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Search Results: 1 - 10 of 401069 matches for " Taupitz M "
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Iron oxide magnetic nanoparticles highlight early involvement of the choroid plexus in central nervous system inflammation
Jason?M. Millward,J?rg Schnorr,Matthias Taupitz,Susanne Wagner
ASN Neuro , 2013, DOI: 10.1042/an20120081
Abstract: Neuroinflammation during multiple sclerosis involves immune cell infiltration and disruption of the BBB (blood–brain barrier). Both processes can be visualized by MRI (magnetic resonance imaging), in multiple sclerosis patients and in the animal model EAE (experimental autoimmune encephalomyelitis). We previously showed that VSOPs (very small superparamagnetic iron oxide particles) reveal CNS (central nervous system) lesions in EAE which are not detectable by conventional contrast agents in MRI. We hypothesized that VSOP may help detect early, subtle inflammatory events that would otherwise remain imperceptible. To investigate the capacity of VSOP to reveal early events in CNS inflammation, we induced EAE in SJL mice using encephalitogenic T-cells, and administered VSOP prior to onset of clinical symptoms. In parallel, we administered VSOP to mice at peak disease, and to unmanipulated controls. We examined the distribution of VSOP in the CNS by MRI and histology. Prior to disease onset, in asymptomatic mice, VSOP accumulated in the choroid plexus and in spinal cord meninges in the absence of overt inflammation. However, VSOP was undetectable in the CNS of non-immunized control mice. At peak disease, VSOP was broadly distributed; we observed particles in perivascular inflammatory lesions with apparently preserved glia limitans. Moreover, at peak disease, VSOP was prominent in the choroid plexus and was seen in elongated endothelial structures, co-localized with phagocytes, and diffusely disseminated in the parenchyma, suggesting multiple entry mechanisms of VSOP into the CNS. Thus, using VSOP we were able to discriminate between inflammatory events occurring in established EAE and, importantly, we identified CNS alterations that appear to precede immune cell infiltration and clinical onset.
Rechtslage der Reproduktionsmedizin in Deutschland
Frommel M,Taupitz J,Ochsner A,Geisth?vel F
Journal für Reproduktionsmedizin und Endokrinologie , 2010,
Abstract: Die juristischen Fragestellungen der Reproduktionsmedizin (RM) werden in Deutschland in einem komplexen Netzwerk gesetzlicher Vorgaben, das durch das Grundgesetz, das Embryonenschutzgesetz, das Bürgerliche Gesetzbuch und das Gewebegesetz ma geblich bestimmt wird, geregelt. Daher ist die RM, obgleich ein spezifisch auf diese Fragestellungen ausgerichtetes Reproduktionsmedizingesetz nicht existiert, dennoch umfassend gesetzlich geregelt. Grundprinzipien hierfür sind die Autonomie der Frau und des Paares, der Lebensschutz und das Wohl des zukünftigen Kindes, wobei der Erfolg der Behandlung und die Erhaltung der Gesundheit des behandelten Paares ausgewogen bilanziert werden müssen. Weiterhin müssen im gesetzlichen Rahmen Qualit tsmanagement, Dokumentation und die Rückverfolgbarkeit medizinischer Handlungsabl ufe gew hrleistet sein. Die hier vorgelegte wissenschaftliche Analyse zeigt, dass im Gegensatz zur herk mmlichen Meinung die Rechtslage in Deutschland weitgehend zufriedenstellend und ausgewogen geregelt ist. Abgesehen von wenigen Verboten, wie z. B. die Durchführung des Klonens, der Eizellspende und der Leihmutterschaft, k nnen alle reproduktionsmedizinischen Ma nahmen mit einem hnlichen Handlungsspielraum wie im Ausland gehandhabt werden. Im Rahmen des sog. Deutschen Mittelwegs wird das Verbot der Vorratshaltung respektiert. Samen- und Embryonenspende, wie auch die Behandlung lesbischer Paare, sind erlaubt. Allerdings besteht eine eindeutige rechtliche Lücke bezüglich des Schutzes des Samengebers vor finanziellen Forderungen des Kindes, die vom Gesetzgeber geschlossen werden muss.
Contrast-enhanced MR imaging of atherosclerosis using citrate-coated superparamagnetic iron oxide nanoparticles: calcifying microvesicles as imaging target for plaque characterization
Wagner S, Schnorr J, Ludwig A, Stangl V, Ebert M, Hamm B, Taupitz M
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S38702
Abstract: ntrast-enhanced MR imaging of atherosclerosis using citrate-coated superparamagnetic iron oxide nanoparticles: calcifying microvesicles as imaging target for plaque characterization Original Research (660) Total Article Views Authors: Wagner S, Schnorr J, Ludwig A, Stangl V, Ebert M, Hamm B, Taupitz M Published Date February 2013 Volume 2013:8 Pages 767 - 779 DOI: http://dx.doi.org/10.2147/IJN.S38702 Received: 01 October 2012 Accepted: 02 December 2012 Published: 20 February 2013 Susanne Wagner,1 J rg Schnorr,1 Antje Ludwig,2 Verena Stangl,2 Monika Ebert,1 Bernd Hamm,1 Matthias Taupitz1 1Department of Radiology, Section of Experimental Radiology, Charité – Universit tsmedizin Berlin, Campus Charité Mitte, and Campus Benjamin Franklin, Berlin, Germany; 2Department of Cardiology, Section of Experimental Cardiology, Charité – Universit tsmedizin Berlin, Campus Charité Mitte, Berlin, Germany Objective: To evaluate the suitability of citrate-coated very small superparamagnetic iron oxide particles (VSOP) as a contrast agent for identifying inflammation in atherosclerotic lesions using magnetic resonance imaging (MRI). Methods and results: VSOP, which have already been evaluated as a blood pool contrast agent for MR angiography in human clinical trials, were investigated in Watanabe heritable hyperlipidemic rabbits to determine to what extent their accumulation in atherosclerotic lesions is a function of macrophage density and other characteristics of progressive atherosclerotic plaques. In advanced atherosclerotic lesions, a significant MRI signal loss was found within 1 hour after intravenous administration of VSOP at the intended clinical dose of 0.05 mmol Fe/kg. Histological examinations confirmed correlations between the loss of MRI signal in the vessel wall and the presence of Prussian blue-stained iron colocalized with macrophages in the plaque cap, but surprisingly also with calcifying microvesicles at the intimomedial interface. Critical electrolyte magnesium chloride concentration in combination with Alcian blue stain indicates that highly sulfated glycosaminoglycans are a major constituent of these calcifying microvesicles, which may serve as the key molecules for binding VSOP due to their highly complexing properties. Conclusion: Calcifying microvesicles and macrophages are the targets for intravenously injected VSOP in atherosclerotic plaques, suggesting that VSOP-enhanced MRI may render clinically relevant information on the composition and inflammatory activity of progressive atherosclerotic lesions at risk of destabilization.
Beyond blood brain barrier breakdown – in vivo detection of occult neuroinflammatory foci by magnetic nanoparticles in high field MRI
Eva Tysiak, Patrick Asbach, Orhan Aktas, Helmar Waiczies, Maureen Smyth, Joerg Schnorr, Matthias Taupitz, Jens Wuerfel
Journal of Neuroinflammation , 2009, DOI: 10.1186/1742-2094-6-20
Abstract: EAE was induced in 17 mice via transfer of proteolipid protein specific T cells. MR images were obtained before and after application of Gd-DTPA and VSOP on a 7 Tesla rodent MR scanner. The enhancement pattern of the two contrast agents was compared, and correlated to histology, including Prussian Blue staining for VSOP detection and immunofluorescent staining against IBA-1 to identify macrophages/microglia.Both contrast media depicted BBB breakdown in 42 lesions, although differing in plaques appearances and shapes. Furthermore, 13 lesions could be exclusively visualized by VSOP. In the subsequent histological analysis, VSOP was localized to microglia/macrophages, and also diffusely dispersed within the extracellular matrix.VSOP showed a higher sensitivity in detecting BBB alterations compared to Gd-DTPA enhanced MRI, providing complementary information of macrophage/microglia activity in inflammatory plaques that has not been visualized by conventional means.A fundamental pathologic feature of multiple sclerosis (MS) is the formation of multifocal plaques in the central nervous system (CNS), accompanied by a disruption of the blood brain barrier (BBB). Gadopentate dimeglumine (Gd-DTPA) does not cross an intact BBB and can thus be used to detect BBB leakage in acute inflammatory lesions by Gd-DTPA enhanced MRI [1]. Recently, iron-oxide based magnetic nanoparticles have evolved as a new class of MRI contrast agents [2-6], bearing the potential to detect macrophage infiltrates into the CNS independently from BBB breakdown [7,8]. Macrophages play a pivotal role in the pathophysiology of MS, since they invade the CNS early during disease and act as effector cells in the inflammatory cascade, leading to persistent structural and functional tissue damage [9,10]. Dextran-coated magnetic nanoparticles have been applied in various animal models to visualize the migration of macrophages by MRI [2,7,8,11-15]. Two recent studies showed that the application of magnetic nanopart
Study of Duct Characteristics Deduced from Low Latitude Ground Observations of Day-Time Whistler at Jammu  [PDF]
M. Altaf, M. M. Ahmad
International Journal of Astronomy and Astrophysics (IJAA) , 2013, DOI: 10.4236/ijaa.2013.33032

Propagation characteristics of low latitude whistler duct characteristics have been investigated based on day-time measurements at Jammu. The morphogical characteristics of low latitude whistlers are discussed and compared with characteristics of middle and high latitude whistlers. The Max. electron density (Nm) at the height of the ionosphere obtained from whistler dispersion comes out to be higher than that of the background which is in accordance with the characteristics of whistler duct. The equivalent width is found to be close to the satellite observations and the characteristics of whistler duct in low latitude ionosphere are similar to those in middle and high latitude ionosphere. The width of ducts estimated from the diffuseness of the whistler track observed during magnetic storm is found to lie in the range of 50 - 200 Km.

Review Article: Immobilized Molecules Using Biomaterials and Nanobiotechnology  [PDF]
Magdy M. M. Elnashar
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2010, DOI: 10.4236/jbnb.2010.11008
Abstract: Immobilized molecules using biomaterials and nanobiotechnology is a very interesting topic that touching almost all aspects of our life. It uses the sciences of biology, chemistry, physics, materials engineering and computer science to develop instruments and products that are at the cutting edge of some of today’s most promising scientific frontiers. In this review article, the author based on his experience in this arena has tried to focus on some of the supports for im-mobilization; the most important molecules to be immobilized such as DNA, cells, enzymes, metals, polysaccharides, etc and their applications in medicine, food, drug, water treatment, energy and even in aerospace. He specified a special section on what is new in the arena of supports and technologies used in enzyme immobilization and finally a recommendation by the author for future work with a special attention to up-to-date references.
Using of the generalized special relativity (GSR) in estimating the neutrino masses to explain the conversion of electron neutrinos  [PDF]
M. H. M. Hilo
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.34044
Abstract: In this work the Generalized Special Relativity (GSR) is utilized to estimate masses of some elementary particles such as, neutrinos. These results are found to be in conformity with experimental and theoretical data. The results obtained may explain some physical phenomena, such as, conversion of neutrinos from type to type when solar neutrino reaches the Earth.
Postischemic Lower Extremity Wounds Treated with and without Negative Pressure Dressing  [PDF]
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.37075
Abstract: Background: Vacuum-assisted dressing is a noninvasive closure system of the wound, which makes localized and controlled negative pressure. Its mechanical tension reduces edema, stimulates granulation tissue formation and angiogenesis, and prepares the wound bed for closure. In this study, a patient has been presented, who suffered from serious lower extremity wounds due to arterial emboli, one of her wounds has been treated with vacuum-assisted dressing and the other with conventional dressing to evaluate the efficacy of vacuum-assisted dressing in acute ischemic wounds. Methods: A 65-year-old female patient was admitted to the emergency clinic, due to complaint of severe pain in her right lower extremity which suggested an acute arterial occlusion. She immediately underwent an embolectomy operation; however, a few days later, severe ischemia on the leg and foot became appearant. All of the necrosis was sharply debrided under sterile conditions in the operating room, and then lower leg wound was covered with vacuum-assisted dressing, also calcaneal wound was dressed with silver sulphadiazine. Results: Eighteen days after the first dressing with negative pressure, distal leg wound became ready for closure, whereas, enough granulation tissue over the calcaneal area developed merely thirty-four days later. Calcaneal wound closed spontaneously within fifty-three days. Conclusions: When dealing with this experience, using the negative pressure dressing in patient with severe lower limb wounds following arterial emboli, accelerates wound healing by means of developing the granulation tissue, and rapidly prepares the wound for closure, so it may reduce the risk of amputation.
Laplace Transform Method for Unsteady Thin Film Flow of a Second Grade Fluid through a Porous Medium  [PDF]
M. Ali, M. Awais
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.53017

In this article, we have effectively used the Numerical Inversion of Laplace transform to study the time-dependent thin film flow of a second grade fluid flowing down an inclined plane through a porous medium. The solution to the governing equation is obtained by using the standard Laplace transform. However, to transform the obtained solutions from Laplace space back to the original space, we have used the Numerical Inversion of Laplace transform. Graphical results have been presented to show the effects of different parameters involved and to show how the fluid flow evolves with time.

An Integral Collocation Approach Based on Legendre Polynomials for Solving Riccati, Logistic and Delay Differential Equations  [PDF]
M. M. Khader, A. M. S. Mahdy, M. M. Shehata
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.515228

In this paper, we propose and analyze some schemes of the integral collocation formulation based on Legendre polynomials. We implement these formulae to solve numerically Riccati, Logistic and delay differential equations with variable coefficients. The properties of the Legendre polynomials are used to reduce the proposed problems to the solution of non-linear system of algebraic equations using Newton iteration method. We give numerical results to satisfy the accuracy and the applicability of the proposed schemes.

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