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Search Results: 1 - 10 of 7242 matches for " Ting-Ting Sheu "
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Premature CD4+ T Cell Aging and Its Contribution to Lymphopenia-Induced Proliferation of Memory Cells in Autoimmune-Prone Non-Obese Diabetic Mice
Ting-Ting Sheu, Bor-Luen Chiang, Jui-Hung Yen, Wen-Chi Lin
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089379
Abstract: Lymphopenia-induced proliferation (LIP), a mechanism to maintain a constant number of T cells in circulation, occurs in both normal aging and autoimmune disease. The incidence of most autoimmune diseases increases with age, and premature CD4+ T cell aging has been reported in several autoimmune diseases. In this study, we tested the hypothesis that premature CD4+ T cell aging can cause autoimmune disease by examining whether premature CD4+ T cell aging exists and causes LIP in our mouse model. Non-obese diabetic (NOD) mice were used because, in addition to Treg defects, the LIP of T cells has been shown to plays a causative role in the development of insulin-dependent diabetes mellitus (IDDM) in these mice. We found that with advancing age, NOD mice exhibited an accelerated decrease in the number of CD4+ T cells due to the loss of na?ve cells. This was accompanied by an increase in the percentage of memory cells, leading to a reduced na?ve/memory ratio. In addition, both the percentage of CD28+ cells in CD4+ T cells and IL-2 production decreased, while the percentage of FAS+CD44+ increased, suggesting that NOD mice exhibit premature CD4+ T cell aging. This process preferentially contributed to LIP of memory cells. Therefore, our results suggest that premature CD4+ T cell aging underlies the development of IDDM in NOD mice. Given that CD28 and IL-2 play important roles in Treg function, the relationships between premature CD4+ T cell aging and lymphopenia as well as Treg defects in autoimmune-prone NOD mice are proposed.
Effects of Shenqi Jiedu Decoction on expressions of transforming growth factor-β1, smad2 and smad3 in renal tissues of rats with chronic renal failure induced by adenine
Ting-ting LI
Zhong Xi Yi Jie He Xue Bao , 2010,
Abstract: Objective: To investigate the effects of Shenqi Jiedu Decoction (SQJDD), a compound traditional Chinese herbal medicine, on expressions of transforming growth factor beta1 (TGF-β1), smad2 and smad3 proteins in renal tissues of rats with chronic renal failure (CRF) induced by adenine, and to explore the mechanisms of SQJDD in treating CRF. Methods: Ninety healthy Wistar male rats were randomly divided into six groups: normal group, untreated group, losartan group, low-dose SQJDD group, medium-dose SQJDD group, and high-dose SQJDD group. Rat model of CRF was established by feeding 2.5% adenine. Levels of plasma creatinine (Cr) and blood urea nitrogen (BUN) in different groups after model establishment were detected to estimate the renal function of rats with CRF. After eight-week treatment, levels of Cr, BUN, triacylglycerol (TAG), cholesterol (Chol) and albumin (ALB) in plasma were detected. Pathological changes of renal tissues were observed by HE staining. Protein expressions of TGF-β1, Smad2 and Smad3 in renal tissues were detected by Western blotting. Results: Compared with pretreatment, levels of Cr and BUN in the losartan group and the SQJDD groups were markedly decreased (P<0.01). After treatment, levels of Cr, BUN and Chol in all treated groups were lower than those in the untreated group (P<0.01, P<0.05). Levels of ALB in all treated groups were higher than that in the untreated group (P<0.01). Pathological lesions of renal tissues in all treated groups were lessened as compared with the untreated group (P<0.01). The Western blotting results showed that the protein expressions of TGF-β1, Smad2 and Smad3 in renal tissues in all treated groups were lower than those in the untreated group (P<0.01). Conclusion: SQJDD can delay the progress of CRF by inhibiting TGF-β1/Smads signal transduction pathway.
An artificial charge-density-wave conductor realized by double quantum wells
Ting-Ting Kang
Physics , 2012,
Abstract: Charge-density-wave (CDW) is a modulation of the conduction electron density in a conductor. Under low temperature, it can spontaneously happen in some compounds that consist of anisotropic one-dimensional crystal structures, via a strong electron-lattice interaction mechanism. Many celebrated phenomena, e.g. non-linear transport, narrow-band noise, mode-locking5 and chaos under AC voltage, etc., have been reported in CDW. However, evaluating the application potential of CDW conductors has been hampered by the inconvenient shapes and sizes of CDW single crystals. Although modern fabrication technology can partly resolve those troubles, (for example, cleaved film and nanowire NbSe3 device), the imperfections induced by fabrication that corrupt measured properties are not easy to control and estimate. Here we demonstrate a convenient CDW conductor fabricated by semiconductor double quantum wells (DQW) in a field-effect transistor (FET) configuration: a modulated electron density in one QW resulted from the charged QW nearby. The electric field dependent depinning transport characteristic of CDW is clearly present. This "artificial" CDW, capable of integrating with semiconductor industry, may give fresh impetus to revive the interests in CDW.
Screening in coupled low-dimensional systems: an effective polarizability picture
Ting-Ting Kang
Physics , 2013,
Abstract: The screening of an individual low-dimensional object can be strongly influenced by the objects nearby. We propose that such environment's influence can be absorbed into an effective polarizability, instead of its intrinsic polarizability. Using a toy system consists of two spatially separated 2DEG layers gas an example, this picture is analytically deduced via a multi-component RPA theoretical method. We show that the resultant effective polarizability of backside layer is just the dielectric function describing the system's collective plasmon excitations. Furthermore, several interesting topics are discussed, e.g. the mutual modulation of Friedel oscillation, the ultimate screening limit imposed by metal layer, smoothing potential inhomogeneity in back screening configuration.
Chen Zhang,Ting-Ting Wang
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810027406
Abstract: In the title polymeric complex, [Cd(C5H3N6)(C2O4)0.5(H2O)]n, the CdII ion is coordinated by four O atoms and three N atoms from two 5-(pyrazin-2-yl)tetrazolate ligands, two oxalate ligands and one water molecule, displaying a distorted monocapped octahedral geometry. The bridging ligands link metal centres, forming a three-dimensional network which is stabilized by intermolecular O—H...N hydrogen-bonding interactions.
Aqua{tris[(1H-benzimidazol-2-yl-κN3)methyl]amine}zinc 5-(dimethylamino)naphthalene-1-sulfonate perchlorate 2.5-hydrate
Zuo-an Xiao,Ting-ting Jiang
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811047453
Abstract: In the title compound, [Zn(C24H21N7)(H2O)](C12H12NO3S)(ClO4)·2.5H2O, the ZnII ion is in a distorted trigonal–bipyramidal coordination geometry. In the crystal, N—H...O and O—H...O hydrogen bonds connect the components into a two-dimensional network parallel to (001). In addition, there are weak C—H...O hydrogen bonds.
(Nitrato-κO){N,N,N′,N′-tetrakis[(1H-benzimidazol-2-yl-κN3)methyl]cyclohexane-1,2-diamine}lead(II) hemiaqua{N,N,N′,N′-tetrakis[(1H-benzimidazol-2-yl-κN3)methyl]cyclohexane-1,2-diamine}lead(II) trinitrate dihydrate
Zuo-an Xiao,Ting-ting Jiang
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811050082
Abstract: In the title compound, [Pb(NO3)(C38H38N10)][Pb(C38H38N10)(H2O)0.5](NO3)3·2H2O, both PbII ions are coordinated in a distorted trigonal–prismatic environment by a hexadentate N,N,N′,N′-tetrakis[(1H-benzimidazol-2-yl)methyl]cyclohexane-1,2-diamine ligand. A nitrate and a half-occupancy water ligand form long coordination bonds to the PbII ions capping the trigonal–prismatic environment. In the crystal, the components are linked by N—H...O and O—H...O hydrogen bonds, forming a three-dimensional network. C—H...O interactions also occur.
Effects of Caulis Sargentodoxae Granule on expressions of vascular endothelial growth factor and its receptor-2 in rats with endometriosis
Yang CAO,Ting-ting ZHANG
Zhong Xi Yi Jie He Xue Bao , 2009,
Abstract: Objective: To investigate the effects of Caulis Sargentodoxae Granule (CSG), a compound traditional Chinese herbal medicine for treating endometriosis, on expressions of vascular endothelial growth factor (VEGF) and its receptor-2 fetal liver kinase-1 (Flk-1) in rats with endometriosis.Methods: A rat model of endometriosis was established by autotransplant of endometria. Forty-eight endometriosis rats were randomly divided into 6 groups: untreated group, castrate group, mifepristone group (5 mg/kg) and low- (20 g/kg), medium- (40 g/kg) and high-dose (80 g/kg) CSG group. After 21-day consecutive treatment, the expressions of VEGF and its receptor Flk-1 in ectopic endometria were detected by immunohistochemical method, and the volume of the ectopic endometria was also measured by using electronic digital calipers.Results: Compared with the untreated group, the endometrial volumes in the treated groups were significantly decreased (P<0.05) except for the low-dose CSG group. Histopathologic observation showed that the epithelial layer of ectopic endometrium was less and the thickness of epithelial layer was thinner than those in the untreated group (P<0.01), but the low-dose CSG group had few changes. The VEGF and its receptor Flk-1 expressed abundantly in the cytoplasm of the glandular epithelium and vascular endothelial cell in all the groups. Compared with the untreated group, the expressions of VEGF and Flk-1 of ectopic endometrium in the CSG-treated groups, the mifepristone group and the castrate group were significantly decreased (P<0.05, P<0.01).Conclusion: CSG can treat the endometriosis in rats, and its action may be associated with decreasing the expressions of VEGF and its receptor Flk-1 in ectopic endometrium.
A theoretical contribution to the fast implementation of null linear discriminant analysis method using random matrix multiplication with scatter matrices
Ting-ting Feng,Gang Wu
Computer Science , 2014,
Abstract: The null linear discriminant analysis method is a competitive approach for dimensionality reduction. The implementation of this method, however, is computationally expensive. Recently, a fast implementation of null linear discriminant analysis method using random matrix multiplication with scatter matrices was proposed. However, if the random matrix is chosen arbitrarily, the orientation matrix may be rank deficient, and some useful discriminant information will be lost. In this paper, we investigate how to choose the random matrix properly, such that the two criteria of the null LDA method are satisfied theoretically. We give a necessary and sufficient condition to guarantee full column rank of the orientation matrix. Moreover, the geometric characterization of the condition is also described.
Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3′,4′-Hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells
Hui-Chi Lai, Ming-Jiuan Wu, Pei-Yi Chen, Ting-Ting Sheu, Szu-Ping Chiu, Meng-Han Lin, Chi-Tang Ho, Jui-Hung Yen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028280
Abstract: 5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavo?ne(5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange. In this research, we report the first investigation of the neurotrophic effects and mechanism of 5-OH-HxMF in PC12 pheochromocytoma cells. We found that 5-OH-HxMF can effectively induce PC12 neurite outgrowth accompanied with the expression of neuronal differentiation marker protein growth-associated protein-43(GAP-43). 5-OH-HxMF caused the enhancement of cyclic AMP response element binding protein (CREB) phosphorylation, c-fos gene expression and CRE-mediated transcription, which was inhibited by 2-naphthol AS-E phosphate (KG-501), a specific antagonist for the CREB-CBP complex formation. Moreover, 5-OH-HxMF-induced both CRE transcription activity and neurite outgrowth were inhibited by adenylate cyclase and protein kinase A (PKA) inhibitor, but not MEK1/2, protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K) or calcium/calmodulin-dependent protein kinase (CaMK) inhibitor. Consistently, 5-OH-HxMF treatment increased the intracellular cAMP level and downstream component, PKA activity. We also found that addition of K252a, a TrKA antagonist, significantly inhibited NGF- but not 5-OH-HxMF-induced neurite outgrowth. These results reveal for the first time that 5-OH-HxMF is an effective neurotrophic agent and its effect is mainly through a cAMP/PKA-dependent, but TrKA-independent, signaling pathway coupling with CRE-mediated gene transcription. A PKC-dependent and CREB-independent pathway was also involved in its neurotrophic action.
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