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Search Results: 1 - 10 of 2559 matches for " Toshihide Yoshida "
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Usefulness of a Japanese herbal medicine, "Bofu-tsusho-san" with tailor-made diet therapy in subjects with metabolic syndrome
Chizuko Hioki,Toshihide Yoshida
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas , 2005,
Abstract: Hemos realizado un estudio del medicamento herbal bofu-tsusho-san (BF) en mujeres obesas con intolerancia a la glucosa (IGT). El estudio se realizó con distribución aleatoria, doble ciego y controlado con placebo. Esta formula Kampo consiste en un total de 18 ingredientes, que incluyen Ephedrae Herba que aumenta la secreción de noradrenalina por las terminaciones del sistema simpático, Glycyrrhizae Radix, Forsythiae Fructus, Schizonepetae Spica y otras 12 drogas vegetales. BF demostró efectos termogénicos y lipolíticos debido a la efedrina, vía inhibición de la acción de la AMPc fosfodiesterasa, que resulta ser 2.5 veces mas fuerte que la de la cafeína. BF fue efectivo no solo reduciendo el peso corporal y la circunferencia de la cintura, sino que también mejoró la resistencia a la insulina sin efectos adversos en el metabolismo de la glucosa o de los lípidos. BF puede ser efectivo para el tratamiento del síndrome metabólico y otros síntomas relacionados con la obesidad
Does Laparoscopic and Endoscopic Cooperative Surgery for Gastric Submucosal Tumors Preserve Residual Gastric Motility? Results of a Retrospective Single-Center Study
Yohei Waseda, Hisashi Doyama, Noriyuki Inaki, Hiroyoshi Nakanishi, Naohiro Yoshida, Shigetsugu Tsuji, Kenichi Takemura, Shinya Yamada, Toshihide Okada
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101337
Abstract: Background Laparoscopic and endoscopic cooperative surgery (LECS) is a minimally invasive surgical technique used to resect gastric submucosal tumors with intraluminal growth. Endoscopic submucosal dissection is used to determine the appropriate resection line from within the stomach lumen as it minimizes the stomach wall resection area and prevents postoperative stomach deformity. Although LECS is intended to preserve gastric function, few reports have evaluated postoperative residual gastric motility. Therefore, we conducted a retrospective analysis of patients who underwent LECS to determine the effects of LECS on residual gastric motility. Methods Twenty-two patients underwent endoscopy 3 to 12 months after LECS. Patients were evaluated for endoscopic evidence of gastric motility disorder, namely food residue and occurrence/exacerbation of reflux esophagitis. We considered patients with new onset of gastric symptoms and endoscopic evidence of gastric motility disorder to have clinically relevant gastric motility disorder. We described patient characteristics, tumor location, and surgical findings. Results Two of 22 patients developed clinically relevant gastric motility disorder after LECS. In one of these patients, the symptoms were not severe; only one had reduced dietary intake and had lost weight. We identified clinically relevant gastric motility disorder in two patients with gastrointestinal stromal tumors located in the lesser curvature of the stomach. The major axis of these two tumors was 34 mm and 38 mm. Conclusions Many patients did not have clinically relevant gastric motility disorder after LECS. Further investigation is required to identify predisposing factors for gastric motility disorder.
Visualization of Sterol-Rich Membrane Domains with Fluorescently-Labeled Theonellamides
Shinichi Nishimura, Kumiko Ishii, Kunihiko Iwamoto, Yuko Arita, Shigeki Matsunaga, Yoshiko Ohno-Iwashita, Satoshi B. Sato, Hideaki Kakeya, Toshihide Kobayashi, Minoru Yoshida
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083716
Abstract: Cholesterol plays important roles in biological membranes. The cellular location where cholesterol molecules work is prerequisite information for understanding their dynamic action. Bioimaging probes for cholesterol molecules would be the most powerful means for unraveling the complex nature of lipid membranes. However, only a limited number of chemical or protein probes have been developed so far for cytological analysis. Here we show that fluorescently-labeled derivatives of theonellamides act as new sterol probes in mammalian cultured cells. The fluorescent probes recognized cholesterol molecules and bound to liposomes in a cholesterol-concentration dependent manner. The probes showed patchy distribution in the plasma membrane, while they stained specific organelle in the cytoplasm. These data suggest that fTNMs will be valuable sterol probes for studies on the role of sterols in the biological membrane under a variety of experimental conditions.
Exploring Potential of REDD+ Readiness with Social Safeguard through Diverse Forest Use Practices in Gunung Palung National Park in West Kalimantan, Indonesia  [PDF]
Toshihide Yoshikura, Masahiro Amano, Gusti Z. Anshari
Open Journal of Forestry (OJF) , 2018, DOI: 10.4236/ojf.2018.82010
Abstract: Implementation is expected to be a measure for sustainable forest management by providing benefit for forest users based on their efforts. Without careful attention for the social safeguard, the mechanism of reducing greenhouse gas emissions from deforestation and forest degradation with forest management (REDD+) might cause negative impact such as depriving of customary forest use rights under unclear tenure and forest use rights typical in Indonesia. This study aimed to explore how REDD+ Safeguard can be applied in readiness activities by analyzing practical forest use situations in a conservation forest, the Gunung Palung National Park as study site. From the results of the questionnaire survey and interviews, characteristics of forest users were identified and compared. The households, mostly Malays, practicing traditional durian collection, were recognized as main forest users depending on on-farm income especially from non-timber forest product (NTFP). Since the income structure is relatively low and unstable, some of them practice farming in forest area or sell their forest use rights to other households. They are inclined to be lack in legal farm land and certain forest use rights. Based on the findings, consideration for diverse forest users and potential readiness activities were discussed and proposed. For achieving REDD+ implementation with sustainable forest management and social safeguard, it will be necessary to respect for customary rights and take comprehensive measures as readiness efforts.
Nitroxide-Mediated Photo-Controlled/Living Radical Polymerization of Methacrylic Acid  [PDF]
Eri Yoshida
Open Journal of Polymer Chemistry (OJPChem) , 2013, DOI: 10.4236/ojpchem.2013.31004

The photo-controlled/living radical polymerization of methacrylic acid (MAA) was performed at room temperature by irradiation with a high-pressure mercury lamp using azo initiators and 4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxyl as the mediator in the presence of (4-tert-butylphenyl)diphenylsulfonium triflate (tBuS) as the accelerator. Whereas the bulk polymerization yielded polymers with a bimodal molecular weight distribution in both the absence and presence of tBuS, the solution polymerization in methanol produced unimodal polymers with the molecular weight distribution of 2.0 - 2.3 in the presence of tBuS. The molecular weight distribution of the resulting poly (MAA) decreased with an in- crease in tBuS. The dilution of the monomer concentration also reduced the molecular weight distribution. The use of the initiator with a low 10-h half-life temperature also effectively controlled the molecular weight. The livingness of the polymerization was confirmed by obtaining linear increases in the first-order conversion versus time, the molecular weight versus the conversion, and the molecular weight versus the reciprocal of the initiator concentration.

Elucidation of Acceleration Mechanisms by a Photosensitive Onium Salt for Nitroxide-Mediated Photocontrolled/Living Radical Polymerization  [PDF]
Eri Yoshida
Open Journal of Polymer Chemistry (OJPChem) , 2014, DOI: 10.4236/ojpchem.2014.43006

The acceleration mechanisms by a photosensitive onium salt for the nitroxide-mediated photocontrolled/living radical polymerization (photo-NMP) were determined. The photo-NMP of methyl methacrylate was performed by irradiation at room temperature using 4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxyl (MTEMPO) as the mediator and (2RS, 2’RS)-azobis(4-methoxy-2,4-dimethylvaleronitrile) as the initiator. The polymerization was accelerated in the presence of (4-tertbutylphenyl)diphenylsulfonium triflate (tBuS) to produce a polymer with a molecular weight distribution as narrow as the polymerization in its absence. (±)-Camphor-10-sulfonic acid or 2-fluoro-1-methylpyridinium p-toluenesulfonate had no effect on the polymerization speed, suggesting that tBuS did not serve as the photo-acid generator for the photo-NMP. It was found that the acceleration of the polymerization was based on the electron transfer from MTEMPO into tBuS in the excited state to temporarily generate a free radical propagating chain end and an oxoaminium salt (OAS), the one-electron oxidant of MTEMPO. This electron transfer mechanism was verified on the basis of the fact that the photo-NMP in the presence of

Strategies for regenerating injured axons after spinal cord injury – insights from brain development
Masaki Ueno,Toshihide Yamashita
Biologics: Targets and Therapy , 2008,
Abstract: Masaki Ueno, Toshihide YamashitaDepartment of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita-shi, Osaka 565-0871, JapanAbstract: Axonal regeneration does not occur easily after an adult central nervous system (CNS) injury. Various attempts have partially succeeded in promoting axonal regeneration after the spinal cord injury (SCI). Interestingly, several recent therapeutic concepts have emerged from or been tightly linked to the researches on brain development. In a developing brain, remarkable and dynamic axonal elongation and sprouting occur even after the injury; this finding is essential to the development of a therapy for SCI. In this review, we overview the revealed mechanism of axonal tract formation and plasticity in the developing brain and compare the differences between a developing brain and a lesion site in an adult brain. One of the differences is that mature glial cells participate in the repair process in the case of adult injuries. Interestingly, these cells express inhibitory molecules that impede axonal regeneration such as myelin-associated proteins and the repulsive guidance molecules found originally in the developing brain for navigating axons to specific routes. Some reports have clearly elucidated that any treatment designed to suppress these inhibitory cues is beneficial for promoting regeneration and plasticity after an injury. Thus, understanding the developmental process will provide us with an important clue for designing therapeutic strategies for recovery from SCI.Keywords: development, regeneration, spinal cord injury
Quantum Dynamics of Electron-Nuclei Coupled System in Quantum Dots
Ozgur Cakir,Toshihide Takagahara
Physics , 2006, DOI: 10.1016/j.physe.2007.06.026
Abstract: We have investigated the dynamics of the electron-nuclei coupled system in quantum dots. The bunching of results of the electron spin measurements and the revival in the conditional probabilities are salient features of the nuclear spin memory. The underlying mechanism is the squeezing of the nuclear spin state and the correlations between the successive electron spin measurements. Further we make a proposal for the preparation and detection of superposition states of nuclear spins merely relying on electron spin measurements. For unpolarized, completely random nuclear spin state one can still trace the quantum interference effects. We discuss the realization of these schemes for electron spins on both single and double QDs.
Theoretical aspects of quantum state transfer, correlation measurement and electron-nuclei coupled dynamics in quantum dots
Toshihide Takagahara,Ozgur Cakir
Physics , 2008,
Abstract: Photons and electrons are the key quantum media for the quantum information processing based on solid state devices. The essential ingredients to accomplish the quantum repeater were investigated and their underlying physics were revealed. The relevant elementary processes of the quantum state transfer between a single photon and a single electron were analyzed, to clarify the conditions to be satisfied to achieve the high fidelity of the quantum state transfer. An optical method based on the Faraday rotation was proposed to carry out the Bell measurement of two electrons which is a key operation in the entanglement swapping for the quantum repeater and its feasibility was confirmed. Also investigated was the quantum dynamics in the electron-nuclei coupled spin system in quantum dots and a couple of new phenomena were predicted related to the correlations induced by the hyperfine interaction, namely, bunching and revival in the electron spin measurements. These findings will pave the way to accomplish the efficient and robust quantum repeater and nuclear spin quantum memory.
Quantum dynamics in electron-nuclei coupled spin system in quantum dots: Bunching, revival, and quantum correlation in electron-spin measurements
Ozgur Cakir,Toshihide Takagahara
Physics , 2008, DOI: 10.1103/PhysRevB.77.115304
Abstract: We investigate quantum dynamics in the electron-nuclei coupled spin system in quantum dots and clarify the fundamental features of quantum correlation induced via successive electron spin measurements. This quantum correlation leads to interesting phenomena such as the bunching of outcomes in the electron spin measurements and the revival of an arbitrary initial electron spin state. The nuclear spin system is also affected by the quantum correlation and is in fact squeezed via conditional measurements or postselection. This squeezing is confirmed by calculating the increase in the purity of the nuclear spin system. Thus the successive electron spin measurements provide a probabilistic method to squeeze the nuclear spin system. These new features are predicted not only for the case of a double quantum dots occupied by a pair of electrons but also for the case of a single quantum dot occupied by a single electron or a pair of electrons.
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