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Search Results: 1 - 10 of 7246 matches for " Timothy JA Chico "
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Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina
Liam Bourke, Garry A Tew, Marta Milo, David C Crossman, John M Saxton, Timothy JA Chico
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-620
Abstract: Sixty patients with stable angina will be recruited and randomised 1:1 to exercise training or conventional care. Patients randomised to exercise training will attend an exercise physiology laboratory up to three times weekly for supervised aerobic interval training sessions of one hour in total duration. Patients will undergo assessments of angina, anxiety, depression, and peripheral blood gene expression at baseline, after six and twelve weeks of training, and twelve weeks after formal exercise training ceases.This study will provide comprehensive data on the effect of exercise training on peripheral blood gene expression in patients with angina. By correlating this with improvement in angina status we will identify candidate peripheral blood transcriptional markers predictive of improvements in angina level in response to exercise training.Clinicaltrials.gov identifier: NCT01147952Regular exercise protects against cardiovascular disease [1] and has beneficial effects on coronary perfusion and ventricular function in patients with established coronary artery disease [2]. However, the exact mechanism whereby exercise training exerts these effects is unclear. Meta-analyses have concluded that exercise based cardiac rehabilitation reduces cardiac mortality in patients with coronary artery disease (prior myocardial infarction, angina, bypass grafting or angioplasty) by 26%-31% [3,4]. Although exercise favourably influences serum lipids and blood pressure, the biological pathway whereby it protects against cardiovascular death remains unclear, though there is substantial evidence that exercise improves myocardial oxygenation. Exercise-induced improvement in myocardial perfusion has been demonstrated in a number of studies [2,5] suggesting exercise training increases absolute myocardial blood flow, rather than by altering myocardial efficiency. Exercise training has also been shown to improve coronary artery endothelial function (even after only 4 weeks training) [6].So
Bone Mineral Metabolism Parameters and Urinary Albumin Excretion in a Representative US Population Sample
Timothy Ellam, James Fotheringham, Martin E. Wilkie, Sheila E. Francis, Timothy J. A. Chico
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088388
Abstract: Background and Hypothesis Even within accepted normal ranges, higher serum phosphorus, dietary phosphorus density, parathyroid hormone (PTH) and alkaline phosphatase (ALP) are independent predictors of cardiovascular mortality. Lower serum 25-hydroxy vitamin D (25(OH)D) also predicts adverse cardiovascular outcomes. We hypothesized that vascular dysfunction accompanying subtle disturbances of these bone metabolism parameters would result in associations with increased low grade albuminuria. Study Population and Measures We examined participants in the National Health and Nutrition Examination Surveys 1999–2010 (N = 19,383) with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 and without severe albuminuria (urine albumin:creatinine ratio (ACR) <300 mg/g). Albuminuria was quantified as ACR and fractional albumin excretion (FEalb). Results Increasing quintiles of dietary phosphorus density, serum phosphorus and ALP were not associated with higher ACR or FEalb. The lowest versus highest quintile of 25(OH)D was associated with greater albuminuria, but not after adjustment for other covariates including cardiovascular risk factors. An association between the highest versus lowest quintile of bone-specific ALP and greater ACR persisted after covariate adjustment, but was not accompanied by an independent association with FEalb. Increasing quintiles of PTH demonstrated associations with both higher ACR and FEalb that were not abolished by adjusting for covariates including age, gender, race, body mass index, diabetes, blood pressure, history of cardiovascular disease, smoking, eGFR, 25(OH)D, season of measurement, lipids, hemoglobin and C-reactive protein. Adjusted increases in ACR and FEalb associated with the highest versus lowest quintile of PTH were 19% (95% confidence interval 7–28% p<0.001) and 17% (8–31% p = 0.001) respectively. Conclusion In this population, of the bone mineral parameters associated with cardiovascular outcomes, only PTH is independently associated with ACR and FEalb.
The Open Annotation Collaboration Phase I: Towards a Shared, Interoperable Data Model for Scholarly Annotation
Timothy W. Cole,Myung-Ja Han
Journal of the Chicago Colloquium on Digital Humanities and Computer Science , 2011,
Abstract: This paper reports on preliminary outcomes from Phase I of the Open Annotation Collaboration (OAC), discussing them in the context of illustrative scholarly annotation use cases drawn largely from the domain of renaissance emblem studies. The OAC Phase I project sought to address problems of dysfunction caused by too many different, insufficiently interoperable annotation clients and tools through the development and promulgation of a more resource-centric and web-centric standard for making and disseminating scholarly annotations of Web resources. By focusing on representative use cases and an underlying data model of scholarly annotation more consistent with Semantic Web and Linked Data principles rather than on application-specific or interface-specific issues to do with annotation, the OAC seeks to foster annotation sharing and interoperability. Results to date confirm diverse and complex user requirements in regard to the creation and use of scholarly annotations. Nonetheless, a reasonably straightforward and elastic data model is emerging with seemingly good potential to work across a broad spectrum of scholarly annotation use cases and applications. This suggests for Phase II an opportunity for in-depth, domain-specific experiments to further test and refine the initial OAC data model created.
Bioinformatics Analysis of the FREM1 Gene—Evolutionary Development of the IL-1R1 Co-Receptor, TILRR
Richard C. Hudson,Caroline Gray,Endre Kiss-Toth,Timothy J. A. Chico,Eva E. Qwarnstrom
Biology , 2012, DOI: 10.3390/biology1030484
Abstract: The TLRs and IL-1 receptors have evolved to coordinate the innate immune response following pathogen invasion. Receptors and signalling intermediates of these systems are generally characterised by a high level of evolutionary conservation. The recently described IL-1R1 co-receptor TILRR is a transcriptional variant of the FREM1 gene. Here we investigate whether innate co-receptor differences between teleosts and mammals extend to the expression of the TILRR isoform of FREM1. Bioinformatic and phylogenetic approaches were used to analyse the genome sequences of FREM1 from eukaryotic organisms including 37 tetrapods and five teleost fish. The TILRR consensus peptide sequence was present in the FREM1 gene of the tetrapods, but not in fish orthologs of FREM1, and neither FREM1 nor TILRR were present in invertebrates. The TILRR gene appears to have arisen via incorporation of adjacent non-coding DNA with a contiguous exonic sequence after the teleost divergence. Comparing co-receptors in other systems, points to their origin during the same stages of evolution. Our results show that modern teleost fish do not possess the IL-1RI co-receptor TILRR, but that this is maintained in tetrapods as early as amphibians. Further, they are consistent with data showing that co-receptors are recent additions to these regulatory systems and suggest this may underlie differences in innate immune responses between mammals and fish.
Vitamin D Deficiency and Exogenous Vitamin D Excess Similarly Increase Diffuse Atherosclerotic Calcification in Apolipoprotein E Knockout Mice
Timothy Ellam, Abdul Hameed, Risat ul Haque, Munitta Muthana, Martin Wilkie, Sheila E. Francis, Timothy J. A. Chico
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088767
Abstract: Background Observational data associate lower levels of serum vitamin D with coronary artery calcification, cardiovascular events and mortality. However, there is little interventional evidence demonstrating that moderate vitamin D deficiency plays a causative role in cardiovascular disease. This study examined the cardiovascular effects of dietary vitamin D deficiency and of vitamin D receptor agonist (paricalcitol) administration in apolipoprotein E knockout mice. Methods Mice were fed atherogenic diets with normal vitamin D content (1.5IU/kg) or without vitamin D. Paricalcitol, or matched vehicle, was administered 3× weekly by intraperitoneal injection. Following 20 weeks of these interventions cardiovascular phenotype was characterized by histological assessment of aortic sinus atheroma, soluble markers, blood pressure and echocardiography. To place the cardiovascular assessments in the context of intervention effects on bone, structural changes at the tibia were assessed by microtomography. Results Vitamin D deficient diet induced significant reductions in plasma vitamin D (p<0.001), trabecular bone volume (p<0.01) and bone mineral density (p<0.005). These changes were accompanied by an increase in calcification density (number of calcifications per mm2) of von Kossa-stained aortic sinus atheroma (461 versus 200, p<0.01). Paricalcitol administration suppressed parathyroid hormone (p<0.001), elevated plasma calcium phosphate product (p<0.005) and induced an increase in calcification density (472 versus 200, p<0.005) similar to that seen with vitamin D deficiency. Atheroma burden, blood pressure, metabolic profile and measures of left ventricular hypertrophy were unaffected by the interventions. Conclusion Vitamin D deficiency, as well as excess, increases atherosclerotic calcification. This phenotype is induced before other measures of cardiovascular pathology associated clinically with vitamin D deficiency. Thus, maintenance of an optimal range of vitamin D signalling may be important for prevention of atherosclerotic calcification.
Avantaje competitive n teritorii identitar-productive din spa iul rural romanesc – cazul zonelor viticole
Alina Chico
Urbanism. Arhitectura. Constructii , 2010,
Abstract: The analysis focused on shaping and describing some identity-producing categories of territories, focusing on those with a potential for the wine industry, starting from the premise according to which natural resources of a territory could not only represent a comparative advantage for the economic development of a region, but especially a competitive advantage. Laborious analyses performed at this stage confirm the competitive advantage theory for the Romanian regions of development as well, since 2003 and 2007 comparative data aggregated per region indicate that the regions with the highest potential for a culture have in 2007 the lowest production for the respective culture, confirming the insufficiency of the comparative advantage, of favorable natural conditions existing in a economy. The objective of the phase proposed initially was reached by demonstrating the importance of competitive advantage in stimulating the increase of competitiveness in the rural space. The detailed presentation of productive potential, presented in graphs at different territorial levels could support the next phase of the project, aiming to analyze the stimulation of rural development in identity producing territories starting from underlining the restrictive factors for the valorization of the agricultural potential of the Romanian rural space, especially those related to the national spatial planning policies.
Vrancea Vineyard: A Rural Area with a European Comparative Advantage –The Wine
Romanian Review of Regional Studies , 2008,
Abstract: This article intends to disseminate the partial results of a work that lasted more than three years and involved a substantial number of resources at both national and international level within the COHESION Project, implemented under the C.I.P. Interreg IIIB CADSES Neighbourhood Program. The Vrancea vineyard was the pilot area for the Romanian study and the main activities of the Romanian team (Urbanproiect Bucuresti, Partner Project no.13) within the project has been focused on this area.The COHESION (Integrated COncepts EnHancing CohESion of EurOpeaN Space) Project aimed at enforcing the cohesion of the CADSES area, through developing policies to meet the problems of the European rural space. To this context, the project developed during 2003-2005 applied a methodology focused on increasing competitiveness of areas. An indicative product (wine), in which the involved areas provide a comparative advantage, has been targeted and integrated development pilot projects have been implemented in the participating areas. The Project's area of intervention consisted in the territories of Karditsa, Achaia and Nemea in Greece, the territory of Steirisches Vulkanland in Austria, Meissen in Germany, Appennino Reggiano in Italy, Northwest Bohemia in Czech Republic, and Vrancea in Romania.The aim of the project was “to investigate the development process in remote agricultural areas from practical point of view, i.e. locate the factors that hamper or promote local development in the remote agricultural zones of the CADSES area, and provide this information to other local development actors, so as to facilitate their action and thus contribute to accelerating convergence of the space in question and cohesion of the European territory” (PINDOS Strategic Planning Centre, 2006). The approach planned and applied by COHESION was the bottom up approach. Parallel and similar development projects (pilot activities) were generated in a number of the areas involved and the experience acquired by the project partners was compared and examined. A synthesis of the particular experience in the form of recommendations and hints to potential local development actors was elaborated under a final manual, a methodological guide for local development actors, so as to help people involved in the development practice to avoid mistakes and better plan their actions and thus become more efficient in their mission.
Estudio de los mecanismos de degradación de la interfase acero (limpio u oxidado)-recubrimiento clorocaucho en su exposición al ensayo de condensación de humedad
Chico, B.,Feliu, S.
Revista de Metalurgia , 1998,
Abstract: The effect of time of exposure to the humidity on the behaviour of the system chlorinated rubber paint-steel substrate (cleaned or pre-rusted) is investigated from the interfacial chemistry and adhesion points of view. After one day of humidity exposure, the paint-rust free steel substrate system shows an increase of adhesion. A maximum adhesion value is obtained after 15 days of exposure. This behaviour is similar to that previously described for a pre-rusted steel substrate. After 30-60 days of exposure, the adhesion strength values show an important reduction and the locus of adhesion loss shifts from the paint inside to the interphase between the metallic substrate and the paint. En el presente trabajo se analiza el efecto de la exposición a la humedad de un recubrimiento orgánico de clorocaucho aplicado a un sustrato de acero (únicamente limpio o previamente oxidado) sobre los valores de adherencia del sistema y la composición química de la interfase metal-pintura. Se ha intentado establecer posibles relaciones entre la degradación de la interfase acero-recubrimiento clorocaucho en su exposición a condiciones de alta humedad y la presencia o ausencia de una capa de óxido sobre el sustrato original. Después de 1 día de exposición a la humedad, se observó un aumento en los valores de adherencia del sistema pintura-acero sin oxidar. Sorprendentemente, estos valores alcanzan un máximo después de 15 días de exposición. Este mismo comportamiento se había encontrado ya en el sistema acero preoxidado-recubrimiento clorocaucho. Tiempos de exposición a la humedad suficientemente largos (30-60 días) producen una acusada disminución en los valores de adherencia y un desplazamiento del lugar donde ocurre el fallo desde el seno de la pintura a la región interfacial entre la pintura y el sustrato.
Negociar la entrada del rey? La entrada real de Juan II en Barcelona
Raufast Chico, Miguel
Anuario de Estudios Medievales , 2006,
Abstract: Based on the archival documents generated by John II’s royal entry to Barcelona as the new king of Aragon in 1458, this article explores the process involved in preparing for this ceremonies. It also aims to show that in certain circumstances the dialogue between king and city —the two parties concerned— that led to the final conception of this elaborate ceremony, might almost be considered a kind of negotiation. Basado en documentación archivística generada por la entrada real de Juan II como nuevo monarca de la Corona de Aragón en Barcelona en 1458, este artículo llama la atención sobre el proceso de preparación de este tipo de ceremonias, en el cual intervienen tanto el rey como la ciudad. Al mismo tiempo, se intenta mostrar que el diálogo que se establece entre ambas partes en relación a este hecho puede llegar, en determinadas circunstancias, a asimilarse a una negociación.
E vingueren los officis e confraries ab llurs entremeses e balls . Una aproximación al estamento artesanal en la Barcelona bajomedieval, a partir del estudio de las ceremonias de entrada real
Raufast Chico, Miguel
Anuario de Estudios Medievales , 2006,
Abstract: This article has two objectives. On the one hand, to show to what extent the study of collective urban ceremonies, and specifically royal entries, in Barcelona in the late Middle Ages, is able to furnish useful information for our knowledge of the artesan class and its associations. At the same time, focusing on the participation of the said class in the above mentioned ceremonies can help to make more vivid the image which we have of these events. Dos son los objetivos que confluyen en este artículo. Por un lado, mostrar hasta qué punto el estudio de las ceremonias colectivas urbanas, y en concreto de las entradas reales, en la Barcelona bajomedieval, es capaz de suministrar información útil para el conocimiento del estamento artesanal y de sus mecanismos asociativos. Al mismo tiempo, la atención sobre la participación de dicho estamento en las mencionadas ceremonias puede contribuir a dinamizar la visión, en ocasiones excesivamente escénica, que poseemos de dichos eventos.
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