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Search Results: 1 - 10 of 902 matches for " Tatjana Vlajnic "
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Annular pancreas associated with duodenal carcinoma
Enrico Br?nnimann, Silke Potthast, Tatjana Vlajnic, Daniel Oertli, Oleg Heizmann
World Journal of Gastroenterology , 2010,
Abstract: Annular pancreas (AP) is a rare congenital anomaly. Coexisting malignancy has been reported only in a few cases. We report what is, to the best of our knowledge, the first case in the English literature of duodenal adenocarcinoma in a patient with AP. In a 55-year old woman with duodenal outlet stenosis magnetic resonance cholangiopancreatography showed an aberrant pancreatic duct encircling the duodenum. Duodenojejunostomy was performed. Eight weeks later she presented with painless jaundice. Duodenopancreatectomy revealed a duodenal adenocarcinoma, surrounded by an incomplete AP. Thus, co-existent malignancy with AP can be present without obstructive jaundice and without being visible through preoperative diagnostics.
Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients
Inti Zlobec, Francesca Molinari, Vittoria Martin, Luca Mazzucchelli, Piercarlo Saletti, Rosangela Trezzi, Sara De Dosso, Tatjana Vlajnic, Milo Frattini, Alessandro Lugli
World Journal of Gastroenterology , 2010,
Abstract: AIM: To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colorectal cancer (mCRC) patients.METHODS: Forty-three patients with mCRC treated with cetuximab or panitumumab were entered into this study. According to the Response Evaluation Criteria in Solid Tumors criteria, 30 patients had stable or progressive disease (non-responsive), while 13 patients had a partial response. Tumor buds were evaluated from whole tissue sections stained for pan-cytokeratin, evaluated in the densest region using a 40 × objective and “high-grade” tumor budding was defined as 15 buds/high-power field.RESULTS: Tumor buds and K-RAS mutation both correctly classified 68% of patients. All patients with K-RAS mutation (n = 7) or high-grade tumor budding (n = 11) were non-responsive, of which 4 patients had both features. All 13 partial responders were K-RAS wild-type with low-grade tumor budding. Combined, the predictive value of K-RAS and tumor budding was 80%. Additionally, high-grade tumor budding was significantly related to worse progression-free survival [HR (95% CI): 2.8 (1.3-6.0, P = 0.008)].CONCLUSION: If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting.
Characterization of Thin Films by Low Incidence X-Ray Diffraction  [PDF]
Mirtat Bouroushian, Tatjana Kosanovic
Crystal Structure Theory and Applications (CSTA) , 2012, DOI: 10.4236/csta.2012.13007
Abstract: Glancing Angle X-ray Diffraction (GAXRD) is introduced as a direct, non-destructive, surface-sensitive technique for analysis of thin films. The method was applied to polycrystalline thin films (namely, titanium oxide, zinc selenide, cadmium selenide and combinations thereof) obtained by electrochemical growth, in order to determine the composition of ultra-thin surface layers, to estimate film thickness, and perform depth profiling of multilayered heterostructures. The experimental data are treated on the basis of a simple absorption-diffraction model involving the glancing angle of X-ray incidence.
Axisymmetric Strain Stability in Sheet Metal Deformation  [PDF]
Tatjana V. Brovman
International Journal of Nonferrous Metallurgy (IJNM) , 2013, DOI: 10.4236/ijnm.2013.23016
Abstract: Production of axisymmetric pieces by technology of sheet metal drawing is widespread nowadays. So the calculation analysis of capacity and forces necessary for deformation is of special interest. The length of cylindrical pieces with axisymmetric deformation is limited by loss of stability and buckling due to the development of side strains. A new technological process is based on making considerable number of folds—18 - 26 with the amplitude of 0.8 - 0.9 mm— before the deformation or immediately after the partial one. That reduces the stiffness of billets and prevents from development of large size buckles. A new technological process is developed for producing a long run of high-quality products.
Development and Evaluation of the Posttraumatic Growth Status Inventory  [PDF]
Tatjana Alexander, Rainer Oesterreich
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.411120
Abstract:


Posttraumatic growth reflects beneficial psychological processes in persons with traumatic experiences. Existing measures of growth were criticized due to their retrospective self-report format that may cause biases in capturing the growth processes in individuals with several specific kinds of trauma, such as physical or psychological disabilities of close family members, bereavement and some others kinds of traumatic experience. In this case, the feelings of guilt may prevent the persons from being aware of the favorable personal changes. The objective of this study was to develop and to evaluate an alternative measuring instrument that uses a status quo response format instead of retrospective items and covers additional areas of growth-related changes. The samples comprised 440 adult persons with traumatic experience, including 181 parents of children with mental and/or physical disabilities. Exploratory and confirmatory factor analyses revealed a 7-factors solution, corresponding to the following subscales: Relationships to Others, New Possibilities, Personal Strength, Appreciation of Life, Spiritual Changes, Generativity, and Openness. Results showed good reliability and concurrent validity. The PGSI is recommended particularly for use in longitudinal studies as well as in samples of persons whose trauma relates to a severe psychological or physical disability in their families.


Sheet Bending Deformation in Production of Thin-Walled Pipes  [PDF]
Tatjana V. Brovman
World Journal of Mechanics (WJM) , 2014, DOI: 10.4236/wjm.2014.412035
Abstract: Nowadays, thin-walled super-diameter pipes are produced by the method of plastic bending of sheets. After a sheet is bent into a pipe and its ends are welded, a pipe billet is subjected to expansion deformation. The technology of forming end areas of a sheet is developed and formulaes forming forces equations are deduced. Experimental investigations of deformation are undertaken.
Raising a Child with Down Syndrome: Do Preferred Coping Strategies Explain Differences in Parental Health?  [PDF]
Tatjana Alexander, Julia Walendzik
Psychology (PSYCH) , 2016, DOI: 10.4236/psych.2016.71005
Abstract: The aim of this study was to determine coping strategies which may represent important personal resources and have a buffering effect in preventing mental health problems in parents of children with Down syndrome. Forty-nine parents of children with Down syndrome completed self-administrated measures of psychological and physical health problems, and coping behaviour, using several established measuring instruments. According to the hierarchical regression analyses, parents who often used regenerative coping strategies, and who experienced positive personal changes in terms of posttraumatic growth suffered from less anxiety and somatisation symptoms, whereas dysfunctional coping was the best predictor for parental depression and physical symptoms. Regenerative coping mediated between parental tendency to recognize their emotional needs and somatisation symptoms. Intervention programs for families of children with Down syndrome may benefit if they address parents’ reflection about their feelings, foster posttraumatic growth processes, and impart knowledge about long-term regenerative coping strategies.
Gene-Environment Interaction: A Genetic-Epidemiological Approach
Tatjana Pekmezovi
Journal of Medical Biochemistry , 2010, DOI: 10.2478/v10011-010-0021-z
Abstract: Classical epidemiology addresses the distribution and determinants of diseases in populations, and the factors associated with disease causation, with the aim of preventing disease. Both genetic and environmental factors may contribute to susceptibility, and it is still unclear how these factors interact in their influence on risk. Genetic epidemiology is the field which incorporates concepts and methods from different disciplines including epidemiology, genetics, biostatistics, clinical and molecular medicine, and their interaction is crucial to understanding the role of genetic and environmental factors in disease processes. The study of gene-environment interaction is central in the field of genetic epidemiology. Gene-environment interaction is defined as a different effect of an environmental exposure on disease risk in persons with different genotypes, or, alternatively, a different effect of a genotype on disease risk in persons with different environmental exposures. Five biologically plausible models are described for the relations between genotypes and environmental exposures, in terms of their effects on disease risk. Therefore, the study of gene-environment interaction is important for improving accuracy and precision in the assessment of both genetic and environmental factors, especially in disorders of less defined etiology. Genetic epidemiology is also applied at the various levels of disease prevention.
Homogeneous cones and abelian theorems
Tatjana Ostrogorski
International Journal of Mathematics and Mathematical Sciences , 1998, DOI: 10.1155/s0161171298000908
Abstract: This paper deals with analysis on homogeneous cones in ¢ n. This subject has its origins in one-dimensional topics that are connected, often implicitely, with some group properties. The homogeneous cones are open convex cones in ¢ n that are at the same time homogeneous spaces, and they are more general than the classical, or symmetric cones. As an example of application of the theory of homogeneous cones we study the asymptotic behaviour of some integral transforms.
Filosofiniai Senekos ra tai: humanizmo pamokos? | Seneca’s philosophic writings: lessons of humanism?
Tatjana Aleknien?
Literatura , 2005,
Abstract: Seneca’s name is often associated with the notion of humanism“. In this article we attempt to verify and define the meaning of this notion in the context of Seneca’s writings. Our question is: what kind of philosophy, according to Seneca, can be useful and delivering to a man afflicted with life’s many misfortunes? This question encompasses all the main meanings of both Latin humanitas and later European “humanism”, because it concerns “humanities” (humanitas as paide%a), which best of all suites the true human nature (humanitas as the true essence of human being); we also ask: what should philosophic education be so that it helps the struggling humankind (humanitas as filanqrwp%a). Such an amalgam of ideas is not our construct, but is actually found in the writings by Seneca himself. However, in this way following Seneca’s thought, we discover rather paradoxical species of “humanism”, the one which should be called “cosmo-centrism”.
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