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Search Results: 1 - 10 of 15275 matches for " Tang ML "
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Clinical implementation of RNA signatures for pharmacogenomic decision-making
Tang W, Hu Z, Muallem H, Gulley ML
Pharmacogenomics and Personalized Medicine , 2011, DOI: http://dx.doi.org/10.2147/PGPM.S14888
Abstract: ical implementation of RNA signatures for pharmacogenomic decision-making Review (2270) Total Article Views Authors: Tang W, Hu Z, Muallem H, Gulley ML Published Date September 2011 Volume 2011:4 Pages 95 - 107 DOI: http://dx.doi.org/10.2147/PGPM.S14888 Weihua Tang1, Zhiyuan Hu2, Hind Muallem1, Margaret L Gulley1,2 1Department of Pathology and Laboratory Medicine, 2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, NC, USA Abstract: RNA profiling is increasingly used to predict drug response, dose, or toxicity based on analysis of drug pharmacokinetic or pharmacodynamic pathways. Before implementing multiplexed RNA arrays in clinical practice, validation studies are carried out to demonstrate sufficient evidence of analytic and clinical performance, and to establish an assay protocol with quality assurance measures. Pathologists assure quality by selecting input tissue and by interpreting results in the context of the input tissue as well as the technologies that were used and the clinical setting in which the test was ordered. A strength of RNA profiling is the array-based measurement of tens to thousands of RNAs at once, including redundant tests for critical analytes or pathways to promote confidence in test results. Instrument and reagent manufacturers are crucial for supplying reliable components of the test system. Strategies for quality assurance include careful attention to RNA preservation and quality checks at pertinent steps in the assay protocol, beginning with specimen collection and proceeding through the various phases of transport, processing, storage, analysis, interpretation, and reporting. Specimen quality is checked by probing housekeeping transcripts, while spiked and exogenous controls serve as a check on analytic performance of the test system. Software is required to manipulate abundant array data and present it for interpretation by a laboratory physician who reports results in a manner facilitating therapeutic decision-making. Maintenance of the assay requires periodic documentation of personnel competency and laboratory proficiency. These strategies are shepherding genomic arrays into clinical settings to provide added value to patients and to the larger health care system.
Clinical implementation of RNA signatures for pharmacogenomic decision-making
Tang W,Hu Z,Muallem H,Gulley ML
Pharmacogenomics and Personalized Medicine , 2011,
Abstract: Weihua Tang1, Zhiyuan Hu2, Hind Muallem1, Margaret L Gulley1,21Department of Pathology and Laboratory Medicine, 2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, NC, USAAbstract: RNA profiling is increasingly used to predict drug response, dose, or toxicity based on analysis of drug pharmacokinetic or pharmacodynamic pathways. Before implementing multiplexed RNA arrays in clinical practice, validation studies are carried out to demonstrate sufficient evidence of analytic and clinical performance, and to establish an assay protocol with quality assurance measures. Pathologists assure quality by selecting input tissue and by interpreting results in the context of the input tissue as well as the technologies that were used and the clinical setting in which the test was ordered. A strength of RNA profiling is the array-based measurement of tens to thousands of RNAs at once, including redundant tests for critical analytes or pathways to promote confidence in test results. Instrument and reagent manufacturers are crucial for supplying reliable components of the test system. Strategies for quality assurance include careful attention to RNA preservation and quality checks at pertinent steps in the assay protocol, beginning with specimen collection and proceeding through the various phases of transport, processing, storage, analysis, interpretation, and reporting. Specimen quality is checked by probing housekeeping transcripts, while spiked and exogenous controls serve as a check on analytic performance of the test system. Software is required to manipulate abundant array data and present it for interpretation by a laboratory physician who reports results in a manner facilitating therapeutic decision-making. Maintenance of the assay requires periodic documentation of personnel competency and laboratory proficiency. These strategies are shepherding genomic arrays into clinical settings to provide added value to patients and to the larger health care system.Keywords: RNA, microarray, preanalytic, quality assurance, translational, clinical laboratory
Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability
Zha YY, Yang B, Tang ML, Guo QC, Chen JT, Wen LP, Wang M
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S30934
Abstract: ncentration-dependent effects of fullerenol on cultured hippocampal neuron viability Original Research (2460) Total Article Views Authors: Zha YY, Yang B, Tang ML, Guo QC, Chen JT, Wen LP, Wang M Published Date June 2012 Volume 2012:7 Pages 3099 - 3109 DOI: http://dx.doi.org/10.2147/IJN.S30934 Received: 16 February 2012 Accepted: 17 April 2012 Published: 29 June 2012 Ying-ying Zha,1 Bo Yang,1 Ming-liang Tang,2 Qiu-chen Guo,1 Ju-tao Chen,1 Long-ping Wen,3 Ming Wang1 1CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 2Suzhou Institute of NanoTech and NanoBionics, Chinese Academy of Sciences, Suzhou, 3Laboratory of Nano-biology, School of Life Sciences, University of Science and Technology of China, Hefei, People's Republic of China Background: Recent studies have shown that the biological actions and toxicity of the water-soluble compound, polyhydroxyfullerene (fullerenol), are related to the concentrations present at a particular site of action. This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons. Methods and results: Fullerenol at low concentrations significantly enhanced hippocampal neuron viability as tested by MTT assay and Hoechst 33342/propidium iodide double stain detection. At high concentrations, fullerenol induced apoptosis confirmed by Comet assay and assessment of caspase proteins. Conclusion: These findings suggest that fullerenol promotes cell death and protects against cell damage, depending on the concentration present. The concentration-dependent effects of fullerenol were mainly due to its influence on the reduction-oxidation pathway.
天然气稳定碳同位素比值数学模拟
tang,yperry,jk,jenden,pd,schoell,ml,郑军卫(译)
天然气地球科学 , 2002,
Abstract: ?根据理论和实验资料,提出了一种新的烃气稳定碳同位素比值数学模拟方法。动力学模型采用了一系列平行的一级天然气生成反应,发生同位素交换的与未发生同位素交换的化学键相对裂解率用方程式表示为:k*/k=(af*/af)exp(―△ea/rt)式中r为气体常量,t为温度。利用量子化学计算估计不同简单分子均裂键裂解的熵(af*/af)和焓(△ea)条件。例如,我们获得短链正构烷烃(≤c6)失去甲基官能团的平均△ea为42.0cal/mol,平均af*/af为1.021。甲烷的生成存在明显差异,预测在200℃的沉积盆地条件下短链正构烷烃产生13ch4的速率比产生12ch4的速率慢2.4%,但在500℃的实验室加热条件下仅慢0.7%。就其它分子均裂纹裂解所进行的类似计算也显示了相似的结果(除少数例外),△ea值介于0~60cal/mol之间,af*/af值介于1.00~1.04之间。大量数据处理结果揭示:(1)在△ea值和化学键裂解能之间存在弱的波型曲线关系;(2)在△ea值和af*/af值之间存在明显的正相关性。这些发现的重要意义在于可以采用适当的动力学模型阐明在恒温密闭系统条件下正十八烷生成甲烷的化学和同位素数据。根据特殊温度文,校正后的模型可以提供与油型干酪根和原油裂解有关的甲烷碳同位素组成、总甲烷生成量和甲烷产率问的定圣关来。不同甲烷源宕动力学反应的明显变化,必须根据特殊研究区域的实验室数据来对这些模型进行应用并充分校准。根据这种方法,天然气碳同位素数据不但可以用于估计沉积盆地中生气的时间,而且可以用于评价形成有效聚集的源宕成熟度,以及恢复圈闭充琪史。
A survey of European primitive breeds of sheep
ML Ryder
Genetics Selection Evolution , 1981, DOI: 10.1186/1297-9686-13-4-381
Abstract:
Social Wellbeing Predictor of illness behavior among HIV seropositive individuals
ML Imasiku
Medical Journal of Zambia , 2009,
Abstract: Objective: The objective of the present study was to compare the social wellbeing of HIV seropositive individuals and individuals the normative population who are not HIV positive to find out how social support affects physical well-being. Design: Amultiple group design was used to assess the intensity and impact of social support on HIV seropositive individuals, and individuals from the normative population. The study utilized a cohort method which lasted a period of four years. Main outcome measure: Social support and physical wellbeing Results: Totals of 120 subjects - drawn from different organizations/institutions in Zambia and India were enrolled into the study. The descriptive analysis of Indian participants shows that HIV seropositive who received inadequate social support obtained 65% on somatic symptoms while individuals from the normative population obtained 43.3% From Zambia 67% of the HIV seropositive individuals who received inadequate social support experienced somatic symptoms in the recent past as against 50% individuals from the normative population. Regarding social support from friends and family, the 'F' ratio for diagnosis and nationality was significant at 0.01 revealing that HIV+ individuals obtained the least social support. Correlation between the level of physical illness behavior [somatic symptoms] and social support from friends was found to be -0.389 while that for social support from family was - 0.307. This indicated that physical illness behavior is negatively and significantly correlated with perceived social support from friends and family. Conclusion: When the level of social support is perceived to be high by an individual, then it's likely that physical illness behavior will be low because those who had adequate social support from either their friends or families had less illness behaviour. The results therefore illustrate that less levels of social support and physical illness behavior seem to co-exist. Therefore provision of adequate social support should be included in the management and treatment of HIVseropositive individuals in order to enhance their quality of life.
Prevalence & characteristics of mothers with multiple pregnancies and associated labour complications at Muhimbili National Hospital, September 2005
ML Sikosana
Dar Es Salaam Medical Students' Journal , 2006,
Abstract: Objective: To determine the prevalence & characteristics of mothers with multiple pregnancies and associated labour complications at Muhimbili National Hospital Design: Retrospective Case control Study Subjects/Materials: A hospital based retrospective study. All women who delivered (live and still births) at Muhimbili National Hospital between January 2005 and June 2005 only. The required information was obtained from the record books of the Department of Obstetrics & Gynaecology. Results: Revealed incidence of multiple pregnancies was 30.1 per 1000 deliveries and a significant difference between the gestational ages at delivery between multiple pregnancies and controls. The twin pregnancies approximately 3 times more likely to deliver prematurely (odd ratio 3.90 {1.08
Therapeutic Potential of Statins in Age-related Macular Degeneration
ML Shahsuvaryan
Sierra Leone Journal of Biomedical Research , 2011,
Abstract: Age-related macular degeneration (ARMD) is the leading cause of irreversible vision loss, affecting one in three people aged 75 and above. Although exciting new pharmaceuticals to treat ARMD such as endothelial growth factor (VEGF) inhibitors, are now available, they are effective only in selected group of patients, and can be used only during a narrow time window. Monthly intravitreal anti-VEGF injections with systemic exposure to anti-VEGF could be replaced by new drugs taken in a non-invasive way. Statins are the most commonly used lipid lowering drugs. The objective of this review is therefore to evaluate the evidence and discuss the rationale behind the recent suggestions that statins may be useful in the prevention and the treatment of age-related macular degeneration. This review recognised that there are potentially multiple biological bases for the protective effect of statins on the risk of ARMD. Thus, it is time to conduct a randomised controlled trial to provide direct evidence of the effectiveness of specific type statin in lowering the incidence and progression of ARMD. New intervention as statins usage to prevent the development of age-related macular degeneration and its progression remain an important strategy to limit the morbidity due to this significant public health problem.
A comparative study of anxiety among HIV seropositive individuals, cancer patients and individuals from the normative population
ML Imasiku
Medical Journal of Zambia , 2008,
Abstract: Excessive anxiety contributes to a sense of helplessness in which a person feels little control over the present or future and continues maladaptive behaviour patterns. In view of the negative influence of long standing anxiety, the present study attempts to find an answer regarding the possible differences between the prevalence and impact of anxiety in HIV seropositive individuals, cancer patients and individuals from the normative population. Anxiety is a major health harzard in HIV seropositive individuals. This is so because it is probably one of the factors responsible for the quick progression of their HIV seropositive status to AIDS. Method: The sample consisted of 180 subjects. Half of these individuals (90) came from Zambia and the remaining 90 came from India. Out of each group of 90 individuals, 30 were HIV seropositive individuals, 30 were HIV negative but with cancer and 30 were individuals from the normative population (having none of the above two mentioned conditions i.e. HIV or Cancer). In Zambia, the sample was drawn from the University Teaching Hospital (UTH), Kara Counseling - Hope house, Mother Theresa Hospice and Network of Zambian people living with HIV (NZP+). In India the sample was drawn from Snehandan, Karnataka network for people living with HIV (KNP+), and Kidwai Hospital. The technique of assessment used was the Symptoms Questionnaire developed 1 used to assess anxiety and physical illness behavior (somatic symptoms). The data obtained was analyzed using‘t’ tests and analysis of covariance. In the present investigation an attempt was made to explore the intensity of anxiety in HIV+ individuals, Cancer patients and individuals from the normative population. Conclusion: The findings of the present study reveal that HIV+ individuals and cancer patients have higher levels of anxiety than individuals from the normative population. Anxiety is also found to be positively correlated with physical illness behavior. This indicates that high level of anxiety and physical illness behavior seem to co- exist. It’s therefore likely that a high level of anxiety is a core factor that might be responsible for the quick progression of HIV infection into AIDS.
Oral glycopyrrolate for the treatment of chronic severe drooling caused by neurological disorders in children
Evatt ML
Neuropsychiatric Disease and Treatment , 2011,
Abstract: Marian L EvattDepartment of Neurology, Atlanta Veterans Administration Hospital and Emory University School of Medicine, Atlanta, GA, USAAbstract: Excessive drooling may complicate the care of children with chronic neurological conditions by socially isolating both patients and families and by causing secondary dermatitis and infection. Normal control of saliva requires normal integrity of oral structures, normal oropharyngeal sensation, and motor functioning, as well as normal cognitive awareness and rate of salivary production. Glycopyrrolate is an anticholinergic medication with a quaternary structure that recently received Food and Drug Administration approval to treat sialorrhea due to neurological problems in children ages 3–16 years. This review summarizes the few published studies of safety and efficacy of glycopyrrolate for drooling in children with chronic neurological conditions.Keywords: drooling, sialorrhoea, sialorrhea, children, glycopyrrolate
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