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Search Results: 1 - 10 of 171542 matches for " Tim E Lenz "
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Prevalence of antibody to Trypanosoma cruzi in Hispanic-surnamed patients seen at Parkland Health & Hospital System, Dallas, Texas
Roberto Arena, Christine E Mathews, Anne Y Kim, Tim E Lenz, Paul M Southern
BMC Research Notes , 2011, DOI: 10.1186/1756-0500-4-132
Abstract: Five hundred serum specimens from Hispanic-surnamed patients were tested by a preliminary ELISA method. On a subset of 50 sera confirmatory testing was also performed using an alternative ELISA, indirect immunofluorescence, and TESA immunoblot. For 274 of 500 Hispanic-surnamed patients, we were able to ascertain immigration status upon medical chart review. Of the 274 sera analyzed, one sample tested as positive for anti-T. cruzi antibody by the preliminary ELISA, and by the three confirmatory methods.The goal of this study is to increase the awareness of T. cruzi infection and Chagas disease in areas where the Latin American immigrant communities are growing. Our study highlights the importance of testing for Chagas disease in the populations most at risk, and the need for current data on the actual seroprevalence in areas where such immigrant populations are conspicuous. Larger-scale epidemiologic surveys on Chagas disease in the immigrant communities from Latin America are warranted.Chagas disease, also known as American trypanosomiasis, is an infection caused by the parasite Trypanosoma cruzi. This parasite is usually transmitted to humans by Triatominae insects as vectors. Transmission of the infection also occurs transplacentally, via blood transfusion, organ transplantation, laboratory incident, and ingestion of triatomine-contaminated food or drink [1-12]. Chagas disease has an acute stage, typically asymptomatic or with mild symptoms (e.g., fever, malaise, swelling at the site of inoculation, and lymphadenopathy) during the first 6 to 8 weeks after infection. This acute stage is often undetected and thus not treated. If not treated, Chagas disease becomes a chronic, lifelong condition which can go undetected for several decades in any given patient. The majority of infected persons remain asymptomatic in the chronic indeterminate phase (i.e., a prolonged period of clinically silent infection that follows acute primary infection). However, an estimated ~30%
"The Practice Doctorate in Nursing: An Idea Whose Time Has Come"
Lenz, E.R
Online Journal of Issues in Nursing , 2005,
Abstract: The practice-focused doctorate is an important alternative to research-focused doctorates in nursing. The goal of this article is to provide the reader with an understanding of the nature and potential benefits of the practice doctorate. After discussing the background of this doctoral degree and the development of the degree by the American Association of Colleges of Nursing (AACN) Task Force on the Practice Doctorate in Nursing, the article will describe patterns in practice-focused doctoral education and issues considered by the task force in developing the position paper on the practice doctorate in nursing. A look ahead provides an update on current steps being taken by AACN and others toward implementing the task force recommendations.
Screening for Somatoform Disorders in Children and Adolescents  [PDF]
S. Winter, C. Quinn, K. Lenz, E. Pfeiffer, U. Lehmkuhl
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.514173
Abstract: Until now, no German diagnostic instrument existed for somatoform disorders in children and adolescents. Therefore the Screening for Somatoform Disorders in Children and Adolescents (SOMS-CA) was developed based on the SOMS-2 (Screening for Somatoform Disorders 2) (Rief & Hiller, 2008). This study investigates to what extent the SOMS-CA can differentiate significantly between children and adolescents with clinically diagnosed somatoform disorders and a control group and whether the SOMS-CA is superior to the GSCL-C (Giessen Subjective Complaint List for Children) (Braehler, 1992). 30 patients (11 - 17 years) with somatoform disorders and a control group (n = 31) were examined with the SOMS-CA (N = 61). The results from the SOMS-CA in both groups were compared with one another by means of a contingency analysis (chi-square test). The sensitivity and specificity were calculated and an optimal cut-off value was determined (Receiver Operating Characteristic curve (ROC-curve) analysis). A comparison analysis of the ROC-curves of the SOMS-CA and the GSCL-C followed. The sum score of complaints in the patients was significantly higher than that in the control group. The ROC-curve for the SOMS-CA demonstrates its excellent ability to differentiate between the two groups with an AUC (area under the curve) = 0.983 (SE = 0.14; N = 61). The sensitivity was 97.6%, the specificity 96.8%. In comparison to the AUC of the GSCL-C the SOMS-CA shows a much higher result. The SOMS-CA successfully identifies patients with somatoform disorders from a paediatric population and differentiates from healthy test subjects. A comparison to the GSCL-C shows a considerable superiority of the SOMS-CA. Further studies on the validity of the SOMS-CA are necessary.
Signatures of Confinement in Axial Gauge QCD
F. Lenz,E. J. Moniz,M. Thies
Physics , 1994, DOI: 10.1006/aphy.1995.1087
Abstract: A comparative dynamical study of axial gauge QED and QCD is presented. Elementary excitations associated with particular field configurations are investigated. Gluonic excitations analogous to linearly polarized photons are shown to acquire infinite energy. Suppression of this class of excitations in QCD results from quantization of the chromelectric flux and is interpreted as a dual Meissner effect, i.e. as expulsion from the QCD vacuum of chromo-electric fields which are constant over significant distances. This interpretation is supported by a comparative evaluation of the interaction energy of static charges in the axial gauge representation of QED and QCD.
Análise da rejei??o nos pacientes transplantados por anemia aplástica severa condicionados com ciclofosfamida ou a associa??o desta ao bussulfano
Silva, Lídice C. Lenz e;Pasquini, Ricardo;
Revista Brasileira de Hematologia e Hemoterapia , 2005, DOI: 10.1590/S1516-84842005000100004
Abstract: bone marrow transplantation is an effective therapy for severe aplastic anemia and is generally considered the preferable treatment for young patients who have an hla (human leukocyte antigen) identical sibling donor. recent studies report 55% to 80% extended survival. graft failure owing to rejection or others causes remains an important life-threatening complication following allogeneic bone marrow transplantation for aplastic anemia. it occurs in 55% to 60% of patients receiving hla identical transplants, using different immunosuppressive therapies before and after transplant. the bmt unit of federal university of paraná had 178 cases of saa transplants from 1993 to 2001 using either cyclophosphamide (cy) alone or associated with busulfan (cy+bu) for conditioning regimen. graft failure occurred in 39 of the cases. among patients conditioned with cy, 24 (46%) presented graft failure, of whom 3 (6%) suffered primary graft failures and 21 (40%) transient engraftment. among patients conditioned with bu+cy, 15 (12%) suffered graft failure, 4 (3%) primary graft failures and 11 (9%) transient engraftment. the patients conditioned with cy and experienced rejection had a survival of around 80%, because they underwent another transplantation or due to immunosuppressive treatment with cyclosporin a. the patients conditioned with bu+cy who suffered rejections had a survival of approximately 35%.
Analysis of the Distribution and Temporal Trends of Grade and Stage in Urothelial Bladder Cancer in Northern New England from 1994 to 2004
Alan R. Schned,Petra Lenz,Lee E. Moore,Alison Johnson
ISRN Pathology , 2012, DOI: 10.5402/2012/283670
Abstract:
Light-Cone Sum Rules for the Nucleon Form Factors
V. M. Braun,A. Lenz,N. Mahnke,E. Stein
Physics , 2001, DOI: 10.1103/PhysRevD.65.074011
Abstract: We argue that soft non-factorisable terms give a significant contribution to the baryon form factors at intermediate momentum transfers and set up a framework for the calculation of such terms in the light-cone sum rule approach. Among them, contributions of three-quark states with different helicity structure compared to the leading twist prove to be the most important. The leading-order sum rules are derived and confronted with the experimental data.
Analysis of light scattering off photonic crystal slabs in terms of Feshbach resonances
I. Evenor,E. Grinvald,F. Lenz,S. Levit
Physics , 2012, DOI: 10.1140/epjd/e2012-30134-1
Abstract: Techniques to deal with Feshbach resonances are applied to describe resonant light scattering off one dimensional photonic crystal slabs. Accurate expressions for scattering amplitudes, free of any fitting parameter, are obtained for isolated as well as overlapping resonances. They relate the resonance properties to the properties of the optical structure and of the incident light. For the most common case of a piecewise constant dielectric function, the calculations can be carried out essentially analytically. After establishing the accuracy of this approach we demonstrate its potential in the analysis of the reflection coefficients for the diverse shapes of overlapping, interacting resonances.
Collisional Cooling of a Charged Granular Medium
Tim Scheffler,Dietrich E. Wolf
Physics , 1999,
Abstract: The dissipation rate due to inelastic collisions between equally charged, insulating particles in a dilute granular medium is calculated. It is equal to the known dissipation rate for uncharged granular media multiplied by a Boltzmann-like factor, that originates from Coulomb interactions. We include particle correlations by introducing an effective potential, that replaces the bare Coulomb potential in the Boltzmann factor. All results are confirmed by computer simulations.
The RNA interference revolution
Lenz, G.;
Brazilian Journal of Medical and Biological Research , 2005, DOI: 10.1590/S0100-879X2005001200003
Abstract: the discovery of double-stranded rna-mediated gene silencing has rapidly led to its use as a method of choice for blocking a gene, and has turned it into one of the most discussed topics in cell biology. although still in its infancy, the field of rna interference has already produced a vast array of results, mainly in caenorhabditis elegans, but recently also in mammalian systems. micro-rnas are short hairpins of rna capable of blocking translation, which are transcribed from genomic dna and are implicated in several aspects from development to cell signaling. the present review discusses the main methods used for gene silencing in cell culture and animal models, including the selection of target sequences, delivery methods and strategies for a successful silencing. expected developments are briefly discussed, ranging from reverse genetics to therapeutics. thus, the development of the new paradigm of rna-mediated gene silencing has produced two important advances: knowledge of a basic cellular mechanism present in the majority of eukaryotic cells and access to a potent and specific new method for gene silencing.
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