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Search Results: 1 - 5 of 5 matches for " Thida Singtoroj "
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Comparison of predicted susceptibility between genotype and virtual phenotype HIV drug resistance interpretation systems among treatment-naive HIV-infected patients in Asia: TASER-M cohort analysis
Awachana Jiamsakul, Rami Kantor, Patrick CK Li, Sunee Sirivichayakul, Thira Sirisanthana, Pacharee Kantipong, Christopher KC Lee, Adeeba Kamarulzaman, Winai Ratanasuwan, Rossana Ditangco, Thida Singtoroj, Somnuek Sungkanuparph, On behalf of the TREAT Asia Studies to Evaluate Resistance – Monitoring Study (TASER-M)
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-582
Abstract: Sequences from 1301 ARV-naive patients enrolled in the TREAT Asia Studies to Evaluate Resistance – Monitoring Study (TASER-M) were analysed by both interpreting systems. Interpretations from both Stanford HIVdb and vircoTYPE? HIV-1 were initially grouped into 2 levels: susceptible and non-susceptible. Discrepancy was defined as a discordant result between the susceptible and non-susceptible interpretations from the two systems for the same ARV. Further analysis was performed when interpretations from both systems were categorised into 3 levels: susceptible, intermediate and resistant; whereby discrepancies could be categorised as major discrepancies and minor discrepancies. Major discrepancy was defined as having a susceptible result from one system and resistant from the other. Minor discrepancy corresponded to having an intermediate interpretation in one system, with a susceptible or resistant result in the other. The level of agreement was analysed using the prevalence adjusted bias adjusted kappa (PABAK).Overall, the agreement was high, with each ARV being in “almost perfect agreement”, using Landis and Koch’s categorisation. Highest discordance was observed for efavirenz (75/1301, 5.8%), all arising from susceptible Stanford HIVdb versus non-susceptible vircoTYPE? HIV-1 predictions. Protease Inhibitors had highest level of concordance with PABAKs all above 0.99, followed by Nucleoside Reverse Transcriptase Inhibitors with PABAKs above 0.97 and non-NRTIs with the lowest PABAK of 0.88. The 68/75 patients with discordant efavirenz results harboured the V179D/E mutations compared to 7/1226 with no efavirenz discrepancy (p-value <0.001). In the 3-level comparison, all but one of the discrepancies was minor.The two systems agreed well with lowest concordance observed for efavirenz. When interpreting HIVDR, especially in non-B subtypes, clinical correlation is crucial, in particular when efavirenz resistance is interpreted based on V179D/E.In recent years, developing
Status report of the blood transfusion services in Myanmar
Aung Thida
Asian Journal of Transfusion Science , 2009,
Loss of Resistance to Nilaparvata lugens May Be Due to the Low-Level Expression of BPH32 in Rice Panicles at the Heading Stage  [PDF]
Jirapong Jairin, Phikul Leelagud, Thida Saejueng, Varapong Chamarerk
American Journal of Plant Sciences (AJPS) , 2017, DOI: 10.4236/ajps.2017.811191
Abstract: The brown planthopper (BPH), Nilaparvata lugens (Stål), is the most important insect pest of rice in Asia. Host plant resistance is one of the strategies currently used to control BPH. The resistant rice cultivar Rathu Heenati (RH) carrying the BPH3 gene (recently renamed as “BPH32”) remains effective despite more than 30 years of deployment. RH has been determined to be resistant against BPH at all growth stages. However, we observed that BPH could feed on panicles but not on the leaf sheaths of RH. The resistance gene BPH32 was introduced into KDML105 through marker-assisted selection, and the introgression line UBN03078 was developed. This rice line was used to observe the patterns of target gene’s regulation. A low-level expression of BPH32 on panicles has been hypothesized to cause susceptibility in UBN03078 at the heading stage. Findings from our gene expression analysis support the hypothesis that the resistance gene was down regulated in the uppermost internodes compared with the leaf sheaths of the heading rice plant. This phenomenon may allow BPH to feed on the panicles of the resistant plants, but this requires further investigation.
Kai HE,Naiqing HU,Joseph D. ORKIN,Daw Thida NYEIN,Chi MA,Wen XIAO,Pengfei FAN,Xuelong JIANG
动物学研究 , 2012, DOI: 10.3724/SP.J.1141.2012.E05-06E104
Abstract: ThegenusTrachypithecusisthemostdiverselangurtaxon,distributedinsouthwesternChina,southandsoutheasternAsia.Inthisstudy,weinclude16recognizedTrachypithecusspeciestoreconstructthephylogenywithparticularconcerntothetaxonomyofthethreesubspeciesofT.phayreiusingmultiplegenes.Ourresultssupportasister-relationshipbetweenT.p.phayreiandT.p.shanicus.However,themitochondrialCYTBgenesupportedT.p.crepusculaasadistinctspecies,butthenuclearPRM1genesuggestedacloserrelationshipbetweenT.p.crepusculaandT.p.phayrei.Theincongruencebetweennuclearandmitochondrialgenessuggeststhathybridizationmayhaveoccurred,afactthatwouldbenefitfromre-examinationusingmultipleunlinkednucleargenes.
The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods
Alan S Go, Chirag R Parikh, T Alp Ikizler, Steven Coca, Edward D Siew, Vernon M Chinchilli, Chi-yuan Hsu, Amit X Garg, Michael Zappitelli, Kathleen D Liu, W Brian Reeves, Nasrollah Ghahramani, Prasad Devarajan, Georgia Faulkner, Thida C Tan, Paul L Kimmel, Paul Eggers, John B Stokes, the Assessment Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study Investigators
BMC Nephrology , 2010, DOI: 10.1186/1471-2369-11-22
Abstract: The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardiovascular events, death, and other important patient-centered outcomes. This prospective study will enroll a cohort of 1100 adult participants with a broad range of AKI and matched hospitalized participants without AKI at three Clinical Research Centers, as well as 100 children undergoing cardiac surgery at three Clinical Research Centers. Participants will be followed for up to four years, and will undergo serial evaluation during the index hospitalization, at three months post-hospitalization, and at annual clinic visits, with telephone interviews occurring during the intervening six-month intervals. Biospecimens will be collected at each visit, along with information on lifestyle behaviors, quality of life and functional status, cognitive function, receipt of therapies, interim renal and cardiovascular events, electrocardiography and urinalysis.ASSESS-AKI will characterize the short-term and long-term natural history of AKI, evaluate the incremental utility of novel blood and urine biomarkers to refine the diagnosis and prognosis of AKI, and identify a subset of high-risk patients who could be targeted for future clinical trials to improve outcomes after AKI.As currently defined, acute kidney injury (AKI) refers to a sudden decrease in kidney function as measured by changes in serum creatinine concentration and/or urine output. This phenomenon has been best studied among hospitalized patients and is associated with a high risk (>30%) of short-term mortality in severe cases [1]. The importance of AKI as a clinical and public health problem is underscored by recent studies showing a rising incidence in the U.S. over the past several decades [2,3].The vast majority of published studies on AKI have focused primarily on
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