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Search Results: 1 - 10 of 93282 matches for " Tie-Lin Yang "
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Genome-Wide Association Study Identified Copy Number Variants Important for Appendicular Lean Mass
Shu Ran, Yong-Jun Liu, Lei Zhang, Yufang Pei, Tie-Lin Yang, Rong Hai, Ying-Ying Han, Yong Lin, Qing Tian, Hong-Wen Deng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089776
Abstract: Skeletal muscle is a major component of the human body. Age-related loss of muscle mass and function contributes to some public health problems such as sarcopenia and osteoporosis. Skeletal muscle, mainly composed of appendicular lean mass (ALM), is a heritable trait. Copy number variation (CNV) is a common type of human genome variant which may play an important role in the etiology of many human diseases. In this study, we performed genome-wide association analyses of CNV for ALM in 2,286 Caucasian subjects. We then replicated the major findings in 1,627 Chinese subjects. Two CNVs, CNV1191 and CNV2580, were detected to be associated with ALM (p = 2.26×10?2 and 3.34×10?3, respectively). In the Chinese replication sample, the two CNVs achieved p-values of 3.26×10?2 and 0.107, respectively. CNV1191 covers a gene, GTPase of the immunity-associated protein family (GIMAP1), which is important for skeletal muscle cell survival/death in humans. CNV2580 is located in the Serine hydrolase-like protein (SERHL) gene, which plays an important role in normal peroxisome function and skeletal muscle growth in response to mechanical stimuli. In summary, our study suggested two novel CNVs and the related genes that may contribute to variation in ALM.
The Fat Mass and Obesity Associated Gene, FTO, Is Also Associated with Osteoporosis Phenotypes
Yan Guo, Hui Liu, Tie-Lin Yang, Siyang M. Li, Siyuan K. Li, Qing Tian, Yong-Jun Liu, Hong-Wen Deng
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027312
Abstract: Obesity and osteoporosis are closely correlated genetically. FTO gene has been consistently identified to be associated with obesity phenotypes. A recent study reported that the mice lacking Fto could result in lower bone mineral density (BMD). Thus, we hypothesize that the FTO gene might be also important for osteoporosis phenotypes. To test for such a hypothesis, we performed an association analyses to investigate the relationship between SNPs in FTO and BMD at both hip and spine. A total of 141 SNPs were tested in two independent Chinese populations (818 and 809 unrelated Han subjects, respectively) and a Caucasian population (2,286 unrelated subjects). Combining the two Chinese samples, we identified 6 SNPs in FTO to be significantly associated with hip BMD after multiple testing adjustments, with the combined P values ranged from 4.99×10?4–1.47×10?4. These 6 SNPs are all located at the intron 8 of FTO and in high linkage disequilibrium. Each copy of the minor allele of each SNP was associated with increased hip BMD values with the effect size (beta) of ~0.025 and ~0.015 in the Chinese sample 1 and 2, respectively. However, none of these 6 SNPs showed significant association signal in the Caucasian sample, by presenting some extent of ethnic difference. Our findings, together with the prior biological evidence, suggest that the FTO gene might be a new candidate for BMD variation and osteoporosis in Chinese populations.
Corrosion Behavior of Cu60Zr30Ti10 Metallic Glass in the Cl Containing Solution  [PDF]
Wei-Ke An, An-Hui Cai, Xiang Xiong, Yong Liu, Yun Luo, Tie-Lin Li, Xiao-Song Li
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.26073
Abstract: Cu60Zr30Ti10 (at. %) ribbon was prepared by melt spinning. Its glassy structure was confirmed by X-ray diffraction (XRD). Its corrosion behavior in HCl and NaCl solutions was investigated by electrochemical polarization measurement. The surfaces before and after corrosion were observed with scanning electron microscope (SEM) and analysis was performed using electron dispersive spectroscopy (EDS). The results show that the decrease of current density is due to the formation of a mixture of simple oxides or complex oxidic compounds. In both cases, the corrosion potential decreases with increasing chloride concentration. The passive film forms easier in HCl than in NaCl. In addition, the higher is the chloride concentration, the easier is the passivation.
Genome-Wide Association Study Identified CNP12587 Region Underlying Height Variation in Chinese Females
Yin-Ping Zhang, Fei-Yan Deng, Tie-Lin Yang, Feng Zhang, Xiang-Ding Chen, Hui Shen, Xue-Zheng Zhu, Qing Tian, Hong-Wen Deng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044292
Abstract: Introduction Human height is a highly heritable trait considered as an important factor for health. There has been limited success in identifying the genetic factors underlying height variation. We aim to identify sequence variants associated with adult height by a genome-wide association study of copy number variants (CNVs) in Chinese. Methods Genome-wide CNV association analyses were conducted in 1,625 unrelated Chinese adults and sex specific subgroup for height variation, respectively. Height was measured with a stadiometer. Affymetrix SNP6.0 genotyping platform was used to identify copy number polymorphisms (CNPs). We constructed a genomic map containing 1,009 CNPs in Chinese individuals and performed a genome-wide association study of CNPs with height. Results We detected 10 significant association signals for height (p<0.05) in the whole population, 9 and 11 association signals for Chinese female and male population, respectively. A copy number polymorphism (CNP12587, chr18:54081842-54086942, p = 2.41×10?4) was found to be significantly associated with height variation in Chinese females even after strict Bonferroni correction (p = 0.048). Confirmatory real time PCR experiments lent further support for CNV validation. Compared to female subjects with two copies of the CNP, carriers of three copies had an average of 8.1% decrease in height. An important candidate gene, ubiquitin-protein ligase NEDD4-like (NEDD4L), was detected at this region, which plays important roles in bone metabolism by binding to bone formation regulators. Conclusions Our findings suggest the important genetic variants underlying height variation in Chinese.
Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking
Yu-Fang Pei, Lei Zhang, Tie-Lin Yang, Yingying Han, Rong Hai, Shu Ran, Qing Tian, Hui Shen, Jian Li, Xue-Zhen Zhu, Xingguang Luo, Hong-Wen Deng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030860
Abstract: Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array. We identified two CNVs, CNV207 (combined p-value 1.91E-03) and CNV1836 (combined p-value 3.05E-03) that were associated with alcohol drinking. CNV207 and CNV1836 are located at the downstream of genes LTBP1 (870 kb) and FGD4 (400 kb), respectively. LTBP1, by interacting TGFB1, may down-regulate enzymes directly participating in alcohol metabolism. FGD4 plays a role in clustering and trafficking GABAA receptor and subsequently influence alcohol drinking through activating CDC42. Our results provide suggestive evidence that the newly identified CNV regions and relevant genes may contribute to the genetic mechanism of alcohol dependence.
Copy Number Variation in CNP267 Region May Be Associated with Hip Bone Size
Shan-Lin Liu, Shu-Feng Lei, Fang Yang, Xi Li, Rong Liu, Shan Nie, Xiao-Gang Liu, Tie-Lin Yang, Yan Guo, Fei-Yan Deng, Qing Tian, Jian Li, Yao-Zhong Liu, Yong-Jun Liu, Hui Shen, Hong-Wen Deng
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022035
Abstract: Osteoporotic hip fracture (HF) is a serious global public health problem associated with high morbidity and mortality. Hip bone size (BS) has been identified as one of key measurable risk factors for HF, independent of bone mineral density (BMD). Hip BS is highly genetically determined, but genetic factors underlying BS variation are still poorly defined. Here, we performed an initial genome-wide copy number variation (CNV) association analysis for hip BS in 1,627 Chinese Han subjects using Affymetrix GeneChip Human Mapping SNP 6.0 Array and a follow-up replicate study in 2,286 unrelated US Caucasians sample. We found that a copy number polymorphism (CNP267) located at chromosome 2q12.2 was significantly associated with hip BS in both initial Chinese and replicate Caucasian samples with p values of 4.73E-03 and 5.66E-03, respectively. An important candidate gene, four and a half LIM domains 2 (FHL2), was detected at the downstream of CNP267, which plays important roles in bone metabolism by binding to several bone formation regulator, such as insulin-like growth factor-binding protein 5 (IGFBP-5) and androgen receptor (AR). Our findings suggest that CNP267 region may be associated with hip BS which might influence the FHL2 gene downstream.
Bivariate Genome-Wide Association Analyses Identified Genes with Pleiotropic Effects for Femoral Neck Bone Geometry and Age at Menarche
Shu Ran, Yu-Fang Pei, Yong-Jun Liu, Lei Zhang, Ying-Ying Han, Rong Hai, Qing Tian, Yong Lin, Tie-Lin Yang, Yan-Fang Guo, Hui Shen, Inderpal S. Thethi, Xue-Zhen Zhu, Hong-Wen Deng
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060362
Abstract: Femoral neck geometric parameters (FNGPs), which include cortical thickness (CT), periosteal diameter (W), buckling ratio (BR), cross-sectional area (CSA), and section modulus (Z), contribute to bone strength and may predict hip fracture risk. Age at menarche (AAM) is an important risk factor for osteoporosis and bone fractures in women. Some FNGPs are genetically correlated with AAM. In this study, we performed a bivariate genome-wide association study (GWAS) to identify new candidate genes responsible for both FNGPs and AAM. In the discovery stage, we tested 760,794 SNPs in 1,728 unrelated Caucasian subject, followed by replication analyses in independent samples of US Caucasians (with 501 subjects) and Chinese (with 826 subjects). We found six SNPs that were associated with FNGPs and AAM. These SNPs are located in three genes (i.e. NRCAM, IDS and LOC148145), suggesting these three genes may co-regulate FNGPs and AAM. Our findings may help improve the understanding of genetic architecture and pathophysiological mechanisms underlying both osteoporosis and AAM.
Genetic Association Study of Common Mitochondrial Variants on Body Fat Mass
Tie-Lin Yang,Yan Guo,Hui Shen,Shu-Feng Lei,Yong-Jun Liu,Jian Li,Yao-Zhong Liu,Na Yu,Jia Chen,Ting Xu,Yu Cheng,Qing Tian,Ping Yu,Christopher J. Papasian,Hong-Wen Deng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0021595
Abstract: Mitochondria play a central role in ATP production and energy metabolism. Previous studies suggest that common variants in mtDNA are associated with several common complex diseases, including obesity. To test the hypothesis that common mtDNA variants influence obesity-related phenotypes, including BMI and body fat mass, we genotyped a total of 445 mtSNPs across the whole mitochondrial genome in a large sample of 2,286 unrelated Caucasian subjects. 72 of these 445 mtSNPs passed quality control criteria, and were used for subsequent analyses. We also classified all subjects into nine common European haplogroups. Association analyses were conducted for both BMI and body fat mass with single mtSNPs and mtDNA haplogroups. Two mtSNPs, mt4823 and mt8873 were detected to be significantly associated with body fat mass, with adjusted P values of 4.94×10-3 and 4.58×10-2, respectively. The minor alleles mt4823 C and mt8873 A were associated with reduced fat mass values and the effect size (β) was estimated to be 3.52 and 3.18, respectively. These two mtSNPs also achieved nominally significant levels for association with BMI. For haplogroup analyses, we found that haplogroup X was strongly associated with both BMI (adjusted P = 8.31×10-3) and body fat mass (adjusted P = 5.67×10-4) Subjects classified as haplogroup X had lower BMI and fat mass values, with the β estimated to be 2.86 and 6.03, respectively. Our findings suggest that common variants in mitochondria might play a role in variations of body fat mass. Further molecular and functional studies will be needed to clarify the potential mechanism.
Multidisciplinary design optimization methods for aircrafts under large-scale system theory
大系统理论体系下的飞行器多学科设计优化方法

MA Tie-lin,MA Dong-li,
马铁林
,马东立

系统工程理论与实践 , 2009,
Abstract: 阐述了飞行器多学科设计优化方法与大系统理论的关系.在大系统理论体系下根据不同的分类原则和系统的特点将系统逐层分解分类,同时依据大系统理论的分解协调法对现有飞行器多学科设计方法进行了分类,阐明了每种算法的理论背景和适用范围.飞行器设计系统是典型的工程大系统,同时飞行器多学科设计优化方法是以大系统理论为基础的,因此要在研究飞行器多学科设计优化的同时对大系统理论方法进行研究,推动多学科设计优化的发展.
Study and application of optimization algorithm about nonlinear partial differential equations with boundary value problem
非线性偏微分方程边值问题的优化算法研究与应用

Hou Xiang-Lin,Liu Tie-Lin,Zhai Zhong-Hai,
侯祥林
,刘铁林,翟中海

物理学报 , 2011,
Abstract: For elliptic nonlinear partial differential equations with boundary value problem, based on difference method and dynamic design variable optimization method, by taking unknown function value on discrete net point as design variables, difference equation of all the discrete net points is constructed as an objective function. A kind of optimization algorithm about solving unknown function value on discrete net point is proposed. Universal computing program is designed. Practical example is analyzed. By comparing the computing result with the analytical solution, effectiveness and feasibility are verified. Thus complicated nonlinear mathematical physics equations can be solved by the numerical calculation method.
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