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Search Results: 1 - 10 of 823 matches for " Tatsuhiko Miyazaki "
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Conservative Medroxyprogesterone Acetate Therapy in Early Stage of Endometrial Carcinoma Associated with Phosphatase and Tensin Homolog Expression  [PDF]
Kenji Niwa, Minako Mori, Tatsuhiko Miyazaki, Takuji Tanaka, Ken-Ichiro Morishige
Open Journal of Pathology (OJPathology) , 2017, DOI: 10.4236/ojpathology.2017.71001
Abstract: Young patients with the endometrial cancer IA who desire to preserve fertility, can select the conservative therapy with progestin. However, the therapy involves risks of progression and relapse. We examined immunohistochemical analyses of phosphatase and tension homolog (PTEN) and p53 expressions to predict the early relapse, and pregnancy and delivery. Twenty women with endometrial cancer, FIGO IA (1988) (FIGO staging was essentially defined post-surgically), instead of the pathogical specimen before surgery without myometrial invasion were estimated by MRI under 40 years at Gifu University Hospital, Japan from 1988 to 2009. Patients were treated with medroxyprogesterone acetate (MPA, 400 - 600 mg/day) for 4 - 10 months, with whole wall endometrial curettage performed every four weeks. Response to the therapy, pregnancy, delivery and relapse of disease during follow-up over a 72-month period. Immunohistochemical expression of PTEN and p53 was also evaluated with pregnancy, delivery and relapse rate. All patients had pathological complete remissions within 4 - 10 months. Relapse rate was high (60%) in more than 72 months. Immunohistochemical PTEN retain in tumor cells before MPA treatment (8/10) was significant better correlation with pregnancy and delivery rate than of lost cases (1/5) in non-obese women (P < 0.05). Conservative therapy is feasible in carefully selected young women with endometrial cancer without myometrial invasion. However, the relapse rate was high. In cases who desire to be a pregnant, an earlier infertility treatment may be considered especially for PTEN loss especially in nonobese cases.
Active Targeting to Osteosarcoma Cells and Apoptotic Cell Death Induction by the Novel Lectin Eucheuma serra Agglutinin Isolated from a Marine Red Alga
Keita Hayashi,Peter Walde,Tatsuhiko Miyazaki,Kenshi Sakayama
Journal of Drug Delivery , 2012, DOI: 10.1155/2012/842785
Abstract:
Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+ regulatory T cells in MRL/lpr mice
Hitoshi Hasegawa, Atsushi Inoue, Masatake Muraoka, Jun Yamanouchi, Tatsuhiko Miyazaki, Masaki Yasukawa
Arthritis Research & Therapy , 2007, DOI: 10.1186/ar2122
Abstract: CD4+CD25+ regulatory T cells are critical for the regulation of host tolerance and are considered to have enormous potential for suppressing pathological immune responses in autoimmune disease, transplantation, and graft-versus-host disease (GVHD) [1,2]. These cells express a specific transcription factor, forkhead box p3 (Foxp3), which has been associated with their development and suppressive function [3-5]. The mechanism by which CD4+CD25+ regulatory T cells suppress immune responses is poorly understood, but these cells appear to suppress a variety of reactions, including CD4+ and CD8+ T-cell responses as well as B-cell responses [6,7]. CD4+CD25+ regulatory T cells have also been reported to act directly on natural killer (NK), natural killer T (NKT), and dendritic cells [8-10]. Therefore, the suppressive characteristics of CD4+CD25+ regulatory T cells have made them an attractive candidate for immunotherapy, and numerous studies using animal models have demonstrated their potential for the control of autoimmune diseases as well as transplant rejection and GVHD.CD4+CD25+ regulatory T cells account for only 5% to 10% of the total CD4+ population in both mice and humans [1,2]. Therefore, administration of sufficient numbers of freshly isolated CD4+CD25+ regulatory T cells is not therapeutically practical, and it is critically important to expand the number of CD4+CD25+ regulatory T cells to facilitate their accumulation in target organs for clinical immunotherapy. Recent studies have shown that suppressive properties and organ-specific tolerance are critically dependent on the antigen specificity of CD4+CD25+ regulatory T cells and that antigen-specific CD4+CD25+ regulatory T cells are more effective for disease protection than polyclonal CD4+CD25+ regulatory T cells, which means that lower numbers of CD4+CD25+ regulatory T cells are needed for therapy [11-16]. Thus, it seems likely that therapy using antigen-specific CD4+CD25+ regulatory T cells has the most pote
Active Targeting to Osteosarcoma Cells and Apoptotic Cell Death Induction by the Novel Lectin Eucheuma serra Agglutinin Isolated from a Marine Red Alga
Keita Hayashi,Peter Walde,Tatsuhiko Miyazaki,Kenshi Sakayama,Atsushi Nakamura,Kenji Kameda,Seizo Masuda,Hiroshi Umakoshi,Keiichi Kato
Journal of Drug Delivery , 2012, DOI: 10.1155/2012/842785
Abstract: Previously, we demonstrated that the novel lectin Eucheuma serra agglutinin from a marine red alga (ESA) induces apoptotic cell death in carcinoma. We now find that ESA induces apoptosis also in the case of sarcoma cells. First, propidium iodide assays with OST cells and LM8 cells showed a decrease in cell viability after addition of ESA. With 50? g/ml ESA, the viabilities after 24 hours decreased to 54.7 ± 11.4% in the case of OST cells and to 41.7 ± 12.3% for LM8 cells. Second, using fluorescently labeled ESA and flow cytometric and fluorescence microscopic measurements, it could be shown that ESA does not bind to cells that were treated with glycosidases, indicating importance of the carbohydrate chains on the surface of the cells for efficient ESA-cell interactions. Third, Span 80 vesicles with surface-bound ESA as active targeting ligand were shown to display sarcoma cell binding activity, leading to apoptosis and complete OST cell death after 48 hours at 2? g/ml ESA. The findings indicate that Span 80 vesicles with surface-bound ESA are a potentially useful drug delivery system not only for the treatment of carcinoma but also for the treatment of osteosarcoma. 1. Introduction Osteosarcoma has one of the worst prognosis among all malignant tumors. Before 1970, the 5-year survival rate of the treated patients was only about 20% [1, 2]. The treatment of osteosarcoma currently involves surgical resection in combination with neoadjuvant chemotherapy. Despite advances in the neoadjuvant chemotherapy and in limb-salvage surgery, the disease-free survival rate still remains poor for patients with metastatic, recurrent, or unresectable osteosarcoma. Thus, novel selective therapeutic approaches against osteosarcoma are highly required. Previously, we found that the novel lectin Eucheuma serra agglutinin (ESA), which was successfully isolated by Kawakubo et al. [3] from the marine red alga Eucheuma serra, specifically binds to carcinoma cell lines of human adenocarcinoma, human cervical squamous cell carcinoma, and marine adenocarcinoma but not to normal human fibroblasts or lymphocytes [4]. We also revealed, that the specific binding of ESA to carcinoma cells is based on specific interactions between ESA and the unique sugar chains of high mannose type on the surface of the carcinoma cells [4]. In a more recent study, Hori et al. [5] investigated the specific interactions between ESA and various unique sugar chains of high mannose type in detail. Furthermore, we successfully elaborated the basis for a novel type of drug delivery system (DDS) for cancer
Characteristic study of silicon sensor for ILD ECAL
Shusuke Takada,Hiroto Hirai,Kiyotomo Kawagoe,Yohei Miyazaki,Yuji Sudo,Taikan Suehara,Hiroki Sumida,Tatsuhiko Tomita,Hiraku Ueno,Tamaki Yoshioka
Physics , 2015,
Abstract: Excellent jet energy measurement is important at the International Linear Collider (ILC) because most of interesting physics processes decay into multi-jet final states. We employ a particle flow method to reconstruct particles, hence International Large Detector (ILD) needs high spatial resolution which can separate each particle in jets. We study pixelized silicon sensors as active material of ILD Silicon electro- magnetic calorimeter (SiECAL). This paper reports studies of temperature and humidity dependence on dark current and response of laser injection.
A Comment on Reis  [PDF]
Kenji Miyazaki
Theoretical Economics Letters (TEL) , 2011, DOI: 10.4236/tel.2011.13019
Abstract: This note gives a counterexample on Reis [1]. Using a certain family of utility functions, this note not only gives a sharper representation than that of Reis but also demonstrates that interest rate inelastic money demand does not lead to superneutrality. This implies that superneutrality does not exist when uncerinty is introduced.
Incentives in Public and Privatized Firms under Incomplete Contracting Situations  [PDF]
Takeshi Miyazaki
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.23059
Abstract: It is argued that incentives for employees in the public service agencies will necessarily be weak because of the multiple dimensions of products, multiple principals, incomplete contract, and socializing. Some empirical studies refer to incomplete contracting situations as part of the cause of the diminishing of the public sector. This work investigates the effects of privatization and ownership shares on incentive schemes for employees who work for public or privatized firms under incomplete contracting situations. Two main results are obtained. First, the incentive intensity of public firms decreases as the government has more ownership shares, and the social benefit declines. Second, privatized firms offer their employees higher-powered incentive contracts than do public firms.
A study of silicon sensor for ILD ECAL
Tatsuhiko Tomita,Shion Chen,Daniel Jeans,Yoshio Kamiya,Kiyotomo Kawagoe,Sachio Komamiya,Chihiro Kozakai,Yohei Miyazaki,Taikan Suehara,Yuji Sudo,Hiraku Ueno,Tamaki Yoshioka
Physics , 2014,
Abstract: The International Large Detector (ILD) is a proposed detector for the International Linear Collider (ILC). It has been designed to achieve an excellent jet energy resolution by using Particle Flow Algorithms (PFA), which rely on the ability to separate nearby particles within jets. PFA requires calorimeters with high granularity. The ILD Electromagnetic Calorimeter (ECAL) is a sampling calorimeter with thirty tungsten absorber layers. The total thickness of this ECAL is about 24 X$_0$, and it has between 10 and 100 million channels to make high granularity. Silicon sensors are a candidate technology for the sensitive layers of this ECAL. Present prototypes of these sensors have 256 5.5$\times$5.5 mm$^2$ pixels in an area of 9$\times$9 cm$^2$.We have measured various properties of these prototype sensors: the leakage current, capacitance, and full depletion voltage. We have also examined the response to an infrared laser to understand the sensor's response at its edge and between pixel readout pads, as well the effect of different guard ring designs. In this paper, we show results from these measurements and discuss future works.
Groups of volume-preserving diffeomorphisms of noncompact manifolds and mass flow toward ends
Tatsuhiko Yagasaki
Mathematics , 2008,
Abstract: Suppose M is a noncompact connected oriented C^infty n-manifold and omega is a positive volume form on M. Let D^+(M) denote the group of orientation preserving diffeomorphisms of M endowed with the compact-open C^infty topology and D(M; omega) denote the subgroup of omega-preserving diffeomorphisms of M. In this paper we propose a unified approach for realization of mass transfer toward ends by diffeomorphisms of M. This argument together with Moser's theorem enables us to deduce two selection theorems for the groups D^+(M) and D(M; omega). The first one is the extension of Moser's theorem to noncompact manifolds, that is, the existence of sections for the orbit maps under the action of D^+(M) on the space of volume forms. This implies that D(M; omega) is a strong deformation retract of the group D^+(M; E^omega_M) consisting of h in D^+(M) which preserves the set E^omega_M of omega-finite ends of M. The second one is related to the mass flow toward ends under volume-preserving diffeomorphisms of M. Let D_{E_M}(M; omega) denote the subgroup consisting of all h in D(M; omega) which fix the ends E_M of M. S.R.Alpern and V.S.Prasad introduced the topological vector space S(M; omega) of end charges of M and the end charge homomorphism c^omega : D_{E_M}(M; omega) to S(M; omega), which measures the mass flow toward ends induced by each h in D_{E_M}(M; omega). We show that the homomorphism c^omega has a continuous section. This induces the factorization D_{E_M}(M; omega) cong ker c^omega times S(M; omega) and it implies that ker c^omega is a strong deformation retract of D_{E_M}(M; omega).
Local and end deformation theorems for uniform embeddings
Tatsuhiko Yagasaki
Mathematics , 2013,
Abstract: A local deformation property for uniform embeddings in metric manifolds (LD) is formulated and its behaviour is studied in a formal view point. It is shown that any metric manifold with a geometric group action, typical metric spaces (Euclidean space, hyperbolic space and cylinders) and for \kappa \leq 0 the \kappa-cone ends over any compact Lipschitz metric manifolds, all of them have the property (LD). We also formulate a notion of end deformation property for uniform embeddings over proper product ends (ED). For example, the 0-cone end over a compact metric manifold has the property (ED) if it has the property (LD). It is shown that if a metric manifold M has finitely many proper product ends with the property (ED), then the group of bounded uniform homeomorphisms of M endowed with the uniform topology admits a strong deformation retraction onto the subgroup of bounded uniform homeomorphisms which are identity over those ends. We also study a role of uniform isotopies in deformation of uniform homeomorphisms and show that Alexander isotopies in \kappa-cones induce contractions of some subgroups of groups of bounded uniform homeomorphisms.
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