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Search Results: 1 - 10 of 407600 matches for " Theodore M Nelson "
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Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice
Theodore M Nelson, Steven D Munger, John D Boughter
BMC Genetics , 2005, DOI: 10.1186/1471-2156-6-32
Abstract: We used brief-access behavioral taste testing of BXD/Ty recombinant inbred (RI) mouse strains to map the major quantitative trait locus (QTL) for taste sensitivity to QHCl. This QTL is restricted to a ~5 Mb interval on chromosome 6 that includes 24 genes encoding T2Rs (Tas2rs). Tas2rs at this locus display in total 307 coding region single nucleotide polymorphisms (SNPs) between the two BXD/Ty RI parental strains, C57BL/6J (quinine-sensitive) and DBA/2J (quinine insensitive); approximately 50% of these mutations are silent. Individual RI lines contain exclusively either C57BL/6J or DBA/2J Tas2r alleles at this locus, and RI lines containing C57BL/6J Tas2r alleles are more sensitive to QHCl than are lines containing DBA/2J alleles. Thus, the entire Tas2r cluster comprises a large haplotype that correlates with quinine taster status.These studies, the first using a taste-salient assay to map the major QTL for quinine taste, indicate that a T2R-dependent transduction cascade is responsible for the majority of strain variance in quinine taste sensitivity. Furthermore, the large number of polymorphisms within coding exons of the Tas2r cluster, coupled with evidence that inbred strains exhibit largely similar bitter taste phenotypes, suggest that T2R receptors are quite tolerant to variation.Animals use the gustatory system to provide information about food quality. For example, sweet-tasting foods may have a high caloric content and are preferred, while bitter-tasting foods often contain toxic substances, and are generally avoided. Two families of G protein-coupled receptors (GPCRs) expressed in subpopulations of taste receptor cells (TRCs) of the gustatory epithelium have been implicated in the detection and transduction of sweet, bitter and umami (i.e., glutamate) taste: T1Rs for sweet-and umami-tasting stimuli [1-8], and T2Rs for bitter-tasting compounds [9-11].The genes that encode T2Rs, the Tas2rs, were first identified by database mining of mammalian genomes near c
Inbred mouse strains C57BL/6J and DBA/2J vary in sensitivity to a subset of bitter stimuli
John D Boughter, Sandeep Raghow, Theodore M Nelson, Steven D Munger
BMC Genetics , 2005, DOI: 10.1186/1471-2156-6-36
Abstract: B6 mice were more sensitive than D2 mice to a subset of bitter stimuli, including quinine hydrochloride (QHCl), 6-n-propylthiouracil (PROP), and MgCl2. D2 mice were more sensitive than B6 mice to the bitter stimulus raffinose undecaacetate (RUA). These strains did not differ in sensitivity to cycloheximide (CYX), denatonium benzoate (DB), KCl or HCl.B6-D2 taste sensitivity differences indicate that differences in consumption of QHCl, PROP, MgCl2 and RUA are based on immediate orosensory cues, not post-ingestive effects. The absence of a strain difference for CYX suggests that polymorphisms in a T2R-type taste receptor shown to be differentially sensitive to CYX in vitro are unlikely to differentially contribute to the CYX behavioral response in vivo. The results of these studies point to the utility of these common mouse strains and their associated resources for investigation into the genetic mechanisms of taste.The majority of heritable traits in humans and other species are complex in nature, determined by interactions among multiple genes and environmental factors. Mouse genetic models have been critical in identifying genes that determine complex behavioral traits (e.g., [1-3]). The standard inbred strains C57BL/6J (B6) and DBA/2J (D2) have played a key role in mouse genetics, and they are among the strains included in the public and private genome sequencing projects. BXD/Ty (BXD) recombinant inbred (RI) mice, created from B6 and D2 progenitors, have been used to identify and map quantitative trait loci (QTLs) that influence diverse phenotypes such as addictive behavior (e.g., [4-6]), lifespan [7], central nervous system anatomy [8-10], and solution consumption [11-13]. Recently, the BXD set has been expanded to about 80 strains, which makes it the largest mouse RI mapping panel and a useful resource for QTL analysis [14].The characterization of behavioral taste sensitivity in B6 and D2 mice would facilitate the use of BXD mice in mapping QTLs for taste sensit
The Determinants of Student Satisfaction Acquired by University Education: The Case of the Hellenic Open University  [PDF]
Anastasia Pseiridis, George M. Agiomirgianakis, Theodore Lianos
Theoretical Economics Letters (TEL) , 2017, DOI: 10.4236/tel.2017.75090
Abstract: The satisfaction of students acquired by their tertiary educational experience can be seen as one of the main satisfactions shaping their overall life satisfaction and professional life after their graduation. Student satisfaction is especially important for universities operating under paid tuition fees, as this may affect both the student retention rates and future student enrollments. In this paper, we consider two facets of student satisfaction, i.e. 1) satisfaction acquired by the level of knowledge provided during university years and 2) satisfaction acquired by broadening the prospects of career development after graduation. The purpose of this paper is twofold. First, we examine the relationship of student satisfaction with various demographic factors such as age, gender, family, and income. Secondly, we study the relationship of student satisfaction to circumstantial factors such as grades earned and support by student family. We are based on data (n = 470) from students attending the Management of Businesses and Organisations Bachelor’s Degree offered by the Hellenic Open University. The findings of our study could be useful for educational policies enhancing quality assurances measures.
An Unusual Case of Gastric Outlet Obstruction in a Ghanaian Woman  [PDF]
Joachim Amoako, Henry Obaka, Nelson Affram, Wordui Theodore, Faizal Z. Asumda
Case Reports in Clinical Medicine (CRCM) , 2017, DOI: 10.4236/crcm.2017.67020
Abstract: Foreign body ingestion is an uncommon cause of gastric outlet obstruction in adults. Not all ingested objects pass the gastrointestinal tract spontaneously. In most cases, endoscopic removal is required. A surgical approach is required if endoscopic removal is unsuccessful or in the event of a complication. We present a case of a 45-year-old woman, previously diagnosed endoscopically with chronic duodenal ulcer with pyloric stenosis, who presented with copious effortless offensive non-bilious vomiting, and epigastric pain of three weeks’ duration. She was dehydrated with positive gastric succussion splash. Esophago-gastro-duodenoscopy showed an impacted neck-pendant occluding a stenosed pylorus which dislodged on attempts to extract it and was later excreted in the stool, with resolution of her symptoms.
Essay Review: Quantitative Technologies, Administrative Practices, and Statistical Minds
Theodore M. Porter
Studium : Tijdschrift voor Wetenschaps- en Universiteits-Geschiedenis , 2009,
Abstract: -
Funny Numbers
Theodore M. Porter
Culture Unbound : Journal of Current Cultural Research , 2012,
Abstract: The struggle over cure rate measures in nineteenth-century asylums provides an exemplary instance of how, when used for official assessments of institutions, these numbers become sites of contestation. The evasion of goals and corruption of measures tends to make these numbers “funny” in the sense of becoming dis-honest, while the mismatch between boring, technical appearances and cunning backstage manipulations supplies dark humor. The dangers are evident in recent efforts to decentralize the functions of governments and corporations using incen-tives based on quantified targets.
Masses of the Sub-Nuclear Particles
Theodore M. Lach
Physics , 2000,
Abstract: The masses of the quarks and leptons are for the most part a mystery to particle physicists. Currently there seems to be no correlation between the masses of the elementary particles. This paper is an attempt to formulate a theory that would begin to explain the relationship between the sub-nuclear particle masses.
M33: A Galaxy with No Supermassive Black Hole
Karl Gebhardt,Tod R. Lauer,John Kormendy,Jason Pinkney,Gary A. Bower,Richard Green,Theodore Gull,J. B. Hutchings,M. E. Kaiser,Charles H. Nelson,Douglas Richstone,Donna Weistrop
Physics , 2001, DOI: 10.1086/323481
Abstract: Galaxies that contain bulges appear to contain central black holes whose masses correlate with the velocity dispersion of the bulge. We show that no corresponding relationship applies in the pure disk galaxy M33. Three-integral dynamical models fit Hubble Space Telescope WFPC2 photometry and STIS spectroscopy best if the central black hole mass is zero. The upper limit is 1500 M_sun. This is significantly below the mass expected from the velocity dispersion of the nucleus and far below any mass predicted from the disk kinematics. Our results suggest that supermassive black holes are associated only with galaxy bulges and not with their disks.
Surgical Coronary Revascularization Using an Off-Pump, No-Touch Technique: The Cyclone (Hexalon) Experience  [PDF]
Jeffrey M. Schussler, Theodore T. Theologes, Baron L. Hamman
Open Journal of Thoracic Surgery (OJTS) , 2014, DOI: 10.4236/ojts.2014.44019
Abstract: The CycloneTM System (Castlewood Surgical, Inc., Concord, MA) is a novel device that facilitates the attachment of the saphenous vein onto the ascending aorta for the purpose of creating a bypass graft during a coronary artery bypass grafting (CABG) operation. It allows the surgeon to perform a hand-sewn anastomosis with no disruption of the intima of the aorta, and no need for partial clamping. During a 36-month period 109 CABG operations were performed, and the CycloneTM System (and its predecessor, the HexalonTM) was utilized to create 138 proximal anastomoses. This study demonstrates that this is a safe and effective method of creating a clampless, no-touch proximal anastomoses during off-pump CABG.
Epidemiology of Hepatitis C Virus (HCV) Infection
Sy Theodore,Jamal M. Mazen
International Journal of Medical Sciences , 2006,
Abstract: Hepatitis C virus remains a large health care burden to the world. Incidence rates across the world fluctuate and are difficult to calculate given the asymptomatic, often latent nature of the disease prior to clinical presentation. Prevalence rates across the world have changed as well with more countries aware of transfusion-related hepatitis C and more and more evidence supporting intravenous drug use as the leading risk factor of spread of the virus. This article reviews current hepatitis C virus prevalence and genotype data and examines the different risk factors associated with the virus.
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