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Search Results: 1 - 10 of 1092 matches for " Tomohiro Katsuya "
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Genetics of Hypertension and Cardiovascular Disease
Tomohiro Katsuya,Stephen B. Harrap,Toshio Ogihara
International Journal of Hypertension , 2010, DOI: 10.4061/2010/951254
Abstract:
Genetics of Hypertension and Cardiovascular Disease
Tomohiro Katsuya,Stephen B. Harrap,Toshio Ogihara
International Journal of Hypertension , 2010, DOI: 10.4061/2010/951254
Abstract:
Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study
Ken Sugimoto,Tomohiro Katsuya,Kei Kamide,Tomomi Fujisawa,Izumi Shimaoka,Mitsuru Ohishi,Ryuichi Morishita,Toshio Ogihara,Hiromi Rakugi
International Journal of Hypertension , 2010, DOI: 10.4061/2010/196307
Abstract: We performed a prospective study to examine the genetic effect on the response to a calcium (Ca) channel blocker, azelnidipine and an ACE inhibitor, temocapril treatment in patients with hypertension, as a part of the prior clinical trial, the Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study (ATTEST).Methods and Results. All subjects who gave informed consent for genetic research were divided into two groups: the subjects treated with azelnidipine or temocapril, for 52 weeks. We selected 18 susceptible genes for hypertension and determined their genotypes using TaqMan PCR method. RNA samples were extracted from peripheral blood, and quantitative real time PCR for all genes was performed using TaqMan method. One of the polymorphisms of the RGS2 gene was extracted as being able to influence the effect of these treatments to reduce BP. At eight weeks, BP change showed a significant interaction between the A-638G polymorphism of Regulator of G protein signaling-2 (RGS2) gene and treatment with azelnidipine or temocapril. There was no gene whose expression was associated with BP phenotypes or the polymorphisms of each gene.Conclusions. A-638G polymorphism of the RGS-2 gene could be a predictive factor for therapeutic performance of Ca channel blockers.
Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study
Ken Sugimoto,Tomohiro Katsuya,Kei Kamide,Tomomi Fujisawa,Izumi Shimaoka,Mitsuru Ohishi,Ryuichi Morishita,Toshio Ogihara,Hiromi Rakugi
International Journal of Hypertension , 2010, DOI: 10.4061/2010/196307
Abstract: We performed a prospective study to examine the genetic effect on the response to a calcium (Ca) channel blocker, azelnidipine and an ACE inhibitor, temocapril treatment in patients with hypertension, as a part of the prior clinical trial, the Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study (ATTEST). Methods and Results. All subjects who gave informed consent for genetic research were divided into two groups: the subjects treated with azelnidipine or temocapril, for 52 weeks. We selected 18 susceptible genes for hypertension and determined their genotypes using TaqMan PCR method. RNA samples were extracted from peripheral blood, and quantitative real time PCR for all genes was performed using TaqMan method. One of the polymorphisms of the RGS2 gene was extracted as being able to influence the effect of these treatments to reduce BP. At eight weeks, BP change showed a significant interaction between the A-638G polymorphism of Regulator of G protein signaling-2 (RGS2) gene and treatment with azelnidipine or temocapril. There was no gene whose expression was associated with BP phenotypes or the polymorphisms of each gene. Conclusions. A-638G polymorphism of the RGS-2 gene could be a predictive factor for therapeutic performance of Ca channel blockers. 1. Introduction Genetic approaches may provide a powerful tool for clarifying the pathogenesis of essential hypertension. Many reports have demonstrated that gene polymorphisms of the renin-angiotensin system (RAS) are associated with hypertension. There have been some reliable reports about susceptible genes for hypertension including the results from “The Millennium Genome Project for Hypertension in Japan (2000 2005) [1, 2]; however, no convincing gene has yet been detected. Some of the genes regulating blood pressure might also be related to the response to antihypertensive medication [3, 4]. Indeed, we and other collaborators have investigated several susceptible genes related to hypertension [5–15], including genes of not only the renin-angiotensin system and sodium handling but also insulin resistance, oxidative stress, and sympathetic nervous system (described in the Section 2); however, the genes involved in the response to antihypertensive medication have not yet been identified. In addition, exhaustive gene expression analysis (transcriptome analysis) for lifestyle-related diseases has not been performed thus far. We performed a large collaboration with the study group led by Professor Katayama at Saitama Medical University to perform a randomized controlled trial
Numerical Simulation of Skin Formation: The Relationship between Transepidermal Water Loss and Corneum Thickness  [PDF]
Katsuya Nagayama, Takeshi Kurihara
Journal of Applied Mathematics and Physics (JAMP) , 2018, DOI: 10.4236/jamp.2018.68150
Abstract:
Skin moisturizing has drawn attention in terms of beauty and anti-aging industries. However, it is difficult to observe the inside of the epidermis and the relationship between the epidermis and water content is not yet clear. Computational simulations can be useful in understanding such mechanisms of skin formation. A particle model was used to simulate three-dimensional skin turnover, and the results reproduced the epidermal skin turnover phenomenon. In this study, a diffusion model is introduced into this simulation model and a moisture diffusion analysis of the epidermis was performed. In particular, transepidermal water loss (TEWL) was modeled by considering diffusion and surface evaporation in the stratum corneum and other layers. The relationship between the moisture content and the keratin detachment was considered, and the exfoliation condition of keratin based on the moisture content was calculated in the model. As a result, it was possible to calculate the intraepidermal water content distribution in the skin using the particle model. It was also possible to reproduce phenomena such as keratin thickening due to increase of TEWL. This phenomenon is consistent with cases of dry skin. In the future, it will be necessary to introduce a change in TEWL according to the thickness of the stratum corneum and the diffusion coefficient.
Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals
Fumihiko Takeuchi, Masato Isono, Tomohiro Katsuya, Mitsuhiro Yokota, Ken Yamamoto, Toru Nabika, Kazuro Shimokawa, Eitaro Nakashima, Takao Sugiyama, Hiromi Rakugi, Shuhei Yamaguchi, Toshio Ogihara, Yukio Yamori, Norihiro Kato
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046385
Abstract: Background/Objective In Japanese populations, we performed a replication study of genetic loci previously identified in European-descent populations as being associated with lipid levels and risk of coronary artery disease (CAD). Methods We genotyped 48 single nucleotide polymorphisms (SNPs) from 22 candidate loci that had previously been identified by genome-wide association (GWA) meta-analyses for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and/or triglycerides in Europeans. We selected 22 loci with 2 parallel tracks from 95 reported loci: 16 significant loci (p<1×10?30 in Europeans) and 6 other loci including those with suggestive evidence of lipid associations in 1292 GWA-scanned Japanese samples. Genotyping was done in 4990 general population samples, and 1347 CAD cases and 1337 controls. For 9 SNPs, we further examined CAD associations in an additional panel of 3052 CAD cases and 6335 controls. Principal Findings Significant lipid associations (one-tailed p<0.05) were replicated for 18 of 22 loci in Japanese samples, with significant inter-ethnic heterogeneity at 4 loci–APOB, APOE-C1, CETP, and APOA5–and allelic heterogeneity. The strongest association was detected at APOE rs7412 for LDL-C (p = 1.3×10?41), CETP rs3764261 for HDL-C (p = 5.2×10?24), and APOA5 rs662799 for triglycerides (p = 5.8×10?54). CAD association was replicated and/or verified for 4 loci: SORT1 rs611917 (p = 1.7×10?8), APOA5 rs662799 (p = 0.0014), LDLR rs1433099 (p = 2.1×10?7), and APOE rs7412 (p = 6.1×10?13). Conclusions Our results confirm that most of the tested lipid loci are associated with lipid traits in the Japanese, further indicating that in genetic susceptibility to lipid levels and CAD, the related metabolic pathways are largely common across the populations, while causal variants at individual loci can be population-specific.
Decrease in Blood Pressure and Regression of Cardiovascular Complications by Angiotensin II Vaccine in Mice
Futoshi Nakagami, Hiroshi Koriyama, Hironori Nakagami, Mariana Kiomy Osako, Munehisa Shimamura, Mariko Kyutoku, Takashi Miyake, Tomohiro Katsuya, Hiromi Rakugi, Ryuichi Morishita
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060493
Abstract: Vaccines have been recently developed to treat various diseases such as cancer, rheumatoid arthritis and Alzheimer’s disease in addition to infectious diseases. However, before use in the clinical setting, vaccines targeting self-antigens must be demonstrated to be effective and safe, evoking an adequate humoral immune response from B cells while avoiding T cell activation in response to self. Although the vaccine targeting angiotensin II (Ang II) is efficient in rodents and humans, little is known regarding the immunological activation and safety of the vaccine. In this study, we evaluated the efficiency and safety of an Ang II peptide vaccine in mice. Immunization with Ang II conjugated to keyhole limpet hemocyanin (KLH) successfully induced the production of anti-Ang II antibody, which blocked Ang II signaling in human aortic smooth muscle cells. However, Ang II itself did not activate T cells, as assessed by the proliferation and lymphokine production of T cells in immunized mice, whereas KLH activated T cells. In an Ang II-infused model, the non-immunized mice showed high blood pressure (BP), whereas the immunized mice (Ang II-KLH) showed a significant decrease in systolic BP, accompanied by significant reductions in cardiac hypertrophy and fibrosis. Importantly, anti-Ang II antibody titer was not elevated even after the administration of large amounts of Ang II, indicating that Ang II itself boosted antibody production, most likely due to less activation of T cells. In addition, no accumulation of inflammatory cells was observed in immunized mice, because endogenous Ang II would not activate T cells after immunization with Ang II-KLH. Taken together, these data indicate that vaccines targeting Ang II might be effective to decrease high BP and prevent cardiovascular complications without severe side effects.
The Impact of Oil Price Volatility on Macroeconomic Activity in Russia
Katsuya Ito
Economic Analysis Working Papers , 2010,
Abstract: Since the beginning of the 1980s a large number of studies using a vector autoregressive (VAR) model have been made on the macroeconomic effects of oil price changes. However, surprisingly few studies have so far focused on Russia, the world’s second largest oil exporter. The purpose of this paper is to empirically examine the impact of oil prices on the macroeconomic variables in Russia using the VAR model. The time span covered by the series is from 1994:Q1 to 2009:Q3, giving 63 observations. The analysis leads to the finding that a 1% increase (decrease) in oil prices contributes to the depreciation (appreciation) of the exchange rate by 0.17% in the long run, whereas it leads to a 0.46% GDP growth (decline). Likewise, we find that in the short run (8 quarters) rising oil prices cause not only the GDP growth and the exchange rate depreciation, but also a marginal increase in inflation rate.
Study of high pressure gas filled RF cavities for muon collider
Katsuya Yonehara
Physics , 2015,
Abstract: Muon collider is a considerable candidate of the next-generation high-energy lepton collider machine. Operating an RF cavity in a multi-Tesla magnet is a critical requirement in a muon accelerator and a cooling channel. However, the maximum RF gradient in a vacuum RF cavity is strongly limited by an external magnetic field. Dense hydrogen gas filled RF cavity has been proposed since it is functional of generating a high RF accelerating gradient in a strong magnetic field and making an ionization cooling process at the same time. A critical issue of the cavity is a beam- induced plasma that consumes a considerable amount of RF power. The gas filled RF test cell was made and measured the RF loading due to a beam-induced plasma by using an intense proton beam at Fermilab. By doping an electronegative gas in dense hydrogen, the plasma loading effect is significantly mitigated. The result shows that the cavity is functional with a muon collider beam. Recent progress is shown in this presentation.
Influences of Diamines on the Morphologies and the Chemical, Thermal, and Mechanical Properties of Polyurethane-Imide Elastomers  [PDF]
Tomohiro Ueda, Tomohiro Nishio, Shinichi Inoue
Open Journal of Organic Polymer Materials (OJOPM) , 2017, DOI: 10.4236/ojopm.2017.74004
Abstract: Polyurethane-imide elastomers (PUIEs) are formed from isocyanate, polyol, acid anhydride, and diamine by liquid polymerization. Unfortunately, many of the diamines have rarely been applied to the formation of PUIEs. Hence, investigating the effect of diamines on PUIEs remains a challenge in polymer chemistry. Herein, PUIEs prepared from 4,4'-diphenylmethane diisocyanate (MDI), polytetramethylene glycol (Mw: 1000), pyromellitic dianhydride, and aromatic diamines (such as p-phenylene diamine, 4,4'-oxydianiline, and 1,3-bis(4-aminophenoxy)benzene), and aliphatic diamines (such as 1,2-ethylene diamine, 1,6-hexamethylene diamine, and 1,12-dodecamethylene diamine) were synthesized by liquid polymerization. The morphologies and the chemical, thermal, and mechanical properties of the various PUIEs were investigated. The obtained elastomeric sheets were characterized in terms of the following tests and methods: solubility and swelling tests, X-ray diffraction and differential scanning calorimetry, dynamic mechanical analysis and thermogravimetric analysis, tensile tests, nuclear magnetic resonance spectroscopy, infrared spectroscopy, atomic force microscopy, contact angle microscopy, and scanning electron microscopy
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