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Search Results: 1 - 10 of 246746 matches for " Thomas C Wascher "
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Effect of repaglinide on endothelial dysfunction during a glucose tolerance test in subjects with impaired glucose tolerance
Isabella Schmoelzer, Thomas C Wascher
Cardiovascular Diabetology , 2006, DOI: 10.1186/1475-2840-5-9
Abstract: A prospective, open, randomised, cross-over study was performed to investigate the effect of 2 mg repaglinide on hyperglycemia and endothelial function during an oral glucose tolerance test (75 g glucose) in 12 subjects with diagnosed IGT. Blood samples for determination of plasma glucose were drawn fasting, 1 and 2 hours after glucose ingestion. Endothelial function was assessed by measuring flow-mediated dilatation (FMD) of the brachial artery with high-resolution ultrasound.Administration of repaglinide resulted in a significant reduction of plasma glucose at 2 hours (172.8+/-48.4 vs. 138.3+/-41.2 mg/dl; p < 0.001). The flow-mediated dilatation (FMD) 2 hours after the glucose-load was significantly reduced in comparison to fasting in the control group (6.21+/-2.69 vs. 7.98+/-2.24 %; p = 0.028), whereas after theadministration of repaglinide the FMD was not significantly different to fasting values (7.24+/-2.57 vs. 8.18+/-2.93 %; p = n.s.). Linear and logistic regression analysis revealed that only the change of glucose was significantly correlated to the change of FMD observed (p < 0.001). Regression analysis after grouping for treatment and time confirmed the strong negative association of the changes of plasma glucose and FMD and indicate that the effect of repaglinide observed is based on the reduction glycemia.In subjects with IGT, the endothelial dysfunction observed after a glucose challenge is related to the extent of hyperglycemia. Reduction of hyperglycemia by repaglinide reduces endothelial dysfunction in a glucose dependent manner.Hyperglycemia, across its entire range including non-diabetic values is established as a strong and independent risk factor for cardiovascular morbidity and mortality[1]. In addition, the DECODE study recently established that acute post-challenge glucose concentration, as measured during a standardized glucose tolerance test (oGTT), is a better predictor of risk than fasting glucose also in the non-diabetic range[2]. The mec
Behavioral Responses to Inequity in Reward Distribution and Working Effort in Crows and Ravens
Claudia A. F. Wascher, Thomas Bugnyar
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056885
Abstract: Sensitivity to inequity is considered to be a crucial cognitive tool in the evolution of human cooperation. The ability has recently been shown also in primates and dogs, raising the question of an evolutionary basis of inequity aversion. We present first evidence that two bird species are sensitive to other individuals' efforts and payoffs. In a token exchange task we tested both behavioral responses to inequity in the quality of reward (preferred versus non-preferred food) and to the absence of reward in the presence of a rewarded partner, in 5 pairs of corvids (6 crows, 4 ravens). Birds decreased their exchange performance when the experimental partner received the reward as a gift, which indicates that they are sensitive to other individuals' working effort. They also decreased their exchange performance in the inequity compared with the equity condition. Notably, corvids refused to take the reward after a successful exchange more often in the inequity compared with the other conditions. Our findings indicate that awareness to other individuals' efforts and payoffs may evolve independently of phylogeny in systems with a given degree of social complexity.
The MHC2TA -168A>G gene polymorphism is not associated with rheumatoid arthritis in Austrian patients
Babak Yazdani-Biuki, Kerstin Brickmann, Klaus Wohlfahrt, Thomas Mueller, Winfried M?rz, Wilfried Renner, Manuela Gutjahr, Uwe Langsenlehner, Peter Krippl, Thomas C Wascher, Bernhard Paulweber, Winfried Graninger, Hans-Peter Brezinschek
Arthritis Research & Therapy , 2006, DOI: 10.1186/ar1974
Abstract: Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disease characterized by inflammation of the synovium and subsequent joint destruction [1]. It is a complex disease, with genetic and environmental factors contributing to its etiology. The prevalence of RA in Europe ranges from 0.3% to 1.6%, with higher prevalence in the north of Europe [2]. Studies in twins suggest that the genetic component of RA accounts for approximately 60% of disease susceptibility [3].The concept of a strong genetic component to susceptibility to RA is well established, and the HLA-DRB1 locus is estimated to account for approximately 30% [4]. Several HLA-DRB1 alleles encoding the 'shared epitope' are recognized as disease-risk alleles or disease-severity alleles [5-7]. In addition, a strong association between RA-specific autoantibodies and PTPN22 has been reported [8,9]. Several genome-wide linkage studies and numerous association studies involving positional and/or functional candidate genes have tried to identify further RA susceptibility loci, with controversial results in different populations [10,11].Swanberg and colleagues recently reported an association of a common -168A>G polymorphism in the MHC2TA gene with differential major histocompatibility complex (MHC) II molecule expression and susceptibility to diseases with inflammatory components, such as multiple sclerosis or RA [12]. Although the results of that study were convincing and biologically plausible, the need for replication of this association has been raised [13].The aim of this study was therefore to validate and extend the reported association of the MHC2TA -168A>G polymorphism with RA in a group of 373 Austrian Caucasian RA cases and 373 healthy Austrian Caucasian controls.A total of 362 RA patients and 351 healthy controls, all Caucasians, were included in the study after informed consent and approval by the local ethics committee were obtained. All patients fulfilled the American College of Rheumatology (
Aktuelles: Proinsulin als Marker für Betazell-Stress: Beeinflussbarkeit durch Insulintherapie?
Wascher TC
Journal für Klinische Endokrinologie und Stoffwechsel , 2011,
Therapie der Adipositas - konservativ oder chirurgisch?
Wascher TC
Journal für Gastroenterologische und Hepatologische Erkrankungen , 2008,
Abstract: Adipositas ist ein zunehmend an Bedeutung gewinnendes Problem in allen Industriestaaten. In der medizinischen Behandlung der Adipositas kommen sowohl konservative als auch chirurgisch-invasive Therapiestrategien zum Einsatz. DieserArtikel versucht beide Therapiestrategien in den Kontext einer integrierten Adipositasversorgung zu stellen.
Sympathikusaktivierung - Bedeutung für den Diabetiker
Wascher TC
Journal für Hypertonie , 2004,
Abstract: Sympathetic activation or, more adequate, autonomic imbalance has been found associated with cardiovascular and total mortality in the general population. It is frequently observed in hypertensive patients. The present mini-review summarizes the evidence that patients with the metabolic syndrome or type-2 diabetes in particular exhibit sympathetic imbalance also in the absence of manifest hypertension. These findings not only suggest that autonomic imbalance is a further feature of the metabolic syndrome but also emphasize the possible benefits of targeted treatment in this cardiovascular high-risk population.
Kurzinformation: Koronares Risiko bei Typ-II-Diabetes - Online Evaluation
Wascher TC
Journal für Kardiologie , 2003,
Postprandiale Hyperglyk mie und koronare Herzkrankheit: Welche therapeutischen Konsequenzen sollen wir aus den klinischen Studien ziehen?
Wascher TC
Journal für Kardiologie , 2004,
Abstract: Zus tzlich zu den klassischen kardiovaskul ren Risikofaktoren wurde für die postprandiale Hyperglyk mie gezeigt, da sie auch bei nichtdiabetischen Personen die Atherogenese und damit kardiovaskul re Morbidit t und Mortalit t f rdert. Die wenn auch limitierte Evidenz aus klinischen Interventionsstudien ist in einer Linie mit basiswissenschaftlichen, klinisch-experimentellen und epidemiologischen Studien und zeigt, da tats chlich das kardiovaskul re Risiko, insbesondere offenbar das für Myokardinfarkte, durch spezifische Senkung der postprandialen Hyper-glyk mie reduziert werden kann. Damit stellt die postprandiale Hyperglyk mie ein weiteres Ziel der kardiovaskul ren Therapie und Pr vention dar.
Mikroalbuminurie bei Diabetes - praxisrelevante Diagnostik und Therapieentscheidung
Wascher TC
Journal für Hypertonie , 1998,
Abstract: Die H ufigkeit der terminalen Niereninsuffizienz bei Diabetes mellitus stellt auf Grund der damit verbundenen Morbidit t und Mortalit t ein zentrales Problem in der Therapie des Diabetikers dar. Bei regelm iger Kontrolle der Albuminurie k nnen Patienten jedoch bereits in frühen Stadien erkannt und rechtzeitig einer ad quaten Therapie zugeführt werden. Die routinem ige, zumindest 2mal j hrliche Messung der Albuminurie sollte daher zur Standard-Diagnostik bei jedem Patienten mit Diabetes mellitus geh ren. Ebenso sollte eine ACE-Hemmer Therapie zumindest bei hypertensiven, albuminurischen Patienten als Standard-Therapie angesehen werden.
Diabetes Mellitus - How to Prevent Macrovascular Disease?
Wascher TC
Journal für Kardiologie , 2003,
Abstract: Diabetes mellitus type-II is a frequent metabolic disorder (5-8 % of the adult population), associated with substantially increased vascular risk. This review summarizes evidence from epidemiological and intervention studies to suggest strategies for optimized prevention of atherosclerosis in these patients. Diabetes mellitus und Pr vention makrovaskul rer Erkrankungen. Diabetes mellitus Typ II ist eine h ufige (5-8 % der Erwachsenen) Erkrankung, die mit einem deutlich erh hten kardiovaskul ren Risiko einhergeht. Diese übersicht fa t die Evidenzen aus epidemiologischen und Interventionsstudien zusammen, um Strategien zur optimierten Atherosklerosepr vention anzuregen.
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