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Search Results: 1 - 10 of 104150 matches for " Tonglin Zhang "
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Existence of the signal in the signal plus background model
Tonglin Zhang
Mathematics , 2006, DOI: 10.1214/074921706000000653
Abstract: Searching for evidence of neutrino oscillations is an important problem in particle physics. Suppose that evidence for neutrino oscillations from an LSND experiment reports a significant positive oscillation probability, but that the LSND result is not confirmed by other experiments. In statistics, such a problem can be proposed as the detection of signal events in the Poisson signal plus background model. Suppose that an observed count $X$ is of the form $X=B+S$, where the background $B$ and the signal $S$ are independent Poisson random variables with parameters $b$ and $\theta$ respectively, $b$ is known but $\theta$ is not. Some recent articles have suggested conditioning on the observed bound for $B$; that is, if $X=n$ is observed, the suggestion is to base the inference on the conditional distribution of $X$ given $B\le n$. This suggestion is used here to derive an estimator of the probability of the existence of the signal event. The estimator is examined from the view of decision theory and is shown to be admissible.
On the false discovery rates of a frequentist: Asymptotic expansions
Anirban DasGupta,Tonglin Zhang
Mathematics , 2006, DOI: 10.1214/074921706000000699
Abstract: Consider a testing problem for the null hypothesis $H_0:\theta\in\Theta_0$. The standard frequentist practice is to reject the null hypothesis when the p-value is smaller than a threshold value $\alpha$, usually 0.05. We ask the question how many of the null hypotheses a frequentist rejects are actually true. Precisely, we look at the Bayesian false discovery rate $\delta_n=P_g(\theta\in\Theta_0|p-value<\alpha)$ under a proper prior density $g(\theta)$. This depends on the prior $g$, the sample size $n$, the threshold value $\alpha$ as well as the choice of the test statistic. We show that the Benjamini--Hochberg FDR in fact converges to $\delta_n$ almost surely under $g$ for any fixed $n$. For one-sided null hypotheses, we derive a third order asymptotic expansion for $\delta_n$ in the continuous exponential family when the test statistic is the MLE and in the location family when the test statistic is the sample median. We also briefly mention the expansion in the uniform family when the test statistic is the MLE. The expansions are derived by putting together Edgeworth expansions for the CDF, Cornish--Fisher expansions for the quantile function and various Taylor expansions. Numerical results show that the expansions are very accurate even for a small value of $n$ (e.g., $n=10$). We make many useful conclusions from these expansions, and specifically that the frequentist is not prone to false discoveries except when the prior $g$ is too spiky. The results are illustrated by many examples.
A Path Planning Method Based on Adaptive Genetic Algorithm for a Shape-shifting Robot
Mengxin Li,Xinghua Xia,Ying Zhang,Tonglin Liu
Computer and Information Science , 2010, DOI: 10.5539/cis.v3n4p208
Abstract: A shape-shifting robot with changeable configurations can accomplish search and rescue tasks which could not be achieved by manpower sometimes. The accessibility of this robot to uneven environment was efficiently enlarged by changing its configuration. In this paper, a path planning method is presented that integrates the reconfigurable ability of the robot with the potential field law. An adaptive genetic algorithm is applied to solve effectively the local minimum problem. The experiments show that the robot’s configurations can be changed to perform the path planning with the environmental variation. Moreover, the path has been shortened effectively.
Oncogenic Function of DACT1 in Colon Cancer through the Regulation of β-catenin
Guohong Yuan, Chongkai Wang, Chaolai Ma, Ning Chen, Qinghe Tian, Tonglin Zhang, Wei Fu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034004
Abstract: The Wnt/β-catenin signaling pathway plays important roles in the progression of colon cancer. DACT1 has been identified as a modulator of Wnt signaling through its interaction with Dishevelled (Dvl), a central mediator of both the canonical and noncanonical Wnt pathways. However, the functions of DACT1 in the WNT/β-catenin signaling pathway remain unclear. Here, we present evidence that DACT1 is an important positive regulator in colon cancer through regulating the stability and sublocation of β-catenin. We have shown that DACT1 promotes cancer cell proliferation in vitro and tumor growth in vivo and enhances the migratory and invasive potential of colon cancer cells. Furthermore, the higher expression of DACT1 not only increases the nuclear and cytoplasmic fractions of β-catenin, but also increases its membrane-associated fraction. The overexpression of DACT1 leads to the increased accumulation of nonphosphorylated β-catenin in the cytoplasm and particularly in the nuclei. We have demonstrated that DACT1 interacts with GSK-3β and β-catenin. DACT1 stabilizes β-catenin via DACT1-induced effects on GSK-3β and directly interacts with β-catenin proteins. The level of phosphorylated GSK-3β at Ser9 is significantly increased following the elevated expression of DACT1. DACT1 mediates the subcellular localization of β-catenin via increasing the level of phosphorylated GSK-3β at Ser9 to inhibit the activity of GSK-3β. Taken together, our study identifies DACT1 as an important positive regulator in colon cancer and suggests a potential strategy for the therapeutic control of the β-catenin-dependent pathway.
Process Mineralogy of Iranian High Sulfur Iron Ore  [PDF]
Tonglin Zhao, Xiaoli Wang, Hongle Ai, Ahmed Sobhy
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2018, DOI: 10.4236/jmmce.2018.64035
Abstract: Processing of Iranian high sulfur iron ore is problematic in minerals industry. The iron ores were studied by the means of polarizing microscopy, chemical analysis, X-ray diffraction. The study shows that the iron ores have high grade of iron, and complex structures. XRD showed that the iron ore consists of metallic minerals such as magnetite with a small amount of hematite and limonite and non-metallic minerals as serpentine, chlorite, and talc. The average particle size of magnetite crystals is 0.182 mm. The ore contains 1.62% sulfur as harmful impurity in form of pyrite mineral. Due to the isomorphism of magnesium and iron, magnetite mono crystal grade is lower than 68%, and difficult to be physically upgraded to a higher-grade iron concentrate using the available mineral processing technologies.
Quantitative analysis of 3-dimensional root architecture based on image reconstruction and its application to research on phosphorus uptake in soybean
Tonglin Zhu,Suqin Fang,Zhiyuan Li,Yutao Liu,Hong Liao,Xiaolong Yan
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-006-2130-0
Abstract: Quantification of 3-dimensional (3-D) plant root architecture is one of the most important approaches to investigating plant root growth and its function in nutrient acquisition and utilization. However, no effective methods have been reported hitherto to quantify 3-D root architecture parameters, making it difficult to further study the 3-D characteristics of the root system and its function. In the present study, we created a rapid algorithm to reconstruct 3-D root system images based on the basic structural features of such linear objects as roots, using 2-D root images taken by digital CCD cameras at multi-viewing angles. This method is very effective in the reconstruction of plant root system images, thus enabling us to obtain the digital model of 3-D root architecture and its 3-D skeleton, based on which some major root architecture parameters can be calculated. Using this method, we were able to acquire 3-D parameters of soybean root architecture whose root diameter was more than 0.3 mm, including tap root length, total root length, average basal root angle, ratio of root width to root depth, percentage distribution of root length in different layers and root distribution in different 3-D regions of the growth medium. We also quantitatively analyzed the relationship between different root architecture parameters and such plant nutrition parameters as soybean biomass and phosphorus (P) uptake. Our study may provide a new tool in studying the growth and nutritional functions of plant root systems.
An Efficient and Concise Algorithm for Convex Quadratic Programming and Its Application to Markowitz’s Portfolio Selection Model  [PDF]
Zhongzhen Zhang, Huayu Zhang
Technology and Investment (TI) , 2011, DOI: 10.4236/ti.2011.24024
Abstract: This paper presents a pivoting-based method for solving convex quadratic programming and then shows how to use it together with a parameter technique to solve mean-variance portfolio selection problems.
Investigation and Analysis of Sexual Harassment in Corporate Workplace of China  [PDF]
Xiaobing Zhang, Zewei Zhang
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.23038
Abstract: At present, sexual harassment in domestic workplace has a high probability of occurrence, which causes more and more attention. In this paper, the form of sexual harassment in workplace, and how to solve the sexual harassment were investigated and analyzed through questionnaires; and countermeasures and management suggestions were put forward from three aspects of corporate, employees and family.
Chaos Control in a Discrete Ecological System  [PDF]
Limin Zhang, Chaofeng Zhang
International Journal of Modern Nonlinear Theory and Application (IJMNTA) , 2012, DOI: 10.4236/ijmnta.2012.13011
Abstract: In research [1], the authors investigate the dynamic behaviors of a discrete ecological system. The period-double bifurcations and chaos are found in the system. But no strategy is proposed to control the chaos. It is well known that chaos control is the first step of utilizing chaos. In this paper, a controller is designed to stabilize the chaotic orbits and enable them to be an ideal target one. After that, numerical simulations are presented to show the correctness of theoretical analysis.
Crystallization and Characterization of a New Fluorescent Molecule Based on Schiff Base  [PDF]
Dehua Zhang, Xiaoyan Zhang
Journal of Crystallization Process and Technology (JCPT) , 2013, DOI: 10.4236/jcpt.2013.31004
Abstract:


In this analysis, the single crystal of schiff base has been synthesized and the purity of material has been increased by repeated recrystallization process. Single crystal was grown by adopting the method growing in a slow evaporation solution using ethanol as solvent at room temperature. A new fluorescent molecule based on Schiff base has been synthesised and its binding properties investigated by fluorescence spectroscopy to show that it can selectively bind Cu2+ with fluorescence quenching.


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