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Search Results: 1 - 10 of 3441 matches for " Tomomi Nakamura "
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Effects of Curing Conditions and Formulations on Residual Monomer Contents and Temperature Increase of a Model UV Gel Nail Formulation  [PDF]
Kentaro Taki, Tomomi Nakamura
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2011, DOI: 10.4236/jcdsa.2011.14017
Abstract: Recently, the application of ultraviolet (UV) curable monomers to human nails, (also known as UV gel nails) has become a popular decoration technique for women’s nails. However, the unreacted layer, the depletion of residual monomers from the cured UV gel nails, which can cause allergy and asthma, and the increase in temperature during curing process, are major concerns. In this study, the thickness of the unreacted layer, the increase in temperature, and the residual contents in cured film of UV gel nail treatment were measured for the first time. The results of this study indicated that the thickness of unreacted layer was not affected by the cast thickness; however, the intensity of UV light and the photoinitiator concentration had significant effect on the thickness of the unreacted layer. To reduce the thickness of the unreacted layer, the intensity of the UV light and the photoinitiator concentration should be increased. However, the maximum temperature observed during the curing of UV gel nails increases with an increase in the intensity of the UV light and the photoinitiator concentration. A suitable cast thickness range (21 ~ 150 μm), which resulted in the formation of a cured film and without producing temperatures that exceed that of the human body, was identified. The mass fraction of the residuals in the cured layer decreased with an increase in the exposure time, the UV intensity, and the photoinitiator concentration.
Longitudinal evaluation of mineral loss at the earliest stage of enamel demineralization using micro-computed tomography  [PDF]
Koji Watanabe, Tomomi Nakamura, Takashi Ogihara, Yoshiyuki Ochiai, Shigeru Watanabe
Health (Health) , 2012, DOI: 10.4236/health.2012.46055
Abstract: As the prevalence of dental caries decreases, the diagnosis and treatment of initial mineral loss resulting in white spot lesions have been getting more and more important. Since dental CT provides computed tomography images of a tooth with radiation exposure similar to panoramic radiography, it will become possible in the near future to evaluate the enamel mineral density using CT in the same way as measurement of the bone mineral density. Such computed tomography images enable dentists to perform longitudinal, three-dimensional, and precise evaluation of the enamel mineral density before a demineralized lesion becomes detectable by any other traditional means. Despite their advantage, there are not enough reports on evalu- ation of the enamel mineral density using CT. This study evaluated the serial changes in mineral density in the earliest stage of enamel demineralization. Eight bovine enamel specimens were coated with nail varnish. On each specimen, 4 square windows measuring 1 mm2 were created. The specimens were incubated in lactic acid solution at 38?C. During incubation, the windows were covered by nail varnish one by one at 30, 60, and 90 minutes, respectively. At 120 minutes, the specimens were removed from the solution. After the nail varnish was removed, X-ray microradiography was performed using SKYSCAN1172 at settings of 100 kV and 100 μA. The mean Hounsfield unit values (HUV) of enamel in a non-window area and those in the window areas were calculated every 180 μm over a depth of 0 - 900 μm and analyzed by two-way ANOVA. Data were affected by the incubation time and depth from the enamel surface, and there was not interaction between the two factors. Considering the incubation time, HUV of the whole measured enamel (0 - 900 μm) in the non-window group was significantly higher than that of the other incubated groups. Considering the depth, HUV was decreased at 721 - 900 μm compared with that at 0 - 180 μm in the 30-minute-incubated group, and the decrease spread to 361 - 900 μm in the 60- and 90- minutes-incubated groups. HUV was additionally calculated at increments of 18 μm and compared within the 60-minute-incubated group, and changes in the mineral density at the boundary of the earliest demineralized lesion could be observed. This study demonstrated detailed mineral density changes in the earliest period of demineralization.
Adrenal Venous Sampling in Patients with Primary Aldosteronism: Which Is the Best Evaluation Method for Laterality Assessments?  [PDF]
Kimei Azama, Masahiro Okada, Akira Yogi, Tomomi Koga, Yuko Iraha, Joichi Heianna, Hideaki Nakamura, Hiroaki Masuzaki, Sadayuki Murayama
Open Journal of Radiology (OJRad) , 2017, DOI: 10.4236/ojrad.2017.74024
Abstract: Purpose: The purpose was to investigate the most accurate method of adrenal venous sampling to diagnose unilateral primary aldosteronism (PA) prior to laterality assessment. Materials and Methods: Sixty-four consecutive PA patients were enrolled in this retrospective study. A catheter was placed in the common-trunk-vein (CTV), below the confluence of the inferior-phrenic-vein and the central-adrenal-vein (CAV) and the right-adrenal-vein (RAV). Blood-sampling was performed both pre- and post-adrenocorticotropic hormone stimulation. Lateralized ratio [LR; aldosterone/cortisol ratio (ACR) on high-value side/ACR on low-value side], contralateral ratio (CR; ACR on low-value side/ACR on inferior-vena-cava ratio), and plasma aldosterone concentration (PAC) were evaluated. The diagnostic accuracy of LR, CR and PAC in CTV/ CAV/RAV during pre- and post-ACTH was compared by receiver-operating-characteristic (ROC) analysis. Results: LR-CAV post-ACTH showed the highest detection rate for unilateral adrenal lesions (93.3%; 14/15), with a sensitivity of 0.93 and a specificity of 0.84 at a cut-off value of 2.5. CR-post-ACTH had the highest Az value (0.89), with a detection rate of 86.7% (13/14), a sensitivity of 0.98, and a specificity of 0.88 at a cut-off value of 0.8. Conclusion: CR-post-ACTH and LR-CAV-post-ACTH are accurate predictors for laterality assessment in PA.
Power of Logistic Model with Surrogate Measures for Both Outcome and Covariate in Genetic-Disease Association Study
Munechika Misumi,Tomomi Yamada,Yoshiaki Nose,Tsuyoshi Nakamura
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
Long-term survival after an aggressive surgical resection and chemotherapy for stage IV pulmonary giant cell carcinoma
Fumihiro Shoji, Riichiroh Maruyama, Tatsuro Okamoto, Jiro Ikeda, Tomomi Nakamura, Hiroshi Wataya, Yukito Ichinose
World Journal of Surgical Oncology , 2005, DOI: 10.1186/1477-7819-3-32
Abstract: We herein report a patient with pulmonary giant cell carcinoma with stage IV disease in whom aggressive multi-modality therapy resulted in a long-term survival. A 51-year-old male underwent an emergent operation with a partial resection of small intestinal metastases due to bleeding from the tumor. The patient also underwent a left pneumonectomy due to hemothorax as a result of the rapid growth of the primary tumor. Thereafter, two different regimens of chemotherapy and a partial resection for other site of small intestinal metastases and a splenectomy for splenic metastases were performed. The patient is presently doing well without any evidence of recurrence for 3 years after the initial operation.This is a first report of a rare case with stage IV pulmonary giant cell carcinoma who has survived long-term after undergoing aggressive surgical treatment and chemotherapy.The recent World Health Organization (WHO) classification of lung tumors has unified the heterogeneous group of non-small cell lung carcinomas that contains sarcoma or sarcoma-like components under the designation of "carcinomas with pleomorphic, sarcomatoid or sarcomatous elements" [1]. This group includes different entities, such as pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma and pulmonary blastoma. In general, these tumors are rare, comprising approximately from 0.1–0.4% of all lung malignancies [2-4]. The patients with these tumors tend to demonstrate a despondent clinical course and the prognosis for them is gernally poor [5], because surgery, irradiation and chemotherapy are ineffective. We experienced a pulmonary giant cell carcinoma patient with stage IV disease in whom aggressive multi-modality therapy consisting of surgical resections for the primary lesion and multi-organ metastases and also chemotherapy which together resulted in a long-term survival.A 51-year-old male was admitted in June 2001, due to hemosputum, cough, hemo-stool and an abnormal s
Antinociceptive Effects of the Serotonin and Noradrenaline Reuptake Inhibitors Milnacipran and Duloxetine on Vincristine-Induced Neuropathic Pain Model in Mice
Soh Katsuyama,Hiromu Aso,Akira Otowa,Tomomi Yagi,Yukinaga Kishikawa,Takaaki Komatsu,Tsukasa Sakurada,Hitoshi Nakamura
ISRN Pain , 2014, DOI: 10.1155/2014/915464
Abstract: Vincristine is an anticancer drug used to treat a variety of cancer types, but it frequently causes peripheral neuropathy. Neuropathic pain is often associated with the appearance of abnormal sensory signs, such as allodynia. Milnacipran and duloxetine, serotonin/noradrenaline reuptake inhibitors, have shown efficacy against several chronic pain syndromes. In this study, we investigated the attenuation of vincristine-induced mechanical allodynia in mice by milnacipran and duloxetine. To induce peripheral neuropathy, vincristine was administered once per day (0.1?mg/kg, intraperitoneally (i.p.)) for 7 days. Mechanical allodynia was evaluated by measuring the withdrawal response to stimulation with a von Frey filament. In vincristine-treated mice, mechanical allodynia was observed on days 3–28 of vincristine administration. A single administration of milnacipran (40?mg/kg, i.p.) or duloxetine (20?mg/kg, i.p.) had no effect on vincristine-induced mechanical allodynia. However, repeated administration of milnacipran (20 or 40?mg/kg, once per day, i.p.) or duloxetine (5, 10, or 20?mg/kg, once per day, i.p.) for 7 days significantly reduced vincristine-induced mechanical allodynia. These results suggest that chronic vincristine administration induces mechanical allodynia, and that repeated milnacipran and duloxetine administration may be an effective approach for the treatment of neuropathic pain caused by vincristine treatment for cancer. 1. Introduction Peripheral neurotoxicity induced by antineoplastic drugs (vinca-alkaloids, taxanes, and platin-based compounds) is a clinically significant complication that can be dose limiting and can substantially diminish the quality of life. Vincristine is a chemotherapeutic agent that can be used in the treatment of many types of human cancer, including leukemias, lymphomas, and sarcomas [1, 2]. The antitumor action of vincristine is due to its binding to beta-tubulin, which leads to disorganization of the axonal microtubule cytoskeleton. However, peripheral neuropathy is a relatively common side effect of chemotherapeutic treatment with vincristine, sometimes greatly reducing patients’ quality of life and their ability to perform activities of daily living [3]. Antidepressants and anticonvulsants have suppressive effects on neuropathic pain [4, 5], and antidepressants are widely used for the treatment of neuropathic pain. Indeed, antidepressants, particularly tricyclic antidepressants (TCAs), are regarded as first-line drugs for the treatment of neuropathic pain [4]. Recently, newer antidepressants have become
Dense Clumps and Candidates for Molecular Outflows in W40
Tomomi Shimoikura,Kazuhito Dobashi,Fumitaka Nakamura,Chihomi Hara,Tomohiro Tanaka,Yoshito Shimajiri,Kouji Sugitani
Physics , 2015,
Abstract: We report results of the CO(J=3-2) and HCO+(J=4-3) observations of the W40 HII region with the ASTE 10 m telescope (HPBW~22 arcsec) to search for molecular outflows and dense clumps.We found that the velocity field in the region is highly complex, consisting of at least four distinct velocity components at V LSR ~ 3, 5, 7, and 10 km/s. The ~7 km/s component represents the systemic velocity of cold gas surroundingthe entire region, and causes heavy absorption in the CO spectra over the velocity range 6 40 K) and are found mostly around the HII region, suggesting that these components are likely to be tracing dense gas interacting with the expanding shell around the HII region. Based on the CO data, we identified 13 regions of high velocity gas which we interpret as candidate outflow lobes. Using the HCO+ data, we also identified six clumps and estimated their physical parameters. On the basis of the ASTE data and near-infrared images from 2MASS, we present an updated three-dimensional model of this region. In order to investigate molecular outflows in W40, the SiO (J=1-0, v=0) emission line and some other emission lines at 40 GHz were also observed with the 45 m telescope at the Nobeyama Radio Observatory, but they were not detected at the present sensitivity.
Association between Children’s Appetite Patterns and Maternal Feeding Practices  [PDF]
Tomomi Ainuki, Rie Akamatsu
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.23032
Abstract: This study explored associations between children’s appetites and maternal feeding practices. The participants, 614 parents of 3- to 6-year-old children from kindergartens in Tokyo, Japan, completed self-administered questionnaires. The children’s appetites were measured using the Enjoyment of Food (EF) and Food Responsiveness (FR) scales of the Child Eating Behaviour Questionnaire. Using cluster analysis, we examined three appetite patterns (“both low,” “high EF and low FR,” and “both high”). The three appetite patterns were associated with children’s obesity index. The “both low” pattern was associated with the highest maternal pressure to eat. The “high EF and low FR” patterns were related to an established snack time. The “both high” pattern was associated with higher maternal instrumental feeding compared with the “high EF and low FR” types. The results of this study will facilitate the development of targeted interventions and better parental guidance on maternal feeding practices and their association with children’s eating behaviours.
Heart Rate Variability Predicts Emotional Flexibility in Response to Positive Stimuli  [PDF]
Tomomi Fujimura, Kazuo Okanoya
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.38086
Abstract: Flexible adaptation to constantly changing environments is linked to mental health and psychological functioning. Heart rate variability (HRV), an index of autonomic flexibility, has been implicated in emotional flexibility, the ability to generate contextually dependent emotional responses in accordance with situational demands. The current study investigated whether HRV during rest is associated with experienced emotion, one of the measures of emotional flexibility. To assess experienced emotion in response to changing events, three types of stimuli sets were created by presenting two stimuli successively. First, two stimuli represented the same valence (i.e., negative/negative or positive/positive). Second, two stimuli represented opposite valences (i.e., negative/positive or positive/negative). Third, a neutral stimulus was followed by negative or positive stimulus (i.e., neutral/negative or neutral/positive). Psychological ratings for experienced emotion to the second stimulus were collected with regard to valence and arousal. The results showed that subjects with lower resting HRV experienced more aroused states in response to successive positive stimuli. Resting HRV may be a proxy of emotional flexibility indexed by subjective arousal states to positive events.
Interaction of Bubbles with Vortex Ring Launched into Bubble Plume  [PDF]
Tomomi Uchiyama, Sou Kusamichi
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.34027
Abstract: This study is concerned with an experimental exploration for the interactions of bubbles with a vortex ring launched vertically upward into a bubble plume. A vortex ring launcher, composed of a cylinder and a piston, is mounted at the bottom of a water tank. Small hydrogen bubbles are released into still water from a cathode, which is wound around the cylinder outlet, by the electrolysis of water. The bubbles rise by the buoyant force and induce a bubble plume. The water in the cylinder is discharged into the bubble plume by the piston, resulting in a laminar vortex ring convecting along the central axis of the plume. Just after the launch of the vortex ring, the bubbles are spirally entrained into the vortex ring with the roll up of the shear layer. The void fraction within the vortex ring increases with the convection of the vortex ring until a certain displacement of the vortex ring, where the reduction occurs. The vortex ring convects with a constant velocity higher than that in still water. The entrained bubbles reduce the strength of the vortex ring.
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