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Search Results: 1 - 10 of 335 matches for " Tomomitsu Hirota "
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An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study
Hironori Masuko, Tohru Sakamoto, Yoshiko Kaneko, Hiroaki Iijima, Takashi Naito, Emiko Noguchi, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-97
Abstract: We conducted a retrospective cohort study of 915 Japanese from a general population. Values of annual decline in FEV1 were computed for each individual using a linear mixed-effect model. Multiple clinical characteristics were assessed to identify associations with annual FEV1 decline. Tag single-nucleotide polymorphisms (SNPs) in the Nrf2 gene (rs2001350, rs6726395, rs1962142, rs2364722) and one functional SNP (rs6721961) in the Nrf2 promoter region were genotyped to assess interactions between the Nrf2 polymorphisms and smoking status on annual FEV1 decline.Annual FEV1 decline was associated with smoking behavior and inversely correlated with FEV1/FVC and FEV1 % predicted. The mean annual FEV1 declines in individuals with rs6726395 G/G, G/A, or A/A were 26.2, 22.3, and 20.8 mL/year, respectively, and differences in these means were statistically significant (pcorr = 0.016). We also found a significant interaction between rs6726395 genotype and smoking status on the FEV1 decline (p for interaction = 0.011). The haplotype rs2001350T/rs6726395A/rs1962142A/rs2364722A/rs6721961T was associated with lower annual decline in FEV1 (p = 0.004).This study indicated that an Nrf2-dependent response to exogenous stimuli may affect annual FEV1 decline in the general population. It appears that the genetic influence of Nrf2 is modified by smoking status, suggesting the presence of a gene-environment interaction in accelerated decline in FEV1.Among pulmonary function test (PFT) measurements, forced expiratory volume in one second (FEV1) is the most reproducible [1]. Therefore, it is suitable for analyzing changes in pulmonary function over time. Accelerated decline in FEV1 is considered as an important predictor for the development of inflammatory obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD) [2,3]. A rapid decline in FEV1 may be affected by multiple factors, including environmental and genetic factors.The most important environmental fa
The Timing of Mortality Decline and Human Capital Accumulation  [PDF]
Yusuke Hirota
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.61005
Abstract: In this paper, we rigorously reinvestigate the effects of childhood mortality decline during different periods on human capital accumulation and economic development. For this purpose, we extend the basic framework of Azarnert (2006) by dividing childhood among three periods—early childhood (the period prior to school enrolment), school age (the school-enrolment period), and late childhood (the period posterior to school enrolment)—and assume a constant mortality rate for each period. We arrive at the following conclusions. The mortality decline after school age promotes human capital accumulation and economic development. The mortality decline after early childhood impedes human capital accumulation and economic development, but has no effect on the same after late childhood.
Haplotypes with Copy Number and Single Nucleotide Polymorphisms in CYP2A6 Locus Are Associated with Smoking Quantity in a Japanese Population
Natsuhiko Kumasaka, Masayuki Aoki, Yukinori Okada, Atsushi Takahashi, Kouichi Ozaki, Taisei Mushiroda, Tomomitsu Hirota, Mayumi Tamari, Toshihiro Tanaka, Yusuke Nakamura, Naoyuki Kamatani, Michiaki Kubo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044507
Abstract: Smoking is a major public health problem, but the genetic factors associated with smoking behaviors are not fully elucidated. Here, we have conducted an integrated genome-wide association study to identify common copy number polymorphisms (CNPs) and single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) in Japanese smokers ( = 17,158). Our analysis identified a common CNP with a strong effect on CPD (rs8102683; ) in the 19q13 region, encompassing the CYP2A6 locus. After adjustment for the associated CNP, we found an additional associated SNP (rs11878604; ) located 30 kb downstream of the CYP2A6 gene. Imputation of the CYP2A6 locus revealed that haplotypes underlying the CNP and the SNP corresponded to classical, functional alleles of CYP2A6 gene that regulate nicotine metabolism and explained 2% of the phenotypic variance of CPD (ANOVA -test ). These haplotypes were also associated with smoking-related diseases, including lung cancer, chronic obstructive pulmonary disease and arteriosclerosis obliterans.
On nonnegative entire solutions of second-order semilinear elliptic systems
Tomomitsu Teramoto
Electronic Journal of Differential Equations , 2003,
Abstract: We consider the second-order semilinear elliptic system $$ Delta u_i=P_i(x)u_{i+1}^{alpha_i}quadhbox{in }mathbb{R}^N, quad i=1,2,dots,m $$ with nonnegative continuous functions $P_i$. We establish nonexistence criteria of nonnegative nontrivial entire solutions for this system. We also proved a Liouville type theorem for nonnegative entire solutions.
Large scale genotyping study for asthma in the Japanese population
Yoshiko Imada, Masaya Fujimoto, Kenji Hirata, Tomomitsu Hirota, Yoichi Suzuki, Hirohisa Saito, Kenji Matsumoto, Akira Akazawa, Toshio Katsunuma, Shigemi Yoshihara, Motohiro Ebisawa, Masanao Shibasaki, Tadao Arinami, Mayumi Tamari, Emiko Noguchi
BMC Research Notes , 2009, DOI: 10.1186/1756-0500-2-54
Abstract: To perform a large-scale genotyping study to identify asthma-susceptibility genes in the Japanese population.We performed a large-scale, three-stage association study on 288 atopic asthmatics and 1032 controls, by using multiplex PCR-Invader assay methods at 82,935 single nucleotide polymorphisms (SNPs) (1st stage). SNPs that were strongly associated with asthma were further genotyped in samples from asthmatic families (216 families, 762 members, 2nd stage), 541 independent patients, and 744 controls (3rd stage).SNPs located in the 5' region of PEX19 (rs2820421) were significantly associated with P < 0.05 through the 1st to the 3rd stage analyses; however, the P values did not reach statistically significant levels (combined, P = 3.8 × 10-5; statistically significant levels with Bonferroni correction, P = 6.57 × 10-7). SNPs on HPCAL1 (rs3771140) and on IL18R1 (rs3213733) were associated with asthma in the 1st and 2nd stage analyses, but the associations were not observed in the 3rd stage analysis.No association attained genome-wide significance, but several loci for possible association emerged. Future studies are required to validate these results for the prevention and treatment of asthma.Asthma is the most common chronic disorder in children, and asthma exacerbation is an important cause of childhood morbidity and hospitalization. Currently, approximately 300 million people worldwide have asthma, and this disease claims the lives of 180,000 people every year [1].Asthma and atopy are complex phenotypes that are influenced by both genetic and environmental factors. Twin studies have supported the role of a strong genetic contribution with a heritability of 0.71 [2], and asthma shows a familial risk higher than that of many common diseases such as stroke, epilepsy, and most types of cancer [3]. Atopy is characterized by increased levels of immunoglobulin E (IgE) against common environmental allergens, and is considered the strongest predisposing factor for asthma. M
Genome-Wide Association Study for Levels of Total Serum IgE Identifies HLA-C in a Japanese Population
Yohei Yatagai, Tohru Sakamoto, Hironori Masuko, Yoshiko Kaneko, Hideyasu Yamada, Hiroaki Iijima, Takashi Naito, Emiko Noguchi, Tomomitsu Hirota, Mayumi Tamari, Yoshimasa Imoto, Takahiro Tokunaga, Shigeharu Fujieda, Satoshi Konno, Masaharu Nishimura, Nobuyuki Hizawa
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080941
Abstract: Most of the previously reported loci for total immunoglobulin E (IgE) levels are related to Th2 cell-dependent pathways. We undertook a genome-wide association study (GWAS) to identify genetic loci responsible for IgE regulation. A total of 479,940 single nucleotide polymorphisms (SNPs) were tested for association with total serum IgE levels in 1180 Japanese adults. Fine-mapping with SNP imputation demonstrated 6 candidate regions: the PYHIN1/IFI16, MHC classes I and II, LEMD2, GRAMD1B, and chr13:60576338 regions. Replication of these candidate loci in each region was assessed in 2 independent Japanese cohorts (n = 1110 and 1364, respectively). SNP rs3130941 in the HLA-C region was consistently associated with total IgE levels in 3 independent populations, and the meta-analysis yielded genome-wide significance (P = 1.07×10?10). Using our GWAS results, we also assessed the reproducibility of previously reported gene associations with total IgE levels. Nine of 32 candidate genes identified by a literature search were associated with total IgE levels after correction for multiple testing. Our findings demonstrate that SNPs in the HLA-C region are strongly associated with total serum IgE levels in the Japanese population and that some of the previously reported genetic associations are replicated across ethnic groups.
Percutaneous Transfistulous Interventions for Intractable Pancreatic Fistula
Masahiko Hirota
Radiology Research and Practice , 2011, DOI: 10.1155/2011/109259
Abstract: Three techniques for the treatment of intractable pancreatic fistula: percutaneous transfistulous pancreatic duct drainage (PTPD), percutaneous transfistulous pancreatojejunostomy (PTPJ), and percutaneous transfistulous pancreatic duct embolization (PTPE) are presented as treatment options for intractable pancreatic fistula. PTPD is effective for most cases of intractable fistula that communicate with the main pancreatic duct. However, PTPD itself is not enough in some specific cases. PTPJ and PTPE are applicable in such cases. 1. Introduction Pancreatic fistula (PF) remains a significant problem in the management of pancreatectomy. Despite decreased morbidity and mortality rates after pancreatic resection, PF remains a common and potentially lethal complication after pancreatectomy. Its reported incidence varies from 6 to 38% [1–7]. If PF occurs, the pancreatic juice must be drained externally to avoid the development of intra-abdominal hemorrhage and sepsis. Eighty five to 95% of PF can be managed by a combination of external drainage and medical therapy [3, 8]. However, occasional patients with inadequate treatment may require further advanced treatments. PF also sometimes becomes a significant problem in severe acute pancreatitis. Pseudocysts and postnecrotic collections of the pancreas are treated by percutaneous drainage if they are large and likely to aggravate the patients’ condition. Approximately 65–90% of patients recover from this disease by percutaneous drainage alone [9–12]. However, recovery is often difficult if the main pancreatic duct is injured [9, 10]. Techniques of percutaneous transfistulous drainage of the main pancreatic duct (percutaneous transfistulous pancreatic duct drainage: PTPD) for intractable PF cases are presented. Furthermore, percutaneous transfistulous pancreatojejunostomy (PTPJ) and percutaneous transfistulous pancreatic duct embolization (PTPE) are also presented as advanced techniques of PTPD. 2. Techniques 2.1. Percutaneous Transfistulous Pancreatic Duct Drainage (PTPD) This technique is useful for major PF in which the main pancreatic duct is visualized in fistulography [13, 14]. Any abscess due to PF is first drained percutaneously. An angled angiography catheter (RIM or RC2, Medikit, Tokyo) is inserted into the main pancreatic duct via the injured site (Figure 1). By twisting and taking the catheter in and out of the fistula, the route into the pancreatic duct can be selected. The abscess drainage tube can be used as a sheath of the catheter. After placing the catheter into the main pancreatic duct, the
Comparative Studies on Vehicle Related Policies for Air Pollution Reduction in Ten Asian Countries
Keiko Hirota
Sustainability , 2010, DOI: 10.3390/su2010145
Abstract: Asian countries are facing major air pollution problems due to rapid economic growth, urbanization and motorization. Mortality and respiratory diseases caused by air pollution are believed to be endemic in major cities of these countries. Regulations and standards are the first requirement for reducing emissions from both fixed and mobile sources. This paper emphasizes monitoring problems such as vehicle registration systems, inspection and maintenance (I/M) systems and fuel quality monitoring systems for vehicles in use. Monitoring problems in developing countries share similar characteristics such as a weakness in government initiatives and inadequate operation of government agencies, which results from a lack of human resources and availability of adequate facilities. Finally, this paper proposes a method to assure air quality improvements under the different shares of emission regulations in these Asian countries and introduces an example of an evaluation method based on a policy survey to improve air quality.
Myoclonus-like involuntary movements under subarachnoid block completely subsided after midazolam administration in a patient undergoing cesarean section: a case report
Kiichi Hirota
PeerJ , 2015, DOI: 10.7287/peerj.preprints.101v1
Abstract: Involuntary movement during and after neuraxial anesthesia, such as spinal and epidural anesthesia, is rarely observed. In this report, we describe a case of myoclonus-like involuntary movement of the upper extremities in a patient undergoing a planned repeat cesarean section under spinal anesthesia with bupivacaine that completely subsided after 2mg midazolam administration. The myoclonus-like movement never recurred or caused any apparent neurological side effects. No abnormal sensation or spontaneous pain of the upper extremities was observed. The patient was discharged on foot on post-operative day 3.
Successful perioperative airway management in a patient with angiomatous macroglossia for laser ablation under general anesthesia
Kiichi Hirota
PeerJ , 2015, DOI: 10.7287/peerj.preprints.99v1
Abstract: Macroglossia is defined as an abnormal enlargement of the tongue that predominantly affects pediatric patients and is not frequent in adult patients. Hypothyroidism and hyperpituitarism may cause macroglossia in adults. In addition, infiltration of the tongue by abnormal tissues, including angiomatous and lymphatic malformations and amyloidosis, is a major cause of macroglossia, particularly in adults. Here we describe the case of a 63-year-old male patient with massive macroglossia due to tongue hemangioma who underwent laser ablation under general anesthesia. Elaborate preanesthetic anatomical and functional airway evaluation facilitated successful airway management in this patient, even in the presence of massive macroglossia.
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