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Search Results: 1 - 10 of 4494 matches for " Tomoyuki Suzuki "
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Resource Bounded Immunity and Simplicity
Tomoyuki Yamakami,Toshio Suzuki
Computer Science , 2004,
Abstract: Revisiting the thirty years-old notions of resource-bounded immunity and simplicity, we investigate the structural characteristics of various immunity notions: strong immunity, almost immunity, and hyperimmunity as well as their corresponding simplicity notions. We also study limited immunity and simplicity, called k-immunity and feasible k-immunity, and their simplicity notions. Finally, we propose the k-immune hypothesis as a working hypothesis that guarantees the existence of simple sets in NP.
Biomechanical Stability of Open-Wedge High Tibial Osteotomy: Comparison of Two Locking Plates  [PDF]
Kota Watanabe, Tomoaki Kamiya, Daisuke Suzuki, Hidenori Otsubo, Atsushi Teramoto, Tomoyuki Suzuki, Toshihiko Yamashita
Open Journal of Orthopedics (OJO) , 2014, DOI: 10.4236/ojo.2014.410042
Abstract: Introduction: Recently, new plates with locking screws have been developed and used for medial open-wedge high tibial osteotomy (HTO). The purpose of this study was to evaluate and compare biomechanical properties of different internal fixations in open-wedge HTO using the two currently available locking plates. Methods: Eight paired fresh-frozen cadaveric lower extremities were vertically embedded in steel boxes. The axial compression load was applied to the legs using the mechanical testing machine. The axial compression load test from 0 N to 550 N and the failure test were performed before and after HTO. One side of the leg of a specimen was fixed with the Puddu locking plate and the other side was fixed with the TomoFix plate to compare the two plates using the same specimen. A mode of failure and vertical displacement of the medial and lateral parts of the tibia at the osteotomy gap was recorded using a video camera in the failure test. The load–displacement data were analyzed to calculate stiffness, failure load, and displacement at failure. Results: The mean failure load was 1471.4 N and 1692.3 N and total vertical displacement at failure was 3.1 mm and 2.9 mm with the Puddu and TomoFix plates, respectively. During axial compression loading, displacements mainly occurred at the lateral osteotomy gap, while the medial gap was well preserved. No significant differences were observed in the failure load, displacement, or mode of failure between the two plates. Conclusions: The Puddu and TomoFix plates had similar biomechanical properties in open-wedge HTO. The results indicated reliable stability after open-wedge HTO without fibular osteotomy.
Generation of pig primary fibroblast cells harboring defective MC4R genes by N-ethyl-N-nitrosourea mutagenesis: A gene-driven, nontransgenic approach to pig improvement  [PDF]
Michiharu Sakurai, Shun-ichi Suzuki, Tadashi Furusawa, Satoshi Mikawa, Tomoyuki Tokunaga, Akira Onishi, Takashi Awata
American Journal of Molecular Biology (AJMB) , 2013, DOI: 10.4236/ajmb.2013.33018

Transgenic pigs have been produced with the aim of further improving pigs in terms of economic and environmental traits, but these animals have not been allowed to enter the food chain. As an alternative approach to generating pigs with novel traits of economic importance that cannot be introduced by conventional breeding, we propose a strategy for combining in vitro mutagenesis of pig primary cells with N-ethyl-N-nitrosourea (ENU) and somatic-cell nuclear transfer (SCNT) technology. To explore the feasibility of this strategy, we treated pig primary fibroblast cells with ENU, estimated the per-base mutation frequency induced by the mutagen, clonally cultured about 4000 of the mutagenized cells, and screened them for mutation within the coding region of the melanocortin-4 receptor (MC4R) gene, a key gene in energy homeostasis. Through this screening, we obtained 14 cell clones, each harboring a heterozygous base change within the coding region for MC4R. Of the mutant cell clones, each of two contained a mutant allele encoding MC4R with greatly reduced receptor activity. By SCNT using these cell clones as donors, pigs harboring mutated MC4R alleles with reduced receptor activity can be produced. Our strategy for generating pigs with novel genetic traits likely will be more acceptable to the public than is the use of transgenic technology.

Monopole Oscillations and Dampings in Boson and Fermion Mixture in the Time-Dependent Gross-Pitaevskii and Vlasov Equations
Tomoyuki Maruyama,Hiroyuki Yabu,Toru Suzuki
Physics , 2005, DOI: 10.1103/PhysRevA.72.013609
Abstract: We construct a dynamical model for the time evolution of the boson-fermion coexistence system. The dynamics of bosons and fermions are formulated with the time-dependent Gross-Pitaevsky equation and the Vlasov equation. We thus study the monopole oscillation in the bose-fermi mixture. We find that large damping exists for fermion oscillations in the mixed system even at zero temperature.
Role of the Landau-Migdal Parameters with the Pseudovector and the Tensor Coupling in Relativistic Nuclear Models -- The Quenching of the Gamow-Teller Strength --
Tomoyuki Maruyama,Haruki Kurasawa,Toshio Suzuki
Physics , 2004, DOI: 10.1143/PTP.113.355
Abstract: Role of the Landau-Migdal parameters with the pseudovector ($g_a$) and the tensor coupling ($g_t$) is examined for the giant Gamow-Teller (GT) states in the relativistic random phase approximation (RPA). The excitation energy is dominated by both $g_a$ and $g_t$ in a similar way, while the GT strength is independent of $g_a$ and $g_t$ in the RPA of the nucleon space, and is quenched, compared with that in non-relativistic one. The coupling of the particle-hole states with nucleon-antinucleon states is expected to quench the GT strength further through $g_a$.
Resonant Monopole Oscillation in the Bose-Fermi Mixed System
Tomoyuki Maruyama,Hiroyuki Yabu,Toru Suzuki
Physics , 2004,
Abstract: We study the monopole oscillation in the bose-fermi mixed condensed system by performing the time-dependent Gross-Pitaevskii and Vlasov equations. We study the resonant oscillation where the intrinsic frequencies of boson and fermion oscillations are same.
Towards Nominal Formal Languages
Alexander Kurz,Tomoyuki Suzuki,Emilio Tuosto
Computer Science , 2011,
Abstract: We introduce formal languages over infinite alphabets where words may contain binders. We define the notions of nominal language, nominal monoid, and nominal regular expressions. Moreover, we extend history-dependent automata (HD-automata) by adding stack, and study the recognisability of nominal languages.
Nominal Regular Expressions for Languages over Infinite Alphabets. Extended Abstract
Alexander Kurz,Tomoyuki Suzuki,Emilio Tuosto
Computer Science , 2013,
Abstract: We propose regular expressions to abstractly model and study properties of resource-aware computations. Inspired by nominal techniques -- as those popular in process calculi -- we extend classical regular expressions with names (to model computational resources) and suitable operators (for allocation, deallocation, scoping of, and freshness conditions on resources). We discuss classes of such nominal regular expressions, show how such expressions have natural interpretations in terms of languages over infinite alphabets, and give Kleene theorems to characterise their formal languages in terms of nominal automata.
Sleep Disturbances Associated with Parkinson's Disease
Keisuke Suzuki,Masayuki Miyamoto,Tomoyuki Miyamoto,Masaoki Iwanami,Koichi Hirata
Parkinson's Disease , 2011, DOI: 10.4061/2011/219056
Abstract: Sleep disturbances are common problems affecting the quality life of Parkinson's disease (PD) patients and are often underestimated. The causes of sleep disturbances are multifactorial and include nocturnal motor disturbances, nocturia, depressive symptoms, and medication use. Comorbidity of PD with sleep apnea syndrome, restless legs syndrome, rapid eye movement sleep behavior disorder, or circadian cycle disruption also results in impaired sleep. In addition, the involvement of serotoninergic, noradrenergic, and cholinergic neurons in the brainstem as a disease-related change contributes to impaired sleep structures. Excessive daytime sleepiness is not only secondary to nocturnal disturbances or dopaminergic medication but may also be due to independent mechanisms related to impairments in ascending arousal system and the orexin system. Notably, several recent lines of evidence suggest a strong link between rapid eye movement sleep behavior disorder and the risk of neurodegenerative diseases such as PD. In the present paper, we review the current literature concerning sleep disorders in PD. 1. Introduction Parkinson’s disease (PD) is a movement disorder characterized by bradykinesia, resting tremors, rigidity, and impaired postural reflexes, which are caused by the degeneration of dopaminergic neurons in the substantia nigra. However, the pathological course of PD has been recognized to be much more extensive, involving the serotoninergic, noradrenergic, and cholinergic systems [1]. These systems may play a role in the development of the nonmotor symptoms commonly observed in PD such as sleep disturbances, depression, olfactory dysfunction, cognitive impairments, fatigue, and autonomic dysfunctions. In a recent large study comprising 1,072 patients with PD, almost all of the patients exhibited at least one type of nonmotor symptoms [2]. Sleep disturbances are among the most common nonmotor symptoms, with a prevalence ranging from approximately 40% to 90%, and these disturbances can interfere with patients’ quality of life [2–5]. Various factors, including nocturnal motor symptoms, psychiatric symptoms, dementia, dopaminergic medications, and circadian cycle disruptions, cause sleep disturbances [6]. Comorbidity with sleep apnea syndrome (SAS), restless legs syndrome (RLS), and rapid eye movement sleep behavior disorder (RBD) is often observed, complicating the sleep disturbances related to PD. The orexin system may be involved in PD, contributing to the daytime sleepiness independent of impaired sleep conditions. RBD preceding or coexisting with PD
Thin anterior uterine wall with incomplete uterine rupture in a primigravida detected by palpation and ultrasound: a case report
Shigeki Matsubara, Kazuhiko Shimada, Tomoyuki Kuwata, Rie Usui, Mitsuaki Suzuki
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-14
Abstract: A 27-year-old Japanese primigravid woman was admitted to our hospital due to weak, irregular uterine contractions in her 38th week of gestation. She had no past history of uterine surgery or known diseases. A hard mass was palpable in her abdomen. An ultrasound revealed that the anterior uterine wall was thin and bulging, with a fetal minor part beneath it which corresponded to the palpated mass. A Cesarean section was performed which revealed a thin anterior uterine wall with incomplete uterine rupture. The woman and baby were healthy.Although extremely rare, an unscarred primigravid uterus can undergo incomplete rupture even without discernable risk factors or labor pains. Abdominal palpation and ultrasound may be useful in detecting this condition.Uterine rupture is an obstetric complication associated with significant maternal and fetal morbidity and mortality. This disorder usually occurs in a scarred uterus, especially secondary to prior Cesarean section, and is therefore considered a disease of multigravida [1,2]. A few reports have indicated that a uterine rupture can occur in primigravida, although this is extremely rare [2,3], with etiological or risk factors including a history of uterine surgery, labor augmentation or underlying connective tissue disease [2-4]. A thin uterine wall, as a result of uterine sacculation [5,6] or uterine diverticulum [7], may also induce uterine rupture.We report the case of a primigravid woman with a thin anterior uterine wall; a feature compatible with incomplete uterine rupture. Underlying etiological factors were indiscernible. Her condition was detected by abdominal palpation and then ultrasound. This case report suggests that an unscarred primigravid uterus can show the features of incomplete rupture even in the absence of discernable risk factors and that abdominal palpation and ultrasound may be useful in diagnosis.A 27-year-old Japanese primigravid woman was admitted to our hospital because of slight uterine contract
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