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Search Results: 1 - 10 of 462099 matches for " Themistoklis A Iliopoulos "
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Apical ballooning syndrome: a case report
Konstantinos M Lampropoulos, Dimitrios Kotsas, Themistoklis A Iliopoulos
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-698
Abstract: This is a case of a 40-year-old Caucasian male without any health related problems that was submitted to an urgent coronary angiography because of acute chest pain and marked precordial T-wave inversions suggestive of acute myocardial ischemia. Coronary angiography showed no significant stenosis of the coronary arteries. Left ventriculography showed systolic apical ballooning with mild basal hypercontraction.Physicians should be aware of the presentation of apical ballooning syndrome, and the chest pain after following acute stress should not be readily attributed to anxiety.Apical ballooning syndrome, also known as Takotsubo cardiomyopathy, apical ballooning cardiomyopathy, stress-induced cardiomyopathy, Gebrochenes-Herz-Syndrom, or simply stress cardiomyopathy, is a type of non-ischemic cardiomyopathy in which there is a sudden temporary weakening of the myocardium. As this weakening can be triggered by emotional stress, such as the death of a loved one, a break-up, or constant anxiety, the condition is also known as the broken heart syndrome. Stress cardiomyopathy is a well-recognized cause of acute heart failure, lethal ventricular arrhythmias, and ventricular rupture [1]. It mimics acute coronary syndromes and is characterized by reversible left ventricular apical ballooning in the absence of angiographically significant coronary artery stenosis. Studies report that 1.7-2.2% of patients originally treated as suspected acute coronary event, were subsequently diagnosed with apical ballooning syndrome. In Japanese, “tako-tsubo” means “fishing pot for trapping octopus,” and the left ventricle of a patient diagnosed with this condition indeed resembles that shape [2]. This is a presentation of a 40-year-old Caucasian male without a pertinent medical history that was referred for an urgent coronary angiography because of acute chest pain and marked precordial T-wave inversions suggestive of acute myocardial ischemia. Coronary angiography revealed no significant steno
Early bare-metal stent thrombosis presenting with cardiogenic shock: a case report
Konstantinos M Lampropoulos, Themistoklis A Iliopoulos, Werner Budts
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-509
Abstract: We present the case of a 64-year-old Caucasian man from Greece, with symptoms and electrocardiographic findings suggestive of acute inferior myocardial infarction, who complained of chest pain and rapidly developed cardiogenic shock 48 hours after primary percutaneous coronary intervention.The most common cause of early bare-metal stent thrombosis is stent malapposition. Intravascular ultrasound is the preferred method to recognize predictors of coronary events that are not detected by angiography.Stents have improved the safety and efficacy of percutaneous coronary interventions (PCI) by reducing acute or imminent vessel closure and by reducing restenosis rates compared with conventional balloon angioplasty [1]. In addition, coronary vasomotor reactivity has been found intact after stent implantation and long-term clinical and angiographic follow-up have attested to the durability of their action [2]. Nevertheless, coronary stent thrombosis remains a serious complication of PCI.A 64-year-old male Caucasian patient was admitted to our hospital with clinical and electrocardiographical findings suggesting acute inferior myocardial infarction. Our patient had a history of hypertension and dyslipidemia but was not taking any medication at the time of admission. Laboratory findings were suggestive of acute cardiac ischemia. His plasma levels of N-terminal pro-B-type natriuretic, troponin I, creatine kinase and creatine kinase MB isoenzyme were increased. The first transthoracic echocardiogram executed at our emergency department showed hypokinesia of the inferior and posterior left ventricular wall. Our patient received 600 mg clopidogrel, 325 mg aspirin and 5000 U of unfractionated heparin and was then transferred to the catheterization laboratory, while receiving glycoprotein IIb/IIIa inhibitors (abciximab) intravenously.Coronary angiography showed atheromatosis of his left anterior descending artery and his left circumflex artery without any evidence of severe stenose
Probabilistic description of extreme events in intermittently unstable systems excited by correlated stochastic processes
Mustafa A. Mohamad,Themistoklis P. Sapsis
Physics , 2014,
Abstract: In this work, we consider systems that are subjected to intermittent instabilities due to external stochastic excitation. These intermittent instabilities, though rare, have a large impact on the probabilistic response of the system and give rise to heavy-tailed probability distributions. By making appropriate assumptions on the form of these instabilities, which are valid for a broad range of systems, we formulate a method for the analytical approximation of the probability distribution function (pdf) of the system response (both the main probability mass and the heavy-tail structure). In particular, this method relies on conditioning the probability density of the response on the occurrence of an instability and the separate analysis of the two states of the system, the unstable and stable state. In the stable regime we employ steady state assumptions, which lead to the derivation of the conditional response pdf using standard methods for random dynamical systems. The unstable regime is inherently transient and in order to analyze this regime we characterize the statistics under the assumption of an exponential growth phase and a subsequent decay phase until the system is brought back to the stable attractor. The method we present allows us to capture the statistics associated with the dynamics that give rise to heavy-tails in the system response and the analytical approximations compare favorably with direct Monte Carlo simulations, which we illustrate for two prototype intermittent systems: an intermittently unstable mechanical oscillator excited by correlated multiplicative noise and a complex mode in a turbulent signal with fixed frequency, where multiplicative stochastic damping and additive noise model interactions between various modes.
A probabilistic decomposition-synthesis method for the quantification of rare events due to internal instabilities
Mustafa A. Mohamad,Will Cousins,Themistoklis P. Sapsis
Physics , 2015,
Abstract: We consider the problem of probabilistic quantification of dynamical systems that have heavy-tailed characteristics. These heavy-tailed features are associated with rare transient responses due to the occurrence of internal instabilities. Here we develop a computational method, a probabilistic decomposition-synthesis technique, that takes into account the nature of internal instabilities to inexpensively determine the non-Gaussian probability density function for any arbitrary quantity of interest. Our approach relies on the decomposition of the statistics into a `non-extreme core', typically Gaussian, and a heavy-tailed component. This decomposition is in full correspondence with a partition of the phase space into a `stable' region where we have no internal instabilities, and a region where non-linear instabilities lead to rare transitions with high probability. We quantify the statistics in the stable region using a Gaussian approximation approach, while the non-Gaussian distributions associated with the intermittently unstable regions of the phase space are inexpensively computed through order-reduction methods that take into account the strongly nonlinear character of the dynamics. The probabilistic information in the two domains is analytically synthesized through a total probability argument. The proposed approach allows for the accurate quantification of non-Gaussian tails at more than 10 standard deviations, at a fraction of the cost associated with the direct Monte-Carlo simulations. We demonstrate the probabilistic decomposition-synthesis method for rare events for two dynamical systems exhibiting extreme events: a two-degree-of-freedom system of nonlinearly coupled oscillators, and in a nonlinear envelope equation characterizing the propagation of unidirectional water waves.
Mapping Functional Associations in the Entire Genome of Drosophila melanogaster Using Fusion Analysis
Ioannis Iliopoulos,Anton J. Enright,Patrick Poullet,Christos A. Ouzounis
Comparative and Functional Genomics , 2003, DOI: 10.1002/cfg.287
Abstract: We have previously shown that the detection of gene fusion events can contribute towards the elucidation of functional associations of proteins within entire genomes. Here we have analysed the entire genome of Drosophila melanogaster using fusion analysis and two additional constraints that improve the reliability of the predictions, viz. low sequence similarity and low degree of paralogy of the component proteins involved in a fusion event. Imposing these constraints, the total number of unique component pairs is reduced from 18 654 to a mere 220 cases, which are expected to represent some of the most reliably detected functionally associated proteins. Using additional information from sequence databases, we have been able to detect pairs of functionally associated proteins with important functions in cellular and developmental pathways, such as spermatogenesis and programmed cell death.
A Distributed Power Control and Transmission Rate Allocation Algorithm over Multiple Channels
Themistoklis Charalambous
Mathematics , 2011,
Abstract: In this paper, we consider multiple channels and wireless nodes with multiple transceivers. Each node assigns one transmitter at each available channel. For each assigned transmitter the node decides the power level and data rate of transmission in a distributed fashion, such that certain Quality of Service (QoS) demands for the wireless node are satisfied. More specifically, we investigate the case in which the average SINR over all channels for each communication pair is kept above a certain threshold. A joint distributed power and rate control algorithm for each transmitter is proposed that dynamically adjusts the data rate to meet a target SINR at each channel, and to update the power levels allowing for variable desired SINRs. The algorithm is fully distributed and requires only local interference measurements. The performance of the proposed algorithm is shown through illustrative examples.
Physics Beyond the Standard Model
Iliopoulos, Jean
High Energy Physics - Phenomenology , 2008,
Abstract: We review our expectations in the last year before the LHC commissioning.
Bryden, J.M. et al., (eds.) 2011. Towards Sustainable Rural Regions in Europe: Exploring Inter-Relationships Between Rural Policies, Farming, Environment, Demographics, Regional Economies and Quality of Life Using System Dynamics. New York: Routledge.
Constantine Iliopoulos
International Journal of the Commons , 2012,
Abstract:
Non-Renormalisation Theorems in Global Supersymmetry
J. Iliopoulos
Physics , 2001, DOI: 10.1016/S0920-5632(01)01496-7
Abstract: We review the history of non-renormalisation theorems in global supersymmetry, as well as their importance in all attempts to apply supersymmetry to the real world.
Symmetries and the Weak Interactions
John Iliopoulos
Physics , 2011,
Abstract: We trace the origin of the concept which was named by the High Energy Physics Community "The Cabibbo angle"
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