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Search Results: 1 - 10 of 251 matches for " Tilo Mathes "
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Ultrafast Laser Energy Density and Retinal Absorption Cross-Section Determination by Saturable Absorption Measurements  [PDF]
Alfons Penzkofer, Meike Luck, Tilo Mathes, Peter Hegemann
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2014, DOI: 10.4236/jasmi.2014.41003
Abstract:

Laser pulse nonlinear transmission measurements through saturable absorbers of known absorption parameters allow the measurement of their energy density. On the other hand, nonlinear transmission measurements of laser pulses of known energy density through absorbing media allow their absorption parameter determination. The peak energy density w0P of second harmonic pulses of a mode-locked titanium sapphire laser at wavelength λP = 400 nm is determined by nonlinear energy transmission measurement TE through the dye ADS084BE (1,4-bis(9-ethyl-3-car-bazovinylene)-2-methoxy-5-(2’-ethyl-hexyloxy)-benzene) in tetrahydrofuran. TE(w0P) calibration curves are calculated for

Lower frequency region mid-infrared spectroscopy by chirped pulse upconversion
Zhu Jingyi,Mathes Tilo,Stahl Andreas D.,Kennis John T.M.
EPJ Web of Conferences , 2013, DOI: 10.1051/epjconf/20134109004
Abstract: UV/visible pump, mid-IR probe spectroscopy measurements based on the chirped upconversion method were expanded to the frequency region below 1800cm 1 with the nonlinear optical crystal AgGaGeS4. Pump-probe experiments were demonstrated with GaAs and the photoreceptor protein Slr1694.
A Set of Engineered Escherichia coli Expression Strains for Selective Isotope and Reactivity Labeling of Amino Acid Side Chains and Flavin Cofactors
Jennifer Mehlhorn, Helena Steinocher, Sebastian Beck, John T. M. Kennis, Peter Hegemann, Tilo Mathes
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079006
Abstract: Biological reactions are facilitated by delicate molecular interactions between proteins, cofactors and substrates. To study and understand their dynamic interactions researchers have to take great care not to influence or distort the object of study. As a non-invasive alternative to a site-directed mutagenesis approach, selective isotope labeling in combination with vibrational spectroscopy may be employed to directly identify structural transitions in wild type proteins. Here we present a set of customized Escherichia coli expression strains, suitable for replacing both the flavin cofactor and/or selective amino acids with isotope enriched or chemically modified substrates. For flavin labeling we report optimized auxotrophic strains with significantly enhanced flavin uptake properties. Labeled protein biosynthesis using these strains was achieved in optimized cultivation procedures using high cell density fermentation. Finally, we demonstrate how this approach is used for a clear assignment of vibrational spectroscopic difference signals of apoprotein and cofactor of a flavin containing photoreceptor of the BLUF (Blue Light receptors Using FAD) family.
Es gibt keine objektive Subjektivit t in der Untersuchung sozialer Interaktionen There Is No Objective Subjectivity in the Study of Social Interaction No hay subjetividad objetiva en el estudio de la interacción social
Tilo Weber
Forum : Qualitative Social Research , 2003,
Abstract: Die Variante der ethnomethodologischen Konversationsanalyse, die von Emanuel A. SCHEGLOFF vertreten wird, will Diskurs in einer streng empirizistischen Weise analysieren. Dies bedeutet insbesondere, dass der Einfluss der subjektiven Vorannahmen und spezifischen Interessen des Forschers/der Forscherin im Untersuchungsprozess neutralisiert werden sollen. Der vorliegende Beitrag skizziert die Forschungsstrategie SCHEGLOFFs und charakterisiert sie als eine Form des methodischen – im Gegensatz zu einem naiven – epistemologischen Realismus. Es wird deutlich, dass dieser Ansatz die ihm gelegentlich unterstellte Zirkularit t vermeidet. Sein Anspruch jedoch, soziale Interaktion "in ihrem eigenen Recht" zur Geltung zu bringen (vgl. SCHELGOFF 1997a, S.174), erweist sich als uneinl sbar. Dies wird hier in seinen praktischen Konsequenzen am Beispiel eines der klassischen Themen der Konversationsanalyse, den "konversationellen Reparaturen" (vgl. SCHEGLOFF, JEFFERSON & SACKS 1977), illustriert. Es wird gezeigt, dass das Ergebnis jeder konversationsanalytischen Datenanalyse von Vorannahmen und -entscheidungen beeinflusst ist, die die Auswahl, die Aufbereitung und die (Re-) Pr sentation der Daten betreffen, ohne selbst empirisch gerechtfertigt werden zu k nnen. Hieraus wird geschlossen, dass die Angemessenheit konversationsanalytischer Befunde viel eher von den "praktischen Zwecken" derjenigen Prozesse abh ngt, die diese Befunde zu Tage f rdern, als von ihrer übereinstimmung mit dem Diskurs als einer "in sich selbst begründeten eigenen Wirklichkeit" (vgl. SCHEGLOFF 1997a, S.171). Mit dieser Schlussfolgerung wird die ethnomethodologische Einsicht in die lokale Konstruiertheit sozialen Sinns und sozialer Realit t auf die Sozialwissenschaft selbst angewendet. URN: urn:nbn:de:0114-fqs0302432 The variant of ethnomethodological Conversation Analysis (CA) represented and advocated by Emanuel A. SCHEGLOFF pursues the goal of analyzing discourse in a strictly empiricist manner that excludes the impact of the researcher's subjective "preoccupations" and "presuppositions" from the investigative process. This paper outlines the SCHEGLOFFian research strategy and characterizes it as representing a methodologist—as opposed to na ve—variant of epistemological realism. It is argued that this approach, while avoiding circularity, fails to make feasible an "account of the object itself" (SCHEGLOFF 1997a, p.174). This line of argument is illustrated by its practical consequences apropos one of CA's classical themes, viz. conversational repair (cf. SCHEGLOFF, JEFFERSON & SACKS 1977). It is
Das Sandm nnchen, das aus der K lte kam – DDR-Filmproduktionen im Kulturaustausch mit Schweden
Tilo Herrmann
Nordeuropaforum , 2006,
Abstract: This essay uses the example of GDR film export to Sweden to examine specific objectives, internal planning, and results of GDR cultural policy in Sweden. It also investigates the Swedish receptions and the appraisals and patterns of argumentation to be found. The study is based on articles in Swedish daily press and technical journals and on internal documents of the East-German bureaucracy. The analysis is divided into several case studies which are restricted to the late 1960s and early 1970s, the heyday of GDR cultural activities in Sweden. After a glance at the situation in commercial film business, the focus shifts to a series of special film showings at the Swedish Film Institute's film club (SFI:s filmklubb).
Predictions of chiral random matrix theory and lattice QCD results
Tilo Wettig
Physics , 1999,
Abstract: Chiral random matrix theory makes very detailed predictions for the spectral correlations of the QCD Dirac operator, both in the bulk of the spectrum and near zero virtuality. These predictions have been successfully tested in lattice QCD simulations by several groups. Moreover, the domain of validity of random matrix theory has been predicted theoretically and identified in lattice data. In this talk, the current numerical evidence is reviewed.
Performance of machines for lattice QCD simulations
Tilo Wettig
Physics , 2005,
Abstract: We review the architecture of massively parallel machines used for lattice QCD simulations and present benchmarks for the performance of popular algorithms on these platforms. We cover commercial supercomputers, PC clusters, and custom-designed machines. We also speculate on future developments.
Facial transplantation: a review of ethics, progress, and future targets
Edwards JA, Mathes DW
Transplant Research and Risk Management , 2011, DOI: http://dx.doi.org/10.2147/TRRM.S6883
Abstract: cial transplantation: a review of ethics, progress, and future targets Review (8787) Total Article Views Authors: Edwards JA, Mathes DW Published Date September 2011 Volume 2011:3 Pages 113 - 125 DOI: http://dx.doi.org/10.2147/TRRM.S6883 James A Edwards1, David W Mathes2 1Department of Plastic and Reconstructive Surgery, Skagit Valley Hospital, Mount Vernon, WA, USA; 2Division of Plastic Surgery, University of Washington Medical Center, Seattle, WA, USA Abstract: The surgical history of transplantation in the modern era begins in 1956 with the successful transplantation of a kidney between identical twins. Since then the field of transplantation has seen remarkable advancements in both surgical techniques and our understanding and ability to manipulate the immune response. Composite tissue allotransplantation involves the transplantation of any combination of vascularized skin, subcutaneous tissue, blood vessels, nerves, muscle, and bone. Orthotopic hand transplantation is considered the first clinical example of CTA and has seen success at many different centers worldwide. Facial allotransplantation is a recent development in the field of CTA and the first successful case was performed as recently as November 2005. Since then there have been a number of successful facial transplants. The purpose of this paper is to examine some of the issues surrounding facial transplantation including the complex ethical issues, the surgical and clinical issues, cost and administrative issues, and future directions for this new, exciting, and controversial field.
Facial transplantation: a review of ethics, progress, and future targets
Edwards JA,Mathes DW
Transplant Research and Risk Management , 2011,
Abstract: James A Edwards1, David W Mathes21Department of Plastic and Reconstructive Surgery, Skagit Valley Hospital, Mount Vernon, WA, USA; 2Division of Plastic Surgery, University of Washington Medical Center, Seattle, WA, USAAbstract: The surgical history of transplantation in the modern era begins in 1956 with the successful transplantation of a kidney between identical twins. Since then the field of transplantation has seen remarkable advancements in both surgical techniques and our understanding and ability to manipulate the immune response. Composite tissue allotransplantation involves the transplantation of any combination of vascularized skin, subcutaneous tissue, blood vessels, nerves, muscle, and bone. Orthotopic hand transplantation is considered the first clinical example of CTA and has seen success at many different centers worldwide. Facial allotransplantation is a recent development in the field of CTA and the first successful case was performed as recently as November 2005. Since then there have been a number of successful facial transplants. The purpose of this paper is to examine some of the issues surrounding facial transplantation including the complex ethical issues, the surgical and clinical issues, cost and administrative issues, and future directions for this new, exciting, and controversial field.Keywords: composite tissue allograft, facial transplantation
Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors
Alexander M Mathes
World Journal of Gastroenterology , 2010,
Abstract: Melatonin, the hormone of darkness and messenger of the photoperiod, is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone’s intense radical scavenging capacity. The present report reviews the hepatoprotective potential of the pineal hormone in various models of oxidative stress in vivo, and summarizes the extensive literature showing that melatonin may be a suitable experimental substance to reduce liver damage after sepsis, hemorrhagic shock, ischemia/reperfusion, and in numerous models of toxic liver injury. Melatonin’s influence on hepatic antioxidant enzymes and other potentially relevant pathways, such as nitric oxide signaling, hepatic cytokine and heat shock protein expression, are evaluated. Based on recent literature demonstrating the functional relevance of melatonin receptor activation for hepatic organ protection, this article finally suggests that melatonin receptors could mediate the hepatoprotective actions of melatonin therapy.
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