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Search Results: 1 - 10 of 14 matches for " Tchirioua Ekou "
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Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA
Lynda Ekou,Tchirioua Ekou,Javier Garcia,Isabelle Opalinski
Journal of Chemistry , 2011, DOI: 10.1155/2011/403129
Histone Deacetylase Inhibitors: Synthesis of Tetrapeptide Analogue SAHA/TPX
Lynda Ekou,Tchirioua Ekou,Isabelle Opalinski,Jean Pierre Gesson
Journal of Chemistry , 2011, DOI: 10.1155/2011/572546
DFT Study, Linear and Nonlinear Multiple Regression in the Prediction of HDAC7 Inhibitory Activities on a Series of Hydroxamic Acids  [PDF]
Doh Soro, Lynda Ekou, Bafétigué Ouattara, Mamadou Guy-Richard Kone, Tchirioua Ekou, Nahossé Ziao
Computational Molecular Bioscience (CMB) , 2019, DOI: 10.4236/cmb.2019.93006
Abstract: In this work, we conducted a QSAR study on 18 molecules using descriptors from the Density Functional Theory (DFT) in order to predict the inhibitory activity of hydroxamic acids on histone deacetylase 7. This study is performed using the principal component analysis (PCA) method, the Ascendant Hierarchical Classification (AHC), the linear multiple regression method (LMR) and the nonlinear multiple regression (NLMR). DFT calculations were performed to obtain information on the structure and information on the properties on a series of hydroxamic acids compounds studied. Multivariate statistical analysis yielded two quantitative models (model MLR and model MNLR) with the quantum descriptors: electronic affinity (AE), vibration frequency of the OH bond (ν(OH)) and that of the NH bond (ν(NH)). The LMR model gives statistically significant results and shows a good predictability R2 = 0.9659, S = 0.488, F = 85 and p-value < 0.0001. Electronic affinity is the priority descriptor in predicting the activity of HDAC7 inhibitors in this study. The results obtained suggest that the descriptors derived from the DFT could be useful to predict the activity of histone deacetylase 7 inhibitors. These models were evaluated according to the criteria of Tropsha et al.
Enquête sur la consommation, la répartition et l'élevage des escargots géants au Togo
Ekoué, SK.,Kuevi-Akue, K.
Tropicultura , 2002,
Abstract: Investigations on Consumption, Distribution and Breeding of Giants Snails in Togo. A subcontracting convention has been signed between the "Programme National Petit Elevage" and the "Institut National Zootechnique et Vétérinaire " which permitted us to investigate African giant snail consumption, distribution and breeding in Togo. Investigations have lasted six months and were realised in "Régions maritime et des plateaux" both in South Togo. A questionnaire was used to obtain data. Hundred fifty questionnaires were given to sellers during market days, but only fourteen to breeders. The methodology used was based on rapid rural appraisal and direct interrogation. From this investigation we distinguish four species of giant snails (Archachatina archachatina, Archachatina degneri, Achatina achatina, Achatina fulica). For the consumtion about 80% of the samples (sellers and breeders) confirmed that there is no difference in taste between species. Our estimation of giant snails gathered per year is about 30 tons and 80% of the sellers said that they got profit from this activity. For the constraints of giant snails breeding we notice lack of extension, high level of mortalities of young snails, red ant problem and lack of training and information. Giant snail breeding in Togo will be developed if solutions are found to the constraints.
Anterior Cerebral Infarction by Fronto-Basal Meningioma  [PDF]
Paul Macaire Ossou-Nguiet, Dieu Donné Gnonlonfoun, Karen Obondzo-Aloba, Hugues Brieux Ekouélé-Mbaki, Gilbert Fabrice Otiobanda
Neuroscience & Medicine (NM) , 2013, DOI: 10.4236/nm.2013.44040

The association between stroke and meningioma is rarely reported in the data. In most etiology classification, there is no compressive cause. The association between meningioma and stroke is increasingly reported. We report a case of 52-year-old woman, previously healthy, presented with sudden right hemiplegia with some transient mood disorders. The CT-scan revealed acute left anterior cerebral artery infarction associated with fronto-basale meningioma infiltrating both anterior cerebral arteries. She was treated by corticosteroid and rehabilitation, with partial recovery. No stroke prevention was used before surgical treatment.

Hypertensive Retinopathy in Normotensive Blacks: About 3 Cases  [PDF]
Benedicte Carine Boka, Iklo Coulibaly, Hermann Yao, Ghyslain Ouffouet, Marie-Paule Bernadette Ncho-Mottoh, Arnaud Kouadio Ekou
World Journal of Cardiovascular Diseases (WJCD) , 2018, DOI: 10.4236/wjcd.2018.87037
Abstract: In case of hypertension, hypertensive retinopathy is normally an indicator of target organ damage. This sign can be frequently detected even in normotensive subjects. Among 94 normotensive volunteers chosen with regard of the hypertensive status of their parents, we could report the case of 3 black women who had hypertensive retinopathy. As changes in retinal microvasculature precede other signs of damage, we suggest fundus photography routine to be performed more frequently in assessing cardiovascular risks in hypertensive individual and their offspring, especially in black African population, where hypertension is severe.
PCR Detection of Entamoeba histolytica in Microscopically Positive Stool Samples of Hospital Patients in Soroti, Eastern Uganda
J Ekou, JI Nakavuma, J Erume, M Ocaido
African Journal of Clinical and Experimental Microbiology , 2013,
Abstract: Amoebiasis is an infection caused by water borne protozoan parasite Entamoeba histolytica. In Uganda where sanitation infrastructure and health education was not adequate, amoebiasis was thought to be still an important health problem. However there was little or no data on prevalence of this very important protozoan infection. In addition, microscopy remained the main method for the diagnosis of amoebiasis but could not differentiate between Entamoeba dispar/moshkovskii and Entamoeba histolytica infections. This made determination of true prevalence of Entamoeba histolytica infections difficult. It was against this background that this study was designed to carry out species specific diagnosis of Entamoeba histolytica and Entamoeba dispar/moshkovskii in Uganda where these species had been reported to be endemic. This study used microscopy and polymerase chain reaction amplification of Serine-rich Entamoeba histolytica (SREHP) gene. It was shown that 36.7% (n=22) of the samples initially diagnosed as positive by microscopy were positive by PCR. The true prevalence of E. histolytica and E.dispar/ moshkovskii was found to be 7.31% and 12.6% respectively. It was concluded that Entamoeba infection in Soroti, Eastern Uganda is more frequently due to E. dispar /moshkovskii (13.3%) the non-pathogenic forms than to E. histolytica, the pathogen (7.31%).
Prognostic Role of Pulse Pressure in the Acute Phase of Myocardial Infarction  [PDF]
Justin Koffi, Christoph Konin, Yves N’goran, Arnaud Ekou, Ambroise Gnaba, Esaie Soya, Marie Paul N’Cho Mottoh, Bénédict Boka, Michel Adoh Adoh
World Journal of Cardiovascular Diseases (WJCD) , 2015, DOI: 10.4236/wjcd.2015.58028
Abstract: Objective: Pulse pressure is a cardiovascular risk factor. The aim of our study was to assess the short and medium term prognosis of myocardial infarction in the African black having a high pulse pressure. Methods: We performed a comparative retrospective study of 200 patients hospitalized in the Cardiology Institute of Abidjan. The first group (100 patients) had a high pulse pressure (≥60 mmHg). The second (100 patients) had normal pulse pressure (≤60 mmHg). The primary outcome was mortality. Secondary endpoints were represented by hemodynamic complications, rhythmic and conduction disturbances. Both groups of patients were matched. The matching is performed by socio-demographic criteria, the seat of necrosis and cardiovascular risk factors. The authors explained the choice of 60 mmHg as references because in all their studies they have realized that it is from 60 mmHg pulse pressure morbid events that occur in prospective studies and retrospective studies in stiffness of the great arteries is responsible for all these events. Pulse pressure is in itself, an independent cardiovascular risk factor in systolic blood pressure, diastolic blood pressure when associated with myocardial infarction, it becomes from 60 mmHg poor prognostic factor especially in the acute phase. Results: The mean age was 54.46 ± 10.10 years for patients with normal pulse pressure and 52.32 ± 10.89 years in patients with high pulse pressure. Patients with elevated pulse pressure were twice as left ventricular failure (Chi2 = 3.71; P = 0.048 = 2 OR 95% CI = 0.93 to 4.29). These patients had an ejection fraction and fractional shortening double bass (Chi2 = 31.23 P = 0.00001, OR = 2.2 95% CI 0.8 to 17.4) 10 mmHg for increased pulse pressure we observed an average growth of 18% mortality rate. Mortality was three times higher in patients with elevated pulse pressure (Khi2 = 15, 06 ddl = 1 P = 0.0001 OR = 3.34 95% CI 1.72 to 6.52). Conclusion: The high pulse pressure represented an independent poor prognostic factor in the acute phase of myocardial infarction in the black African.
Prostate Biopsy: Which Technique for Which Results at Lomé University Hospital in 2017?  [PDF]
Tchilabalo Matchonna Kpatcha, Tchin Darré, Essodina Padja, Adolphe Essomindedou Leloua, Gnimdou Botcho, Edoé Viyomé Sewa, Kodjo Tengue, Komi Hola Sikpa, Ekoué David Dosseh
Open Journal of Urology (OJU) , 2018, DOI: 10.4236/oju.2018.84014
Abstract: Background: Diagnosis of prostate cancer is certified by histology true prostate biopsies. The aim of our study was to evaluate our prostate biopsy method. Material and Methods: It was a prospective study including patients underwent prostate biopsy. Inclusion criteria were prostate specific antigen (PSA) level up to 4ng/ml and/or abnormal prostate at digital rectal examination. Patients who had risk factors of bleeding have been excluded of the study. The preparation before biopsy included antibioprophylaxy (Ciprofloxacine-Tinidazole) and rectal hypertonic cleaning (Normacol*). Twelve cores have been taken in each prostate by transrectal digital-guided way, using Biopty Gun 18 Gauge. Local anesthesia has been done previously by intrarectal application of 20 ml of gel of Lidoca?ne. Two other cores were taken into each abnormal area at rectal examination. The follow-up have been done during twelve weeks. Results: Eighty patients of 65 years of age were included. Nine patients had familial history of prostate cancer. PSA levels ranged from 5 to 6400 ng/ml with a median of 26.77 ng/ml ± 11.2. Complications occurred in 11.25% of patients, principally infectious complications which caused death of one patient by septicemia. The rate of cancer detection was 20%. Prostate abnormality at digital rectal examination and the presence of familial history of prostate cancer were not predictive factors of the presence of cancer on cores. Conclusion: Our prostate biopsy method is limited by the lack of ultrasonographic guidance and is at important risk of infectious complications.
Factors Associated with Non-Adherence to Antiretroviral Therapy among HIV-Infected Adolescents at Pediatric Department of Yopougon University Hospital, C?te d’Ivoire  [PDF]
Tanoh Kassi Fran?ois Eboua, Marcellin Nouaman, Marie-Hélène Ake-Assi, Yvette Bleu, Bherat Kouadio, Ekou Niamien, Laurence Adonis-Koffy
Open Journal of Pediatrics (OJPed) , 2018, DOI: 10.4236/ojped.2018.83025
Abstract: Context: The consequences of non-adherence to antiretroviral therapy (ART) are harmful in terms of morbidity and mortality among HIV-infected adolescents. There is a little data in this population in West Africa, about non-adherence to ART. Objective: To identify factors associated with non-adherence to ART in adolescents at the Pediatric Ambulatory Treatment Center (PATC) of the pediatric department of Yopougon University Hospital. Materials and Methods: A cross-sectional study was conducted from May to July 2017 among adolescents aged 10 to 19 years old at PATC of pediatrics department of Yopougon University Hospital. We have considered that adolescent was not adherent to ART when he affirm that he have not taking ART at least once in the week before the survey. A logistic regression model was used to identify factors associated with non-adherence to ART. Results: Overall 166 adolescents were included. The median age was 15 years old [IQI = 13 - 17 years]. They had a detectable viral load greater than 1000 copies/ml in 41.8% of cases. The rate of non-adherence to ART was 40.4%. The factors associated with non-adherence to ART were male [OR = 2.5 (CI = 1.1 - 10.0)], having parent widowed [OR = 7.8 (CI = 1.6 - 39.3)] or divorced [RC= 3.7 (IC=1.1 - 13.5)], CD4 inclusion rate ≥ 500 cells/ml [OR = 8.5 (CI = 1.6 - 45.5)] and duration on ART 10 years [OR = 8.9 (CI = 1.6 - 50)]. Conclusion: A rigorous
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