrogenase (DPD) inhibitor, 5-chloro-2,4-dihydrogenase (CDHP). As DPD is a rate-limiting enzyme that degrades 5-FU, CDHP is expected to enhance the cytotoxicity of 5-FU by prolonging high 5-FU concentrations in blood and tumor tissues [2]. In Japan, S-1 has been clinical
Hypoxia Stimulates the EMT of Gastric Cancer Cells through Autocrine TGFβ Signaling
Junko Matsuoka, Masakazu Yashiro, Yosuke Doi, Yuhiko Fuyuhiro, Yukihiro Kato, Osamu Shinto, Satoru Noda, Shinichiro Kashiwagi, Naoki Aomatsu, Toshiki Hirakawa, Tsuyoshi Hasegawa, Kiyoshi Shimizu, Toshiyuki Shimizu, Atsushi Miwa, Nobuya Yamada, Tetsuji Sawada, Kosei Hirakawa
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062310
Abstract: Epithelial mesenchymal transition (EMT) is considered to be correlated with malignancy of cancer cells and responsible for cancer invasion and metastasis. We previously reported that distant metastasis was associated with hypoxia in gastric cancer. We therefore investigated the effect of hypoxic condition on EMT of gastric cancer cells. Gastric cancer cells were cultured in normoxia (21% O2) or hypoxia (1% O2) for 24 h. EMT was evaluated as the percentage of spindle-shaped cells in total cells. Effect of transforming growth factor β1 (TGFβ1) or tyrosine kinase inhibitors on the EMT was evaluated. The expression level of TGFβ1 and TGFβR was evaluated by real time RT-PCR. The TGFβ1 production from cancer cells was measured by ELISA. Hypoxia stimulated EMT of OCUM-2MD3 and OCUM-12 cells, but not that of OCUM-2M cells. The expression level of TGFβ1 mRNA under hypoxia was significantly higher than that under normoxia in all of three cell lines. The expression level of TGFβR mRNA was significantly increased by hypoxia in OCUM-2MD3 cells, but not in OCUM-2M cells. TGFβR inhibitor, SB431542 or Ki26894, significantly suppressed EMT of OCUM-2MD3 and OCUM-12. TGFβ1 production from OCUM-2MD3 and OCUM-12 cells was significantly increased under hypoxia in comparison with that under normoxia. These findings might suggest that hypoxia stimulates the EMT of gastric cancer cells via autocrine TGFβ/TGFβR signaling.
Possibility to Realize the Brain-Computer Interface from the Quantum Brain Model Based on Superluminal Particles  [PDF]
Takaaki Musha, Toshiki Sugiyama
Journal of Quantum Information Science (JQIS) , 2011, DOI: 10.4236/jqis.2011.13015
Abstract: R. Penrose and S. Hameroff have proposed an idea that the brain can attain high efficient quantum computation by functioning of microtubular structure of neurons in the cytoskelton of biological cells, including neurons of the brain. But Tegmark estimated the duration of coherence of a quantum state in a warm wet brain to be on the order of 10>–13
Epsilon Systems on Geometric Crystals of type A_n
Toshiki Nakashima
Symmetry, Integrability and Geometry : Methods and Applications , 2010,
Abstract: We introduce an epsilon system on a geometric crystal of type A_n, which is a certain set of rational functions with some nice properties. We shall show that it is equipped with a product structure and that it is invariant under the action of tropical R maps.
Quantum R-matrix and Intertwiners for the Kashiwara Algebra
Toshiki Nakashima
Physics , 1993, DOI: 10.1007/BF02101701
Abstract: We study the algebra $B_q(\ge)$ presented by Kashiwara and introduce intertwiners similar to $q$-vertex operators. We show that a matrix determined by 2-point functions of the intertwiners coincides with a quantum R-matrix (up to a diagonal matrix) and give the commutation relations of the intertwiners. We also introduce an analogue of the universal R-matrix for the Kashiwara algebra.
Unification of Gravity, Gauge and Higgs Fields by Confined Quantum Fields-Mathematical Formulation-
Toshiki Isse
Physics , 1992, DOI: 10.1142/S0217732393000878
Abstract: Dynamics of quantized free fields ( of spin 0 and 1/2 ) contained in a subspace $V_*$ of an N+4 dimensional flat space $V$ is studied. The space $V_*$ is considered as a neighborhood of a four dimensional submanifold $M$ arbitrarily embedded into $V$. We study the system as a simple model of unified theory of gravity ($g$), SO(N) gauge fields ($A$) and Higgs fields ($\phi $). In this paper classical treatment of the system is given. We show that, especially when the fields have spin 1/2, the system is described by an infinite number of fields in $M$ interacting with $g$, $A$ and $\phi $. The fields $g$, $A$ and $\phi $ are induced themselves by embedding functions of $M$ and correspond respectively to induced metric, normal connection and extrinsic curvature of $M$.
Unification of Gravity, Gauge and Higgs Fields by Confined Quantum Fields II -Effective Theory-
Toshiki Isse
Physics , 1992, DOI: 10.1142/S0217732393000970
Abstract: Dynamics of quantized free fields ( of spin 0 and 1/2 ) contained in a subspace $V_*$ of an N+4 dimensional flat space $V$ is studied. The space $V_*$ is considered as a neighborhood of a four dimensional submanifold $M$ arbitrarily embedded into $V$. We show that Einstein SO(N)-Yang-Mills Higgs theory is induced as a low energy effective theory of the system. Gravity, SO(N) gauge fields and Higgs fields are obtained from embedding functions of $M$.
Operator Methods of the Parabolic Potential Barrier
Toshiki Shimbori
Physics , 1999, DOI: 10.1016/S0375-9601(00)00462-X
Abstract: The one-dimensional parabolic potential barrier dealt with in an earlier paper is re-examined from the point of view of operator methods, for the purpose of getting generalized Fock spaces.
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