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Search Results: 1 - 10 of 194944 matches for " Théodora Mahoukèdè Zohoncon "
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Distribution of High-Risk Human Papillomavirus Genotypes in Precancerous Cervical Lesions in Ouagadougou, Burkina Faso  [PDF]
Charlemagne Ouédraogo, Théodora Mahoukèdè Zohoncon, Esther M. A. Traoré, Souleymane Ouattara, Prosper Bado, Clarisse T. Ouedraogo, Florencia W. Djigma, Djénéba Ouermi, Dorcas Obiri-Yeboah, Olga Lompo, Simon A. Akpona, Jacques Simpore
Open Journal of Obstetrics and Gynecology (OJOG) , 2016, DOI: 10.4236/ojog.2016.64025
Abstract: Aims: We aimed at identifying the high-risk HPV genotypes associated with high-grade dysplastic cervical lesions in Burkina Faso. The available vaccines to Burkina Faso only protect against two high risk HPV genotypes: HPV 16 and 18. Are the genotypes identified in the high-grade precan-cerous lesions in this survey covered by the available vaccines? Methods: The detection and genotyping of high-risk HPV have been conducted based on 118 formalin-fixed and paraffin-embedded archived tissues using the “HPV Genotypes 14 Real-TM Quant” (Sacace biotechnologies®, Italy) kit allowing for the detection of fourteen high-risk HPV genotypes: HPV 16, 31, 18, 39, 45, 59, 33, 35, 56, 68, 51, 52, 58 and 66. Results: The prevalence of high-risk HPV infections was 48.8% based on the appropriate PCR results (21/43). The most common HPV genotypes were HPV 39 (21.7%), HPV 35 (13.0%) and HPV 45 (13.0%). Two cases of multiple infections between HPV 39 - 45 and HPV 39 - 59 have been observed. HPV 16 was not detected in this study. Conclusions: We noted a high prevalence rate for HPV 39, HPV 35 and HPV 45, which are not covered by the commercial vaccines. We also found that the prevalence of HPV 18 was very low in this study and HPV 16 was not detected.
Antimicrobial and antioxidant activities of the extracts and compounds from the leaves of Psorospermum aurantiacum Engl. and Hypericum lanceolatum Lam.
Tchakam Patricia D,Lunga Paul K,Kowa Théodora K,Lonfouo Antoine Honoré N
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-136
Abstract: Background Psorospermun aurantiacum and Hypericum lanceolatum are plants locally used in Cameroon and other parts of Africa for the treatment of gastrointestinal and urinary tract infections, skin infections, venereal diseases, gastrointestinal disorder, infertility, epilepsy as well as microbial infections. The present study was designed in order to investigate the in vitro antimicrobial and radical scavenging activities of the extracts and isolated compounds from the leaves of these plants. Methods The plant extract was prepared by maceration in ethyl acetate and methanol and fractionated by column chromatography. The structures of isolated compounds were elucidated by spectroscopic analyses in conjunction with literature data. The broth microdilution method was used to evaluate the in vitro antimicrobial activity against bacteria, yeasts and dermatophytes. The antioxidant potentials of the extracts and their isolated compounds were evaluated using the DPPH radical scavenging method. Results Five known compounds: physcion (1), 1,8-dihydroxy-3-geranyloxy-6-methylanthraquinone (2), kenganthranol B (3), vismiaquinone (4), and octacosanol (5) were isolated from the leaves of P. aurantiacum while six compounds including friedelin (6), betulinic acid (7), 2,2’,5,6’-tetrahydroxybenzophenone (8), allanxanthone A (9), 1,3,6- trihydroxyxanthone (10) and isogarcinol (11) were isolated from H. lanceolatum. Compound 8 and 4 exhibited the highest antibacterial and antifungal activities with MIC ranges of 2–8 μg/ml and 4–32 μg/ml respectively. P. aurantiacum crude extract (Rsa50 = 6.359 ± 0.101) showed greater radical scavenging activity compared with H. lanceolatum extract (Rsa50 = 30.996 ± 0.879). Compound 11 showed the highest radical scavenging activity (RSa50 = 1.012 ± 0.247) among the isolated compounds, comparable to that of L-arscobic acid (RSa50 = 0.0809 ± 0.045). Conclusions The experimental findings show that the ethyl acetate and methanol extracts and isolated compounds from P. aurantiacum and H. lanceolatum stem bark possess significant antimicrobial and antioxidant activities justifying the use of these plants in traditional medicine, which may be developed as phytomedicines.
Evaluation of Toxicological Risk Related to Presence of Lead and Cadmium in Moringa oleifera Lam. Leaves Powders Marketed in Cotonou (Benin)  [PDF]
Alain K. Aissi, Elisabeth Yehouenou Pazou, Théodora A. Ahoyo, Lauris Fah, Brice Fanou, Luc Koumolou, Hornel Koudokpon, Clément Agbangla, Kissao Gnandi, Frédéric Loko, Patrick A. Edorh
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.59087

To evaluate lead and cadmium contamination in Moringa oleifera leaves powders marketed in Cotonou and health risks associated with its consumption, cross-sectional and analytical study were done from October 23th, 2012 to June 20th, 2013. Samples of Moringa powders were purchased at different outlets (health centers, supermarkets, pharmacy, etc.). Assays were performed by atomic absorption spectrophotometry after digestion according calcination method. Pb and Cd levels were compared with Codex Alimentarius standards, using the Student t test. Daily Exposure Doses (DDE) and Hazard Quotients (HQ) specific to each contaminant were calculated using a conventional method. Results revealed that the mean concentration of lead for all samples (1.526 mg/kg) exceeded of about 5.08 times the maximum allowable limit whereas cadmium levels (0.246 mg/kg) was not statistically higher than the standard. The highest concentrations of Pb and Cd are respectively 4.263 mg/kg and 0.354 mg/kg. Children are 2.3 to 3.8 times in greater danger than adults although all QD calculated are less than 1, reflecting that there is a low risk to consumers in general. For both metals, DJE specifically linked to the consumption of Moringa was less than 2% compared to other kinds of food intake. In conclusion, the current level of contamination (with lead and cadmium) of Moringa leaves powders marketed in Cotonou is not yet an alarming threat to consumers’ health. However, care must be taken to reduce chemical pollution especially soils where these plants grow.

La formation interculturelle des enseignants de langues étrangères: enjeux et perspectives / Théodora Nikou & Vassiliki Pantazi La formation interculturelle des enseignants de langues étrangères: enjeux et perspectives
Théodora Nikou,Vassiliki Pantazi
Research Papers in Language Teaching and Learning , 2011,
Abstract: La prise en compte de la diversité culturelle et linguistique dans la mesure où les sociétés européennes deviennent des mosa ques pluriculturelles, rend la formation a visée interculturelle des enseignants des langues étrangères plus qu’indispensable. La formation tout au long de la vie qui recouvre les activités d’apprentissage, entreprises à tout moment de la vie, dans le but d’améliorer les connaissances, les qualifications et les compétences, dans une perspective personnelle, civique, sociale et/ou liée à l’emploi, ne doit pas ignorer l’ouverture à une telle perspective humaniste et interactive qui, selon le Conseil de l’Europe, implique l’échange, l’élimination des barrières, la réciprocité, la solidarité ainsi que la reconnaissance des valeurs, des modes de vie et des représentations symboliques des êtres humains. L’enseignant d’aujourd’hui dans son nouveau r le de médiateur entre la culture-source et la culture-cible est-il outillé pour conduire l’apprenant, à travers l’enseignement de la langue étrangère, à la découverte d’un monde différent et à la compréhension de l’Autre? Dans le cadre de cette intervention après avoir mis les fondements théoriques de l’interculturel, nous focaliserons sur les enjeux et les perspectives de la formation interculturelle à distance des enseignants des langues étrangères.Η πολιτισμικ και γλωσσικ διαφορετικ τητα που παρατηρε ται στι ευρωπα κ κοινων ε που χουν μετατραπε σε πολυπολιτισμικ μωσα κ , καθιστ τη διαπολιτισμικ επιμ ρφωση των εκπαιδευτικ ν ξ νων γλωσσ ν κ τι περισσ τερο απ απαρα τητη. Η δια β ου επιμ ρφωση που περιλαμβ νει δραστηρι τητε εκμ θηση που αποσκοπο ν στην βελτ ωση γν σεων, δεξιοτ των και ικανοτ των, τ σο προσωπικ ν σο και κοινωνικ ν, που συνδ ονται χι με την εργασ α, δεν πρ πει να αγνοε το νοιγμα σε μια τ τοια ανθρωπιστικ διαδραστικ προοπτικ η οπο α σ μφωνα με το Συμβο λιο τη Ευρ πη οικοδομε την ανταλλαγ , τον περιορισμ των συν ρων, την αμοιβαι τητα, την αλληλεγγ η καθ και την α
Beyrouth: Quarante ans de croissance urbaine
Ghaleb Faour,Théodora Haddad,Sébastien Velut,éric Verdeil
M@ppemonde , 2005,
Abstract: There is a lack of statistical data available in Lebanon. This study therefore uses remote sensing to assess the physical growth of Beirut, in 1963, 1987, 1994, 1998 and 2003, on the basis of morphological criteria. Over time, the city has expanded substantially and become linear. The reconstruction period after the civil war saw a massive increase in urbanisation, contrasting with the war years, which did not give rise to such dramatic change, despite the political upheavals.
Phenotypic and Genotypic Characterization of Extended Spectrum β-Lactamase Klebsiella pneumoniae and Fluorescent Pseudomonas spp. Strains from Market Garden Products and Their Watering Water in Benin (West Africa)  [PDF]
Wassiyath Moussé, Pac?me A. Noumavo, Nicodème W. Chabi, Haziz Sina, Majoie G. Tohoyessou, Théodora A. Ahoyo, Lamine Baba-Moussa
Food and Nutrition Sciences (FNS) , 2016, DOI: 10.4236/fns.2016.73021
Abstract: Market garden products can carry several types of microorganisms, and their consumption is the source of many cases of food poisoning. This work aimed to improve food safety in Benin. In characterizing strains of K. pneumoniae and fluorescent Pseudomonas spp. at the biochemical and molecular level, the target was to identify contaminated watering water and garden products sold during Cotonou in both the dry and rainy seasons. A total of 164 samples of market garden products and 22 samples of watering water were investigated. The results showed that 5.91% of market garden products and watering water were contaminated by K. pneumoniae and 20.43% by fluorescent Pseudomonas spp. During the dry season, cabbage was most contaminated by fluorescent Pseudomonas spp. (50%). Pool water was more contaminated with K. pneumoniae (17%). All isolated strains were resistant to both amoxicillin and penicillin. All strains of K. pneumoniae and fluorescent Pseudomonas spp. were not resistant to imipenem, and 22% of them produced penicillinase. Among the 49 strains producing penicillinase isolated, 64.29% and 21.43% carried blaTEM and blaSHV respectively while 14.28% carried blaCTX-M genes. In light of the previously-developed results and considering the importance of horticultural products in Beninese food habits, we must improve national awareness of the risk for foodborne illness.
Phenolic Compounds and Terpenoids from Hypericum lanceolatum
Hippolyte K. Wabo,Théodora K. Kowa,Antoine Honoré N. Lonfouo,Alembert T. Tchinda
Records of Natural Products , 2012,
Abstract: A benzophenone, 2,2’,5,6’-tetrahydroxybenzophenone (1), and one xanthone, 5-hydroxy-3-methoxyxanthone (2), were newly described as natural products from the leaves and the stem barks of Hypericumlanceolatum, along with the known compounds friedelin (3), betulinic acid (4), allanxanthone A (5), 1,3,6-trihydroxyxanthone (6), isogarcinol (7), sitosterol 3-O- β -D-glucopyranoside (8), 1-hydroxy-6-methoxyxanthone (9), 6,7-dihydroxy-1,3-dimethoxyxanthone (10), 3-hydroxy-5-methoxyxanthone (11), 1,7-dihydroxy-3,6-dimethoxyxanthone (12) and calophyllumin A (13). Their structures were elucidated by spectroscopic means and comparison with published data.
Changing Mad2 Levels Affects Chromosome Segregation and Spindle Assembly Checkpoint Control in Female Mouse Meiosis I
Théodora Niault, Khaled Hached, Rocío Sotillo, Peter K. Sorger, Bernard Maro, Robert Benezra, Katja Wassmann
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0001165
Abstract: The spindle assembly checkpoint (SAC) ensures correct separation of sister chromatids in somatic cells and provokes a cell cycle arrest in metaphase if one chromatid is not correctly attached to the bipolar spindle. Prolonged metaphase arrest due to overexpression of Mad2 has been shown to be deleterious to the ensuing anaphase, leading to the generation of aneuploidies and tumorigenesis. Additionally, some SAC components are essential for correct timing of prometaphase. In meiosis, we and others have shown previously that the Mad2-dependent SAC is functional during the first meiotic division in mouse oocytes. Expression of a dominant-negative form of Mad2 interferes with the SAC in metaphase I, and a knock-down approach using RNA interference accelerates anaphase onset in meiosis I. To prove unambigiously the importance of SAC control for mammalian female meiosis I we analyzed oocyte maturation in Mad2 heterozygote mice, and in oocytes overexpressing a GFP-tagged version of Mad2. In this study we show for the first time that loss of one Mad2 allele, as well as overexpression of Mad2 lead to chromosome missegregation events in meiosis I, and therefore the generation of aneuploid metaphase II oocytes. Furthermore, SAC control is impaired in mad2+/? oocytes, also leading to the generation of aneuploidies in meiosis I.
Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark
Denis Zofou, Théodora K Kowa, Hippolyte K Wabo, Moses N Ngemenya, Pierre Tane, Vincent PK Titanji
Malaria Journal , 2011, DOI: 10.1186/1475-2875-10-167
Abstract: The anti-plasmodial activity was assayed by the lactate dehydrogenase method (pLDH) against the multidrug-resistant W2mef laboratory strain, and a field isolate (SHF4) of Plasmodium falciparum. Cytotoxicity tests were carried out using the LLC-MK2 monkey kidney epithelial cells.Five compounds were isolated from the most active and least cytotoxic ethylacetate sub-extract: betulinic acid (HLT1), 2,2',5,6'-tetrahydroxybenzophenone (HLT2), 5-hydroxy-3-methoxyxanthone (HLT3), 3-hydroxy-5-methoxyxanthone (HLT4) and HLT0 (yet to be identified). Three of the tested compounds presented significant anti-plasmodial activities (with 50% inhibitory concentration, IC50 < 5 μM), with 5-hydroxy-3-methoxyxanthone exerting the highest activity, followed by HLT0 and betulinic acid. All the compounds with significant anti-plasmodial activity were non-cytotoxic, except betulinic acid which showed a 50% cytotoxic concentration, CC50 of 25 μg/mL.These findings justify the use of H. lanceolatum stem bark as anti-malarial by traditional healers of Western Cameroon, and could constitute a good basis for further studies towards development of new drug candidates or phytomedicines for malaria.The fight against malaria was identified by the United Nations in the Millennium Development Goals as an objective and remains one of the priorities for the World Health Organization. Chemotherapy is central to any strategy for effective reduction of mortality related to malaria, since an efficient vaccine is yet to be approved [1]. The emergence and relentless spread of resistance against all the drugs in current use, including the newly introduced artemisinin-based combination therapy, have aggravated the disease burden in endemic regions [2,3]. Hence, there is an urgent need to discover new efficacious and safe anti-malarial drugs in order to face this situation.For decades, traditional herbal medicine had constituted a good basis for anti-malarial lead discovery and drug development. A typical exampl
Molecular Epidemiology of High-Risk Human Papilloma Virus Infection in Sexually Active Women at Bobo-Dioulasso University Teaching Hospital  [PDF]
Souleymane Ouattara, Der Adolphe Somé, Adama Dembélé, Salif Sanfo, Théodorat Zohoncon, Abdoul-Karim Ouattara, Moussa Bambara, Blami Dao, Jacque Simporé
Open Journal of Obstetrics and Gynecology (OJOG) , 2019, DOI: 10.4236/ojog.2019.98114
Abstract: The objective of this study was to determine the prevalence of HPV-HR genotypes in the population of sexually active women in Bobo-Dioulasso, Burkina Faso. Methods: This study took place at Souro Sanou Teaching Hospital in Bobo-Dioulasso from September to June 2017. A total of 234 women in the gynecological period and also sexually active were enrolled after they gave an individual consent. Swabbing of the endocervical canal was done. From the sample stored at -20°C, the viral DNA was extracted using the “DNA-Sorb-A” kit from SACACE biotechnologies®. Amplification of the PCR of the extracted DNA was made, using the “HPV Genotypes 14 Real-TM Quant” V67-100 FRT kit. Data were analyzed with SPSS software version 17.0 and Epi Info 6. Chi-square and Fisher’s tests were used to compare proportions and averages; a link was significant when p < 0.05. Results: The mean age was 30.7 ± 7.3 years (median: 30 years); 84.5% of them were married, 43.5% had a socio-
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