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Lymphomatoidgastropathy mimicking extranodal NK/T cell lymphoma, nasal type: A case report
Tomohiro Terai,Mitsushige Sugimoto,Hiroki Uozaki,Tetsushi Kitagawa
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i17.2140
Abstract: Extranodal natural killer (NK)/T-cell lymphoma, nasal type, exhibits aggressive tumor behavior and carries a poor prognosis. Recently, lymphomatoid gastropathy with NK/T cell infiltration into gastric mucosa has been recognized as a pseudo-malignant disease which regresses without treatment. Because the conventional immunohistochemical criteria of lymphomatoid gastropathy is similar to that of extranodal NK/T-cell lymphoma nasal type, it is difficult to distinguish between the two conditions by histopathological evaluation only. Here, we report a rare case of lymphomatoid gastropathy in a 57-year-old female. Gastroendoscopy on routine check-up revealed elevated reddish lesions < 1 cm in diameter in the gastric fornix and body. Although repeat endoscopies at 1 and 6 mo later revealed no gastric lesions at any locations without any treatments, at 12 mo later gastric lymphomatoid lesions recurred at gastric fornix and body. Histological examination of endoscopic biopsy specimens at 12 mo showed atypical NK cell infiltration with CD3+, CD4-, CD5-, CD7+, CD8-, CD20-, CD30-, CD56+, CD79a- and T-cell-restricted intracellular antigen-1+ into gastric mucosa. After treatment for Helicobacter pylori (H. pylori) eradication, the lesions disappeared in all locations of the gastric fornix and body over the subsequent 12 mo. Here, we report a case of H. pylori-positive lymphomatoid gastropathy with massive NK-cell proliferation, and also review the literature concerning newly identified lymphomatoid gastropathy based on comparison of extra nodal NK/T-cell lymphoma nasal type. In any case, these lesions are evaluated with biopsy specimens, the possibility of this benign entity should be considered, and excessive treatment should be carefully avoided. Close follow-up for this case of lymphomatoid gastropathy is necessary to exclude any underlying malignancy.
On the exponential Diophantine equation (4m^2+1)^x+(5m^2-1)^y=(3m)^z
N. Terai
International Journal of Algebra , 2012,
Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis
Hong Tao, Kazuya Shinmura, Hidetaka Yamada, Masato Maekawa, Satoshi Osawa, Yasuhiro Takayanagi, Kazuya Okamoto, Tomohiro Terai, Hiroki Mori, Toshio Nakamura, Haruhiko Sugimura
BMC Research Notes , 2010, DOI: 10.1186/1756-0500-3-305
Abstract: Nine germline APC mutations, but no large deletions, were identified in the APC locus of 8 (A)FAP patients, and 5 of the mutations, c.446A > T (p.Asp149Val), c.448A > T (p.Lys150X), c.454_457insAGAA (p.Glu152ArgfsX17), c.497insA (p.Thr166AsnfsX2), and c.1958G > C (p.Arg653Ser), were novel mutations. In one patient the p.Asp149Val mutation and p.Lys150X mutation were detected in the same APC allele. The c.1958G > C mutation was located in the last nucleotide of exon 14, and RT-PCR analysis revealed that the mutation resulted in abnormal splicing. The above findings meant that a nonsense mutation, a frameshift mutation, or an exonic mutation leading to abnormal splicing was found in every patient. The following phenotypes, especially extracolonic manifestations, were observed in our (A)FAP patients: (1) multiple gastroduodenal adenomas and early-onset gastric carcinoma in AFAP patients with an exon 4 mutation; (2) a desmoid tumor in two FAP patients with a germline APC mutation outside the region between codons 1403 and 1578, which was previously reported to be associated with the development of desmoid tumors in FAP patients; (3) multiple myeloma in an AFAP patient with an exon 4 mutation.Nine germline APC mutations, 5 of them were novel, were identified in 8 Japanese (A)FAP patients, and some associations between germline APC mutations and extracolonic manifestations were demonstrated. These findings should contribute to establishing relationships between germline APC mutations and the extracolonic manifestations of (A)FAP patients in the future.Familial adenomatous polyposis (FAP) is an autosomal dominant familial cancer syndrome characterized by the early onset of large numbers of adenomatous polyps throughout the entire colon and a nearly 100% lifetime risk of colorectal cancer (CRC) if the colon is not removed [1]. A small proportion of familial colorectal polyposis cases were recently found to be associated with biallelic germline mutations of the MutYH gene [2
Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma
Satoshi Osawa, Takahisa Furuta, Ken Sugimoto, Takashi Kosugi, Tomohiro Terai, Mihoko Yamade, Yasuhiro Takayanagi, Masafumi Nishino, Yasushi Hamaya, Chise Kodaira, Takanori Yamada, Moriya Iwaizumi, Kosuke Takagaki, Ken-ichi Yoshida, Shigeru Kanaoka, Mutsuhiro Ikuma
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-408
Abstract: Between January 2003 and June 2008, 33 patients with clinical stage I to IVB esophageal squamous cell carcinoma were enrolled. Nedaplatin (10 mg/body/day) was administered daily and 5-FU (500 mg/body/day) was administered continuously for 20 days. Fractionated radiotherapy for a total dose of 50.4-66 Gy was administered together with chemotherapy. Additional chemotherapy with nedaplatin and 5-FU was optionally performed for a maximum of 5 courses after chemoradiotherapy. The primary end-point of this study was to evaluate the tumor response, and the secondary end-points were to evaluate the toxicity and the overall survival.Twenty-two patients (72.7%) completed the regimen of chemoradiotherapy. Twenty patients (60.6%) achieved a complete response, 10 patients (30.3%) a partial response. One patient (3.0%) had a stable disease, and 2 (6.1%) a progressive disease. The overall response rate was 90.9% (95% confidence interval: 75.7%-98.1%). For grade 3-4 toxicity, leukopenia was observed in 75.8% of the cases, thrombocytopenia in 24.2%, anemia in 9.1%, and esophagitis in 36.4%, while late grade 3-4 cardiac toxicity occurred in 6.1%. Additional chemotherapy was performed for 26 patients (78.8%) and the median number of courses was 3 (range, 1-5). The 1-, 2- and 3-year survival rates were 83.9%, 76.0% and 58.8%, respectively. The 1- and 2-year survival rates were 94.7% and 88.4% in patients with T1-3 M0 disease, and 66.2% and 55.2% in patients with T4/M1 disease.The treatment used in our study may yield a high complete response rate and better survival for each stage of esophageal squamous cell carcinoma.ClinicalTrials.gov Identifier: NCT00197444Results of a series of clinical trials indicate that definitive chemoradiotherapy (CRT) for esophageal cancer produces more promising results than radiation therapy alone, and is considered to be the standard treatment for patients with medically inoperable or surgically unresectable esophageal cancer [1-3]. Recently reported resu
Influences of Diamines on the Morphologies and the Chemical, Thermal, and Mechanical Properties of Polyurethane-Imide Elastomers  [PDF]
Tomohiro Ueda, Tomohiro Nishio, Shinichi Inoue
Open Journal of Organic Polymer Materials (OJOPM) , 2017, DOI: 10.4236/ojopm.2017.74004
Abstract: Polyurethane-imide elastomers (PUIEs) are formed from isocyanate, polyol, acid anhydride, and diamine by liquid polymerization. Unfortunately, many of the diamines have rarely been applied to the formation of PUIEs. Hence, investigating the effect of diamines on PUIEs remains a challenge in polymer chemistry. Herein, PUIEs prepared from 4,4'-diphenylmethane diisocyanate (MDI), polytetramethylene glycol (Mw: 1000), pyromellitic dianhydride, and aromatic diamines (such as p-phenylene diamine, 4,4'-oxydianiline, and 1,3-bis(4-aminophenoxy)benzene), and aliphatic diamines (such as 1,2-ethylene diamine, 1,6-hexamethylene diamine, and 1,12-dodecamethylene diamine) were synthesized by liquid polymerization. The morphologies and the chemical, thermal, and mechanical properties of the various PUIEs were investigated. The obtained elastomeric sheets were characterized in terms of the following tests and methods: solubility and swelling tests, X-ray diffraction and differential scanning calorimetry, dynamic mechanical analysis and thermogravimetric analysis, tensile tests, nuclear magnetic resonance spectroscopy, infrared spectroscopy, atomic force microscopy, contact angle microscopy, and scanning electron microscopy
On the rank of the elliptic curve y^2=x^3-nx
Y. Fujita,N. Terai
International Journal of Algebra , 2012,
Reexamination of Finite-Lattice Extrapolation of Haldane Gaps
Hiroki Nakano,Akira Terai
Physics , 2008, DOI: 10.1143/JPSJ.78.014003
Abstract: We propose two methods of estimating a systematic error in extrapolation to the infinite-size limit in the study of measuring the Haldane gaps of the one-dimensional Heisenberg antiferromagnet with the integer spin up to S=5. The finite-size gaps obtained by numerical diagonalizations based on Lanczos algorithm are presented for sizes that have not previously been reported. The changes of boundary conditions are also examined. We successfully demonstrate that our methods of extrapolation work well. The Haldane gap for S=1 is stimated to be $0.4104789 \pm 0.0000013$. We successfully obtain the gaps up to S=5, which make us confirm the asymptotic formula of the Haldane gap in $S\to\infty$.
High-Precision Measurements of Brightness Variation of Nereid
Tsuyoshi Terai,Yoichi Itoh
Physics , 2012, DOI: 10.1093/pasj/65.2.46
Abstract: Nereid, a satellite of Neptune, has a highly eccentric prograde orbit with a semi-major axis larger than 200 Neptune radius and is classified as an irregular satellite. Although the capture origin of irregular satellites has been widely accepted, several previous studies suggest that Nereid was formed in the circumplanetary disk of Neptune and was ejected outward to the present location by Triton. Our time-series photometric observations confirm that the spin is stable and non-chaotic with a period of 11.5 hr as indicated by Grav et al. (2003). The optical colors of Nereid are indistinguishable from those of trans-Neptunian objects and Centaurs, especially those with neutral colors. We also find the consistency of Nereid's rotation with the size-rotation distribution of small outer bodies. It is more likely that Nereid originates in an immigrant body captured from a heliocentric orbit which was 4-5 AU away from Neptune's orbit.
Size Distribution of Main-Belt Asteroids with High Inclination
Tsuyoshi Terai,Yoichi Itoh
Physics , 2010, DOI: 10.1093/pasj/63.2.335
Abstract: We investigated the size distribution of high-inclination main-belt asteroids (MBAs) to explore asteroid collisional evolution under hypervelocity collisions of around 10 km/s. We performed a wide-field survey for high-inclination sub-km MBAs using the 8.2-m Subaru Telescope with the Subaru Prime Focus Camera (Suprime-Cam). Suprime-Cam archival data were also used. A total of 616 MBA candidates were detected in an area of 9.0 deg^2 with a limiting magnitude of 24.0 mag in the SDSS r filter. Most of candidate diameters were estimated to be smaller than 1 km. We found a scarcity of sub-km MBAs with high inclination. Cumulative size distributions (CSDs) were constructed using Subaru data and published asteroid catalogs. The power-law indexes of the CSDs were 2.17 +/- 0.02 for low-inclination (< 15 deg) MBAs and 2.02 +/- 0.03 for high-inclination (> 15 deg) MBAs in the 0.7-50 km diameter range. The high-inclination MBAs had a shallower CSD. We also found that the CSD of S-like MBAs had a small slope with high inclination, whereas the slope did not vary with inclination in the C-like group. The most probable cause of the shallow CSD of the high-inclination S-like MBAs is the large power-law index in the diameter-impact strength curve in hypervelocity collisions. The collisional evolution of MBAs may have advanced with oligopolistic survival during the dynamical excitation phase in the final stage of planet formation.
H-vectors of simplicial complexes with Serre's conditions
Satoshi Murai,Naoki Terai
Mathematics , 2009,
Abstract: We study $h$-vectors of simplicial complexes which satisfy Serre's condition ($S_r$). We say that a simplicial complex $\Delta$ satisfies Serre's condition ($S_r$) if $\tilde H_i(\lk_\Delta(F);K)=0$ for all faces $F \in \Delta$ and for all $i < \min \{r-1,\dim \lk_\Delta(F)\}$, where $\lk_\Delta(F)$ is the link of $\Delta$ with respect to $F$ and where $\tilde H_i(\Delta;K)$ is the reduced homology groups of $\Delta$ over a field $K$. The main result of this paper is that if $\Delta$ satisfies Serre's condition ($S_r$) then (i) $h_k(\Delta)$ is non-negative for $k =0,1,...,r$ and (ii) $\sum_{k\geq r}h_k(\Delta)$ is non-negative.
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