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Search Results: 1 - 10 of 4237 matches for " Thassila Nogueira Pitanga "
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Sickle cell disease: Only one road, but different pathways for inflammation  [PDF]
Wendell Vilas-Boas, Bruno Ant?nio Veloso Cerqueira, Thassila Nogueira Pitanga, Magda Oliveira Seixas, Joelma Menezes, Cyntia Cajado de Souza, Elisangela Vitória Adorno, Marilda Souza Goncalves
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.324071
Abstract: Sickle cell disease (SCD) is a genetic disorder characterized by a chronic inflammatory process, and new biomarkers have been studied as promising molecules for understanding the inflammation in its pathophysiology. The hemolysis and the release of molecules associated to the hemoglobin (Hb) catabolism, such as free Hb, iron, and heme, generating a oxidant environment with production of reactive oxygen and nitrogen species. The immune system plays a very important role in the inflammation, with cells secreting pro-inflammatory cytokines and chemokines. There is also a nitric oxide (NO) resistance state, with an impaired NO bioactivity, leading to a vascular dys-function; activation of platelet, leukocytes, erythrocytes, and endothelial cells, with expression of adhesion molecules and its ligands, and several receptors, that altogether participate at inflammatory process. During inflammation, there is an increase of dendritic cells (DCs) expresse toll like receptors (TLR), but the role of DCs and TLR in SCD pathogenesis is unclear. Also, there are molecules contributing for enhance the endothelium dysfunction, such as homocysteine that has been associated with vascular complications in the pathology of other diseases and it may contribute to the vascular complications presented by SCD patients. Circulating microparticules (MPs) levels are augmented in several diseases and have been described in SCD, where cells membrane compounds are associated to cell’s thrombotic and coagulation state, such as tissue factor and phosphatidylserine (PS), which may contribute to endothelial dysfunction. The knowledge of all these biomarkers may contribute to new therapeutic approach discover, improveing SCD patient life quality.
Cytokine profiles in sickle cell anemia: Pathways to be unraveled  [PDF]
Thassila Nogueira Pitanga, Wendell Vilas-Boas, Bruno Ant?nio Veloso Cerqueira, Magda Oliveira Seixas, Cynara Gomes Barbosa, Elisangela Vitória Adorno, Marilda Souza Goncalves
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.47A1002
Abstract: Sickle cell anemia (SCA) is a genetically inherited hemolytic disorder characterized by chronic inflammation. Cytokine expression affects the pivotal pathways that contribute to disease pathogenesis, but the mechanisms involved are not well understood. SCA is associated with a proinflammatory state, and an enhanced inflammatory response occurs during vasoocclusive crisis. The immune system thus plays an important role in this inflammatory condition, with several cell types secreting pro-inflammatory cytokines that contribute to the occurrence of common cyclical events in SCA patients, such as hemolysis, vascular occlusion and inflammation. Studies of these cytokines and chemokines in SCA patients have clarified the mechanisms that underlie this disease and highlighted the need for a better understanding of cytokine participation in SCA pathophysiology.
The boundary of G?del's spacetime and the chronology protection conjecture
P. Pitanga
Physics , 2012,
Abstract: We present a homogenous anisotropic conformal spacetime manifold that provide an example of Hawking's chronology protection conjecture in three-dimensional gravity theory. The solution is based upon the fact that the seven-dimensional group of the automorphism of the Heisenberg motion group H1{\times}U(1), modulo discrete sub-group \Gamma, is the symmetry group of the sub-Riemannian (SR)- manifold, boundary of the Cauchy-Riemann (CR)-manifold, allowing the existence of positive mass, momentum, angular-momentum and timelike-translation. It is shown that many mirror symmetric self-similar G\"odel's surfaces are hidden behind a Cauchy spacelike surface so that causality violation is not visible from outside.
G?del's universe and the chronology protection conjecture
P. Pitanga
Physics , 2011,
Abstract: We present a solution for the geodesic motion in G\"odel's universe that provides a particular proof of Hawking's chronology protection conjecture in three-dimensional gravity theory. The solution is based upon the fact that the group of the automorphisms of the Heisenberg motion group H1\timesU(1), modulo discrete sub-group Z, act isometrically on the boundary of the hyperbolic three-dimensional manifold. Closed timelike curves do not exist due to the presence of a closed Cauchy-Riemann surface for chronology protection, with two mirror symmetric sets of helicoidal self-similar modules inside. The present solution is isometrically equivalent to a cylindrical gravitational monochromatic wave front.
The Heavy Dirac Monopole
P. Pitanga
Physics , 2000,
Abstract: We present a model for the Dirac magnetic monopole, suitable for the strong coupling regime. The magnetic monopole is static, has charge g and mass M, occupying a volume of radius R ~ O (g^2/M). It is shown that inside each n-monopole there exist infinite multipoles. It is given an analytical proof of the existence of monopole-antimonopole bound state. Theses bound-states might give additional strong light to light scattering in the proton-antiproton collision process at FermiLab TEVATRON.
Associa??o entre atividade física no tempo livre e proteína C reativa em adultos na cidade de Salvador, Brasil
Pitanga, Francisco;Lessa, Ines;
Arquivos Brasileiros de Cardiologia , 2009, DOI: 10.1590/S0066-782X2009000400009
Abstract: background: leisure time physical activity (ltpa), defined as any type of bodily movement performed during leisure time, is associated with a reduction in the risk for many cardiovascular injuries. objective: to investigate the existence of an association between leisure time physical activity (ltpa) and c-reactive protein (crp) levels in adults, in the city of salvador, state of bahia, brazil. methods: this was a cross-sectional study, with a sample of 822 men and women, aged > 20 years. active in leisure time were those with a self-reported practice of physical activities in leisure time; high serum crp levels were those with values > 3.0 mg/l. logistic regression analysis was used to compute the odds ratio (or) with a 95% confidence interval (ci). results: using multivariate analysis to adjust for potential confounders, we found an or of 0.73 (0.68-0.79) among the men which shows the existence of an association between ltpa and high crp levels only in male individuals. after a stratification by gender, obesity, diabetes and smoking habit, we found an association between ltpa and high crp in non-obese and non-diabetic male smokers or former smokers; and in obese and non-smoking females. conclusion: the results of this study may bring contributions to public health, since they can be used to raise awareness of the importance of ltpa as a prospective strategy for population health improvement.
Antropometria na avalia??o da obesidade abdominal e risco coronariano
Pitanga, Francisco José Gondim;
Revista Brasileira de Cineantropometria & Desempenho Humano , 2011, DOI: 10.5007/1980-0037.2011v13n3p238
Abstract: the incidence of diabetes, atherosclerosis and sudden cardiac death is high among obese individuals, with significant metabolic and cardiovascular adverse effects being observed when obesity is centered in the abdominal region. the objective of this study was to determine which of the anthropometric indicators of abdominal obesity commonly used show the highest predictive power to discriminate a high coronary risk (hcr) and to propose cut-off values for their use in clinical practice and in population studies on brazilian adults. the studies published by the research group on non-transmissible chronic diseases of the public health institute (phi), federal university of bahia (ufba), that compare different anthropometric indicators as predictors of hcr were analyzed. the evidence provided by the studies analyzed suggests the use of the conicity index for the evaluation of abdominal obesity in clinical practice, with cut-off values of 1.25 for men and of 1.18 and 1.22 for women < 49 years and > 50 years, respectively. the waist-height ratio should be used in population studies, with the recommendation that waist should not exceed half the height of a particular subject.
Anthropometric indices of obesity as screening tools for coronary high risk among women
Francisco Pitanga,Ines Lessa
Revista Brasileira de Cineantropometria e Desempenho Humano , 2006,
Abstract: To identify the cut-off points and furthermore to discriminate, among different obesity anthropometrics indicators, the best performing ones in predicting high coronary risk profile (HCR) among women of two different age groups. This cross-sectional study involved 577 women aged 30–74 year. The analyses used receiver-operatingcharacteristic (ROC) curves to identify and compare the statistical significance between conicity index (C index), body mass index (BMI), waist-to-hip ratio (WHR) and waist circumference (WC), and also to discriminate CHR between women in age groups of 30-49 and 50-74 years. A 95% confidence interval (CI) was used. Areas underROC curve between the several obesity indicators and HCR were statistically significant and did not differ among 30-49 year old women, while among women aged 50-74 years, only areas under ROC curve using C index and WHR with HCR showed statistical significance. Cut-off points were defined for the several obesity indicators as a screening tool among women grouped into 30-49 years and 50-74 years. In women aged 30-49 years, the obesity indicators showed the same discriminating power for HCR. However, in 50-74 year-old women, the indicators were less effective discriminators and just central obesity indicators, C index and WHR, performed well for predicting HCR. RESUMOO principal objetivo do trabalho foi Identificar os pontos de corte de diferentes indicadores antropométricos de obesidade e determinar qual apresenta maior poder para discriminar risco coronariano elevado (RCE) em mulheres de dois diferentes grupos etários. O estudo foi de corte transversal realizado em 577 mulheres, com idade entre 30-74 anos, residentes na cidade de Salvador-Ba. A análise foi feita através das curvas ROC (Receiver Operating Characteristic) para identificar e comparar a significancia estatística da área sob a mesma entre o índice de conicidade (índice C), índice de massa corporal (IMC), raz o circunferência cintura-quadril (RCCQ) e circunferência de cintura (CC) para discriminar RCE entre mulheres de 30-49 anos e 50-74 anos de idade. Foi utilizado intervalo de confian a a 95%. As áreas sob a curva ROC entre os diversos indicadores de obesidade e RCE s o statisticamente significativas e n o apresentam diferen as em mulheres de 30-49 anos. Nas mulheres de 50-74 anos, apenas as áreas sob a curva ROC entre índice C e RCCQ com RCE apresentam significado estatístico. Pontos de corte foram definidos para os diversos indicadores de obesidade como instrumento de triagem em mulheres de 30-49 anos e 50-74 anos de idade. Os resultados do estu
Anthropometry for the assessment of abdominal obesity and coronary risk. DOI: 10.5007/1980-0037.2011v13n3p238
Francisco José Gondim Pitanga
Revista Brasileira de Cineantropometria e Desempenho Humano , 2011,
Abstract: The incidence of diabetes, atherosclerosis and sudden cardiac death is high among obese individuals, with significant metabolic and cardiovascular adverse effects being observed when obesity is centered in the abdominal region. The objective of this study was to determine which of the anthropometric indicators of abdominal obesity commonly used show the highest predictive power to discriminate a high coronary risk (HCR) and to propose cut-off values for their use in clinical practice and in population studies on Brazilian adults. The studies publi-shed by the research group on non-transmissible chronic diseases of the Public Health Institute (PHI), Federal University of Bahia (UFBA), that compare different anthropometric indicators as predictors of HCR were analyzed. The evidence provided by the studies analyzed suggests the use of the conicity index for the evaluation of abdominal obesity in clinical practice, with cut-off values of 1.25 for men and of 1.18 and 1.22 for women ≤ 49 years and > 50 years, respectively. The waist-height ratio should be used in population studies, with the recommendation that waist should not exceed half the height of a particular subject.
A análise de sonhos nas terapias cognitivas e comportamentais
Vandenbergue, Luc;Pitanga, Artur Vandré;
Estudos de Psicologia (Campinas) , 2007, DOI: 10.1590/S0103-166X2007000200010
Abstract: dream analysis has followed psychotherapy from its early beginnings. in fact it is older than psychotherapy. both beck's cognitive therapy and different streams within behavioral therapy suppose that dreams clarify aspects of the dreamer's daily life. both the cognitive and the behavioral traditions propose strategies to use this hypothesized continuity between woken life and dream. the practices of dream analysis are highly similar in the two therapeutic styles. the fundamental difference resides in the causal theories: daily life problems and dream production are attributed by behavioral authors to contingencies and by cognitive therapists to mental structures and processes.
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