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Search Results: 1 - 10 of 258 matches for " Teruhito Mochizuki "
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Usefulness of an Anisotropic Diffusion Method in Cerebral CT Perfusion Study Using Multi-Detector Row CT  [PDF]
Kenya Murase, Takafumi Nanjo, Yoshifumi Sugawara, Masaaki Hirata, Teruhito Mochizuki
Open Journal of Medical Imaging (OJMI) , 2015, DOI: 10.4236/ojmi.2015.53015
Abstract: Purpose: To present an application of the anisotropic diffusion (AD) method to improve the accuracy of the functional images of perfusion parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) generated from cerebral CT perfusion studies using multi-detector row CT (MDCT). Materials and Methods: Continuous scans (1 sec/rotation ×60 sec) consisting of four 5-mm-thick contiguous slices were acquired after an intravenous injection of iodinated contrast material in 6 patients with cerebrovascular disease using an MDCT scanner with a tube voltage of 80 kVp and a tube current of 200 mA. New image data were generated by thinning out the above original images at an interval of 2 sec or 3 sec. The thinned-out images were then interpolated by linear interpolation to generate the same number of images as originally acquired. The CBF, CBV and MTT images were generated using deconvolution analysis based on singular value decomposition. Results: When using the AD method, the correlation coefficient between the MTT values obtained from the original and thinned-out images was significantly improved. Furthermore, the coefficients of variation of the CBF, CBV and MTT values in the white matter significantly decreased as compared to not using the AD method. Conclusion: Our results suggest that the AD method is useful for improving the accuracy of the functional images of perfusion parameters and for reducing radiation exposure in cerebral CT perfusion studies using MDCT.
Myocardial Segmentation of Area at Risk Based on Coronary Computed Tomography Angiography and Voronoi Diagram in Comparison with Magnetic Resonance Perfusion Imaging  [PDF]
Naoki Fukuyama, Teruhito Kido, Akira Kurata, Yuki Tanabe, Tomoyuki Kido, Takahiro Yokoi, Ryo Ogawa, Hikaru Nishiyama, Teruyoshi Uetani, Teruhito Mochizuki
Open Journal of Radiology (OJRad) , 2017, DOI: 10.4236/ojrad.2017.71002
Abstract: Purpose: To assess the clinical feasibility of automated segmentation of the myocardial area at risk (MAAR) using coronary computed tomography angiography (CT-MAAR), as compared to stress magnetic resonance myocardial perfusion imaging (MR-MPI). Materials and Methods: Thirty patients who underwent coronary computed tomography angiography (CTA) and stress MR-MPI were retrospectively evaluated. The myocardial territory of the left ventricle (LV) distal to coronary artery stenosis (≥50% or ≥70% stenosis on coronary CTA) was three-dimensionally quantified using a Voronoi diagram. The ratio of all stenosis-related territories to the LV volume was defined as CT-MAAR (%-LV volume). The proportion of segments with perfusion defects in stress MR-MPI to the total of 16 segments (range: 0% - 100%; with a 6.3%-interval scale) was defined as the reference. Correlation was assessed using Spearman’s test. The capability of CT-MAAR to predict the ischemic burden was assessed. Results: Stress MR-MPI depicted a median ischemic burden of 25.2% (range: 18.9% - 44.1%) in 30 patients without myocardial infarction. When CTA stenosis criteria of ≥50% (n = 30) and ≥70% (n = 27) were applied to estimate CT-MAAR, the median CT-MAAR values were 48.2% (31.6% - 64.3%) and 32.5% (23.7% - 51.9%), respectively. The correlations between the CT-MAAR values and the MR-based ischemic burden were significant (0.73 and 0.97 for ≥50% and ≥70% stenosis, respectively). CT-MAAR predicted the MR-based ischemic burden within ±1 segment of %-LV (6.3%) in 40% (12/30) of patients with ≥50% stenosis, and in 81.5% (22/27) of patients with ≥70% stenosis. Conclusions: Comprehensive assessment of resting coronary CTA combined with Voronoi diagram-based myocardial segmentation may help predict the myocardial ischemic burden in patients with severe coronary CTA stenosis.
BAFF Controls Neural Cell Survival through BAFF Receptor
Satoru Tada, Teruhito Yasui, Yuji Nakatsuji, Tatsusada Okuno, Toru Koda, Hideki Mochizuki, Saburo Sakoda, Hitoshi Kikutani
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070924
Abstract: Various neuroprotective factors have been shown to help prevention of neuronal cell death, which is responsible for the progression of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). However, most of these therapeutic potentials have been tested by administration of recombinant proteins, transgenic expression or virus vector-mediated gene transfer. Therefore, it remains to be clarified whether any endogenous factors has advantage for neuroprotection in a pathological nervous system. Here we show the role of BAFF-R signaling pathway in the control of neural cell survival. Both B cell–activating factor (BAFF) and its receptor (BAFF-R) are expressed in mouse neurons and BAFF-R deficiency reduces the survival of primary cultured neurons. Although many studies have so far addressed the functional role of BAFF-R on the differentiation of B cells, impaired BAFF-R signaling resulted in accelerated disease progression in an animal model of inherited ALS. We further demonstrate that BAFF-R deficient bone marrow cells or genetic depletion of B cells does not affect the disease progression, indicating that BAFF-mediated signals on neurons, not on B cells, support neural cell survival. These findings suggest opportunities to improve therapeutic outcome for patients with neurodegenerative diseases by synthesized BAFF treatment.
Qualitative and Quantitative Assessment of Adenosine Triphosphate Stress Whole-Heart Dynamic Myocardial Perfusion Imaging Using 256-Slice Computed Tomography
Akira Kurata, Naoto Kawaguchi, Teruhito Kido, Katsuji Inoue, Jun Suzuki, Akiyoshi Ogimoto, Jun-ichi Funada, Jitsuo Higaki, Masao Miyagawa, Mani Vembar, Teruhito Mochizuki
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083950
Abstract: Background The aim of this study was to investigate the correlation of the qualitative transmural extent of hypoperfusion areas (HPA) using stress dynamic whole-heart computed tomography perfusion (CTP) imaging by 256-slice CT with CTP-derived myocardial blood flow (MBF) for the estimation of the severity of coronary artery stenosis. Methods and Results Eleven patients underwent adenosine triphosphate (0.16 mg/kg/min, 5 min) stress dynamic CTP by 256-slice CT (coverage: 8 cm, 0.27 s/rotation), and 9 of the 11 patients underwent coronary angiography (CAG). Stress dynamic CTP (whole–heart datasets over 30 consecutive heart beats in systole without spatial and temporal gaps) was acquired with prospective ECG gating (effective radiation dose: 10.4 mSv). The extent of HPAs was visually graded using a 3-point score (normal, subendocardial, transmural). MBF (ml/100g/min) was measured by deconvolution. Differences in MBF (mean ± standard error) according to HPA and CAG results were evaluated. In 27 regions (3 major coronary territories in 9 patients), 11 coronary stenoses (> 50% reduction in diameter) were observed. In 353 myocardial segments, HPA was significantly related to MBF (P < 0.05; normal 295 ± 94; subendocardial 186 ± 67; and transmural 80 ± 53). Coronary territory analysis revealed a significant relationship between coronary stenosis severity and MBF (P < 0.05; non-significant stenosis [< 50%], 284 ± 97; moderate stenosis [50–70%], 184 ± 74; and severe stenosis [> 70%], 119 ± 69). Conclusion The qualitative transmural extent of HPA using stress whole-heart dynamic CTP imaging by 256-slice CT exhibits a good correlation with quantitative CTP-derived MBF and may aid in assessing the hemodynamic significance of coronary artery disease.
Subendocardial contractile impairment in chronic ischemic myocardium: assessment by strain analysis of 3T tagged CMR
Michinobu Nagao, Masamitsu Hatakenaka, Yoshio Matsuo, Takeshi Kamitani, Ko Higuchi, Fumiaki Shikata, Mitsugi Nagashima, Teruhito Mochizuki, Hiroshi Honda
Journal of Cardiovascular Magnetic Resonance , 2012, DOI: 10.1186/1532-429x-14-14
Abstract: 3T tagged CMR was performed at rest in 12 patients with severe coronary artery disease who had been scheduled for coronary artery bypass grafting. Circumferential strain (C-strain) at end-systole on subendocardial and epicardial layers was measured using the short-axis tagged images of the LV and available software (Intag; Osirix). The myocardial segment was divided into stenotic and non-stenotic segments by invasive coronary angiography, and ischemic and non-ischemic segments by stress myocardial perfusion scintigraphy. The difference in C-strain between the two groups was analyzed using the Mann-Whitney U-test. The diagnostic capability of C-strain was analyzed using receiver operating characteristics analysis.The absolute subendocardial C-strain was significantly lower for stenotic (-7.5 ± 12.6%) than non-stenotic segment (-18.8 ± 10.2%, p < 0.0001). There was no difference in epicardial C-strain between the two groups. Use of cutoff thresholds for subendocardial C-strain differentiated stenotic segments from non-stenotic segments with a sensitivity of 77%, a specificity of 70%, and areas under the curve (AUC) of 0.76. The absolute subendocardial C-strain was significantly lower for ischemic (-6.7 ± 13.1%) than non-ischemic segments (-21.6 ± 7.0%, p < 0.0001). The absolute epicardial C-strain was also significantly lower for ischemic (-5.1 ± 7.8%) than non-ischemic segments (-9.6 ± 9.1%, p < 0.05). Use of cutoff thresholds for subendocardial C-strain differentiated ischemic segments from non-ischemic segments with sensitivities of 86%, specificities of 84%, and AUC of 0.86.Analysis of tagged CMR can non-invasively demonstrate predominant impairment of subendocardial strain in the chronic ischemic myocardium at rest.Systolic wall thickening of the left ventricle (LV) is distributed transmurally inhomogeneously. In the normal myocardium, subendocardial deformation becomes markedly greater than subepicardial deformation [1]. The progression of myocardial ischemia ha
Simultaneous Measurability of Error and Disturbance  [PDF]
Riuji Mochizuki
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.42036

The uncertainty relation, which displays an elementary property of quantum theory, was originally described by Heisenberg as the relation between error and disturbance. Ozawa presented a more rigorous expression of the uncertainty relation, which was later verified experimentally. Nevertheless, the operators corresponding to error and disturbance should be measurable in the identical state if we follow the presupposition of Heisenbergs thought experiment. In this letter, we discuss simultaneous measurability of error and disturbance and present a new inequality using error and disturbance in the identical state. A testable example of this inequality is also suggested.

Role on Moment of Inertia and Vortex Dynamics for a Thin Rotating Plate  [PDF]
Yoshihiro Kubota, Osamu Mochizuki
World Journal of Mechanics (WJM) , 2013, DOI: 10.4236/wjm.2013.36028

In this study, we focused on the lift generation with a thin rotating plate. The objective of this study is to understand the appropriate shape and the role of vortex for rotating thin plate. We determined the shape of the plate through free-flight tests of paper strips and investigated the aerodynamic characteristics of the rotating plate with the selected shape. The rectangular plate with an aspect ratio 7 was relevant from moment of inertia and bending stress. An endplate on a wing tip increased the stability on the lateral vortex structure behind the rotating plate. Velocity field measurement by Particle Image Velocimetry (PIV) showed that the lift force was generated twice in a rotating cycle.

Numerical Investigation of Aerodynamic Characteristics by a Rotating Thin Plate  [PDF]
Yoshihiro Kubota, Osamu Mochizuki
World Journal of Mechanics (WJM) , 2015, DOI: 10.4236/wjm.2015.53005
Abstract: In this study, we use a thin rotating plate to generate propulsion and lift for a paper plate. And the thin plate rotates along the spanwise axis. We numerically determine the influence on aerodynamic characteristics with a rotational velocity of the thin plate. The rotational velocity is obtained with spin parameter which is the ratio of the peripheral speed of the plate to the main flow velocity. And the numerical simulations based on the discrete vortex method show that the autorotation mode of the plate in a uniform flow appears naturally when the spin parameter is unity. Vortex formed from the backward-rotating edge is weaker than those generated from the forward-rotating edge of thin plate. The maximum lift generated at S = 0.75 if S < 1. The negative moment becomes negative for the nondimensional rotating speed S ≤ 1.75. The most negative moment appears when S = 1; at that time, autorotation occurs naturally.
Splash Formation Due to a Frog Diving into Water  [PDF]
Yoshihiro Kubota, Osamu Mochizuki
World Journal of Mechanics (WJM) , 2015, DOI: 10.4236/wjm.2015.57014
Abstract: Herein, we present the results of our experimental investigation of splashes formed by a frog diving into water from the ground or from a leaf and the accompanying sound generated by the impact of the frog on the water. The experiments are performed by visualizing the flow with a high-speed camera. In addition, we used physical models comprising hydrophilic bodies made from hydrogel or acrylic resin to experimentally study how hydrophilicity affects the splash. In these experiments, we use the degree of swelling to define the hydrophilicity degree. The results show that different splashes are caused by the increase in water-film velocity upon an increase in hydrophilicity. For a body with strong hydrophilicity, at a relatively high film velocity, the water film forms when the body impacts the water surface separates from the body surface. In addition, an aircavity forms when the film separates from the body. We empirically examine the relation between the hydrophilicity degree and film velocity. The results indicate that increased hydrophilicity does not reduce the splash. Therefore, we conclude that reducing of the formation of water from the biomimetic point of view is related to the shape of body.
New roles of osteoblasts involved in osteoclast differentiation
Teruhito Yamashita,Naoyuki Takahashi,Nobuyuki Udagawa
World Journal of Gastroenterology , 2012, DOI: 10.5312/wjo.v3.i11.175
Abstract: Bone-resorbing osteoclasts are formed from a monocyte/macrophage lineage under the strict control of bone-forming osteoblasts. So far, macrophage colony-stimulating factor (M-CSF), receptor activator of nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG) produced by osteoblasts play major roles in the regulation of osteoclast differentiation. Recent studies have shown that osteoblasts regulate osteoclastogenesis through several mechanisms independent of M-CSF, RANKL, and OPG production. Identification of osteoclast-committed precursors in vivo demonstrated that osteoblasts are involved in the distribution of osteoclast precursors in bone. Interleukin 34 (IL-34), a novel ligand for c-Fms, plays a pivotal role in maintaining the splenic reservoir of osteoclast-committed precursors in M-CSF deficient mice. IL-34 is also able to act as a substitute for osteoblast-producing M-CSF in osteoclastogenesis. Wnt5a, produced by osteoblasts, enhances osteoclast differentiation by upregulating RANK expression through activation of the non-canonical Wnt pathway. Semaphorin 3A produced by osteoblasts inhibits RANKL-induced osteoclast differentiation through the suppression of immunoreceptor tyrosine-based activation motif signals. Thus, recent findings show that osteoclast differentiation is tightly regulated by osteoblasts through several different mechanisms. These newly identified molecules are expected to be promising targets of therapeutic agents in bone-related diseases.
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