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Search Results: 1 - 10 of 31671 matches for " Thomas JL "
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A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation
Mark T Mc Auley, Darren J Wilkinson, Janette JL Jones, Thomas BL Kirkwood
BMC Systems Biology , 2012, DOI: 10.1186/1752-0509-6-130
Abstract: The model was used to test the hypothesis that alterations to the rate of cholesterol absorption and changes to the rate of removal of LDL-C from the plasma are integral to understanding why LDL-C rises with age. The model demonstrates that increasing the rate of intestinal cholesterol absorption from 50% to 80% by age 65 years can result in an increase of LDL-C by as much as 34 mg/dL in a hypothetical male subject. The model also shows that decreasing the rate of hepatic clearance of LDL-C gradually to 50% by age 65 years can result in an increase of LDL-C by as much as 116 mg/dL.Our model clearly demonstrates that of the two putative mechanisms that have been implicated in the dysregulation of cholesterol metabolism with age, alterations to the removal rate of plasma LDL-C has the most significant impact on cholesterol metabolism and small changes to the number of hepatic LDL receptors can result in a significant rise in LDL-C. This first whole-body systems based model of cholesterol balance could potentially be used as a tool to further improve our understanding of whole-body cholesterol metabolism and its dysregulation with age. Furthermore, given further fine tuning the model may help to investigate potential dietary and lifestyle regimes that have the potential to mitigate the effects aging has on cholesterol metabolism.Lipid metabolism has a key role to play in human longevity and healthy ageing. This has been emphasized by recent genetic studies examining the lipoprotein phenotype in individuals with exceptional longevity [1,2]. It is highly probable such subjects with exceptional longevity and favourable lipoprotein profiles have avoided CVD. CVD is the primary cause of mortality in developed countries, with almost 40% of males and 30% of females in the United Kingdom over the age of 85 years living with the condition [3]. Of the components of lipid metabolism, elevated LDL-C has consistently stood out as a risk factor for CVD [4]. This cholesterol sub-frac
In vitro suppression of oral squamous cell carcinoma growth by ultrasound-mediated delivery of curcumin microemulsions
Lin HY, Thomas JL, Chen HW, Shen CM, Yang WJ, Lee MH
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S28510
Abstract: vitro suppression of oral squamous cell carcinoma growth by ultrasound-mediated delivery of curcumin microemulsions Original Research (2984) Total Article Views Authors: Lin HY, Thomas JL, Chen HW, Shen CM, Yang WJ, Lee MH Published Date February 2012 Volume 2012:7 Pages 941 - 951 DOI: http://dx.doi.org/10.2147/IJN.S28510 Received: 23 November 2011 Accepted: 12 January 2012 Published: 21 February 2012 Hung-Yin Lin1,2, James L Thomas3, Huan-Wen Chen1, Chih-Min Shen4, Wen-Jen Yang2, Mei-Hwa Lee4 1Department of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung, Taiwan; 2Institute of Biotechnology, National University of Kaohsiung, Kaohsiung, Taiwan; 3Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM; 4Department of Materials Science and Engineering, I-Shou University, Kaohsiung, Taiwan Abstract: There is increasing interest in using natural products as anticancer agents, as many have antioxidative properties that may help to prevent cellular damage that can lead to cancer. In addition, there is the expectation that many natural products will have low toxicity and few side effects. However, most anticancer and antioxidative agents are hydrophobic, reducing their bioavailability in vivo and making them problematic to deliver. Curcumin provides a good model system for study. In low doses it shows both anticancer and antioxidation effects, whereas in high doses and delivered locally it could be cytotoxic for cancer cells. In this paper, curcumin microemulsions were formed with food-grade chemicals, including soybean lecithin, soybean oil, and Tween 80, a Food and Drug Administration-approved surfactant. The optimized composition formed curcumin microemulsions with a mean size of 40–50 nm, carrying a concentration of curcumin as high as 15 μM. The stability of curcumin microemulsions refrigerated at 5°C over at least 968 days was assessed by size distribution and zeta potential. The effects of low-frequency ultrasound on two oral squamous cell carcinoma cell lines (OSCC-4 and OSCC-25), and the synergy between treatment with curcumin microemulsions and low-frequency sonic stimulation, were tested. Finally, microscopic imaging of the cells confirmed the toxic effects of the curcumin microemulsions, showing damaged and ruptured cells after treatment. Brief exposure to the curcumin-containing microemulsions did have cytotoxic effects, but the addition of ultrasound strongly enhanced those effects, especially on OSCC-25 cells.
Some considerations on selection criteria and optimization for terminal sire breeds
JL Foulley
Genetics Selection Evolution , 1976, DOI: 10.1186/1297-9686-8-1-89
ECM approaches to heteroskedastic mixed models with constant variance ratios
JL Foulley
Genetics Selection Evolution , 1997, DOI: 10.1186/1297-9686-29-3-297
Prediction of selection response for Poisson distributed traits
JL Foulley
Genetics Selection Evolution , 1993, DOI: 10.1186/1297-9686-25-3-297
La ense?anza de la Medicina Legal en Sevilla (1824-2006): nómina de catedráticos
Cuadernos de Medicina Forense , 2005, DOI: 10.4321/S1135-76062005000400003
Abstract: the present article is a new contribution to the knowledge of the genealogy of professors who have taught forensic medicine in the various schools existing in seville from 1824 up until today.
MB ChB curriculum modernisation in South Africa – growing doctors for Africa
JL Seggie
African Journal of Health Professions Education , 2010,
Madagascar rosewood, illegal logging and the tropical timber trade
JL Innes
Madagascar Conservation & Development , 2010,
Abstract: Although deforestation rates in the tropics are reportedly slowing, the loss of both forest area and forest quality remains a significant issue for many countries. This is particularly true of Madagascar, where recent government instability has enabled a significant increase in the incidence of illegal logging of Dalbergia species from National Parks such as Marojejy and Masoala. The logs are exported with relative ease as export permits are being made available. While attempts have been made to improve the management of tropical forests, in 2005, the International Tropical Timber Organization considered that only 7 % of tropical production forests were being managed sustainably. Given the challenges associated with halting illegal logging at source, emphasis has shifted to the control of the trade in forest products. The Convention on the International Trade in Endangered Species provides a mechanism to restrict such trade, but the Madagascan Dalbergia species are not listed. In the USA, the recent amendments to the ‘Lacey Act’ could provide a significant disincentive to the import of illegally logged wood products, but it remains to be seen whether this Act can be enforced effectively.
Review: "Jacobus" (Willem Krog)
JL Coetser
Tydskrif vir letterkunde , 2012,
Abstract: Jacobus. Willem Krog. Pretoria: Protea Boekhuis, 2011. 164 pp. ISBN: 978-1-86919-440-6.
Die mishandelde vrou in die strafreg: 'n regsvergelykende ondersoek
JL Matthee
Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad , 2009,
Abstract: Male killing is about power and control. Women killing abusers is about avoiding power and control … Women do not often kill from anger, while anger is what fuels many male killings. Oliver Quick en Celia Wells Gesinsgeweld bestaan sedert die man en vrou begin het om saam te leef. Gesinsgeweld is diep gewortel in die Suid-Afrikaanse gemeenskap en het traumatiese newe-effekte op die slagoffers daarvan. Gesinsgeweld is geslag-spesifiek deurdat dit meestal geweld deur mans teenoor vroue behels. Daar word beraam dat 18% tot 25% van Suid-Afrikaanse vroue aan mishandeling binne 'n intieme verhouding onderwerp word. Vir vroue is die risiko om deur 'n lewensmaat gedood te word ook veel ho r as vir mans.
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