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Search Results: 1 - 10 of 506 matches for " Testosterone "
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Functioning Adrenocortical Oncocytic Carsinoma: A Case Report  [PDF]
Murat Atmaca, Saliha Y?ld?z, I??lay Kalan, Mehmet Fatih ?zbay, Deniz Y?lmaz, Müge Kara Tanr?tan?r, Mustafa ?ztürk
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2013, DOI: 10.4236/ojemd.2013.31006

Introduction: Oncocytic neoplasms of the adrenal cortex are extremely rare and are usually nonfunctioning. Only a little more than fifty cases have been described in the literature. Case Presentation: We report the case of an adrenocortical oncocytic neoplasm with malignant potential in a 21-year-old female with co-secrete testosterone and cortisol. The patient had been operated of adrenal mass. Fallowing operation, the Cushing’s syndrome and high testosterone levels resolved. Conclusion: In our knowledge this is the first case in the l?terature which co-secret cortizol and testosterone in malign oncystoma.

Strength, But Not Direction, of Handedness Is Related to Height  [PDF]
Ruth E. Propper, Tad T. Brunye, Karly Hrank, Sean E. McGraw
Open Journal of Medical Psychology (OJMP) , 2013, DOI: 10.4236/ojmp.2013.24025
Abstract: Left-handers are reputed to be shorter than right-handers. However, previous research has confounded handedness direction (left-versus right-handedness) with handedness strength (consistency with which one hand is chosen across a variety of tasks; consistent-versus inconsistent-handedness). Here, we support a relationship between handedness strength, but not direction, and stature, with increasing inconsistent-handedness associated with increasing self-reported height.
Testosterone Levels Do Not Decline with Age in Healthy Men  [PDF]
Akanksha Mehta, Alexander Bolyakov, Raymond C. Sultan, Laurent Vaucher, Anna Mielnik, Joseph Kiper, Darius A. Paduch
Open Journal of Urology (OJU) , 2013, DOI: 10.4236/oju.2013.34032

Aim: To establish norms for reproductive hormones in healthy males with normal urologic and sexual function, and to assess the change in reproductive hormone levels with respect to age among healthy males. Methods: Healthy volunteers aged 18 - 29 (group 1) and 45 - 65 (group 2) were recruited for enrollment in a prospective study. Inclusion criteria comprised normal urinary, ejaculatory, orgasmic, and erectile function, as determined by IPSS, MSHQ, and IEFF-15. Men with history of chronic medical illnesses or chronic medication use were excluded. Fifty men met the study criteria. Each participant underwent physical examination and standardized serum hormone evaluation using ELISA and EIA methods. Statistical analysis was performed using JMP 8.0 software (SAS Institute Inc., Cary, NC), to compare hormone levels between the two groups of men. Results: There were 25 men each in groups 1 (mean age 26) and 2 (mean age 51). Overall, 46% were Caucasian, 31% African American, 15% Hispanic, and 8% Asian. There was no statistically significant difference in serum total T, SHBG, E2, or LH between groups 1 and 2. Notably, the 95% CI for serum T levels for both groups of men were considerably higher than commonly accepted lower-end cut-off limits. Conclusion: Serum T levels do not vary significantly with age, in otherwise healthy men with normal sexual and urologic function. Furthermore, healthy men have much higher serum total and free T levels than the lower-end reference limits provided by commercial laboratories.

Oxytocin but Not Testosterone Modulates Behavioral Patterns in Autism Spectrum Disorders  [PDF]
Silvia Lakatosova, Sheinberg Nurit, Pivovarciova Anna, Husarova Veronika, Rozenfeld Irina, Ostatnikova Daniela, Castejon Ana Maria
Open Journal of Medical Psychology (OJMP) , 2014, DOI: 10.4236/ojmp.2014.31006
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder of unknown etiology. Social deficits represent one of the core symptoms of the diagnosis. The aim was to reveal possible correlations among peripheral levels of oxytocin and testosterone with behavioral and symptom characteristics in patients with ASD. 8 children with ASD were recruited and underwent psychological profiling. Blood oxytocin and testosterone levels were analyzed using ELISA method. Oxytocin levels positively correlated with Adaptation to change category of CARS-2 (P = 0.008, R = 0.848) and Vineland-II maladaptive behavior scores (P = 0.004, R = 0.884). No significant correlations were found among testosterone levels and behavioral parameters. Higher oxytocin levels were connected with more severe adaptive behavior in ASD patients. Increased oxytocin levels in children with more severe phenotype could be a result of compensatory mechanism of impaired oxytocin signaling. Oxytocin seems to employ distinct mechanisms in regulating social behavior in autism and healthy population.
Effects of Sertraline on Sperm Motility, Number and Viability and Its Relation to Blood Levels of Testosterone, FSH and LH in Adult Male Mice  [PDF]
Mahsa Hadipour Jahromy, Anousheh Amini Moghadam
Advances in Sexual Medicine (ASM) , 2014, DOI: 10.4236/asm.2014.42004
Abstract: The aim of this study was to investigate the effects of Sertraline on gonad-pituitary cycle (Testosterone, FSH and LH) and reproductive cells in adult male Balb/C mice. Adult male Balb/C mice were divided into the following 5 groups: control group with no treatment, sham group which received solvent, and the experimental groups which received one dose of Sertraline (0.0178 mg/kg) in the first group, two doses of Sertraline (0.0356 mg/kg) in the second group, and three doses of Sertraline (0.0534 mg/kg) in the third group. Mice were anaesthetized after 7 weeks. Serum samples were collected and Testosterone, FSH and LH levels of serum were assayed. Vase deferans were analyzed for motility, number and viability of sperms. The results of this study showed that the viability, count and motility of sperms were decreased. Testosterone level of blood was also decreased while FSH was increased. There was no significant change in LH level. It is suggested that Sertraline at higher dose decreases sperm production and has the potential to affect adversely fertility in male mice.
Cardiovascular Benefits of Testosterone Replacement Therapy in the Andropausal Male  [PDF]
Satya K. Vatti, Raef Madanieh, Abed Madanieh, Constantine E. Kosmas, Timothy J. Vittorio
Health (Health) , 2015, DOI: 10.4236/health.2015.79135
Abstract: Androgen deficiency has been receiving a lot of attention as an evolving health concern in the in-dustrialized world. With population aging, hypogonadism has become a challenging medical problem confronting practicing physicians. The importance of this increasingly prevalent disease arises from its potentially debilitating and serious consequences, such as atherosclerosis, diabetes mellitus, metabolic disorders, muscular weakness, psychiatric illness, sexual dysfunction and vascular inflammation. When left untreated, testosterone deficiency is associated with increased cardiovascular mortality.
Use of Basal Serum Testosterone Level as Predictor for Poor Ovarian Response in Women with Unexplained Infertility Undergoing In Vitro Fertilization Cycle: Prospective Study  [PDF]
Waleed M. Khalaf, Hayam Fathy, Sarah Safwat
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.814153
Abstract: Background: Delayed pregnancy in women and marked increase in the numbers of older women who fail to respond to ovarian stimulation had been a significant issue. This study aims to assess the value of basal serum testosterone level as a predictor of ovarian response for induction of ovulation in women with unexplained infertility undergoing IVF (in vitro fertilization) cycle. Patients and Methods: A prospective study was conducted in Ain Shams University Maternity hospital Infertility Center during a period of time from October 2016 to June 2017. This study recruited 89 women. On day 2 or 3 of a spontaneous menstrual cycle of the included women within 3 months before fresh IVF cycle, basal hormonal (FSH, LH, estradiol, total testosterone) concentrations, AFC (antral follicle count) were performed. Using the Long-protocol for induction of ovulation, serial monitoring of ovarian response was assessed by transvaginal ultrasound. When the expected ovarian response was reached (at least three oocytes 17 mm), we gave trigger dose of HCG. Ultrasound guided oocyte aspiration was performed 34 -
Slow movement resistance training in women  [PDF]
Shunsuke Yamaji, Shinichi Demura, Narihiro Watanabe, Masanobu Uchiyama
Health (Health) , 2010, DOI: 10.4236/health.2010.210169
Abstract: A resistance training protocol of low intensity and short duration allows for increased training frequency and improved compliance. This study aimed to examine the short-term (response of growth hormone (GH) and testosterone after one exercise session) and long-term (change of fitness level and body fat percentage after the exercise period) effects of slow movement resistance training using the individual’s body mass (hiroNARI style training) in adult women and to clarify their subjective sense of training continuity. Nineteen healthy adult women performed hiroNARI style training three times a week for 12 weeks. This protocol consisted of 12 types of exercise for 7 muscle groups. GH and testosterone increased significantly after one exercise session (70% and 23.3%, p < 0.05, respectively). Height and the circumferences of the upper arm (flexed), chest, waist, hip, and thigh changed significantly. Except for the upper arm circumference, these parameters improved significantly after 6 weeks. There were significant improvements in measurements of physical fitness after 6 weeks including one leg raise with eyes closed, side step, and repeated sit ups for 30 s. After 12 weeks, anteflexion from a long sitting position improved as well. Triglycerides and HDL and LDL cholesterol changed significantly after 12 weeks. In conclusion, resistance training may have positive effects and is associated with high compliance. However, it will be necessary to reexamine the training protocol for increasing back and lower limb muscle strength and necessary variations to prevent overtraining of certain muscle groups.
Radio Frequency-Microchannels for Transdermal Delivery: Characterization of Skin Recovery and Delivery Window  [PDF]
Yossi Kam, Hagit Sacks, Keren Mevorat Kaplan, Meir Stern, Galit Levin
Pharmacology & Pharmacy (PP) , 2012, DOI: 10.4236/pp.2012.31004
Abstract: Transdermal delivery through Radio-Frequency-MicroChannels (RF-MCs) was proven to be a promising delivery method for hydrophilic drugs and macromolecules that must be injected. An important issue in assessing this technology is the life span of the microchannels (MCs). The time window in which the MCs remain open affects the delivery rate and determine the effective delivery duration. The present work focused on the characterization of the ViaDor-MCs recovery and closure process by measurements of transepidermal water loss (TEWL) before and after the formation of MCs, evaluation of the delivery window, and assessment of skin histology. Testosterone-cyclodextrin complex was used as the model drug for evaluation of the transdermal delivery. In-vitro permeation system and in-vivo guinea pig animal model were used in the delivery studies. Our findings demonstrate the recovery process of MCs created by the RF ablation technology. The observed gradual skin recovery affected the transdermal delivery rate. A significant transdermal delivery was shown up to 24 hrs post device application suggesting that an extended delivery of water soluble drugs, including macromolecules, is possible. The histology assessments demonstrated repair and healing of the induced MCs indicating that the RF micro-channeling technology is minimally invasive, transient in nature with no resulting skin trauma.
Investigation of minerals, testosterone, and transaminases in the semen and serum of fertile and infertile men belongs to different age groups  [PDF]
Zahed Mahmood, Muhammad Riaz, Imtiaz Mahmood Tahir, Abdul Shakoor, Zia-ur Rahman, Muhammad Usman Qamar Saeed
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.35074
Abstract: The present study was aimed to assess the potential of infertility to induce the adverse effects with reference to testosterone, Triiodothyronine (T3), Thyroxine (T4), Alanine Aminotransferase (ALT), Aspartate Amino-transferase (AST), zinc, copper and iron. All the samples were divided into four groups according to age and disorder (Group 1, 10 infertile men of 25-40 years; Group 2, 10 fertile men of 25-40 years; Group 3, 10 infertile men of 41- 60 years and Group 4, 10 fertile men of 41-60 years). Semen and blood samples were analyzed by atomic absorption spectrophotometry to determine minerals while, Testosterone, T3 and T4 were determined by enzyme immunoassay kits. ALT and AST were determined using standard kit assay method. The levels of testosterone and T3 and AST in the fertile semen of 41-60 years age group were increased significantly (P ≤ 0.001) as compared to that of fertile semen of 25-40 years age group. While, the level of T4 in the fertile semen of 41-60 years age group was decreased significantly (P ≤ 0.001) as compared to that of fertile semen of 25-40 years age group. In case of fertile serum, only the level of testosterone was significantly decreased (P ≤ 0.05) in the 41-60 years age group as compared to 25-40 years age group. The levels of testosterone and Cu in the infertile serum of 41-60 years age group were decreased significantly (P ≤ 0.001). While, the levels of T3, T4, ALT and Fe in the infertile serum of 41-60 years age group were increased significantly (P ≤ 0.05) as compared to that of infertile serum of 25-40 years age group.
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