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Search Results: 1 - 10 of 260 matches for " Tore Gutteberg "
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Triage of Women with Minor Cervical Lesions: Data Suggesting a “Test and Treat” Approach for HPV E6/E7 mRNA Testing
Sveinung Wergeland S?rbye,Silje Fismen,Tore Gutteberg,Elin Synn?ve Mortensen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012724
Abstract: Human papillomavirus (HPV) testing is included in the cervical cancer screening program in the triage of women with equivocal (ASC-US) or low-grade (LSIL) cytological lesions. These women have an increased risk for developing high grade dysplasia and cancer (CIN2+) compared to women with normal cytology. However, in order to avoid unnecessary follow-up, as well as overtreatment, a high positive predictive value (PPV) of the triage test is important.
HPV E6/E7 mRNA Testing Is More Specific than Cytology in Post-Colposcopy Follow-Up of Women with Negative Cervical Biopsy
Sveinung Wergeland S?rbye, Marc Arbyn, Silje Fismen, Tore Jarl Gutteberg, Elin Synn?ve Mortensen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026022
Abstract: Background In Norway, women with negative or low-grade cervical biopsies (normal/CIN1) are followed up after six months in order to decide on further follow-up or recall for screening at three-year intervals. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures whereas a low risk of high-grade disease among triage negative women assures safety. Materials and Methods At the University Hospital of North Norway, cytology and the HPV mRNA test PreTect HPV-Proofer, detecting E6/E7 mRNA from HPV types 16, 18, 31, 33 and 45, are used in post-colposcopy follow-up of women with negative or low-grade biopsy. In this study, women with negative biopsy after high grade cytology (ASC-H/HSIL) and/or positive HPV mRNA test in the period 2005–2009 were included (n = 520). Histologically confirmed cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) was used as study endpoint. Results Of 520 women with negative or low-grade biopsy, 124 women (23.8%) had CIN2+ in follow-up biopsy. The sensitivity and specificity of the HPV mRNA test were 89.1% (95% CI, 80.1–98.1) and 92.5% (95% CI, 88.2–96.7), respectively. The ratios of sensitivity, specificity and PPV of HPV mRNA testing compared to repeat cytology for finding CIN2+ was 1.05 (95% CI: 0.92–1.21), 1.21 (95% CI: 1.12–1.32), and 1.49 (95% CI: 1.20–1.86), respectively. The PPV of mRNA was 77.3% (95% CI, 59.8–94.8) in women aged 40 or older. Conclusion Women with negative cervical biopsy require follow-up before resumption of routine screening. Post-colposcopy HPV mRNA testing was as sensitive but more specific than post-colposcopy cytology. In addition, the HPV mRNA test showed higher PPV. A positive mRNA test post-colposcopy could justify treatment in women above 40 years.
Triage of Women with Low-Grade Cervical Lesions - HPV mRNA Testing versus Repeat Cytology
Sveinung Wergeland S?rbye, Marc Arbyn, Silje Fismen, Tore Jarl Gutteberg, Elin Synn?ve Mortensen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024083
Abstract: Background In Norway, women with low-grade squamous intraepithelial lesions (LSIL) are followed up after six months in order to decide whether they should undergo further follow-up or be referred back to the screening interval of three years. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures. Materials and Methods At the University Hospital of North Norway, repeat cytology and the HPV mRNA test PreTect HPV-Proofer, detecting E6/E7 mRNA from HPV types 16, 18, 31, 33 and 45, are used in triage of women with ASC-US and LSIL. In this study, women with LSIL cytology in the period 2005–2008 were included (n = 522). Two triage methods were evaluated in two separate groups: repeat cytology only (n = 225) and HPV mRNA testing in addition to repeat cytology (n = 297). Histologically confirmed cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) was used as the study endpoint. Results Of 522 women with LSIL, 207 had biopsies and 125 of them had CIN2+. The sensitivity and specificity of repeat cytology (ASC-US or worse) were 85.7% (95% confidence interval (CI): 72.1, 92.2) and 54.4 % (95% CI: 46.9, 61.9), respectively. The sensitivity and specificity of the HPV mRNA test were 94.2% (95% CI: 88.7, 99.7) and 86.0% (95% CI: 81.5, 90.5), respectively. The PPV of repeat cytology was 38.4% (95% CI: 29.9, 46.9) compared to 67.0% (95% CI: 57.7, 76.4) of the HPV mRNA test. Conclusion HPV mRNA testing was more sensitive and specific than repeat cytology in triage of women with LSIL cytology. In addition, the HPV mRNA test showed higher PPV. These data indicate that the HPV mRNA test is a better triage test for women with LSIL than repeat cytology.
Accuracy of Helicobacter pylori serology in two peptic ulcer populations and in healthy controls
Rolv-Ole Lindsetmo, Roar Johnsen, Tor Jac Eide, Tore Gutteberg, Hanne Haukland Husum, Arthur Revhaug
World Journal of Gastroenterology , 2008,
Abstract: AIM: To estimate the test characteristics of Helicobacter pylori (H pylori) serology and of C14-urea breath test (C14-UBT) in two different peptic ulcer populations and in community controls. Second, the aim was to explore the association between the level of H pylori IgG antibodies and severity of inflammation as to active peptic ulceration in the same populations.METHODS: Vagotomized (n = 83), medically treated peptic ulcer patients (n = 73) and one reference group of community controls (n = 88) were gastroscoped. H pylori status was determined by histology, bacterial growth, C14-UBT and serology. Based on the updated Sydney System, cumulative scores from biopsies from the prepyloruos, incisura angularis, corpus and fundus were calculated.RESULTS: The prevalence of H pylori infection varied from 70% to 79%. The C14-UBT had high accuracy compared to the serology test. The sensitivity of the serology test was good, but the specificity was low (41%-71%). The association between H pylori IgG antibodies and scores of gastric mucosal inflammation and current or previous peptic ulcer were weak.CONCLUSION: The accuracy of C14-UBT to diagnose H pylori infection was good, and the clinical utility of a negative H pylori serology test was substantial, while the gain in clinical information of a positive test was meagre. Positive H pylori titres could not distinguish between subjects with or those without active peptic ulceration.
The art of being negative: Metonymical morphological constructions in contrast
Tore Nesset
Oslo Studies in Language , 2011,
Abstract: This paper explores the metonymic nature of grammar by contrasting a Russian and a Norwegian morphological construction that give (mostly) negative characterizations of people. The meanings of the constructions are strikingly similar, and it is argued that they cannot be properly understood without recourse to metonymy. However, while Norwegian employs compounding, the morphological strategy used in the Russian construction is derivation. It is demonstrated that these differences are not idiosyncratic facts about Norwegian and Russian, since there is systemic motivation for the differences between the two languages.
Truncation without Truncation?
Tore Nesset
Poljarnyj Vestnik , 2004,
Abstract: This article investigates the relationship between the so-called One-Stem System and the Two-Stem System from the perspective of cognitive linguistics.
The Realization of (In)definiteness in Russian
Tore Nesset
Poljarnyj Vestnik , 1999,
Abstract: How are indefiniteness and definiteness realized formally in Russian? This article discusses the question with regard to word order, case-marking and pronouns.
The Path to Neutralization: Image Schemas and Prefixed Motion Verbs
Tore Nesset
Poljarnyj Vestnik , 2007,
Abstract: This paper investigates the path image schema in Russian motion verbs. It is argued that this image schema provides a principled explanation why Russian has a contrast between unidirectional and non-directional unprefixed motion verbs, but no such contrast for prefixed verbs.
Dissimilation, Assimilation and Vowel Reduction: Constraint Interaction in East Slavic Dialects with so-called Dissimilative Akan’e and Jakan’e
Tore Nesset
Poljarnyj Vestnik , 2002,
Abstract: This paper presents an Optimality Theory-based analysis of the unstressed vocalism in Russian. It is argued that an account of the so-called dissimilative akan’e and jakan’e patterns in terms of dissimilation alone is simplistic and that the vowel patterns in question arise as a result of complex interaction of three factors, viz. dissimilation, assimilation and vowel reduction.
Second-Order Schemas and Active Subschemas: Vowel Reduction in Cognitive Grammar
Tore Nesset
Poljarnyj Vestnik , 2006,
Abstract: This paper discusses vowel reduction in Russian and shows how phonological neutralization can be accounted for in Cognitive Grammar.
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