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Search Results: 1 - 10 of 153236 matches for " Tim H Mauchline "
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The genome of Rhizobium leguminosarum has recognizable core and accessory components
J Peter W Young, Lisa C Crossman, Andrew WB Johnston, Nicholas R Thomson, Zara F Ghazoui, Katherine H Hull, Margaret Wexler, Andrew RJ Curson, Jonathan D Todd, Philip S Poole, Tim H Mauchline, Alison K East, Michael A Quail, Carol Churcher, Claire Arrowsmith, Inna Cherevach, Tracey Chillingworth, Kay Clarke, Ann Cronin, Paul Davis, Audrey Fraser, Zahra Hance, Heidi Hauser, Kay Jagels, Sharon Moule, Karen Mungall, Halina Norbertczak, Ester Rabbinowitsch, Mandy Sanders, Mark Simmonds, Sally Whitehead, Julian Parkhill
Genome Biology , 2006, DOI: 10.1186/gb-2006-7-4-r34
Abstract: The 7.75 Mb genome comprises a circular chromosome and six circular plasmids, with 61% G+C overall. All three rRNA operons and 52 tRNA genes are on the chromosome; essential protein-encoding genes are largely chromosomal, but most functional classes occur on plasmids as well. Of the 7,263 protein-encoding genes, 2,056 had orthologs in each of three related genomes (Agrobacterium tumefaciens, Sinorhizobium meliloti, and Mesorhizobium loti), and these genes were over-represented in the chromosome and had above average G+C. Most supported the rRNA-based phylogeny, confirming A. tumefaciens to be the closest among these relatives, but 347 genes were incompatible with this phylogeny; these were scattered throughout the genome but were over-represented on the plasmids. An unexpectedly large number of genes were shared by all three rhizobia but were missing from A. tumefaciens.Overall, the genome can be considered to have two main components: a 'core', which is higher in G+C, is mostly chromosomal, is shared with related organisms, and has a consistent phylogeny; and an 'accessory' component, which is sporadic in distribution, lower in G+C, and located on the plasmids and chromosomal islands. The accessory genome has a different nucleotide composition from the core despite a long history of coexistence.The symbiosis between legumes and N2-fixing bacteria (rhizobia) is of huge agronomic benefit, allowing many crops to be grown without N fertilizer. It is a sophisticated example of coupled development between bacteria and higher plants, culminating in the organogenesis of root nodules [1]. There have been many genetic analyses of rhizobia, notably of Sinorhizobium meliloti (the symbiont of alfalfa), Bradyrhizobium japonicum (soybean), and Rhizobium leguminosarum, which has biovars that nodulate peas and broad beans (biovar viciae), clovers (biovar trifolii), or kidney beans (biovar phaseoli).The Rhizobiales, an α-proteobacterial order that also includes mammalian pathogens B
Rezension: Abraham David, Anke K ltsch und Stephan Wendehorst: Leipziger Judentümer in Stadt und Universit t. Katalog zur gleichnamigen Ausstellung in der Bibliotheca Albertina Leipzig vom 13. Januar bis 25. April 2010 Leipzig 2010
Tim H. Deubel
AEON : Forum für Junge Geschichtswissenschaft , 2010,
Abstract: Abraham David, Anke K ltsch und Stephan Wendehorst Leipziger Judentümer in Stadt und Universit t.Katalog zur gleichnamigen Ausstellung in der Bibliotheca AlbertinaLeipzig vom 13. Januar bis 25. April 2010Leipzig 2010
Charge Symmetry Breaking in 500 MeV Nucleon-Trinucleon Scattering
Tim Mefford,Rubin H. Landau
Physics , 1995, DOI: 10.1103/PhysRevC.52.1212
Abstract: Elastic nucleon scattering from the 3He and 3H mirror nuclei is examined as a test of charge symmetry violation. The differential cross-sections are calculated at 500 MeV using a microsopic, momentum-space optical potential including the full coupling of two spin 1/2 particles and an exact treatment of the Coulomb force. The charge-symmetry-breaking effects investigated arise from a violation within the nuclear structure, from the p-nucleus Coulomb force, and from the mass-differences of the charge symmetric states. Measurements likely to reveal reliable information are noted.
Array Size Reduction for High-Rank LOS MIMO ULAs
Tim H?lsig,Berthold Lankl
Mathematics , 2015,
Abstract: In this paper we propose an extended LOS MIMO channel model, which considers an additional phase shifting term in the transmission path, and which provides the potential to improve channel conditioning significantly. We show that this phase shifting can, for example, be achieved by adding a dielectric material between the transmitting and receiving antennas, where the phase shift is dependent on the distance the waves travel in the medium. Using that distance as a design parameter we demonstrate that the optimal spacing between antenna elements of uniform linear arrays, achieving full spatial multiplexing, can be reduced compared with the well-known spacing criterion from previous investigations.
Update on the pathophysiology of degenerative disc disease and new developments in treatment strategies
Adam H Hsieh, S Tim Yoon
Open Access Journal of Sports Medicine , 2010, DOI: http://dx.doi.org/10.2147/OAJSM.S9057
Abstract: ate on the pathophysiology of degenerative disc disease and new developments in treatment strategies Review (4449) Total Article Views Authors: Adam H Hsieh, S Tim Yoon Published Date October 2010 Volume 2010:1 Pages 191 - 199 DOI: http://dx.doi.org/10.2147/OAJSM.S9057 Adam H Hsieh1,2 , S Tim Yoon3 1Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA; 2Department of Orthopedics, University of Maryland, Baltimore, MD, USA; 3Department of Orthopedic Surgery, Emory University, Chief of Orthopedic Surgery, Veterans Affairs Medical Center, Atlanta, GA, USA Abstract: Degenerative disc disease (DDD) continues to be a prevalent condition that afflicts populations on a global scale. The economic impact and decreased quality of life primarily stem from back pain and neurological deficits associated with intervertebral disc degeneration. Although much effort has been invested into understanding the etiology of DDD and its relationship to the onset of back pain, this endeavor is a work in progress. The purpose of this review is to provide focused discussion on several areas in which recent advances have been made. Specifically, we have categorized these advances into early, middle, and late phases of age-related or degenerative changes in the disc and into promising minimally invasive treatments, which aim to restore mechanical and biological functions to the disc.
The Retention of Experienced Faculty in Online Distance Education Programs: Understanding Factors that Impact their Involvement
Tim Green,Jeffery Alejandro,Abbie H. Brown
International Review of Research in Open and Distance Learning , 2009,
Abstract: The study sought to determine factors that affect faculty decisions regarding their involvement in teaching online distance education courses. A survey was administered to online distance education faculty across the United States to determine those factors that encourage or discourage them from continuing to teach online courses. The factors were examined and reported from the standpoint of each of four faculty groups: (1) tenured, (2) tenure-track, (3) full-time non-tenured/fixed term, and (4) part-time/adjunct. From the survey responses (N = 135), a list of retention strategies that university administrators may use for retention of online distance education faculty are offered.
Update on the pathophysiology of degenerative disc disease and new developments in treatment strategies
Adam H Hsieh,S Tim Yoon
Open Access Journal of Sports Medicine , 2010,
Abstract: Adam H Hsieh1,2 , S Tim Yoon31Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA; 2Department of Orthopedics, University of Maryland, Baltimore, MD, USA; 3Department of Orthopedic Surgery, Emory University, Chief of Orthopedic Surgery, Veterans Affairs Medical Center, Atlanta, GA, USAAbstract: Degenerative disc disease (DDD) continues to be a prevalent condition that afflicts populations on a global scale. The economic impact and decreased quality of life primarily stem from back pain and neurological deficits associated with intervertebral disc degeneration. Although much effort has been invested into understanding the etiology of DDD and its relationship to the onset of back pain, this endeavor is a work in progress. The purpose of this review is to provide focused discussion on several areas in which recent advances have been made. Specifically, we have categorized these advances into early, middle, and late phases of age-related or degenerative changes in the disc and into promising minimally invasive treatments, which aim to restore mechanical and biological functions to the disc.Keywords: degenerative disc disease, quality of life, intervertebral, aging
Cosmological back-reaction in modified gravity and its implications for dark energy
Anthony W. H. Preston,Tim R. Morris
Physics , 2014, DOI: 10.1088/1475-7516/2014/09/017
Abstract: We study the effective stress-energy tensor induced by cosmological inhomogeneity in $f(R)=R+cR^2$ and equivalent scalar-tensor theories, motivated both by models of early universe inflation and by phenomenological alternative cosmologies to the standard $\Lambda$-CDM. We use Green and Wald's framework for averaging over classical fluctuations of short-wavelength $\lambda$. By ensuring that the leading non-linear terms from the fluctuations of the Einstein terms and the corrections both contribute in the formal limit as $\lambda\to0$, we derive a diffeomorphism invariant effective stress-energy tensor whose trace is non-vanishing and of the right sign to potentially account for the current acceleration of the universe. However a more phenomenologically acceptable dark energy model would be required if this effect were to fully account for the current acceleration.
A Study on Configuration and Integration of Sub-Systems to System-of-Systems with Rule Verification  [PDF]
Tim Warnecke
Engineering (ENG) , 2015, DOI: 10.4236/eng.2015.710056
Abstract: Increasing complexity of today’s software systems is one of the major challenges software engineers have to face. This is aggravated by the fact that formerly isolated systems have to be interconnected to more complex systems, called System-of-Systems (SoS). Those systems are in charge to provide more functionality to the user than all of their independent sub-systems could do. Reducing the complexity of such systems is one goal of the software engineering paradigm called component-based software engineering (CBSE). CBSE enables the developers to treat individual sub-systems as components which interact via interfaces with a simulated environment. Thus those components can be developed and implemented independently from other components. After the implementation a system integrator is able to interconnect the components to a SoS. Despite this much-used approach it is possible to show that constraints, which are valid in an isolated sub-system, are broken after this system is integrated into a SoS. To emphasize this issue we developed a technique based on interconnected timed automata for modelling sub-systems and System-of-Systems in the model checking tool UPPAAL. The presented modelling technique allows it to verify the correctness of single sub-systems as well as the resulting SoS. Additionally we developed a tool which abstracts the complicated timed automata to an easy to read component based language with the goal to help system integrators building and verifying complex SoS.
Open-Label, Pilot Study of the Safety and Clinical Effects of Rituximab in Patients with Rheumatoid Arthritis-Associated Interstitial Pneumonia  [PDF]
Eric L. Matteson, Tim Bongartz, Jay H. Ryu, Cynthia S. Crowson, Thomas E. Hartman, Paul F. Dellaripa
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2012, DOI: 10.4236/ojra.2012.23011
Abstract: Objective: To investigate the clinical effect of rituximab (RTX) in the management of progressive rheumatoid arthritis related interstitial lung disease (RA-ILD). Methods: A total of 10 patients with progressive RA-ILD were enrolled into this 48-week, open-label treatment study. Treatment was with RTX at 1000 mg at day 1, day 15, and again at weeks 24 and 26, with concomitant methotrexate therapy. Results: The study included 4 men and 6 women. Of 7 evaluable patients at week 48, the diffusing capacity to carbon monoxide had worsened by at least 15% in 1 patient, was stable in 4 patients, and increased by >15% of baseline value in 2 patients. The forced vital capacity declined by at least 10% in 1 patient, was stable in 4 patients, and increased by at least 10% in 2 patients. High resolution computed tomo-graphy of the chest showed improvement in 1 patient, and was unchanged in 5. Three patients were withdrawn, one who had an infusion reaction at week 0, one at week 5 who was hospitalized for congestive heart failure at week 5 and who later died at week 32 of complications following a traumatic hip fracture, and one died at week 6 of possible pneumonia. Conclusions: In this pilot study of 10 patients with RA-ILD treated with RTX, measures of lung disease remained stable in the majority of study completers. Further research is needed to clarify whether this treatment has a role in management of RA-ILD.
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