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Fisiopatogenia, epidemiologia e diagnóstico laboratorial da candidemia
Giolo, Muriel Padovani;Svidzinski, Terezinha Inez Estivalet;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2010, DOI: 10.1590/S1676-24442010000300009
Abstract: candidemia is a bloodstream infection caused by yeasts of the genus candida spp. the most commonly isolated species in venous blood samples of hospitalized patients are: c. albicans, c. tropicalis, c. parapsiolosis, c. glabrata and c. krusei. this study aimed at providing a review of candidemia, showing some important aspects of etio-epidemiology, fungus/host relation, and laboratorial diagnosis of this emerging systemic infection. during the onset of candidemia, yeasts play a major role on several virulence factors, which ultimately promote its pathogenesis. among them, it may be highlighted the extracellular enzyme production, dimorphism, hemolysin synthesis, adhesion ability and biofilm development. in infected patients, medicines must be administered in the early stages to minimize the risks of complications and antimicrobial resistance. therefore, an efficient laboratory diagnosis is required. the study of these factors associated with genotype analysis may contribute decisively to the discovery of new substances that may have a preventive and/or therapeutic effect on patients with candidemia or prone to develop it.
Leveduras nos tratos urinário e respiratório: infec??o fúngica ou n?o?
Vidigal, Pedrina Gon?alves;Svidzinski, Terezinha Inez Estivalet;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2009, DOI: 10.1590/S1676-24442009000100009
Abstract: the beginning of 80s was noticeable by hospital fungal infections, mainly in immunocompromised patients, resulting in serious health problems. yeasts from candida genus are among the most important agents of these infections. however, non-albicans species appear not only as colonizers, but also as pathogens responsible for severe infections. the urinary and the respiratory tracts are anatomical sites colonized by these microorganisms and they are susceptible to infections, which may cause hematogenic dissemination. nevertheless, there are some controversies about the medical approach towards laboratory yeast findings in samples from the urine or respiratory tract, as the criteria used for the mycoses diagnosis in these sites are still not well established. the objective of this study was to discuss the aspects related to the difficulties in evaluating yeast findings in samples from the urinary and respiratory tracts in hospitalized patients, and also their involvement in invasive infection processes.
Virulence potential of filamentous fungi isolated from poultry barns in Cascavel, Paraná, Brazil
Taira, Cleison Ledesma;Mota, Valdeci Aparecido;Svidzinski, Terezinha Inez Estivalet;
Brazilian Journal of Pharmaceutical Sciences , 2011, DOI: 10.1590/S1984-82502011000100019
Abstract: opportunistic fungi are those that normally would not cause diseases in otherwise healthy people, but are able to cause problems under some circumstances, and for this they need to possess a certain virulence potential. the objective of this study was to identify samples of filamentous fungi isolated from poultry barns in cascavel, paraná, and also to evaluate their virulence potential by assessing proteinase production, hemolytic activity, urease production, and growth rate at 37 oc. we have evaluated the following samples: acremonium hyalinulum (1 sample), aspergillus sp. (12), beauveria bassiana (1), curvularia brachyspora (1), paecilomyces variotti (1), and penicillium sp. (2). out of the 18 samples analyzed, 44.4% showed proteolytic activity using albumin as the substrate versus 66.7% when using casein; 66.7% showed hemolytic activity, 83.3% were positive for urea, and 88.9% grew at a temperature of 37 oc. the results demonstrated that the majority of the isolates expressed virulence factors. therefore, these isolates have the potential to harm human hosts, such as those working at poultry barns, especially predisposed or susceptible individuals.
Dissocia??o clínico-radiológica nas manifesta??es pulmonares da paracoccidioidomicose
Gomes, Elenice;Wingeter, Márcia Arias;Svidzinski, Terezinha Inez Estivalet;
Revista da Sociedade Brasileira de Medicina Tropical , 2008, DOI: 10.1590/S0037-86822008000500004
Abstract: lungs are among the main sites affected by paracoccidioidomycosis. however, the alterations are not always easy to differentiate from other respiratory disorders. the objectives of the present study were to investigate the frequency of lung impairment in paracoccidioidomycosis cases and to investigate whether any clinical-radiological association exists. a retrospective study was carried out from march 1996 to november 2006, among patients with paracoccidioidomycosis at the regional university hospital of maringá, paraná, brazil. over this period, 45 cases were confirmed, of which 79.5% presented radiological abnormalities on chest x-rays, and four of them also presented pulmonary tuberculosis. out of the total of 40 patients with paracoccidioidomycosis alone, 57.5% presented respiratory clinical manifestations, whereas 77.5% presented radiological abnormalities, thus demonstrating clinical-radiological dissociation. on the other hand, 80.6% of the patients who presented radiological abnormalities said that they smoked. we concluded that although morphological abnormalities in the lungs are frequent, they do not always correspond to respiratory signs and symptoms and cannot easily be attributed exclusively to paracoccidioidomycosis.
Ocorrência de onicomicose em Maringá, Estado do Paraná, Brasil = Occurrence of the onychomycosis in Maringá, Paraná State, Brazil
Isabel Cristina Martelozo,Eliana Guilhermetti,Terezinha Inez Estivalet Svidzinski
Acta Scientiarum : Health Sciences , 2005,
Abstract: Onicomicoses s o infec es fúngicas que atingem as unhas e acometem cerca de 30% da popula o. Recentemente tem sido relatado aumento dessas infec es e também altera es em sua etiologia. O objetivo deste estudo foi avaliar a freqüência das onicomicoses e perfil dos pacientes acometidos em Maringá, Estado do Paraná, Brasil. Entre janeiro de 1999 a junho de 2003 foram analisadas, no Laboratório de Micologia do Lepac (Laboratório de Ensino e Pesquisa em Análises Clínicas) da Universidade Estadual de Maringá, um total de 435 amostras de pacientes com suspeita clínica de onicomicose. Destas amostras 74,25% (N=323) foram positivas, sendo 15,48% confirmadas por exame direto (N=50), 20,43% exclusivamente por cultura (N=66) e 64,09% por exame direto e cultura (N=207). As mulheres foram mais afetadas que os homens (72,67% e 27,33%), respectivamente, e a maior prevalência foi em indivíduos com mais de 40 anos. As unhas dos pés foram mais acometidas que as unhas das m os (65,90% e 34,10%), respectivamente. Os agentes etiológicos mais freqüentes foram as leveduras (52,17%) isoladas especialmente das unhas das m os. Os fungos filamentosos foram prevalentes nas unhas dos pés, destacando-se os dermatófitos responsáveis por 33,85% das onicomicoses e os n o dermatófitos (FFND) por 13,97%. Onychomycosis are fungal infections that reach the nails and affect about 30% of the population. Recently has been observed increase of these infections and also alterations in its etiology. The objective of this study was to evaluate the frequency of these mycosis and profile of the patients attacked in Maringá, Paraná State, Brazil. Between January 1999 to June 2003 were analyzed at the Mycological Laboratory from the Teaching and Research Laboratory in Clinical Analyses (Lepac) a total of 435 samples of patients with clinical symptoms of onychomycoses. Of those samples 74,25% (N=323), were positive, being 15,48% confirmed by direct examination (N=50), 20,43% by culture exclusively (N=66) and 64,09% by direct examination plus culture (N=207). Females were more affected than males (72,67% and 28,33%) respectively and the higher prevalence was in patients more than 40 years old. Toenails were more frequently infected than fingernails (65,90% and 34,10%) respectively. Yeasts were isolated in 52,17% of nail samples analysed, specially from finger nails. Filamentous fungi were isolated mainly from toenails. The dermatophytes and Non-dermatophytes filamentous fungi (NDFF) wereresponsible for 33,85% and 13,97% of cases respectively.
Antifungal Activity of Brazilian Propolis Microparticles against Yeasts Isolated from Vulvovaginal Candidiasis
Kelen Fátima Dalben Dota,Marcia Edilaine Lopes Consolaro,Terezinha Inez Estivalet Svidzinski,Marcos Luciano Bruschi
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/neq029
Abstract: Propolis, a resinous compound produced by Apis mellifera L. bees, is known to possess a variety of biological activities and is applied in the therapy of various infectious diseases. The aim of this study was to evaluate the in vitro antifungal activity of propolis ethanol extract (PE) and propolis microparticles (PMs) obtained from a sample of Brazilian propolis against clinical yeast isolates of importance in the vulvovaginal candidiasis (VVC). PE was used to prepare the microparticles. Yeast isolates (=89), obtained from vaginal exudates of patients with VVC, were exposed to the PE and the PMs. Moreover, the main antifungal drugs used in the treatment of VVC (Fluconazole, Voriconazole, Itraconazole, Ketoconazole, Miconazole and Amphotericin B) were also tested. Minimum inhibitory concentration (MIC) was determined according to the standard broth microdilution method. Some Candida albicans isolates showed resistance or dose-dependent susceptibility for the azolic drugs and Amphotericin B. Non-C. albicans isolates showed more resistance and dose-dependent susceptibility for the azolic drugs than C. albicans. However, all of them were sensitive or dose-dependent susceptible for Amphotericin B. All yeasts were inhibited by PE and PMs, with small variation, independent of the species of yeast. The overall results provided important information for the potential application of PMs in the therapy of VVC and the possible prevention of the occurrence of new symptomatic episodes.
Paracoccidioidomicose e tuberculose: diagnóstico diferencial
Bertoni, Thamara Aline;Takao, Elisa Keiko Hirayama;Dias, José Ricardo Colleti;Svidzinski, Terezinha Inez Estivalet;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2010, DOI: 10.1590/S1676-24442010000100004
Abstract: this study reports the case of a patient who allegedly had paracoccidioidomycosis (pcm) for fifteen years. despite the fact that his baciloscopy result had always been negative, he was empirically treated for tuberculosis twice without clinical improvement. pcm diagnosis through simple methodology draws attention to the importance of parallel investigation into tuberculosis and paracoccidioidomycosis as differential diagnosis in chronic symptomatic patients.
Candidíase vulvovaginal: fatores predisponentes do hospedeiro e virulência das leveduras
álvares, Cassiana Aparecida;Svidzinski, Terezinha Inez Estivalet;Consolaro, Márcia Edilaine Lopes;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2007, DOI: 10.1590/S1676-24442007000500004
Abstract: introduction: vulvovaginal candidiasis (vvc) is a vulva and vagina infection caused by comensal yeasts that inhabit the vaginal mucosa and eventually become patogenic, depending on host conditions. eighty percent to 90% of the infections are due to c. albicans, and 10% to 20% to other species called non-c. albicans (c. tropicalis, c. glabrata, c. krusei, c. parapsilosis, c. pseudotropicalis, c. lusitaniae). c. glabrata is the second agent in frequency in vvc and yeasts of other genus can also cause this infection, as saccahromyces cerevisiae, rhodutorula sp. and trichosporon sp. besides host inherent factors, it has been postulated that differences exist in the patogenicity of different isolates of candida sp. the fungus is not a mere passive participant in the infectious process, and a series of virulence factors has been proposed, but little was investigated in vvc. the objective of this work is to enlarge knowledge on vvc and rvvc, as well as to discuss the influences of host and virulence factors, aiming to identify their importance in this pathology. these aspects are of great importance for professionals that act in the area of women?s health.
Antifungal activity of propolis extract against yeasts isolated from onychomycosis lesions
Oliveira, Ana Carla Pozzi;Shinobu, Cristiane Suemi;Longhini, Renata;Franco, Selma Lucy;Svidzinski, Terezinha Inez Estivalet;
Memórias do Instituto Oswaldo Cruz , 2006, DOI: 10.1590/S0074-02762006000500002
Abstract: the aim of this study was to determine the in vitro activity of propolis extract against 67 yeasts isolated from onychomycosis in patients attending at the teaching and research laboratory of clinical analysis of the state university of maringá. the method used was an adaptation made from the protocol approved by the national committee for clinical laboratory standards. the yeasts tested were: candida parapsilosis 35%, c. tropicalis 23%, c. albicans 13%, and other species 29%. the propolis extract showed excellent performance regarding its antifungal activity: the concentration capable of inhibiting the all of the yeasts was 5 ′ 10-2 mg/ml of flavonoids and 2 ′ 10-2 mg/ml of flavonoids stimulated their cellular death. trichosporon sp. were the most sensitive species, showing mic50 and mic90 of 1.25 ′ 10-2 mg/ml of flavonoids, and c. tropicalis was the most resistant, with cfm50 of 5 ′ 10-2 mg/ml of flavonoids and mfc90 of 10 ′ 10-2 mg/ml. in view of the fact that propolis is a natural, low cost, non-toxic product with proven antifungal activity, it should be considered as another option in the onychomycosis treatment.
Studies on fungal and bacterial population of air-conditioned environments
Ross, Claudia;Menezes, Jose Roberto de;Svidzinski, Terezinha Inez Estivalet;Albino, Ulisses;Andrade, Galdino;
Brazilian Archives of Biology and Technology , 2004, DOI: 10.1590/S1516-89132004000500020
Abstract: in tropical countries such as brazil, there is not enough information about microbial contaminants in indoor environments with air conditioning systems. microbial monitoring of such environments is important for the quality of human life. the aim of this work was to assess the fungal genera and bacterial morphotypes occurring in such environments. air samples were taken indoors and outdoors from a public auditorium, a hospital, a company and a shopping center during the 2001 winter by using a six-stage impactor millipore m air t? . twenty-one fungal genera were identified. bacterial morphological groups found were gram positive and negative rods and gram positive coccus.
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