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Search Results: 1 - 10 of 1702 matches for " Tatsuo Sakai "
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Inflation, moduli (de)stabilization and supersymmetry breaking
Tatsuo Kobayashi,Manabu Sakai
Physics , 2010, DOI: 10.1007/JHEP04(2011)121
Abstract: We study the cosmological inflation from the viewpoint of the moduli stabilization. We study the scenario that the superpotential has a large value during the inflation era enough to stabilize moduli, but it is small in the true vacuum. This scenario is discussed by using a simple model, one type of hybrid models.
Cancer-Associated Lymphatic and Venous Vessels in Colonic Carcinomas  [PDF]
Tatsuo Tomita
Open Journal of Pathology (OJPathology) , 2014, DOI: 10.4236/ojpathology.2014.43016
Abstract:

Objective: Colonic carcinomas spread to regional lymph nodes and liver. There are cancer-associated lymphatic and venous vessels at the margin of colonic carcinomas, which facilitate spreading carcinoma through lymphatic and venous vessels. This study aimed to examine cancer-associated lymphatic and venous vessels in TNM T1 to T3 carcinomas using lymphatic vessel hyaluronan receptor for lymphatic vessels and von Willebrand factor for venous vessels by immunocytochemical staining. Materials and Methods: A total of 40 cases of moderately differentiated colonic carcinoma were studied using routinely formalin-fixed and paraffin-embedded sections. The cases consisted of 10 cases of TNM T1, 15 cases each of T2 and T3 cases. Immunocytochemical staining was performed using goat antihuman LYVE-1for lymphatic vessels and rabbit antihuman von Willebrand factor for venous vessels. Results: In TNM T1 carcinoma, increased, irregular and narrow lymphatic and venous vessels were present in the adjacent normal mucosa to the carcinoma, some of which penetrated cancerous lesion. There were no tumor emboli in lymphatic and venous vessels. In TNM T2 carcinoma, there were few lymphatic and venous vessels in midst of the carcinoma whereas numerous small lymphatic and venous vessels were present within muscle layers adjacent to the invading carcinoma. Extramural tumor embolus

Tumor-Associated Lymphatic and Venous Vessels in Medullary Thyroid Carcinomas  [PDF]
Tatsuo Tomita
Open Journal of Pathology (OJPathology) , 2015, DOI: 10.4236/ojpathology.2015.52008
Abstract: Objective: Medullary thyroid carcinomas (MTCs) invade local lymph node through lymphatic vessels and metastasize to distant organs hematogenously and account for a significant mortality. There are possibly increased lymphatic and venous vessels, through which the tumor spreads to lymph nodes and distant organs. Materials and Methods: By immunocytochemical staining for lymphatic and venous vessels, MTC lesions with adjacent normal thyroid and both normal and metastatic lymph nodes were studied for the peritumoral lymphatic and venous vessels, which were morphometrically compared with those of normal thyroid and lymph nodes. Sixteen cases of MTC cases with adjacent thyroid tissues and attached lymph nodes were immunocytochemically stained for lymphatic vessels using lymphatic vessel hyaluronan receptor (LYVE-1) and venous vessels for factor VIII (F-8). The immunostained sections of MTC lesions and metastatic lymph nodes were morphometrically compared for the number and sizes of the vessels with those of normal thyroid tissues and lymph nodes. Results: Significantly increased lymphatic vessels and markedly increased blood vessels were identified in many MTC cases at the peritumoral tissues and metastatic lymph nodes whereas a few lymphatic vessels and no venous vessels were identified in midst of MTCs. The irregular peritumoral lymphatic vessels resembled that of immature lymphatic vessels observed in papillary thyroid carcinomas and increased irregularly, entrapped venous vessels in peritumoral tissues resembled those observed in follicular thyroid carcinomas. Conclusion: The significantly increased lymphatic vessels and markedly increased venous vessels in the peritumoral thyroid tissue support a propensity of MTCs for providing an easy access of tumor cells to both lymphatic spread to the regional lymph nodes and venous spread to distant organs with further tumor spread through metastatic lymph nodes by moderately increased lymphatic and venous vessels.
Asymmetric Electrostatic Force  [PDF]
Katsuo Sakai
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2014, DOI: 10.4236/jemaa.2014.610026
Abstract: Asymmetric electrostatic forces are a very interesting and new phenomenon. The magnitude of an electrostatic force that acts on a point charge does not change when the direction of the electric field is reversed. On the contrary, the magnitude of the electrostatic force that acts on a charged asymmetric shaped conductor does change when the direction of the electric field is reversed. 5 years ago, this phenomenon was reported by a simple experiment and a simulation and named as an Asymmetric electrostatic force unofficially by the author. After that, several simulations confirmed this phenomenon. However, several experiments did not yet confirm it clearly. The difference between the simulations and the experiments depends upon differences of their conditions. The simulations had been done under ideal (perfect) conditions; the experiments, on the contrary, had been done under actual (not perfect) conditions. In the new experiment, its conditions were improved to near ideal (perfect) conditions. As a result the existence of the Asymmetric electrostatic force was more clearly confirmed.
Surface Properties of Cement Paste Evaluated by Scanning Probe Microscopy  [PDF]
Yuya Sakai
Open Journal of Civil Engineering (OJCE) , 2016, DOI: 10.4236/ojce.2016.64052
Abstract: The microscopic physical properties of Hardened Cement Paste (HCP) surfaces were evaluated by using Scanning Probe Microscopy (SPM). The cement pastes were cured under a hydrostatic pressure of 400 MPa and the contacting surfaces with a slide glass during the curing were studied. Scanning Electron Microscope (SEM) observation at a magnification of 7000 revealed smooth surfaces with no holes. The surface roughness calculated from the SPM measurement was 4 nm. The surface potential and the frictional force measured by SPM were uniform throughout the measured area 24 h after the curing. However, spots of low surface potential and stains of low frictional force and low viscoelasticity were observed one month after curing. This change was attributed to the carbonation of hydrates.
A Study of Weighted Polynomial Approximations with Several Variables (II)  [PDF]
Ryozi Sakai
Applied Mathematics (AM) , 2017, DOI: 10.4236/am.2017.89093
Abstract: In this paper we investigate weighted polynomial approximations with several variables. Our study relates to the approximation for \"\" by weighted polynomial. Then we will give some results relating to the Lagrange interpolation, the best approximation, the Markov-Bernstein inequality and the Nikolskii- type inequality.
A Study of Weighted Polynomial Approximations with Several Variables (I)  [PDF]
Ryozi Sakai
Applied Mathematics (AM) , 2017, DOI: 10.4236/am.2017.89095
Abstract: In this paper, we investigate the weighted polynomial approximations with several variables. Our study relates to the approximation for \"\" by weighted polynomials. Then we will estimate the degree of approximation.
Cyclic Changes of Nerve Fibers in Human Endometrium  [PDF]
Tatsuo Tomita, Kuni Mah
Open Journal of Pathology (OJPathology) , 2014, DOI: 10.4236/ojpathology.2014.42011
Abstract:

Objective: The presence of nerve fibers in human endometrium remains unsettled but recent immunocytochemical studies have shown that there was increased innervation in the endometrium from women with endometriosis and some nerve fibers in the normally cycling human endometrium. In the current study, we used uterine tissue cryosections from normal cycling women, which previously provided better immunocytochemical staining for lymphatic vessels than in paraffin sections. Materials and Methods: A total of 16 cases from normally cycling women were included representing menstrual, early proliferative, early to late secretary phase. Neurofilament and CD 56 were used as immunocytochemical markers for nerve fibers with cryosections. Results: There were consistent presence of nerve fibers in myometrium and basalis. Few small nerve fibers were identified in early proliferative endometrium and more nerve fibers were present in lower-half functionalis from mid-secretary phase. Late-secretary functionalis showed less nerve fibers in the upper-half than the lower-half functionalis, implying growing nerve fibers from lower functionalis to upper functionalis in late-secretary phase. Conclusion: Nerve fibers appeared to cyclically grow from basalis to lower functionalis and then from lower functionalis to upper functionalis concomitantly with blood vessels in normally cycling human endometrium. These cycling endometrial nerve fibers consisted mostly of nonmyelinated small nerve fibers, which may transmit pelvic pain in the normally cycling women.

Cyclic Changes of Lymphatic Vessels in Human Endometrium  [PDF]
Tatsuo Tomita, Kuni Mah
Open Journal of Pathology (OJPathology) , 2014, DOI: 10.4236/ojpathology.2014.41002
Abstract:

Objective: The presence of lymphatic vessels in endometrium has been controversial and recent immunocytochemical studies with routinely paraffin embedded sections revealed lymphatic vessels in basalis and occasionally in functionalis. We aimed to investigate endometrial lymphatic vessels by immunocytochemical staining using cryosections, which provided better and consistent immunostaining for lymphatic vessels with a lymphatic marker, D2-40. We aimed further to explore the structure-function relationship of lymphatic vessels in the menstrual cycle. Materials and Methods: Sixteen cases of endometrium from menstrual, early-proliferative to latesecretary phase were immunostained for D2-40 and lymphatic vessels were morphometrically analyzed for functionalis, basalis and myometrium, respectively. Results: Lymphatic vessels were consistently most numerous in myometrium, followed by basalis in all phases whereas menstrual endometrium showed small, fragmented aggregates of lymphatic vessels in thin basalis. Earlyto mid-secretary endometrium revealed many lymphatic vessels in basalis and lower-functionalis with few lymphatic vessels in upper-functionalis. Late-secretary endometrium revealed more lymphatic vessels in upper-functionalis with dilated walls, which then burst at the surface of functionalis. Conclusions: These degenerating lymphatic vessels with markedly dilated lumen in upper-functionalis may contribute to lymphatic leakage in late-secretary phase. These immunostained lymphatic vessels in functionalis support proliferating and degenerating lymphatic vessel cycle synchronized with the menstrual cycle of endometrial arteries to maintain adequate fluid leakage.

Cyclic Changes of Lymphatic and Venous Vessels in Human Endometrium  [PDF]
Tatsuo Tomita, Kuni Mah
Open Journal of Pathology (OJPathology) , 2014, DOI: 10.4236/ojpathology.2014.44025
Abstract: Context: Cyclic changes of endometrial arteries are well established but possible cyclic changes of lymphatic and venous vessels have not been fully documented. There are no published morphological reports to support cyclic changes of endometrial lymphatic and venous vessels. Objective: Using cryosections of human endometrium, this study aimed to unveil possible cyclic changes of lymphatic and venous vessels. We previously reported cyclic changes of lymphatic vessels in human endometrium using D2-40. Design: A total of 16 cases representing menstrual, proliferative and mid and late secretary phase were studied. For Immunocytochemical staining, lymphatic vessel endothelial hyaluronan receptor 1 and von Willebr and factor were used for lymphatic and venous vessels, respectively. We used polyclonal LYVE-1 in this study, which revealed more lymphatic vessels than using D2-40. Results: Residual lymphatic and venous vessels were present in menstrual basalis. In Day 5 - 9 endometrium, there were sparse lymphatic vessels but were numerous growing venous vessels in thin proliferating functionalis. In Day 14 - 22 endometrium, there were scattered lymphatic vessels and numerous venous vessels in functionalis. In Day 25 - 26 endometrium, there were many dilated lymphatic vessels and numerous dilated, disintegrating venous vessels in upper functionalis than lower functionalis. Conclusion: The above findings support that lymphatic vessels are sparse but venous vessels are numerous in early proliferative functionalis. Lymphatic vessels grow from basalis to thin functionalis. In premenstrual phase, lymphatic vessels proliferate from lower to upper functionalis, and both lymphatic and venous vessels disintegrate for shedding by this immunocytochemical study using lymphatic and venous markers. Thus, all lymphatic, venous and arterial vessels undergo menstrual cyclic changes and shed for menstruation.
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